Clinical trials: Frail Elderly Syndrome, active
Frailty, Frail Elderly Syndrome
The NADage Study: Nicotinamide Riboside Replenishment Therapy Against Functional Decline in Aging
This clinical study, designed as a double-blind, randomized, placebo-controlled trial, aims to investigate the potential of nicotinamide riboside (NR) to decelerate functional decline in the elderly frail population.
- Conditions
- Frailty, Frail Elderly Syndrome, Frailty Syndrome, Aging
- Trial name
- NADage (NCT06208527)
- Testing
- Nicotinamide Riboside (NR)
- Where
- 2 sites in Norway
- Volunteers
- 100 people
- Sponsor
- Haukeland University Hospital
Frail Elderly Syndrome, Coronary Heart Disease
Frailty Syndrome in Daily Practice of Interventional Cardiology Ward
The impact of frailty on immediate and long term outcomes of invasive treatment of coronary artery disease is not fully characterized.
- Conditions
- Frail Elderly Syndrome, Coronary Heart Disease, Acute Coronary Syndrome, Coronary Artery Bypass Grafting
- Trial name
- FRAPICA (NCT03209414)
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- Medical University of Silesia
Frailty Syndrome, Older Adults
Feasibility and Effects of Inspiratory Muscle Training Combined With Blood Flow Restriction for Frail Older Adults
This randomized controlled trial study aims to evaluate the feasibility and preliminary efficacy of a combined inspiratory muscle training (IMT) and blood flow restriction (BFR) intervention in frail older adults.
- Conditions
- Frailty Syndrome, Older Adults, Blood Flow Restriction (BFR) Training Effects, Inspiratory Muscle Training
- Trial name
- NCT07573995
- Testing
- Exercise
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taipei Medical University
Cardiovascular-kidney-metabolic Syndrome
Mechanisms and Interventions for Physical Activity in Frail Cardiovascular-kidney-metabolic Syndrome Patients: A Temporal Self-Regulation Approach
Longitudinal physical activity data and associated factors were collected at baseline (diagnosis), 3-month, 6-month, and 9-month follow-ups in cardiovascular-kidney-metabolic syndrome patients.
- Trial name
- CKM (NCT07131488)
- Volunteers
- 614 people
- Sponsor
- Nanjing Medical University
Heart Failure, Prefrail Elderly
High-technology TeleRehabilitation for the Treatment of the FRAgile Patient
The aim of this randomized controlled clinical trial is to evaluate the efficacy of an 8-week sensorimotor and cognitive telerehabilitation program in frail and pre-frail older adults with stable chronic heart failure.
- Conditions
- Heart Failure, Prefrail Elderly, Frail Elderly Syndrome
- Trial name
- TeleRiab4Fra (NCT07561021)
- Testing
- Telerehabilitation, Caregiver-Supervised Home Exercise Program
- Volunteers
- 70 people
- Sponsor
- University of Salerno
Frail Elderly Syndrome, Primary Prevention
Non-pharmacological Prevention of POD in Frailty Elderly Undergoing Elective Surgery Applied by Nursing Teams
The increase in the population over 60 years of age who could receive surgery due to changes in life expectancy and advances in surgical and anesthetic techniques.
- Conditions
- Frail Elderly Syndrome, Primary Prevention, Postoperative Delirium, Frailty
- Trial name
- NPPOD (NCT05993754)
- Testing
- Non-pharmacological intervention
- Where
- Chile
- Volunteers
- 400 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Heart Failure, Frailty
INTEgRated Health CARE for Patients With Frailty and Heart Failure
Frailty, an aging-related syndrome of physiological decline characterized by marked vulnerability to adverse health outcomes, has attracted increasing attention in cardiology due to the growing elderly population with heart…
- Conditions
- Heart Failure, Frailty, Frail Elderly Syndrome, Symptom, Behavioral
- Trial name
- INTERCARE-HF (NCT06444321)
- Testing
- INTERCARE-HF
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Vestre Viken Hospital Trust
Frailty Syndrome, Geriatric Health
Longitudinal Assessment of Lung Function and Respiratory Muscle Strength Following Training of the Inspiratory Muscles in Frail Older Adults (IMT-3)
This study aims to evaluate the effects of an 8-week inspiratory muscle training program on lung function and respiratory muscle strength in frail older adults aged 80 years and above.
- Conditions
- Frailty Syndrome, Geriatric Health, Respiratory Muscle Weakness, Age-Related Frailty
- Trial name
- NCT07556445
- Testing
- Inspiratory Muscle Training
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Francisco de Vitoria
Frail Elderly Syndrome
The Importance of Anesthesia Method in Fragile Patients
The aim of this study is to comparatively evaluate the effects of different anaesthesia methods (spinal anaesthesia and general anaesthesia) administered to frail elderly patients scheduled for transurethral surgery (e.g.
- Trial name
- NCT07191769
- Testing
- general anaesthesia, regional anaesthesia
- Volunteers
- 180 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Frailty Syndrome, Prefrail Elderly
Comparıson of the Effıcacy of Conventıonal Exercıse and Pılates ın Pre-fraıl and Fraıl Older Adults
Brief Summary This clinical study aims to compare the effects of a conventional exercise program and a Pilates exercise program in prefrail and frail older adults.
- Conditions
- Frailty Syndrome, Prefrail Elderly, Frail Elderly, Geriatric
- Trial name
- NCT07458048
- Testing
- PILATES EXERCISES GROUP, CONVENTIONAL EXERCISES GROUP
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul University - Cerrahpasa
Frailty, Frailty Syndrome
Prevalence, Determinants and Natural History of Frailty and Pre-frailty in Elderly People
Frailty syndrome (i.e. frailty) is a geriatric syndrome which relies on the reduction of multisystem reserve capacity. Frail people have a lower potential to respond to external stressors and various life incidents as well as…
- Conditions
- Frailty, Frailty Syndrome, Frail Elderly Syndrome, Fragility
- Trial name
- FRAILPOL (NCT04518423)
- Where
- Poland
- Volunteers
- 1,093 people, healthy volunteers welcome
- Sponsor
- The Opole University of Technology
Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI)
CPAP Randomized Controlled Trial
The overall goal of this randomized controlled trial is to test the hypothesis that in older adults with mild cognitive impairment (MCI) and previously untreated obstructive sleep apnea (OSA), 4 months of web-based sleep…
- Conditions
- Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI), Cognitive Decline Prevention in Pre-frail Older Adults
- Trial name
- NCT06773416
- Testing
- CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health, Delayed CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health
- Where
- Canada
- Volunteers
- 206 people
- Sponsor
- Sunnybrook Health Sciences Centre
Frailty Syndrome
PREhabilitation of Frail Elderly PAtients Undergoing majoR surgEry at HOME (PREPARE-HOME) Using Smart Wearables
The goal of this clinical trial is to evaluate whether a prehabilitation program using wearable technology can improve physical function and postoperative outcomes in elderly patients (65 years or older) undergoing major elective…
- Trial name
- PREPARE@HOME (NCT06633614)
- Testing
- Supervised prehabilitation programme
- Volunteers
- 190 people
- Sponsor
- Singapore General Hospital
Frail Elderly Syndrome, Major Surgery
Multimodal Prehabilitation for Surgery in the Elderly: a Randomised, Prospective, Multicenter, Multidisciplinary Trial
This multicentric, randomised controlled trial is to the investigators knowledge the first implementation of a multimodal, multidisciplinary prehabilitation approach using knowledge from different specialties to lower…
- Trial name
- PREHABIL (NCT04461301)
- Testing
- Multimodal Prehabilitation
- Where
- Switzerland
- Volunteers
- 466 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Frailty in Adult Surgery, Frail Elderly Syndrome
Patient's Database: Prepare for Your Surgery Program
Frailty is a multidimensional syndrome that predominantly affects older people and people with long-term treatments such as cancer and chronic pain.
- Conditions
- Frailty in Adult Surgery, Frail Elderly Syndrome, Database, Perioperative Care
- Trial name
- NCT06857981
- Testing
- Clinical data collection
- Where
- 2 sites in Chile
- Volunteers
- 120 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Aging, Frail Elderly
Effect of Animation-Based Digital Education on Risk Knowledge and Frailty in Older Adults
With the global aging trend, the management of geriatric risks faced by older adults and the effectiveness of health education for this population are gaining increasing importance.
- Conditions
- Aging, Frail Elderly, Geriatric Syndromes
- Trial name
- NCT07547358
- Testing
- Branching Scenario Animation Education
- Volunteers
- 66 people
- Sponsor
- Saglik Bilimleri Universitesi
Diabetes Type 2, Frail Elderly Syndrome
Involvement of Muscle Mitochondrial Dysfunction in Frailty in Older Adults. Role of Exercise
This study aims to investigate the role of skeletal muscle mitochondrial dysfunction in the development of frailty in older adults and to evaluate whether a short-term, supervised resistance training intervention can improve…
- Conditions
- Diabetes Type 2, Frail Elderly Syndrome, Mitochondrial Function, Bioenergetics, Functionality
- Trial name
- MITOSTRENGTH (NCT07828847)
- Testing
- Short-duration resistance training
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Type2diabetes, Frail Elderly Syndrome
The Impact of Geriatric Assessment on the Treatment Plan of Elderly Patients With T2DM
Introduction: With the aging of the world population and the increasing incidence of type 2 diabetes mellitus (T2DM) with age, the number of elderly individuals living with diabetes has been considerably rising.
- Conditions
- Type2diabetes, Frail Elderly Syndrome, Frailty, Geriatric Assessment
- Trial name
- NCT06469437
- Testing
- Providing the physicians with a proposed glycated hemoglobin target
- Where
- Brazil
- Volunteers
- 220 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Frailty Syndrome, Respiratory Muscle Weakness
Longitudinal Ultrasound Assessment of Diaphragmatic and Respiratory Muscle Function Following Respiratory Muscle Training in Frail Older Adults
This study aims to evaluate the effects of an 8-week inspiratory muscle training program on diaphragmatic and respiratory muscle function in frail older adults aged 80 years and above.
- Conditions
- Frailty Syndrome, Respiratory Muscle Weakness, Age-Related Frailty, Geriatric Health
- Trial name
- IMT-1 (NCT07258615)
- Testing
- Inspiratory Muscle Training
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad Francisco de Vitoria
Frail Elderly Patients, Geriatric Syndromes
Improving Care for Frail Older Adults Using a Digital Needs Assessment Tool
The goal of this trial is to evaluate whether a digital needs-assessment tool can improve care planning and outcomes for frail older adults (aged 60 years and above) hospitalized in Singapore.
- Conditions
- Frail Elderly Patients, Geriatric Syndromes, Frail Older Adults
- Trial name
- Frailty (NCT07580690)
- Testing
- Core: SST-informed care planning, Additional telephone calls
- Where
- Singapore
- Volunteers
- 200 people
- Sponsor
- Duke-NUS Graduate Medical School