Clinical trials: Frailty
Frailty, Caregiver Burden
Benefits of Strength Training in Informal Caregivers of Patients With Alzheimer's Disease
Informal caregivers of people with Alzheimer's disease experience high physical and psychological burden, increasing their risk of frailty, anxiety, and caregiver burnout.
- Conditions
- Frailty, Caregiver Burden, Anxiety
- Trial name
- NCT07388186
- Testing
- Progressive Muscle Relaxation, Functional Strength Training
- Where
- Spain
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Heart Failure, Acute Heart Failure (AHF)
OPTIMUM Study of Remote Patient Monitoring in Ambulatory Heart Failure Care
Heart failure is a leading cause of hospitalization and readmission, particularly among older adults with multiple comorbidities.
- Trial name
- OPTIMUM (NCT07439081)
- Testing
- Satelia® Cardio Remote Patient Monitoring System
- Where
- France
- Volunteers
- 504 people
- Sponsor
- Médipôle Lyon-Villeurbanne
Heart Failure
AI-Based Conversational Social Support for Older Adults With Heart Failure
This three-year study aims to investigate gender differences in social frailty and evaluate the effects of an artificial intelligence (AI)-based conversational social-support intervention among older adults with chronic heart…
- Trial name
- NCT07862933
- Testing
- AI-Based Conversational Social Support, Community Social Participation
- Where
- 2 sites in Taiwan
- Volunteers
- 174 people
- Sponsor
- Chang Gung University of Science and Technology
Frailty
Metformin for Preventing Frailty in High-risk Older Adults
Frailty is a geriatric syndrome which leads to poor health outcomes in older adults, such as falls, disability, hospitalization, institutionalization, and death. Due to the dramatic growth in the U.S.
- Trial name
- NCT02570672
- Testing
- Metformin
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Fall Injury, Hip Fractures
Fall, Fracture and Frailty
This project aims to improve the global outcome for an aging individual after a traumatic fall, through identifying conditions contributing to a fall and promoting recovery and rehabilitation.
- Conditions
- Fall Injury, Hip Fractures, Risk Reduction, Osteoporosis, Osteopenia
- Trial name
- FFF (NCT05712252)
- Where
- Sweden
- Volunteers
- 1,200 people
- Sponsor
- Region Skane
Colo-rectal Cancer
NURSE-led Geriatric Assessment in Older Colorectal Cancer Patients
Older colorectal cancer patients frequently present with frailty, comorbidity, and other age-related vulnerabilities that may affect treatment tolerance and outcomes.
- Trial name
- NURSE-GA (NCT07872787)
- Testing
- Nurse-led Geriatric Assessment
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Helse Stavanger HF
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Frailty
Immune Aging and Advanced Therapy Outcomes in Older Adults With IBD
The goal of this observational study is to learn whether signs of immune aging and frailty can help predict the balance of benefits and risks of advanced therapies in adults aged 60 years or older with inflammatory bowel disease…
- Conditions
- Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Frailty, Immunosenescence
- Trial name
- NCT07828886
- Volunteers
- 300 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Geriatric Patients
The Effect of Training Prepared in Line With Fracture Liaison Service Model on Frailty in Hip Surgery Patients
This study is a randomized controlled experimental research with pretest-posttest control group. The aim of this study is to evaluate the effect of the training prepared in line with the fracture liaison service model on the…
- Trial name
- NCT05900804
- Testing
- Training Prepared in Line with the Fracture Liaison Service Model
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Aydin Adnan Menderes University
Cataract
General Anesthesia on Blood Pressure and Intraocular Pressure in Geriatric Patients Undergoing Cataract Surgery
The primary aim of the study is to investigate the correlation between preoperative hemodynamics and frailty scores in patients undergoing cataract surgery under general anesthesia.
- Trial name
- NCT06482996
- Testing
- Intraocular pressure (IOP) was measured
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Umraniye Education and Research Hospital
Cardiac Arrest, Frailty
The Impact of Frailty on Cardiopulmonary Resuscitation Adverse Outcomes in Patients Requiring Code Blue Activation
The aim of this study was to determine the independent association of frailty with cardiopulmonary resuscitation and predictive factors in patients triggering code blue response
- Conditions
- Cardiac Arrest, Frailty, Respiratory Arrest
- Trial name
- NCT06405581
- Testing
- Edmonton frailty scale calculation
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people
- Sponsor
- Umraniye Education and Research Hospital
Postoperative Mortality, Frailty at Older Adults
Predictive Value of Frailty Scores and Admission Laboratory Markers for Postoperative ICU Mortality
This prospective observational study aims to evaluate the predictive value of the Clinical Frailty Scale (CFS), the Katz Activities of Daily Living (ADL) scale, and admission laboratory markers for postoperative mortality among…
- Conditions
- Postoperative Mortality, Frailty at Older Adults, Activities of Daily Living, Postoperative Complications
- Trial name
- GERI-MORTAL (NCT07279519)
- Where
- Turkey (Türkiye)
- Volunteers
- 393 people
- Sponsor
- Malatya Egitim Ve Arastirma Hastanesi
Chronic Kidney Disease, Abdominal Muscles/Ultrasonography
Biomarkers, Abdominal Muscle, and Frailty in CKD
In chronic kidney disease (CKD), inflammation and oxidative stress are important processes that may be associated with the development of muscle loss and frailty.
- Conditions
- Chronic Kidney Disease, Abdominal Muscles/Ultrasonography, Frailty
- Trial name
- NCT07854275
- Testing
- total antioxidant status, total oxidant status, monocyte chemotactic protein-1
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Ankara City Hospital Bilkent
Frailty, Aging
Community-Based Multicomponent Exercise and Recreational Programme for Older Adults
This quasi-experimental, non-randomized controlled evaluation examined whether participation in ELDERPLAY, a community-based programme combining Vivifrail-based multicomponent exercise with adapted traditional games, was…
- Conditions
- Frailty, Aging, Physical Functional Performance, Postural Balance
- Trial name
- ELDERPLAY (NCT07864831)
- Testing
- ELDERPLAY multicomponent exercise and recreational programme
- Where
- Spain
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Frailty at Older Adults, Mastication
Oral Function Intervention in Community-Dwelling Older Adults
Oral frailty is a potentially reversible condition associated with physical frailty and functional decline in older adults. Interventions targeting oral function may therefore improve broader physical health.
- Conditions
- Frailty at Older Adults, Mastication, Physical Functional Performance, Aging
- Trial name
- NCT07866781
- Testing
- Integrated Oral Function Intervention
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Aging, Frailty
Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults
This is a randomized, double-blind, placebo-controlled, two-arm crossover clinical trial evaluating the effects of nicotinamide mononucleotide (NMN) combined with trimethylglycine (TMG) supplementation, compared to NMN alone.
- Conditions
- Aging, Frailty, Exercise Tolerance, Healthy Male and Female Subjects
- Trial name
- NCT07144527
- Testing
- NMN and TMG (Euexia), Nicotinamide Mononucleotide (NMN)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Scott Silveira
Inpatients, Frail
Effect of Using a Reminder to Encourage Patients to be Active During Their Hospital Stay.
Around 30% of patients aged 65 and over experience functional decline due to hospitalization. Physical inactivity, often without medical justification, is common during hospital stays.This immobility leads to loss of autonomy…
- Trial name
- REMOTIVE (NCT07492745)
- Testing
- Vibrating reminder, Control group
- Where
- 4 sites in Belgium, France
- Volunteers
- 204 people
- Sponsor
- Groupe Hospitalier du Havre
Frailty, Neuromuscular Blockade
Incidence of Residual Neuromuscular Blockade in Fraility in OncoGynae Surgery
Frailty among patients undergoing surgery is strongly associated with an elevated risk of adverse perioperative outcomes, heightened incidence of postoperative complications, increased mortality rates, and prolonged hospital…
- Conditions
- Frailty, Neuromuscular Blockade, General Anesthetic Drug Adverse Reaction, Gynecologic Cancer
- Trial name
- FIGO (NCT06216002)
- Testing
- Train of four nerve stimulator
- Where
- Thailand
- Volunteers
- 356 people
- Sponsor
- Mahidol University
Spinal Induced Hypotension, Old Age; Debility
Efficacy of Subclavian Vein/Artery Diameter Index in Predicting the Incidence of the Spinal-Induced Hypotension in Geriatric Patients
The hypothesis of the study will be that the subclavian vein/subclavian artery diameter (SCVD/SCAD) index will be a good predictor of spinal-induced hypotension in geriatric patients.
- Trial name
- NCT07286422
- Testing
- Assessment of the SCV & SCA, Assessment of the IVC and aorta
- Where
- Egypt
- Volunteers
- 107 people
- Sponsor
- Tanta University
Chronic Disease, Chronic Disease Management
Taining Golden Lake Comprehensive Chronic Disease Management Initiative
This study aims to establish the first county-level, population-based prospective cohort in Taining County, Fujian Province, China. The cohort will include at least 20,000 residents aged 18 years or older.
- Conditions
- Chronic Disease, Chronic Disease Management, Hypertension, Diabetes Mellitus
- Trial name
- TAIGOLD-CDM (NCT07308314)
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Frailty, Quality of Life
VOCALE: A Digital Intervention to Improve Quality of Life and Reduce Frailty Among Older Adults in Retirement Communities
The goal of this clinical trial is to learn whether an 8-week online program called VOCALE can improve quality of life and reduce frailty in adults age 65 and older who live independently in retirement communities and have mild…
- Trial name
- VOCALE AGING (NCT07860892)
- Testing
- VOCALE Healthy Aging Online Program
- Volunteers
- 128 people
- Sponsor
- University of Washington