Clinical trials: Extubation Failure
Weaning Failure
Interest of High Flow Nasal Cannula Oxygen Therapy in Pediatric Intensive Care Unit
monocentric randomized controlled trial starting from Mars 2017, recruitment is still ongoing. Patients aged between 0-45 days needing mechanical ventilation (MV) with tracheal intubation were included random assignation in two…
- Trial name
- NCT03505814
- Testing
- High Flow Nasal Cannula Oxygen therapy (OPTIFLOW®), Conventional oxygen therapy
- Where
- Tunisia
- Volunteers
- 126 people
- Sponsor
- Hôpital d'enfants Béchir-Hamza
Myocardial Ischemia
Beta-blocker Before Extubation
Silent myocardial ischemia is known to occur in the general medical intensive care unit population immediately following tracheal extubation.
- Trial name
- NCT00563238
- Testing
- Metoprolol
- Where
- United States
- Sponsor
- Gregory A. Schmidt
Weaning From Mechanical Ventilation
Post Extubation Chest Physiotherapy in ICU
The purpose of this study is to examine the efficacy of chest physiotheray treatment in preventing pulmonary complications and weaning faliure, in extubated critically ill patients.
- Trial name
- NCT01967108
- Testing
- chest physiotherapy
- Where
- Israel
- Volunteers
- 65 people
- Sponsor
- Rambam Health Care Campus
Extubation Failure
Noninvasive Ventilation Versus High-Flow Nasal Cannula After Extubation in High-Risk ICU Patients
Extubation failure is associated with increased morbidity and mortality in critically ill patients. High-risk patients may benefit from preventive respiratory support after extubation.
- Trial name
- NIV-HFNC (NCT07630766)
- Testing
- NIV, HFNC
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Benha University
Airway Extubation
Maximum Expiratory Pressure in Induced Cough as a Predictor of Extubation Failure
Clinical trial for the evaluation of diagnostic tests. The sample was composed of adults under mechanical ventilation who passed the spontaneous breathing trial and was ready to be extubated.
- Trial name
- NCT04356625
- Testing
- MEPic
- Where
- Argentina
- Volunteers
- 80 people
- Sponsor
- Hospital Nacional Profesor Alejandro Posadas
Ventilatory Failure
Postextubation Management in Patients at Risk for Extubation Failure
At the time of weaning from mechanical ventilation, patients with heart and/or lung conditions will be given oxygen support with alternating bilevel positive airway pressure (BiPAP; oxygen via face mask) and heated high flow…
- Trial name
- NCT04258020
- Testing
- BiPAP, HFNC
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- OhioHealth
Weaning From Mechanical Ventilation, Weaning Failure
Characterization of Weaning Practices in ICUs of Global South Countries
This is a prospective observational study to be conducted in intensive care units of Global South countries. Patients on mechanical ventilation for more than 12 hours who have initiated the weaning process and for whom the…
- Conditions
- Weaning From Mechanical Ventilation, Weaning Failure, Weaning From Mechanical Ventilation, Extubation
- Trial name
- NCT07337408
- Where
- Brazil
- Volunteers
- 900 people
- Sponsor
- Hospital do Coracao
Premature
dTDI During a SBT to Predict Extubation Failure in Preterm Infants
Weaning from mechanical ventilation is a critical issue and the diaphragmatic disfunction has been demonstrated to play an important role in extubation failure.
- Trial name
- NCT05865977
- Testing
- diaphragmatic tissue Doppler imaging，dTDI
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Wang Jianhui
Weaning Failure, Acute Respiratory Failure
Impact of Nasal High-flow vs Venturi Mask Oxygen Therapy on Weaning Outcome: a Multicenter, Randomized, Controlled Trial
The purpose of this study is to determine whether, as compared with the Venturi mask, a nasal, high-flow oxygenation device (Optiflow) may reduce the extubation failure rate in patients needing oxygen therapy after extubation.
- Trial name
- RINO (NCT02107183)
- Testing
- Optiflow (Fisher & Paykel Healthcare), Venturi mask
- Where
- 14 sites in France, Greece and 2 more
- Volunteers
- 500 people
- Sponsor
- Catholic University of the Sacred Heart
Stroke, Dysphagia
PES to Avoid Extubation Failure in Intubated Stroke Patients at High Risk of Severe Dysphagia
Post-extubation dysphagia (PED) recently became a growing concern as a major risk factor for extubation failure and significant contributor to poor patient outcomes with prevalence rates ranging from 12% to 69%, being highest in…
- Conditions
- Stroke, Dysphagia, Extubation Failure
- Trial name
- NCT04010617
- Testing
- Pharyngeal Electrical Stimulation (PES)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Muenster
Airway Extubation
Analysis of the Magnetic Tape Bandage on Respiratory Functional Effects.
Invasive mechanical ventilation (IMV) is the mainstay of supportive care in acute respiratory failure. However, maintaining ventilatory support beyond what is necessary may increase the risk of nosocomial infections, favour…
- Trial name
- NCT05356299
- Testing
- Magnetictape bandage application
- Where
- Spain
- Volunteers
- 31 people
- Sponsor
- Hospital Universitario Doctor Peset
Pediatric Patients After Cardiothoracic Surgery
High Flow Nasal Cannula in Pediatric Patients After Cardiothoracic Surgery
High flow nasal cannula(HFNC) ventilation can provide such effects as wash-out effect of the carbon dioxide inside the anatomical dead space,some level of continuous airway pressure and humidified oxygen gases.
- Trial name
- OSACA CATS (NCT04451057)
- Testing
- high flow nasal cannula therapy, low flow nasal cannula therapy
- Where
- Japan
- Volunteers
- 286 people
- Sponsor
- Osaka University
Brain Injury
Criteria of Extubation Failure of Brain Injured Patients. Elaboration of a Prognostic Score.
Identification of criteria associated with extubation failure of brain injured patients. Elaboration of a prognostic score of extubation failure of brain injured patients.
- Trial name
- GODWEAN (NCT02235376)
- Testing
- weaning trial of mechanical ventilation
- Where
- France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Clermont-Ferrand
Post-extubation Dysphagia
High-frequency Repetitive Transcranial Magnetic Stimulation for Patients With Dysphagia After Extubation
Post-extubation dysphagia (PED) is characterized by a range of clinical manifestations, including absence of visible swallowing effort, coughing or choking following liquid intake, and post-swallowing dysarthria.
- Trial name
- Dysphagia (NCT07381946)
- Testing
- Swallowing training, a bilateral high-frequency repetitive transcranial magnetic stimulation, No intervention
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Wuhan University
Weaning Failure, Mechanical Ventilation Complication
Comparison of Two Extubation Techniques in Critically Ill Adult Patients
Orotracheal extubation consists in the removal of the endotracheal tube (ETT) when it is no longer required. This procedure may carry a considerable risk of complications and extubation failure.
- Trial name
- ExtubAR (NCT03918811)
- Testing
- Positive Pressure Extubation Technique, Traditional Extubation Technique
- Where
- Argentina
- Volunteers
- 725 people
- Sponsor
- Hospital Donación Francisco Santojanni
Extubation Readiness, Respiratory Failure With Hypoxia
Identifying the Best Flow Setting Strategy for High-Flow Nasal Cannula
The goal of this randomized trial is to compare four different flow-setting approaches for post-extubation use of high-flow nasal cannula (HFNC).
- Trial name
- NCT07007715
- Testing
- Flow of 40L/min, Peak tidal inspiratory flow (PTIF) guided, PaO2/FiO2 ratio guided
- Where
- Taiwan
- Volunteers
- 480 people
- Sponsor
- National Taiwan University Hospital
Hypoxemia
'Optiflow + Duet' Interface' vs 'Standard' High Flow Nasal Cannula
High-flow nasal cannula (HFNC) therapy is increasingly used in the management of acute respiratory failure. Its clinical application has been largely investigated in chronic obstructive pulmonary disease (COPD) patients but only…
- Trial name
- OPTIMARF (NCT05838326)
- Testing
- Symmetrical high flow nasal cannula (HFNO), Asymmetrical high flow nasal cannula (DUET HFNO)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Padova
Airway Extubation, Weaning Mechanical Ventilation
One-Hour Positive Pressure Ventilation After a Pressure Support Spontaneous Breathing Trial
This is a randomized, open, multicenter, pragmatic, adaptive clinical trial with intention-to-treat analysis. The study will compare two weaning strategies from mechanical ventilation in critically ill patients admitted to…
- Conditions
- Airway Extubation, Weaning Mechanical Ventilation, Extubation Failure
- Trial name
- NCT07324460
- Testing
- One-hour positive pressure ventilation, Immediate extubation
- Volunteers
- 4,000 people
- Sponsor
- Hospital do Coracao
Prematurity, Respiratory Failure
Non-invasive Neurally Adjusted Ventilatory Assist Versus Nasal Intermittent Positive Pressure Ventilation for Preterm Infants After Extubation
Non-invasive respiratory support has been emerging in the management of respiratory distress syndrome (RDS) in preterm infants to minimise the risk of lung injury.
- Conditions
- Prematurity, Respiratory Failure, Ventilator Lung; Newborn
- Trial name
- NCT03388437
- Testing
- NI-NAVA, NIPPV
- Where
- Saudi Arabia
- Volunteers
- 36 people
- Sponsor
- King Fahad Armed Forces Hospital
Respiratory Failure, Weaning Failure
HVNI for Successful Weaning in Respiratory Failure
The goal of this randomized active-controlled study is to investigate the role of high velocity nasal insufflation (HVNI) in the immediate post-extubation period and compare it with non-invasive positive pressure ventilation…
- Trial name
- REVIVER (NCT05855213)
- Testing
- High Velocity Nasal Insufflation, Non-invasive positive pressure ventilation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alexandria University