Clinical trials: Functional Bowel Disorder, active
IBS - Irritable Bowel Syndrome, IBS
Ebastine Versus Mebeverine in IBS Patients
Multicenter randomized controlled clinical trial comparing ebastine and mebeverine as treatment of irritable bowel syndrome Trial rationale 1.
- Trial name
- NCT05815602
- Testing
- Ebastine, Duspatalin
- Where
- 5 sites in Belgium
- Volunteers
- 200 people
- Sponsor
- Guy Boeckxstaens
Functional Constipation, Irritable Bowel Syndrome
NutriPlant - Opportunities for Increasing Consumption of Local Fruits and Vegetables
The effects of different foods to normal bowel function in adult population will be investigated. A randomised controlled intervention trial will be conducted on about 120 (30 per group) adult (18-70 years) subjects with…
- Trial name
- NutriPlant (NCT06785831)
- Testing
- Psyllium, Sauerkraut, Fresh apples
- Where
- Slovenia
- Volunteers
- 120 people
- Sponsor
- Institute of Nutrition, Slovenia (Nutris)
Irritable Bowel Syndrome (IBS)
Prospective Observational Study of Naturopathic Approaches to IBS
Irritable bowel syndrome (IBS) is a common condition affecting about 4% of people worldwide and can significantly impact quality of life and healthcare costs.
- Trial name
- NCT06721624
- Testing
- Naturopathic medicine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National University of Natural Medicine
Early Gastric Cancer, Adenocarcinoma of the Stomach
SPADE Clinical Trial.
Purpose: This multicenter, prospective, single-arm phase 2 clinical trial aims to evaluate the safety, feasibility, and clinical outcomes of the SPADE operation (Spade-Shaped Anastomosis) in patients undergoing laparoscopic or…
- Conditions
- Early Gastric Cancer, Adenocarcinoma of the Stomach, Proximal Gastric Cancer, SPADE Operation
- Trial name
- SPADE (NCT07892183)
- Testing
- Spade-Shaped Anastomosis after Laparoscopic or Robotic Proximal Gastrectomy Using Double Suture Anchoring between the Posterior Wall of the Esophagus and the Anterior Wall of the Stomac
- Where
- South Korea
- Volunteers
- 159 people
- Sponsor
- National Cancer Center, Korea
Bodily Distress Syndrome, Functional Somatic Disorder
DISTRESS Trial Functional Disorders - the DISTRESS Trial
A Diagnostic Clinic for Functional Somatic Disorders (FSD) has been set up at the outpatient diagnostic center at Regionshospitalet Silkeborg.
- Trial name
- DISTRESS (NCT06025617)
- Testing
- Diagnostic evaluation at the Diagnostic Clinic for Functional Disorders, Diagnostic as usual
- Where
- Denmark
- Volunteers
- 290 people
- Sponsor
- Regionshospitalet Silkeborg
Irritable Bowel Syndrome (IBS), Small Intestinal Bacterial Overgrowth Syndrome (SIBO)
Herbal Supplement (Biocidin REMOVE) for Bacterial Overgrowth in Irritable Bowel Syndrome
The goal of this clinical trial is to learn if an herbal supplement called Biocidin REMOVE can clear small intestinal bacterial overgrowth (SIBO) in adults with irritable bowel syndrome (IBS).
- Trial name
- NCT07768267
- Testing
- Biocidin REMOVE
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Irritable Bowel Syndrome
Donor Versus Autologous Fecal Microbiota Transplantation for Irritable Bowel Syndrome
Many patients with irritable bowel syndrome (IBS) do not experience adequate symptom relief with current treatments. The pathophysiology of IBS is diverse, controversial and not completely understood.
- Trial name
- NCT04691544
- Testing
- Fecal microbiota transplantation (FMT)
- Where
- Norway
- Volunteers
- 450 people
- Sponsor
- University Hospital of North Norway
Crohn Disease, Ulcerative Colitis
Safety and Efficacy of Fecal Microbiota Transplantation
The gut microbiota is critical to health and functions with a level of complexity comparable to that of an organ system. Dysbiosis, or alterations of this gut microbiota ecology, have been implicated in a number of disease…
- Conditions
- Crohn Disease, Ulcerative Colitis, Celiac Disease, Irritable Bowel Syndrome
- Trial name
- NCT04014413
- Testing
- Fecal Microbiota Transplantation
- Where
- Hong Kong
- Volunteers
- 450 people
- Sponsor
- Chinese University of Hong Kong
Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma
Understanding New Cachexia Subtypes Through Observational Epidemiological Research
The UNCOVER study is a longitudinal observational cohort focused on patients at high risk for cancer cachexia. At Kaiser Permanente Northern California, up to 800 individuals with advanced or unresectable non-small cell lung…
- Conditions
- Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma, Advanced Pancreatic Adenocarcinoma, Stage IV Colorectal Cancer AJCC v8
- Trial name
- UNCOVER (NCT07776353)
- Testing
- Biospecimen Collection, Computed Tomography, Electronic health record review
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Kaiser Permanente
Irritable Bowel Syndrome, Dyspepsia
Visible Abdominal Distension
Background. Abdominal distention is produced by an abnormal somatic postural tone. The authors developed an original biofeedback technique.
- Conditions
- Irritable Bowel Syndrome, Dyspepsia, Functional Bloating
- Trial name
- NCT06369753
- Testing
- Biofeedback
- Where
- 7 sites in United States, Canada and 5 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Irritable Bowel Syndrome
Effects of Vivatlac Synbiotic on Gut Micribiota of IBS Patients
Multi-center, randomized, double-blind, placebo-controlled, 12 weeks trial investigating the effects of a nine-strain synbiotic (Vivatlac Synbiotikum) on the gut microbiota of IBS patients
- Trial name
- ViIBS3 (NCT07235228)
- Testing
- Vivatlac Synbiotic
- Where
- 2 sites in Poland
- Volunteers
- 20 people
- Sponsor
- The President Stanisław Wojciechowski State University of Applied Sciences in Kalisz
Type 2 Diabetes
Diet With or Without Metarecod® in Obese Subjects With Type 2 Diabetes
Obesity is considered the largest chronic non-communicable disease (globesity) worldwide with a growing trend in the near future.
- Trial name
- MONDO (NCT06813170)
- Testing
- Metarecod, Diet
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Neurogenic Bowel Dysfunction, Spinal Cord Injury
Kinesio Taping for Neurogenic Bowel Dysfunction in Spinal Cord Injury
Neurogenic bowel dysfunction is a common complication of spinal cord injury and may cause constipation, difficulty with defecation, prolonged bowel care, incomplete evacuation, fecal incontinence, and reduced quality of life.
- Trial name
- NCT07705984
- Testing
- Kinesio Taping, Routine Bowel Management Program
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Pamukkale University
Diabetes Mellitus, Type 2, End Stage Renal Disease
Drug Interaction Potential of Pro-Inflammatory Conditions
Pro-inflammatory cytokines, which are elevated in pro-inflammatory disease states (e.g., type II diabetes mellitus [T2DM], irritable bowel diseases [IBD], and end stage renal disease [ESRD]) have been shown to inhibit hepatic…
- Conditions
- Diabetes Mellitus, Type 2, End Stage Renal Disease, Irritable Bowel Syndrome
- Trial name
- DIPPIC (NCT07360938)
- Testing
- None (Observational)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Irritable Bowel Syndrome, Lactose Intolerance
The Role of Irritable Bowel Syndrome in Lactose Intolerance (LION)
Irritable bowel syndrome (IBS) is a functional gastrointestinal disease. There is no well-defined pharmacological treatment. This clinical trial is a prospective, double-blind, two-armed randomized controlled, single-center…
- Conditions
- Irritable Bowel Syndrome, Lactose Intolerance, Lactose Malabsorption
- Trial name
- LION (NCT05100719)
- Testing
- alverine-citrate + simethicone and lactase
- Where
- Hungary
- Volunteers
- 200 people
- Sponsor
- University of Pecs
Rectal Cancer
The Impact of Probiotic Intervention on the Gut Microbiota and Bowel Function
This study aims to propose a novel, easy-to-operate intervention strategy that effectively improves defecation function after stoma reversal and to assess its impact on the gut microbiota.The efficacy and safety of antegrade…
- Trial name
- NCT07369830
- Testing
- Clostridium butyricum (live) Tablets(Meiya)
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Huashan Hospital
Functional Gastrointestinal Disorders (FGIDs), Cyclic Vomiting Syndrome
Autonomic Reactivity and Personalized Neurostimulation
Disorders of gut-brain interaction (DGBI) affect up to 25% of U.S. children. Patients often suffer from disabling, multisystem comorbidities that suggest a common root (sleep disturbances, fatigue, anxiety, etc).
- Conditions
- Functional Gastrointestinal Disorders (FGIDs), Cyclic Vomiting Syndrome, Functional Dyspepsia, Dysautonomia
- Trial name
- NCT06863207
- Testing
- Percutaneous electrical nerve field stimulation, Hypnotherapy
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Disorders of Gut-brain Interaction, Inflammatory Bowel Disease (IBD)
A Pilot Study Using Gut-Directed Hypnotherapy for Hospitalized Patients
The purpose of the study is to compare the effectiveness of recorded gut-directed hypnosis to an educational recording in people with chronic problems in their gastrointestinal (GI) system.
- Conditions
- Disorders of Gut-brain Interaction, Inflammatory Bowel Disease (IBD), Irritable Bowel Syndrome, Abdominal Pain
- Trial name
- NCT07676136
- Testing
- Gut directed hypnotherapy via telephone intervention, Educational recording
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Stanford University
Rectal Cancer, Surgical Anastomosis
The Impact of Two-Stage Turnbull-Cutait Pull-Through Coloanal Anastomosis on Stoma-free Survival in Low Rectal Anal-preserving Surgery
The goal of this clinical trial is to explore the difference in 3-year stoma-free survival between the Turnbull-Cutait delayed coloanal anastomosis (TCA) surgery and the low anterior resection combined with protective stoma (LAR)…
- Conditions
- Rectal Cancer, Surgical Anastomosis, Survival , Tumor, Anal Function
- Trial name
- FIAS (NCT07369531)
- Testing
- Turnbull-Cutait anastomosis, LAR
- Where
- 2 sites in China
- Volunteers
- 520 people
- Sponsor
- The First Hospital of Jilin University
Irritable Bowel Syndrome
Effect of Neurodynamic Mobilization of Vagus Nerve on Irritable Bowel Syndrome in Women
goal of this interventional study to investigate the effect of neurodynamic mobilization of vagus nerve on irritable bowel syndrome in women.
- Trial name
- NCT07560345
- Testing
- neurodynamic mobilization of vagus nerve, Standard care
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Cairo University