Clinical trials: Functional Dysphagia, active
Eosinophilic Esophagitis (EoE)
Effect of Dupilumab on the Muscle Function of the Esophagus (food Pipe) in Participants with Eosinophilic Esophagitis (EoE)
The goal of this study is to research Dupilumab, an FDA approved medication in treating patients diagnosed with Eosinophilic esophagitis (EoE). The drug works by controlling allergic inflammation of the esophagus.
- Trial name
- NCT06665971
- Testing
- Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT]
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Eosinophilic Esophagitis (EoE), Dysphagia, Esophageal
The DiNAM-EoE-C Study: Esophageal Distensibility and Novel Assessment of Motility in Eosinophilic Esophagitis
Eosinophilic esophagitis is a chronic immune-mediated disease that may progress to fibrostenotic remodeling, leading to symptoms such as dysphagia, chest pain, and food impaction.
- Trial name
- DiNAM-EoE-C (NCT07708467)
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Gastroesophageal Reflux, Sleeve Gastrectomy
Post-sleeve Gastrectomy Gastroesophageal Reflux Disease Prediction
Researchers are trying to identify predictors for gastroesophageal reflux disease after sleeve gastrectomy.
- Conditions
- Gastroesophageal Reflux, Sleeve Gastrectomy, Bariatric Surgery Complication
- Trial name
- NCT04411823
- Testing
- EndoFLIP measurement
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic
Functional Gastrointestinal Disorders, Gastroesophageal Reflux
Prevalence and Natural History of Functional Gastrointestinal Disorders Among At-risk Infants.
The goal of this observational study is to learn about the prevalence and characteristics of functional gastrointestinal disorders (FGID) in at risk infants (former preterm infants and those with birth asphyxia) during the first…
- Conditions
- Functional Gastrointestinal Disorders, Gastroesophageal Reflux, Constipation - Functional, Diarrhea
- Trial name
- FUSID (NCT06031025)
- Testing
- Questionnaire, clinical examination
- Where
- Italy
- Volunteers
- 71 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Stroke, Dysphagia
Effect of Kinesiology Taping and Swallowing Exercises on Suprahyoid Muscle Thickness and Swallowing Function in Stroke Patients With Dysphagia
This randomized controlled single-blind study aims to investigate the effect of kinesiology taping combined with resistance exercises on suprahyoid muscle thickness and swallowing function in patients with stroke-related…
- Conditions
- Stroke, Dysphagia, Cerebrovascular Disorders
- Trial name
- NCT06988215
- Testing
- Kinesiology Taping with Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Acute Stroke, Dysphagia
The Effects of Chin Tuck Against Resistance Exercise on Acute Stroke Patients With Dysphagia
The aim of this study is to investigate the effects of chin tuck against resistance exercise on swallowing function, depression, and quality of life in acute stroke patients with dysphagia.
- Trial name
- NCT06674356
- Testing
- chin tuck against resistance exercise
- Where
- Taiwan
- Volunteers
- 74 people
- Sponsor
- National Taiwan University Hospital
ALS, Respiratory Insufficiency
Combined Respiratory Training in Persons With ALS
The goal of this interventional trial is to learn about lung volume recruitment (LVR) and expiratory muscle strength training (EMST) in a total of up to 39 patients diagnosed with ALS. The following aims will be addressed: 1.
- Conditions
- ALS, Respiratory Insufficiency, Dysphagia
- Trial name
- NCT05913882
- Testing
- Respiratory Muscle Strength Training (LVR+EMST)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Nova Southeastern University
Dysphagia
Effect of Direct Chin-tuck Against Resistance on Swallowing Function
Chin-tuck Against Resistance (CTAR) is a widely used training method in swallowing rehabilitation that strengthens the suprahyoid muscles, enhancing their contraction during swallowing and promoting the anterior-superior movement…
- Trial name
- NCT07479680
- Testing
- dCTAR
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Mitral Valve (MV) Regurgitation
A Prospective, Multicenter, Single-Arm Study to Support the Clinical Evidence Base for MRace as a Treatment Option for FMR Patients With Complex M-TEER Anatomies (AU)
A pilot study to evaluate the safety and performance of the MRace System to treat severe mitral regurgitation and to gather data on its performance thereby providing guidance for future clinical development.
- Trial name
- ACCESS-MR (AU) (NCT07757698)
- Testing
- Transcatheter mitral valve repair
- Volunteers
- 15 people
- Sponsor
- Polares Medical SA
Dysphagia, Swallowing Disorder
SURE Trial: Swallowing Ultrasound Reliability Evaluation Trial
This study aims to explore the reliability of using ultrasonography (US) for the assessment of swallowing function in patients with dysphagia.
- Trial name
- NCT07098767
- Testing
- ultrasound evaluation, Fiberoptic endoscopic evaluation of swallowing (FEES)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Irritable Bowel Syndrome, Gallstone Disease
Pharmacokinetics, Bioequivalence, and Safety Study of Trimedat® 76,95 mg Orally Disintegrating Tablets and Trimedat® 100 mg Tablets in Healthy Volunteers.
This study aims to evaluate pharmacokinetic profile, safety and establish bioequivalence of the investigational drug Trimedat® 76,95 mg orally disintegrating tablets compared to the reference drug Trimedat® 100 mg tablets in…
- Conditions
- Irritable Bowel Syndrome, Gallstone Disease, GERD, Biliary Dyskinesia
- Trial name
- NCT07421011
- Testing
- Trimedat®
- Where
- Russia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Valenta Pharm JSC
Infantile Colic, Gastroesophageal Reflux (GER)
BioAmicus Complete for Functional Gastrointestinal Symptoms in Infants Aged 0 to 24 Months
Infants often experience functional gastrointestinal symptoms (e.g., colic, excessive gas, regurgitation, constipation, or loose stools) that distress families and may reflect an imbalance of the gut microbiome.
- Conditions
- Infantile Colic, Gastroesophageal Reflux (GER), Functional Constipation, Functional Diarrhea
- Trial name
- CTBE2503 (NCT07148583)
- Testing
- BioAmicus Complete, Usual Care (No Probiotic)
- Where
- Vietnam
- Volunteers
- 110 people
- Sponsor
- Haiphong University of Medicine and Pharmacy
ALS (Amyotrophic Lateral Sclerosis), ALS - Amyotrophic Lateral Sclerosis
Tongue-strengthening Exercises in People With ALS.
This study is testing a tongue exercise program for people living with ALS to see if it can help support speech and swallowing. All participants will receive the treatment, and researchers will measure changes over time by…
- Trial name
- NCT07295990
- Testing
- Isometric Lingual Strength Exercises
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Nova Southeastern University
Dysphagia, Esophageal
Striated Esophageal Motor Function Modulation in Health and Disease
The investigators hypothesize that striated esophagus deglutitive motor function is modulated by pharyngeal phase swallowing biomechanics.
- Trial name
- NCT05708885
- Testing
- Concurrent manometry/impedance and fluoroscopy with and without laryngeal restriction, Concurrent manometry/impedance and fluoroscopy before and after six weeks of using swallow muscle exercising device
- Where
- United States
- Volunteers
- 557 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Oral Dryness and Saliva Altered, Oral Manifestations
The Effects of Using Augmented Reality (AR) System to Train Foreign Care Workers.
The aim of this study was to evaluate the effect of augmented reality (AR) system training intervention of foreign care workers on the salivary biomarker and oral function of older people.
- Conditions
- Oral Dryness and Saliva Altered, Oral Manifestations, Swallowing Disorder
- Trial name
- NCT05938166
- Testing
- oral care augmented reality (AR), video-based oral hygiene education course
- Where
- Taiwan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Mitral Valve (MV) Regurgitation
A Prospective, Multicenter, Single-Arm Study to Support the Clinical Evidence Base for MRace as a Treatment Option for FMR Patients With Complex M-TEER Anatomies (FR)
A pilot study to evaluate the safety and performance of the MRace System to treat severe mitral regurgitation and to gather data on its performance thereby providing guidance for future clinical development.
- Trial name
- ACCESS-MR (FR) (NCT07757607)
- Testing
- Transcatheter mitral valve repair (MRace Implant and Delivery System)
- Volunteers
- 20 people
- Sponsor
- Polares Medical SA
Gastro Esophageal Reflux
Esophageal and Gastric Registry and Biorepository
The evaluation of the foregut, the esophagus and stomach, has come a long way over the past two decades, and continues to experience exciting discoveries in the clinical evaluation of foregut physiology.
- Trial name
- NCT05180253
- Testing
- Esophageal studies
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Esophageal Achalasia
Effects of Malnutrition on Respiratory and Renal Functions in Patients Undergoing Peroral Endoscopic Myotomy (POEM)
The hypothesis of this study is to investigate cardiorespiratory and renal complications in patients under general anesthesia undergoing POEM surgery.
- Trial name
- NCT06405412
- Testing
- MUST malnutrition score
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Umraniye Education and Research Hospital
Dysphagia, Dysphagia, Swallowing Function, Diet Modification, Dysphagia Diet, Diet Standardization
GUSS-ICU Safe Nutrition Program After Extubation in ICU Patients
The aim of this study is to evaluate the effects of using the GUSS-ICU Safe Nutrition Program after extubation in Intensive Care Unit patients.
- Trial name
- NCT07195383
- Testing
- Nutrion plan based on GUSS-ICU scale
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Istanbul University - Cerrahpasa
Multiple Sclerosis, Nutrition
Nutritional Status and Muscle Function in Ambulatory Multiple Sclerosis Patients With Dysphagia
The aim of this study is to evaluate the relationship between dysphagia severity and indicators of nutritional status and muscle function in ambulatory patients diagnosed with Multiple Sclerosis (MS) who have swallowing…
- Conditions
- Multiple Sclerosis, Nutrition, Swallowing
- Trial name
- NCT07564921
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Sanko University