Clinical trials: Esmolol
Preoperative, Phentolamine
Pre-operative Phentolamine Vs Intraoperative Esmolol Efficacy for Hypotensive Anesthesia in Functional Endoscopic Sinus Surgery
The aim of this study is to evaluate the efficacy of intra-operative phentolamine vs intraoperative esmolol for hypotensive anesthesia in functional endoscopic sinus surgery.
- Conditions
- Preoperative, Phentolamine, Intraoperative, Esmolol
- Trial name
- NCT06620991
- Testing
- Phentolamine, Esmolol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Tachycardia, Septic Shock
Echocardiographic and Arterial Pressure Waveform Changes After Reducing Heart Rate With Esmolol in Septic Shock Patients
Clinical study suggests that beta-blockers by decreasing heart rate together with an increase in stroke volume do not negatively affect cardiac output allowing an economization of cardiac work and oxygen consumption in patients…
- Trial name
- NCT02188888
- Testing
- esmolol
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- University of Roma La Sapienza
Esmolol Adverse Reaction
Efficacy of Esmolol Versus Magnesium Sulphate on Quality of Recovery in Patients Undergoing Laparoscopic Cholecystectomy: Randomized Controlled Study
sixty patients, of both sexes, of ASA I or II planned for ambulatory laparoscopic cholecystectomy under general anaesthesia were engaged into 2 groups.
- Trial name
- NCT05850832
- Testing
- Esmolol, Magnesium sulfate
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Hypertensive Intracerebral Hemorrhage
Efficacy and Safety Study of Urapidil Alone or With Esmolol in Treating Acute Hypertensive Intracerebral Hemorrhage
The objective of this study is to investigate the efficacy and safety of urapidil monotherapy versus the combination of esmolol in treating participants with acute hypertensive intracerebral hemorrhage through a prospective…
- Trial name
- NCT06635707
- Testing
- Urapidil, Urapidil and Esmolol
- Volunteers
- 600 people
- Sponsor
- Qianfoshan Hospital
Cerebral Aneurysm Unruptured, Intracranial Pressure
Remifentanil vs Esmolol During Intubation for Cerebral Aneurysm Coil Embolization
Endotracheal intubation may cause significant increases in blood pressure, heart rate, and intracranial pressure, particularly in patients undergoing cerebral aneurysm coil embolization.
- Trial name
- NCT07660861
- Testing
- Remifentanil, Esmolol
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Laminectomy
Esmolol Infusion During Laminectomy: Effect on Quality of Recovery
The purpose of this study is to evaluate the effects of esmolol, a drug which is commonly administered during surgery to help control blood pressure and heart rate, on postoperative pain levels and requirements for pain…
- Trial name
- NCT01179113
- Testing
- Esmolol, Saline
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Cedars-Sinai Medical Center
Lumbar Disc Herniation
Lidocaine Versus Esmolol for Optimizing Surgical Field Visibility
Intra-operative blood loss is an important attribution and predictor of the lumbar spine surgery and patient outcome. Stripping the muscle off bone makes more exposed bleeding spine surface is one of causes for blood loss during…
- Trial name
- NCT04260685
- Testing
- Lidocaine, Esmolol
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Shock, Septic
Effect of a Continuous Infusion of Esmolol on Stroke Volume in Patients With Hyperdynamic Vasoplegic Septic Shock
The main objective of this study is to evaluate the effectiveness of the administration of a short acting beta-blocker in terms of effective increase in stroke volume (at least 15%) after 4 hours initiation of therapy in septic…
- Trial name
- BétaSep (NCT02609152)
- Testing
- Continuous perfusion of esmolol, Continuous perfusion of saline
- Where
- 2 sites in France
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Subarachnoid Hemorrhage
Study to Evaluate Esmolol (Brevibloc) to Manage Cardiac Function in Patients With Subarachnoid Hemorrhage
The purpose of this study is to evaluate the clinical effect of esmolol treatment on cardiac function and electrophysiology; to assess the effects of esmolol treatment on serum adrenergic and cardiac biomarkers; to explore the…
- Trial name
- ABASH (NCT01232400)
- Testing
- Esmolol
- Where
- United States
- Sponsor
- University of Michigan
Septic Shock
Heart Rate Control With Esmolol in Septic Shock
The purpose of this study is investigate the effects on systemic hemodynamics and organ function of esmolol when used to maintain heart rate below a predefined threshold in patients with septic shock.
- Trial name
- NCT01231698
- Testing
- esmolol, control
- Where
- Italy
- Volunteers
- 154 people
- Sponsor
- Andrea Morelli
Vascular Disease, Hypertension
Tight Hemodynamic Control in Patients Who Are Chronically on Metoprolol
This study proposes to assess the effect of the standard of care, which is continuation of the pre op beta blocker dose into the post operative period compared to the administration of esmolol titrated to a pre determined target…
- Conditions
- Vascular Disease, Hypertension, Angina, Cardiac Disease
- Trial name
- NCT01404767
- Testing
- Esmolol, Metoprolol
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Anesthesia
Influence of Esmolol on a Closed-Loop Anesthesia System
Main objective is to evaluate the sparing effect of esmolol on the required doses of propofol and remifentanil
- Trial name
- NCT00922467
- Testing
- NaCl 9/00, Esmolol
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Hopital Foch
High-risk, Non-cardiovascular Surgeries
Esmolol for Treatment of Perioperative Tachycardia
The purpose of this study is to find out if Esmolol is a safe and effective alternative treatment compared to standard treatment using a long acting beta blocker drug, in controlling abnormal heart rate before, during and…
- Trial name
- NCT01208402
- Testing
- Esmolol
- Where
- 3 sites in United States
- Volunteers
- 76 people
- Sponsor
- Duke University
Sepsis, Lymphocyte Disorder T
Esmolol in Sepsis Management:Evaluating Immunomodulatory Effects and Impact on Patient Outcomes
Evaluate the effectiveness of esmolol, a selective β1-adrenergic receptor blocker, in modulating immune responses and improving patient outcomes in sepsis.
- Conditions
- Sepsis, Lymphocyte Disorder T, Immunologic Paralysis, Catecholamine; Overproduction
- Trial name
- NCT06390748
- Testing
- esmolol
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Lin Chen
Pain
Esmolol Pretreatment on Pain During Injection of Propofol
Pain on injection of propofol is a common side effect. The present study was designed to investigate the effect of esmolol on pain on propofol injection and to compare it with remifentanil and placebo.
- Trial name
- NCT01885364
- Testing
- Normal saline, Esmolol, Remifentanil
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Kyungpook National University Hospital
Diabetic Foot Ulcer
Phase 3 Study to Evaluate the Safety and Efficacy of Galnobax® in Treating Diabetic Foot Ulcers
The purpose of the current Study is to determine the safety and effectiveness of Galnobax® plus Standard of Care versus only Standard of Care, in treating Diabetic Foot Ulcers (DFU).
- Trial name
- NCT03998436
- Testing
- Esmolol Hydrochloride, Only Standard of Care, Vehicle Gel
- Where
- 14 sites in India
- Volunteers
- 176 people
- Sponsor
- Novalead Pharma Private Limited
Myocardial Ischemia
A Comparison of the Effects of Intraoperative Administration of Metoprolol or Esmolol on General Anesthetic Requirement
We will compare three study groups receiving metoprolol, esmolol, or placebo. Level of anesthesia will be titrated to achieve the same range of BIS value in all groups.
- Trial name
- NCT00756236
- Testing
- Metoprolol, Esmolol, P-Group
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Oklahoma
Septic Shock
POCUS-Guided Esmolol in Septic Shock: A Pilot RCT
The goal of this pilot clinical trial is to determine if conducting a larger study using point-of-care ultrasound (POCUS) to guide beta-blocker therapy in patients with septic shock is feasible.
- Trial name
- Epic-Beta (NCT07313605)
- Testing
- Esmolol
- Volunteers
- 100 people
- Sponsor
- John Basmaji
Intracranial Aneurysm, Intracranial Neoplasms
Esmolol Versus Dexmedetomidine During Intracranial Procedures
Patients undergoing intracranial procedures may experience severe hypertension and tachycardia due to intracranial hypertension and to increased release of adrenaline.
- Trial name
- NCT02563288
- Testing
- Esmolol, Dexmedetomidine
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- George Papanicolaou Hospital
Sepsis
The Effect of Esmolol on Patients With Sepsis
The investigators conduct an RCT to explore the efficacy of esmolol in patients with septic shock and sepsis.
- Trial name
- NCT04537767
- Testing
- Esmolol
- Volunteers
- 120 people
- Sponsor
- Shanghai Zhongshan Hospital