Clinical trials: Frailty
Chronic Kidney Disease
Chronic Kidney Disease Among Frail Elderly
Chronic kidney disease is a common diagnosis in the elderly population and it is associated with significant morbidity and health care costs. The prevalence rates increase with age to about 40% for adults aged > 65 years.
- Trial name
- FRED-CKD (NCT02351349)
- Testing
- multidisciplinary intervention
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Sameena Iqbal
Frail Elderly, Clostridioides Difficile
Clostridioides Difficile and Frailty
CDI is a major cause of antibiotics-associated diarrhoea. More than half of the patients affected are 70 years or older and frail. Mortality among older patients with CDI is high.
- Conditions
- Frail Elderly, Clostridioides Difficile, Geriatric Assessment, Faecal Microbiota Transplantation
- Trial name
- CLODIFRAIL (NCT05447533)
- Testing
- Comprehensive geriatric assessment (CGA), Continued geriatric care, Faecal microbiota transplantation (FMT)
- Where
- Denmark
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Diffuse Parenchymal Lung Disease, Frailty
Evaluation of Patients With Diffuse Parenchymal Lung Diseases Regarding Frailty
There are very few studies in the literature examining the frailty levels of diffuse parenchymal lung disease (DPLD) patients and its effect on their functional status despite the high prevalance of frailty in patients with DPLD…
- Conditions
- Diffuse Parenchymal Lung Disease, Frailty, Physical Inactivity
- Trial name
- NCT06171425
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Frailty, Geriatrics
Combating Hospital-related Function Decline Among Prefrail Older Adults: A Pilot Study
This study focuses on the "Strength-based Tailored-Exercise Program at Home (STEP@Home)" aimed at improving health outcomes for geriatric patients at risk of hospitalization-associated functional decline.
- Trial name
- STEP@Home (NCT06191276)
- Testing
- STEP@Home Intervention, Usual care
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The University of Hong Kong
Atrial Fibrillation
The European Registry of Older Subjects With Atrial Fibrillation (EUROSAF)
Preliminary data suggest that: 1. a different risk of mortality, as assessed by the Multidimensional Prognostic Indices (MPI), may influence the anticoagulant prescription in older subjects with Atrial Fibrillation (AF); 2.
- Trial name
- EUROSAF (NCT02973984)
- Where
- Italy
- Volunteers
- 3,000 people
- Sponsor
- Alberto Pilotto
Frailty
Feasibility of a Multidisciplinary Student-Led Program to Improve Frailty in Nursing Home Residents
BACKGROUND Frailty, regarded as a potentially reversible process and defined as a progressive deterioration of physiological systems and intrinsic capacity, constitutes a key risk factor for disability, dependency and…
- Trial name
- CUIDAFRAIL (NCT07182747)
- Testing
- Nursing students' intervention programme, Standard care from Public Andalusian Health Service
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Universidad de Almeria
Frailty, Multiple Myeloma
ICOPE Program Feasibility in the Management of Myeloma Patients
This project proposes to adapt monthly the existing ICOPE (Integrated Care for Older People) MONITOR program for elderly myeloma patients. This adaptation aims to detect earlier functional decline and prevent loss of autonomy.
- Trial name
- Onco-ICOPE (NCT06247189)
- Testing
- ICOPE Monitoring
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Sarcopenia, Frailty
Oral Nutritional Supplementation With HMB Enhance Muscle Quality in Sarcopenic Surgical Patients
Aims: Clinical frailty severely impacts the physical, functional and physiological reserves necessary for the recovery after surgery.
- Trial name
- HEROS (NCT05344313)
- Testing
- Ensure Plus Advance
- Where
- Singapore
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Sengkang General Hospital
Frailty At Older Adults
Telerehabilitation on Physical Fitness, Functional Status, and Quality of Life in Frail Older Adults
The goal of this randomized controlled trial (RCT) is to analyze whether the effectiveness of a synchronous telerehabilitation program is better than a face-to-face physical therapy program in improving the physical fitness…
- Trial name
- Teleactivate 3 (NCT06784245)
- Testing
- TeleActivate
- Where
- Chile
- Volunteers
- 58 people
- Sponsor
- Marina Alvarado
Frail Elderly Syndrome, Primary Prevention
Non-pharmacological Prevention of POD in Frailty Elderly Undergoing Elective Surgery Applied by Nursing Teams
The increase in the population over 60 years of age who could receive surgery due to changes in life expectancy and advances in surgical and anesthetic techniques.
- Conditions
- Frail Elderly Syndrome, Primary Prevention, Postoperative Delirium, Frailty
- Trial name
- NPPOD (NCT05993754)
- Testing
- Non-pharmacological intervention
- Where
- Chile
- Volunteers
- 400 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Frailty
Perioperative Prehabilitation on Markers of Fitness and Frailty in Patients Undergoing Elective Surgery
A growing body of evidence suggests that patients who receive good perioperative care (i.e. care prior to surgery, during surgery, and after surgery) tend to have fewer complications, quicker recovery times, and shorter hospital…
- Trial name
- NCT05977556
- Testing
- Combined neuromuscular exercise training and 'sit less, move more' program
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Cardiovascular Diseases, Frailty
Managing Frailty Through Mobilization in Males and Female Inpatients With Cardiovascular Disease
Frailty describes the overall health of a person. Inpatients with cardiovascular problems have a higher risk for frailty - or the sick are more likely to get sicker - causing longer hospital stays, hospital readmission, and…
- Trial name
- NCT06810661
- Testing
- Mobility promotion
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Université de Sherbrooke
Frailty Syndrome, Aging
Safety and Preliminary Efficacy of Adipose-Derived Stem Cell Secretome in Frailty (VinVital)
This is a Phase I, open-label, non-randomized clinical trial to evaluate the safety and preliminary efficacy of adipose-derived mesenchymal stem cell secretome capsules (VinVital) in patients with frailty syndrome.
- Trial name
- VinVital (NCT07856602)
- Testing
- VinVital
- Volunteers
- 20 people
- Sponsor
- Vinmec Research Institute of Stem Cell and Gene Technology
Anemia, Clonal Hematopoiesis
Aging of Hematopoietic Stem Cells - Molecular Architecture of Marrow Dysplasia and Clinical Contribution of Ineffective Hematopoiesis to Frailty in the Elderly
The prevalence and incidence of anemia tend to increase with advancing age. Relatively low hemoglobin concentrations are a common laboratory finding in the elderly, for the most part judged by physicians as a sign without…
- Trial name
- NCT03907553
- Testing
- targeted genome sequencing
- Where
- Italy
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Chronic Kidney Disease (CKD), Kidney Transplant
Remote vs In-Person Prehabilitation for Kidney Transplant Candidates
Patients with advanced chronic kidney disease awaiting deceased-donor kidney transplantation frequently experience progressive functional decline, frailty, reduced mobility, and poor quality of life while on the transplant…
- Conditions
- Chronic Kidney Disease (CKD), Kidney Transplant, Frailty, Prehabilitation
- Trial name
- KIDFIT (NCT07701382)
- Testing
- In-Person Multimodal Prehabilitation, Remote Multimodal Prehabilitation
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Hospital Clinic of Barcelona
Heart Failure, Frail Elderly Syndrome
Frailty Heart Failure Study
A prospective longitudinal cohort study aimed at measuring frailty and its associated risk factors community dwelling older adults aged 65 years or older.
- Trial name
- NCT03887351
- Volunteers
- 280 people
- Sponsor
- Jewish General Hospital
Frailty Syndrome
Adaptation and Validation of Frailty Scales in Intensive Care Units in Spain
Increased life expectancy leads to population aging, increased morbidities and aging of hospitalized patients. The acquisition of frailty leads to worse outcomes derived from hospitalization, but although frailty has been related…
- Trial name
- NCT04830865
- Where
- Spain
- Volunteers
- 512 people
- Sponsor
- Hospital Universitario Getafe
Femoral Fragility Fractures, Malnutrition
The Taste and Acceptability of a High Protein Ice Cream Compared With Hospital Milkshake Nutritional Supplement
This study aims to compare the acceptability of a new high protein, fortified, ice cream called Nottingham-Ice cream (N-ICE CREAM) with a standard milkshake-style oral nutritional supplement (ONS); Fortisip Compact Protein in…
- Trial name
- NCT05711277
- Testing
- Standard milkshake ONS (Fortisip Compact Protein), High protein, fortified, ice cream
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Sarcopenia
Neuromuscular Electrical Stimulation Study
In this study, the investigators will use feasibility RCT design to determine whether it is justifiable to conduct a large-scale clinical trial of neuromuscular electrical stimulation with or without additional protein…
- Trial name
- IMMI (NCT04792307)
- Testing
- Neuromuscular electrical stimulation , no high protein ice cream supplementation
- Volunteers
- 66 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Frail Elderly Syndrome, Postoperative Delirium
Different Frailty Scores to Incidence of Post-operative Delirium and Cognitive Dysfunction
Patients who are frail will have higher rate for post-operative morbidities, mortality, prolonged hospital stays, loss of independence, increase in institutionalization, post-operative cognitive dysfunction (POCD) and delirium…
- Conditions
- Frail Elderly Syndrome, Postoperative Delirium, Postoperative Cognitive Dysfunction
- Trial name
- NCT04056871
- Testing
- Frailty Screening Tools
- Where
- Malaysia
- Volunteers
- 400 people
- Sponsor
- University of Malaya
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