Clinical trials: Fibrosis Myocardial
Aortic Valve Stenosis, Myocardial Fibrosis
Quantification of Myocardial Fibrosis in Aortic Stenosis
This study is a long term follow-up of patients that were included as part of a previous study (NCT03422770), where patients with aortic stenosis and healthy controls went through echocardiography, cardiac MRI, long-term…
- Trial name
- SAS-F-5 (NCT06571175)
- Testing
- High frame rate echocardiography, MRI, Blood test
- Where
- Norway
- Volunteers
- 79 people
- Sponsor
- Norwegian University of Science and Technology
Atrial Fibrillation, Fibrosis Myocardial
Atrial Fibrillation Driver Study
Atrial Fibrillation (AF) is an abnormal rhythm of the heart which is increasingly common and can be associated with serious consequences.
- Trial name
- NCT05743829
- Testing
- Tissue excision as part of routine clinical care
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Congenital Heart Disease, Fibrosis Myocardial
Atrial Late Gadolinium Enhancement in Patients With Repaired Congenital Heart Disease
In this research study the investigators want to learn more about how well the investigators can visualize scar tissue in the heart by MRI.
- Conditions
- Congenital Heart Disease, Fibrosis Myocardial, Fibrosis; Heart
- Trial name
- NCT05241418
- Testing
- Atrial 3D late gadolinium enhancement
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
Friedreich Ataxia, Cardiomyopathies
Phase IA and IB Study of AAVrh.10hFXN Gene Therapy for the Cardiomyopathy of Friedreich's Ataxia
The purpose of this study is to test the safety and preliminary efficacy of AAVrh.10hFXN to treat the cardiomyopathy associated with Friedreich's ataxia (FA).
- Conditions
- Friedreich Ataxia, Cardiomyopathies, Cardiac Hypertrophy, Myocardial Fibrosis
- Trial name
- NCT05302271
- Testing
- AAVrh.10hFXN, serotype rh.10 adeno-associated virus (AAV) gene transfer vector expressing the cDNA coding for human FXN, Prednisone
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Weill Medical College of Cornell University
Myocardial Diseases, Perfusion Imaging
Validation of Myocardial Perfusion and Extracellular Volume Assessment Using Photon-Counting Computed Tomography (PCCT) Compared With Cardiac Magnetic Resonance (CMR) in Patients Undergoing Transcatheter Aortic Valve Implantation (TAVI)
Cardiovascular diseases are the leading cause of death worldwide, responsible for about 30% of all deaths. This substantial burden highlights the need for accurate diagnostic tools that help doctors detect heart disease early and…
- Conditions
- Myocardial Diseases, Perfusion Imaging, Stress Perfusion, Myocardial Fibrosis
- Trial name
- NCT07799363
- Testing
- Stress myocardial perfusion imaging with PCCT. Extracellular volume quantification with PCCT.
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska University Hospital
Heart Failure With Preserved Ejection Fraction, Myocardial Fibrosis
Neprilysin Inhibition to Reduce Myocardial Fibrosis in Heart Failure With Preserved Ejection Fraction
Cardiac magnetic resonance imaging (MRI) measures of myocardial interstitial fibrosis (MIF) are elevated in heart failure with preserved ejection fraction (HFpEF) patients and associated with poor prognosis.
- Trial name
- NCT06536309
- Testing
- Sacubitril-valsartan, Valsartan
- Sponsor
- Brigham and Women's Hospital
Menopause, Perimenopause
Hormone thERapy Effects on BRAin-HEART Health During the Menopausal Transition
The goal of this clinical trial is to learn whether it is feasible to conduct a larger study comparing transdermal menopausal hormone therapy (MHT) versus no hormone therapy in menopausal women with vasomotor symptoms (hot…
- Conditions
- Menopause, Perimenopause, Vasomotor Symptoms, Cardiovascular Disease Risk Factor
- Trial name
- HERBRAVEHEART (NCT07732452)
- Testing
- Transdermal estradiol, Standard of care - non hormonal
- Volunteers
- 100 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Sickle Cell Disease, Diffuse Myocardial Fibrosis
Losartan for Diffuse Myocardial Fibrosis in Sickle Cell Disease
This study is a pilot, phase II, open-label study of the angiotensin II receptor blocker, losartan, in patients with Sickle Cell Disease (SCD) 6 years or older for 12 months.
- Trial name
- NCT05012631
- Testing
- Losartan
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Obesity and Obesity-related Medical Conditions, Diabetes
Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)
The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, which is necessary to perform high quality research…
- Conditions
- Obesity and Obesity-related Medical Conditions, Diabetes, Atherosclerotic Disease, Heart Failure
- Trial name
- VALD (NCT07083557)
- Testing
- Endothelial cell collection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bettina Mittendorfer
HFpEF, LVDD
Triple Combination Therapy (ARNI, SGLT2i, MRA) in Advanced HFpEF
Patients with advanced heart failure with preserved ejection fraction (HFpEF) will be randomly assigned in open-label multicenter study to receive triple combination therapy with [angiotensin receptor/neprilysin inhibitor [ARNI]…
- Conditions
- HFpEF, LVDD, Myocardial Fibrosis
- Trial name
- NCT06655480
- Testing
- [ARNI + SGLTi + AMR], [SGLTi + previously taken RAAS blocker]
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Aortic Valve Stenosis, Myocardial Fibrosis
Echocardiography Findings in Patients With Myocardial Fibrosis and Severe Aortic Stenosis
Patients with aortic stenosis waiting for aortic valve repair were investigated with echocardiography preoperatively, and a myocardial biospy was taken during the operation.
- Trial name
- SAS-fibrosis (NCT07331116)
- Testing
- Transthoracic echocardiography, Cardiac magnetic resonance imaging
- Where
- Norway
- Volunteers
- 22 people
- Sponsor
- Norwegian University of Science and Technology
Myocardial Fibrosis, Left Ventricle Hypertrophy
A Health Coach-Led Digital Lifestyle Intervention (HEALDI)
Aim: To evaluate the effectiveness of an artificial intelligence (AI)-assisted 12-month Health Coach-Led Digital Lifestyle Intervention (HEALDI) versus control on diffuse myocardial fibrosis and ambulatory blood pressure in…
- Conditions
- Myocardial Fibrosis, Left Ventricle Hypertrophy, Hypertensive Disease, Hypertension
- Trial name
- NCT07530562
- Testing
- HEALDI Intervention
- Volunteers
- 200 people
- Sponsor
- National University of Singapore
Myocardial Fibrosis
High Relaxivity Contrast Agent for Cardiac MR in the Myocardial Scar Assessment
Elucirem (Gadopiclenol) is a new macrocyclic gadolinium-based contrast agent (GBCA) with high relaxivity indicated for use in adults and children aged 2 years and older for contrast-enhanced magnetic resonance imaging.
- Trial name
- NCT05954559
- Testing
- Elucirem (Gadopiclenol)
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Breast Cancer, Myocardial Fibrosis
Losartan in Prevention of Radiation-Induced Heart Failure
This study is being done to see if losartan affects the chances of developing radiation-induced heart failure in patients who are receiving radiation therapy as part of standard of care treatment for breast cancer.
- Conditions
- Breast Cancer, Myocardial Fibrosis, Radiation-Induced Fibrosis
- Trial name
- NCT05607017
- Testing
- Losartan, Radiation Therapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Massachusetts General Hospital
Aortic Valve Stenosis, Aortic Valve Replacement
Effects of Aortic Valve Replacement on Myocardial T1 Values in Severe Aortic Valve Stenosis
Background: Severe aortic valve stenosis (AS) is the commonest valve disease. Aortic valve replacement (AVR) is primarily indicated when symptoms occur and/or when there is a drop in left ventricular ejection fraction.
- Conditions
- Aortic Valve Stenosis, Aortic Valve Replacement, Myocardial Fibrosis, Cardiac Magnetic Resonance
- Trial name
- FIBROTIC (NCT05404100)
- Testing
- Aortic valve replacement
- Where
- Denmark
- Volunteers
- 86 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Myocarditis, Heart Failure
IMPRoving Cardiovascular RiSk Stratification Using T1 Mapping in General populatION
Magnetic properties of myocardial tissue change in the presence of disease. This is detectable in the change of rate of magnetic relaxation, and measurable by T1 and T2 mapping using cardiovascular magnetic resonance (CMR).
- Conditions
- Myocarditis, Heart Failure, Myocardial Fibrosis, Vascular Inflammation
- Trial name
- IMPReSSION (NCT04444128)
- Testing
- Cardiac Imaging
- Where
- Germany
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Myocardial Fibrosis, Heart Failure
⁶⁸Ga-FAPI PET/CT for Cardiac Fibrosis in Heart Failure
Heart failure (HF) is a clinical syndrome with increasing incidence and prevalence, associated with high morbidity, mortality, and economic impact, despite therapeutic advances.
- Trial name
- MY-FAPI (NCT07296081)
- Testing
- 68Ga-FAPI PET/CT
- Where
- Portugal
- Volunteers
- 30 people
- Sponsor
- University of Coimbra
Ventricular Tachycardia, Myocardial Fibrosis
Ventricular Tachycardia Ablation and Myocardial Scar Characterization With Magnetic Resonance
Previous monocentric experiences have already highlighted the role of preoperative cardiac imaging, in particular of cardiac magnetic resonance (CMR) and tomography (CT), in improving the ablation results of scar-related…
- Trial name
- VOYAGE (NCT04694079)
- Testing
- Group 1, CMR-guided/aided VT ablation, Group 2, CMR-aided VT ablation, Group 3, Electroanatomical guided ablation
- Where
- 7 sites in Italy
- Volunteers
- 104 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Breast Cancer, Breast Cancer Female
Ultrahypofractionation and Normal Tissue Toxicity
This research is being done to see if proton beam radiation therapy (PBT) results in fewer changes to a participant's heart measured with MRI-imaging than conventional or "photon" radiation therapy (XRT) for participants with…
- Conditions
- Breast Cancer, Breast Cancer Female, Breast Cancer Stage II, Breast Cancer Stage III
- Trial name
- NCT05912231
- Testing
- Accelerated Proton Beam Radiation Therapy (PBT), Accelerated Photon Radiation Therapy (XRT)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Myocardial Infarction, Myocardial Ischemia
MRI of Myocardial Infarction
Heart failure (HF) is an enormous health burden affecting approximately 5.1 million people in the US and is the cause of 250,000 deaths each year.
- Conditions
- Myocardial Infarction, Myocardial Ischemia, Myocardial Injury, Myocardial Fibrosis
- Trial name
- MRIMI (NCT03531151)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Pennsylvania