Clinical trials: Fluid Resuscitation
Septic Shock, Critically Ill
Resuscitation Strategies in Septic Shock
The purpose of this study, in mechanically ventilated septic shock patients, is to determine whether a fluid loading strategy based on parameters derived from the transpulmonary thermodilution technique may lead to more…
- Trial name
- ReSSeS (NCT02150512)
- Testing
- Transpulmonary Thermodilution, Surviving Sepsis Guidelines (SSG)
- Where
- Netherlands
- Volunteers
- 170 people
- Sponsor
- Medisch Spectrum Twente
Intensive Care
Crystalloid Versus Hydroxyethyl Starch Trials
The aim of this study is to determine whether patients in the Intensive Care Unit who receive fluid resuscitation with either hydroxyethyl starch (a synthetic colloid solution) or saline (a salt solution), have an increased rate…
- Trial name
- CHEST (NCT00935168)
- Testing
- 6% Hydroxy-ethyl starch (130/0.4), Saline
- Where
- Australia
- Volunteers
- 7,000 people
- Sponsor
- The George Institute
Sepsis
Early Resuscitation in Paediatric Sepsis Using Inotropes
Septic shock in children still carries substantial mortality and morbidity. While resuscitation with 40-60 mL/kg intravenous fluid boluses remains a cornerstone of initial resuscitation, an increasing body of evidence indicates…
- Trial name
- ANDES-CHILD (NCT06478797)
- Testing
- Fluid, Adrenalin
- Where
- 4 sites in Argentina, Bolivia and 1 more
- Volunteers
- 40 people
- Sponsor
- NATALIA LOPERA MUNERA
Shock, Septic
Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis: A Pilot Feasibility Study
The objective of this pilot study is to assess overall feasibility prior to embarking on a larger randomized pragmatic trial comparing the clinical effectiveness of fluid resuscitation with NS versus LR for pediatric patients…
- Trial name
- PRoMPT BOLUS (NCT03340805)
- Testing
- Lactated Ringer, Normal saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Children's Hospital of Philadelphia
Septic Shock
Fluid Resuscitation for Suspected Sepsis in Paediatric Emergency Departments
With 25.2 million children affected and 3.4 million deaths in 2017, paediatric sepsis is the leading cause of under-five mortality worldwide and has recently been described as "significant global health threat" by the World…
- Trial name
- FRESSPED (NCT05066464)
- Testing
- Fluid Resuscitation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Change in Serum Chloride Level
Change in Serum Chloride Level After Loading Dose of Sterofundin Solution Compared With Normal Saline Solution
Prospective, crossover, randomized trial to evaluate plasma compositions after loading dose of sterofundin solution given to healthy volunteer in the resuscitation manner compared with normal saline solution.
- Trial name
- NCT02950974
- Testing
- Sterofundin, NSS
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ramathibodi Hospital
Septic Shock, Fluid Reponsiveness
This Study Compares Two Noninvasive Dynamic Tools: Lung Ultrasound and Transthoracic Echocardiography Using LVOT VTI. It Aims to Measure the Sensitivity and Specificity of LUS in Guiding Fluid Resuscitation and Early Detection of Fluid Responsiveness and to Prevent Volume Overload
Reliability of the LVOT-VTI versus lung ultrasonography for early detection of fluid intolerance during fluid resuscitation of septic patients.
- Trial name
- lvotvti (NCT07797751)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Respiratory Distress
Efficacy and Safety of Gastric Suctioning During Neonatal Resuscitation
The stomach of the newborn baby is often emptied soon after birth to prevent breathing problems (respiratory distress). Babies born with meconium-stained amniotic fluid and those with increased secretions associated with birth by…
- Trial name
- NCT00729989
- Testing
- Gastric suctioning
- Where
- United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Benjamin T. Stevens
Sepsis
Mechanistic Inflammatory Sub-study Embedded Within the Albumin vs Balanced Crystalloid Trial
MIS-ABC Sepsis is a sub-study looking to understand how the immune response in patients with infection changes during the early stages of the illness, as well as after intravenous fluid treatment.
- Trial name
- MIS-ABC Sepsis (NCT04963569)
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Edinburgh
Sepsis
Feasibility of 5% Albumin Compared With Balanced Crystalloid, as Intravenous Fluid Resuscitation in Adult Patients With Sepsis, Presenting as an Emergency to Hospital
The aim of this research study is to compare two different fluids (Human Albumin Solution (HAS) and Balanced Crystalloid that are given via a drip to patients with severe infection (sepsis).
- Trial name
- ABC Sepsis (NCT04540094)
- Testing
- Human albumin, Balanced crystalloid solution
- Where
- 15 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- University of Edinburgh
Sepsis
Lactate Clearance Goal-directed Therapy in Sepsis
Serum lactate level is depended on the balance between lactate production and clearance. It is seen as a sensitive indicator reflecting not only the low systemic perfusion but microcirculatory dysfunction which cause global or…
- Trial name
- NCT03256461
- Testing
- Lactate clearance 10% target group, Lactate clearance 20% target group, Standard EGDT group
- Where
- China
- Volunteers
- 1,128 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Bleeding, Massive Hemorrhage
Initial Resuscitation With Albumin in Hemorrhagic Shock to Reduce Positive Fluid Balance
This study is designed to evaluate the effect of early albumin transfusion within massive transfusion protocol on fluid balance and reduced requirement of transfusion.
- Conditions
- Bleeding, Massive Hemorrhage, Massive Transfusion Protocol
- Trial name
- ABSOLUTE (NCT06111261)
- Testing
- Albumin solution, Balanced crystalloid solution
- Volunteers
- 36 people
- Sponsor
- Seoul National University Hospital
Pancreatitis
Fluid Resuscitation Goal in Early Stage of Severe Acute Pancreatitis
To compare different goals of fluid resuscitation in early stage of acute pancreatitis
- Trial name
- NCT01974466
- Testing
- Goal A, Goal B
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ruijin Hospital
Scoliosis Idiopathic, Scoliosis;Congenital
Hypertonic Saline in Posterior Spinal Fusion
This is a prospective, randomized study in patients greater than or equal to 10 years of age scheduled for an posterior spinal fusion that requires invasive monitoring of arterial blood pressure.
- Trial name
- NCT06822374
- Testing
- Normosol-R, buffered 2% hypertonic saline
- Where
- United States
- Sponsor
- Joseph D. Tobias
Critical Illness, Trauma
Fluid Resuscitation Optimization in Surgical Trauma Patients (FROST)
The aim of this study is to determine if the incidence of post-operative complications can be decreased by the implementation of intra-operative, minimally invasive hemodynamic monitoring (MIHM) via FloTrac™ and EV1000™ in trauma…
- Trial name
- FROST (NCT02742974)
- Testing
- Device: FloTrac™ and EV1000™, Volume Challenge, Vasopressor Therapy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- CAMC Health System
Category II Fetal Heart Rate Tracing
Recovery Rate From Category II to Category I EFM Tracings in Pregnant Women Receiving Bolus vs Continuous Intravenous Fluid Administration
This randomized trial compared a normal saline bolus regimen with continuous normal saline infusion. The participants were low-risk pregnant women at term with Category II fetal heart rate tracings.
- Trial name
- IUR-RCT (NCT07260240)
- Testing
- Normal saline bolus infusion, Continuous normal saline infusion
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Queen Savang Vadhana Memorial Hospital, Thailand
Cardiac and Aortic Surgery, Cardiac Anaesthesia
Impact of Fluid Resuscitation on Venous Congestion in Cardiac Critically-ill Patients
The objective of this study is to assess how fluid resuscitation, in the context of fluid responsiveness, affects the incidence and progression of systemic venous congestion in critically ill cardiac patients.
- Conditions
- Cardiac and Aortic Surgery, Cardiac Anaesthesia, Venous Congestion, Fluid Resuscitation
- Trial name
- VExUS-CS (NCT07183397)
- Testing
- VExUS & Cardiac Ultrasound
- Volunteers
- 250 people
- Sponsor
- Medical University of Vienna
Cardiac Diseases
The Use of Colloid Versus Crystalloid in Post-operative Pediatric Cardiac Patients for Fluid Resuscitation
The purpose of the study is to help determine if either crystalloid solution or colloid solution is more advantageous as a resuscitative fluid in post-operative pediatric cardiac patients.
- Trial name
- NCT00464126
- Testing
- 5% albumin, crystalloid
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Vanderbilt University Medical Center
Sepsis, Septic Shock
The Effect of Fluid Resuscitation With 0.9% Sodium Chloride Versus Balanced Crystalloid Solution on Renal Function of Sepsis Patients
The high chloride content of 0.9%sodium chloride (0.9%NaCl) leads to adverse pathophysiological effects in both animals and healthy human volunteers.
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- NCT03277677
- Testing
- Normal saline, Ringer's Acetate
- Where
- Thailand
- Volunteers
- 116 people
- Sponsor
- Chulalongkorn University
Septic Shock, Fluid Resuscitation
Bicarbonated Ringer's Solution Versus Lactated Ringer's Solution in Patients With Septic Shock
In this prospective randomized controlled trial, investigators aim to study the effects and safety of bicarbonated Ringer's solution in patients with septic shock compared with lactated ringer's solution, and provide evidence for…
- Conditions
- Septic Shock, Fluid Resuscitation, Crystalloid Solution, Intensive Care Unit
- Trial name
- NCT04449757
- Testing
- Bicarbonated Ringer's solution, Lactated Ringer's solution
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Zhongnan Hospital