Clinical trials: Extubation Readiness
Mechanical Ventilator Weaning, Acute Brain Injury
Brain-injured Patients Extubation Readiness Study
The BIPER study is a stepped wedge cluster randomised clinical trial aiming to decrease extubation failure in critically-ill brain-injured patients with residual impaired consciousness using a simple clinical score.
- Conditions
- Mechanical Ventilator Weaning, Acute Brain Injury, Altered Level of Consciousness, Mechanical Ventilation
- Trial name
- Biper (NCT04080440)
- Testing
- Extubation readiness clinical score, Usual Care
- Where
- 21 sites in France
- Volunteers
- 660 people
- Sponsor
- University Hospital, Clermont-Ferrand
Transpulmonary Pressure, Pressure.Rate Product
Measuring Lung Pressures in Critically Ill Children Who Are on Mechanical Ventilation
Typically doctors adjust the settings on the ventilator to ensure that children receive enough help to decrease the work they perform to breathe, receive enough oxygen through the machine to pass into the blood and to the organs…
- Conditions
- Transpulmonary Pressure, Pressure.Rate Product, Guide to Mechanical Ventilator Management, Extubation Readiness
- Trial name
- NCT02354365
- Testing
- Transpulmonary Pressure measurement
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Children's Hospital Los Angeles
Extubation Readiness, Respiratory Failure With Hypoxia
Identifying the Best Flow Setting Strategy for High-Flow Nasal Cannula
The goal of this randomized trial is to compare four different flow-setting approaches for post-extubation use of high-flow nasal cannula (HFNC).
- Trial name
- NCT07007715
- Testing
- Flow of 40L/min, Peak tidal inspiratory flow (PTIF) guided, PaO2/FiO2 ratio guided
- Where
- Taiwan
- Volunteers
- 480 people
- Sponsor
- National Taiwan University Hospital
Mechanical Ventilation, Spontaneous Breathing Trial
Trial of Spontaneous Breathing Test
The hypothesis is that the Spontaneous Breathing Test (SBT) without pressure support (PS) is not inferior to the SBT with pressure support in relation to the following outcomes: a) extubation failure; b) time on MV.
- Conditions
- Mechanical Ventilation, Spontaneous Breathing Trial, Extubation Readiness, Extubation Failures
- Trial name
- NCT06593288
- Testing
- Pressure Support Ventilation, continuous positive airway pressure (CPAP)
- Where
- Brazil
- Volunteers
- 170 people
- Sponsor
- University of Sao Paulo
Mechanical Ventilation Complication, Premature Birth
Ultrasound for Assessment of Extubation Readiness
Preterm infants are at high-risk for the negative implications of both prolonged mechanical ventilation and extubation failure. Pre-extubation assessments of lung parenchyma and diaphragmatic function of these infants can be…
- Trial name
- NCT04957264
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Mount Sinai Hospital, Canada
Critical Illness
Using sEMG of the Diaphragm to Assess Readiness for Extubation
As part of an admission to an Intensive Care Unit (ICU) many patients have breathing tube inserted into their windpipe, also referred to as intubation .
- Trial name
- NCT07110129
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cardiff and Vale University Health Board
Extubation
Electrical Activity of the Diaphragm During Extubation Readiness Testing
Neurally adjusted ventilatory assist (NAVA) is a FDA approved mode of mechanical ventilation. This mode of ventilation is currently in routine use in adult, pediatric and neonatal intensive care units.
- Trial name
- NAVA (NCT00814853)
- Testing
- NAVA (Extubation readiness testing failures)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Boston Children's Hospital
Neonatal Respiratory Failure, Invasive Mechanical Ventilation
A Model for Predicting Extubation Success in Premature Babies
Invasive mechanical ventilation is a life-saving treatment in critically ill newborns with respiratory failure. However, continuing this treatment for a long time may have negative consequences, especially bronchopulmonary…
- Conditions
- Neonatal Respiratory Failure, Invasive Mechanical Ventilation, Extubation Failure
- Trial name
- NCT05081973
- Testing
- A model for predicting extubation success based on extubation readiness estimator and lung ultrasonography score
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 114 people
- Sponsor
- Marmara University
Respiratory Distress of Newborn
Lung Ultrasound - Prospective Study
The goal of this clinical trial is to determine whether lung ultrasound can predict extubation success in neonates with respiratory distress. Participants will undergo a lung ultrasound pre- and post-extubation.
- Trial name
- NCT06140615
- Testing
- Ultrasound
- Where
- 2 sites in United States
- Volunteers
- 71 people
- Sponsor
- University of Wisconsin, Madison
Respiratory Insufficiency
Integrated Pulmonary Index (IPI) as a Determinate of Weaning Success and/or Failure in the Pediatric Population
Integrated pulmonary index (IPI) is a tool that monitors respiratory status. It takes into account four parameters: respiratory rate, end-tidal CO2, heart rate and O2 saturation using a pulse oximeter and specialized sidestream…
- Trial name
- IPI (NCT01795196)
- Where
- United States
- Sponsor
- Rush University Medical Center
Respiratory Insufficiency
Music Therapy During Pediatric Extubation Readiness Trials
This study seeks to research the effects of music therapy during pediatric extubation readiness trials. Amount of sedation, physiological measures, and parent/staff satisfaction surveys will be measured.
- Trial name
- MTPERT (NCT02845947)
- Testing
- Music Therapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Northwell Health
Ventilator Weaning, Respiration, Artificial
A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score
Liberation from mechanical ventilation involves three steps: weaning, readiness assessment, and extubation. Readiness is determined using clinical criteria such as improvement of the underlying condition, hemodynamic stability…
- Conditions
- Ventilator Weaning, Respiration, Artificial, Respiratory Failure, Extubation Readiness
- Trial name
- REXs (NCT07098611)
- Where
- 7 sites in Chile, Egypt and 4 more
- Volunteers
- 470 people
- Sponsor
- Medipol University
Anesthesia, Laryngospasm on Emergence
Investigation of Pupillometry as Guide for Extubation Readiness in Anesthetized Children
Investigation of pupillometry as guide for extubation readiness in anesthetized children.
- Trial name
- NCT04947397
- Testing
- Pupillometry
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Respiratory Distress Syndrome
Extubation Readiness Study in Very Low Birthweight Infants
The objective of this study is to determine whether use of the spontaneous breathing trial allows for earlier successful extubation of very low birth weight (VLBW) infants who are intubated for >48 hours and have not yet been…
- Trial name
- NCT01471431
- Testing
- spontaneous breathing trial
- Where
- 2 sites in United States
- Volunteers
- 81 people
- Sponsor
- University of Pennsylvania
PreTerm Neonate, Extubation Readiness
Prospective Multicentre Mixed Methods Study to Explore Extubation Practices and Respiratory Outcomes in Extremely Preterm Neonates.
The purpose of this observational study is to learn about neonatologists' perceptions of extubation readiness and extubation and reintubation practices in extremely preterm infants in the first 2 weeks of life using prospective…
- Conditions
- PreTerm Neonate, Extubation Readiness, Extubation Failure, Respiratory Morbidity
- Trial name
- CERAINE (NCT06808997)
- Where
- 31 sites in France
- Volunteers
- 166 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Intubation
Introducing and Evaluating Extubation Advisor
Knowing when to liberate critically ill patients from mechanical ventilation (i.e. extubation) is of great importance as both prolonged ventilation and failed extubation are associated with increased morbidity, mortality \&…
- Trial name
- EA (NCT02988167)
- Where
- Canada
- Volunteers
- 121 people
- Sponsor
- Ottawa Hospital Research Institute
General Anesthesia Using Endotracheal Intubation, Ophthalmologic Surgical Procedure
Sugammadex and Time to Extubation in Ophthalmic Surgery
This study is to invastigate if patients treated with sugammadex compared to neostigmine/atropine would be extubate faster upon emergence of anesthesia.
- Conditions
- General Anesthesia Using Endotracheal Intubation, Ophthalmologic Surgical Procedure, Sugammadex, Neostigmine
- Trial name
- NCT06632067
- Testing
- sugammadex, Neostigmine + Atropine
- Where
- Taiwan
- Volunteers
- 262 people
- Sponsor
- China Medical University Hospital
Respiratory Failure
Extubation Readiness and Neuroventilatory Efficiency After Acute Respiratory Failure
The aim of this study was to compare the indices of rapid shallow breathing, neuromechanical efficiency (NME), and neuroventilatory efficiency (NVE) between patients being successfully extubated and those who failed weaning.
- Trial name
- NCT01065428
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Southeast University, China
Prediction of Extubation Readiness
Prediction of Extubation Readiness in Extreme Preterm Infants by the Automated Analysis of CardioRespiratory Behavior
The investigators hypothesize that machine learning methods using a combination of novel, quantitative measures of cardio-respiratory variability can accurately predict the optimal time to extubate extreme preterm infants.
- Trial name
- NCT01909947
- Testing
- Cardiorespiratory signal acquisition
- Where
- 5 sites in United States, Canada
- Volunteers
- 266 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre