Clinical trials: Estrogen Replacement Therapy
Hypoactive Sexual Desire Disorder
A Pharmacokinetic (PK) Study to Compare the Absorption of Two Formulations of Transdermal Testosterone Spray and Intrinsa®
The purpose of this study is to determine if the absorption of the testosterone spray is the same as the Intrinsa® Patch.
- Trial name
- NCT01096329
- Testing
- Testosterone Spray 5% and 1%, Intrinsa® Patch and Testosterone Spray 5%, Intrinsa® Patch and Testosterone Spray 1%
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- VIVUS LLC
Postmenopause
Use of the Synthetic Hormone CDB-2914 in Treating Symptoms of Menopause
This study will examine the safety and effectiveness of a synthetic hormone, CDB-2914, for treating symptoms of menopause. It will compare the effects of estrogen and CDB-2914 with those of estrogen and progesterone in…
- Trial name
- NCT00009659
- Testing
- CDB 2914
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Healthy, Osteoporosis
Hormone Replacement in Young Women With Premature Ovarian Failure
The human ovary produces male sex hormones (androgen) and female sex hormones (estrogen). Currently, androgen is not included in hormone replacement therapy for women with premature ovarian failure.
- Conditions
- Healthy, Osteoporosis, Premature Ovarian Failure
- Trial name
- NCT00001951
- Testing
- TMTDS
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Estrogen Replacement Therapy
Study Comparing Bioavailability of 3 New Formulations of Premarin/MPA With Premarin/MPA (PREMPRO) Reference Formulation
This study will compare the bioavailabity of three new investigational combination formulations of Premarin and medroxyprogesterone acetate (MPA) with a currently marketed formulation of Premarin and MPA, Prempro™.
- Trial name
- NCT00401219
- Testing
- conjugated estrogens/progestin (MPA)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Menopause
A Comparison of Patch vs. Pill Estrogen Therapy on Testosterone Levels and Thyroid Tests in Menopausal Women
This study compares the effects of 12 weeks of treatment with transdermal versus oral estrogen therapy on testsoterone levels and thyroid tests in healthy, naturally menopausal women.
- Trial name
- NCT00224094
- Testing
- Premarin® (oral) vs. Alora® (transdermal)
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Watson Pharmaceuticals
Healthy, Postmenopause
Fat Distribution in Healthy Early Postmenopausal Women
The aim of this study is to explore the effects of hormone replacement therapy with EV/DNG on abdominal fat distribution measured by magnetic resonance imaging.
- Trial name
- NCT00335218
- Testing
- Climodien / Lafamme (BAY86-5027)
- Where
- 3 sites in Austria
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Bayer
Postmenopause, Aging
Postmenopausal Women Estrogen and Progesterone Infusion
The purpose of the study is to study the effects of aging, estrogen and progesterone on the brain. Specifically, we want to look at how the hypothalamus and pituitary (two small glands in the brain) respond to estrogen.
- Trial name
- NCT00455741
- Testing
- Estradiol infusion, Progesterone infusion
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Healthy
Estrogen Alternatives Study
Healthy postmenopausal women not currently taking hormone replacement or hormone modulating therapy take a 3-month course of estradiol/raloxifene/placebo to evaluate the effects of each on vascular function, as indicated by PET…
- Trial name
- NCT00108238
- Testing
- Estradiol followed by progesterone, Raloxifene
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Primary Ovarian Insufficiency, Vaginitis
A Study To Compare The Amount Of Premarin Components That Is Absorbed Into The Blood Of Japanese Healthy Postmenopausal Women Following Oral Administration Of Two Different Tablets Of Premarin Under Fast and Fed Conditions.
The purpose of this study is to assess the bioequivalence and food effect for a new Premarin formulation compared with a Premarin reference tablet in Japanese healthy postmenopausal women.
- Conditions
- Primary Ovarian Insufficiency, Vaginitis, Metrorrhagia, Menopause
- Trial name
- NCT01436513
- Testing
- Premarin reference tablet (fasted), Premarin new tablet (fasted), Premarin reference tablet (fed)
- Where
- Japan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy, Estrogen Replacement Therapy
Beneficial Effects of Oral Premarin Estrogen Replacement Therapy Assessed by Human Genome Array
The purpose of this study is to assess the immunological status of patients using Premarin. Premarin use is associated with an enhanced immune status, and possibly even some anti-cancer effect.
- Trial name
- NCT00318318
- Testing
- Premarin
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Aging, Menopause
Estrogen Use in Protection From Cognitive Decline
This study is designed to assess the effects of estrogen therapy among postmenopausal women at risk for cognitive decline.
- Trial name
- NCT00097058
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Stanford University
Turner Syndrome, Hypogonadism; Ovarian
Long Term Effects of Oral Versus Transdermal Estrogen Replacement Therapy in Turner Syndrome
This 14-month, phase IV, randomized controlled crossover trial aims to compare the effects of oral versus transdermal estrogen replacement therapy (ERT) in women with Turner syndrome (TS).
- Conditions
- Turner Syndrome, Hypogonadism; Ovarian, Hormone Replacement Therapy, Estrogen Replacement Therapy
- Trial name
- NCT06570460
- Testing
- 17-beta estradiol
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Hot Flashes
Gabapentin Versus Estrogen for the Treatment of Hot Flashes
To compare the efficacy and safety of gabapentin, estrogen and placebo in the treatment of hot flashes and other climacteric symptoms.
- Trial name
- NCT00276081
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Premature Ovarian Insufficiency
Ventricular Repolarization in Patients With Premature Ovarian Insufficiency (QTIOP)
Ventricular repolarization, measured by corrected QT interval (QTc), is influenced by sex hormones. A QTc above 460msec predisposes to the risk of "torsades-de-pointes"(TdP).
- Trial name
- QTIOP (NCT04167033)
- Testing
- Hormone replacement therapy:effect on ventricular repolarization, ECG
- Where
- 3 sites in France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Depressive Disorder, Mood Disorder
Progestin (Progesterone-Like Hormones) Induced Dysphoria (Depressed Mood, Irritability, Anxiety)
Often women are prescribed hormone replacement therapy (HRT) during the perimenopause or menopause. Hormone replacement therapy includes both estrogen and progesterone.
- Conditions
- Depressive Disorder, Mood Disorder, Psychomotor Agitation
- Trial name
- NCT00001770
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Primary Ovarian Insufficiency
Primary Ovarian Insufficiency: Phenotype and Optimal Treatment
This pilot study will observe the progression of newly diagnosed POI patients physical and psychology outcomes after initiating standard of care HRT treatment in comparison to healthy female control participants' physical and…
- Trial name
- NCT03568708
- Testing
- Transdermal Estrogen
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Menopause, Thrombophilia
Effect of DT56a (Femarelle) on the Coagulation System in the Treatment of Postmenopausal Women
The purpose of this study is to determine if Femeralle (DT56a) has an effect on the coagulation system, measured by platelet adhesion and aggregation, of normal and thrombophilic postmenopausal women.
- Trial name
- NCT00883272
- Testing
- DT56a (Femarelle) [Se-cure pharmaceuticals, Dalton, Israel]
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Menopause, Arteriosclerosis
Kronos Early Estrogen Prevention Study (KEEPS)
The study will examine the effects of estrogen and progesterone on the development of atherosclerosis in menopausal women when hormone treatment is initiated within 3 years of the menopausal transition.
- Trial name
- NCT00154180
- Testing
- Conjugated equine estrogens 0.45 mg/day, Transdermal estradiol, 50 mcg/day, Micronized progesterone, 200 mg/day x 12 d/month
- Where
- 9 sites in United States
- Volunteers
- 728 people, healthy volunteers welcome
- Sponsor
- Kronos Longevity Research Institute
Primary Ovarian Insufficiency, Premature Menopause
Effects of Estrogen on Heart Health in Women With Primary Ovarian Insufficiency
The goal of this observational study is to study the effects of treating women with Primary Ovarian Insufficiency (POI) with estrogen replacement therapy to bolster the evidence backing cardiometabolic preventive care in women…
- Conditions
- Primary Ovarian Insufficiency, Premature Menopause, Metabolic Complications, Endothelial Function (FMD)
- Trial name
- ENCODE (NCT06866119)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Transgenderism
Transgender Estradiol Affirming Therapy
The purpose of this open label, pilot, randomized clinical trial is to evaluate the effectiveness, safety and tolerability of estrogen use in transgender female and the degree of testosterone suppression achieved in this…
- Trial name
- TREAT (NCT05010707)
- Testing
- Transdermal patch, Pro-thrombotic markers, Metabolic markers
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine