Clinical trials: Epiphora
Anterior Cruciate Ligament Tear
Comparison of Early Versus Delay Reconstruction in Anterior Cruciate Ligament Tearing
The purpose of this study is to determine which surgical method is better for anterior cruciate ligament teas in outcomes.
- Trial name
- NCT01580722
- Testing
- early reconstruction, delay reconstruction
- Where
- Iran
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Vaginal Tearing
Does the Use of Dianatal Reduce the Rate of Episiotomy and Vaginal Tears in Birth?
The purpose of the study is to see whether the use of DIANATAL during active labor, reduces the rates of episiotomy and vaginal tears.
- Trial name
- NCT02492152
- Testing
- Study group
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Epiphora
Determination of the Optimum Delivery Route for Botulinum Toxin A in Patients With Epiphora
Epiphora or excessive tearing is a significant disability for many affected patients diminishing their quality of life. There is a growing consensus that injection of Botulinum Toxin A (BTX-A) into the lacrimal gland provides…
- Trial name
- NCT01282541
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Merbs, Shannath, M.D., Ph.D.
Seasonal Allergic Rhinitis
A Phase III Efficacy Study of the Symptomatic Treatment of Seasonal Allergic Rhinitis With Bilastine
The objective of the study was to determine the efficacy and tolerability of 20 mg of Bilastine, compared to Desloratadine and placebo for the treatment of Seasonal Allergic Rhinitis.
- Trial name
- NCT01108783
- Testing
- Bilastine, Desloratadine
- Volunteers
- 720 people
- Sponsor
- Faes Farma, S.A.
Pregnancy, Childbirth
Comparison of the Flexibility of the Perineum in Primiparous Women Using the Medical Device Emagina During 90 Days of Their Pregnancy Compared to Those Having a Standard Pregnancy Follow-up
The goal of this clinical investigation is to learn if training with Emagina device can improve flexibility of the perineum during childbirth with the help of a balloon that inflates in the genital area according to a…
- Trial name
- PeriFlex (NCT06542744)
- Testing
- Training with the Emagina device at home until birth, No intervention
- Where
- 15 sites in France
- Volunteers
- 88 people
- Sponsor
- Mumming
Childbirth
A Clinical Phase II Study of the Materna Device to Shorten Delivery Time During Childbirth
This feasibility study is a prospective, non-randomized, single arm study to evaluate safety and prevention of maternal pelvic soft-tissue damage using the Materna Medical Device.
- Trial name
- NCT06698185
- Testing
- Materna Prep Device
- Where
- United States
- Sponsor
- Materna Medical
Epiphora, Dacryostenosis
Does Topical Ophthalmic Anesthetic Prior to Probing and Irrigation Decrease Pain?
Purpose: It is unknown whether instillation of a drop of anesthetic ophthalmic solution into the eye such as proparacaine hydrochloride 0.5% prior to probing and irrigation of the tear duct (lacrimal drainage) system improves…
- Conditions
- Epiphora, Dacryostenosis, Dacryocystitis
- Trial name
- NCT04229771
- Testing
- Proparacaine Hydrochloride ophthalmic solution, USP 0.5%, Balanced salt solution
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Corewell Health East
Primary Acquired Nasolacrimal Duct Obstruction
External Versus Powered Endoscopic Dacryocystorhinostomy With Mitomycin C for Primary Acquired Nasolacrimal Duct Obstruction
Primary acquired nasolacrimal duct obstruction causes persistent tearing because tears cannot drain normally from the eye into the nose.
- Trial name
- NCT07754058
- Testing
- External Dacryocystorhinostomy, Powered Endoscopic Dacryocystorhinostomy, Mitomycin C 0.02%
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Military Institute od Medicine National Research Institute
Allergic Conjunctivitis
Safety and Efficacy Study of AL-53817 and AL-78843 Ophthalmic Solutions for Allergic Conjunctivitis
The purpose of this study is to evaluate two investigational ophthalmic solutions for reduction in ocular redness in subjects with allergic conjunctivitis.
- Trial name
- NCT02079649
- Testing
- AL-53817 Ophthalmic Solution, 0.1%, AL-78843 Ophthalmic Solution, 0.03%, Dexamethasone Ophthalmic Suspension, 0.1%
- Volunteers
- 224 people
- Sponsor
- Alcon Research
Epiphora, Dacryocystitis
Comparative Study Between Wide and Narrow Fenstrum Endoscopic DCR
The aim of the study is to compare the efficacy and effectiveness of Endoscopic Endonasal DCR with narrow fenstrum approach and Endoscopic Endonasal DCR with wide fenstrum approach .
- Conditions
- Epiphora, Dacryocystitis, Dacryocystocele
- Trial name
- NCT04833452
- Testing
- Endoscopic dacryocystorhinostomy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Menoufia University
Epiphora, Conjunctivitis
Perforated Punctal Plugs for Treatment of Papillary Conjunctivitis in Otherwise Healthy Patients
Assessing efficacy of punctal dilatation with insertion of perforated punctal plugs for the management of acquired punctal stenosis due to allergic conjunctivitis in otherwise healthy patients.
- Trial name
- NCT02503956
- Testing
- Perforated Punctal plugs, Crawford tube insertion, Crawford lacrimal tube
- Where
- Israel
- Volunteers
- 14 people
- Sponsor
- Rabin Medical Center
Dry Eye Syndrome, Epiphora
Optical Coherence Tomography of Ocular Structures in Epiphora and Dry Eye Syndrome.
The primary aim of the study is to investigate whether optical coherence tomography (OCT) may be a useful tool for investigating the in-vivo histology of ocular structures in patients with tear film pathology.
- Conditions
- Dry Eye Syndrome, Epiphora, Sjögren's Syndrome
- Trial name
- OCT (NCT02849093)
- Testing
- Non-invasive OCT imaging
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bedford Hospital NHS Trust
Punctal Stenosis
Diagnosis of Acquired Punctal Stenosis Using Anterior Segment Optical Coherence Tomography
Purpose of the study To evaluate the lower puntum dimensions in cases of acquired punctal stenosis(APS), using anterior segment optical coherence tomography (AS-OCT).
- Trial name
- NCT03498144
- Testing
- Anterior segment OCT
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Minia University
Functional Epiphora (Tearing Without Any Anatomical Block)
Functional Epiphora Management Via Different Dacryocystorhinostomy (DCR) Techniques
135 eyes of 135 patients treated between 2005 and 2017 will be included in this study. The diagnosis of functional epiphora was made based on a patent lacrimal system with a delay in the fluorescein dye disappearance test (FDDT)…
- Trial name
- NCT04952454
- Testing
- External Dacryocystorhinostomy, Endonasal Dacryocystorhinostomy, Transcanalicular Dacryocystorhinostomy
- Where
- 2 sites in Canada, Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- Istanbul University
Epiphora, Ptosis
Bupivacaine Epiphora Trial
The objective of this study is to investigate quantitative improvement in excessive tearing after administration of Bupivacaine, a local anesthetic, into the affected eyelids.
- Trial name
- NCT03266081
- Testing
- 0.75% bupivacaine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Migraine, Cluster Headache
Pain Biomarker Study
This study investigates molecular and physical biomarkers of headaches in order to better understand mechanisms of these diseases. There are 3 main parts: 1.
- Conditions
- Migraine, Cluster Headache, Trigeminal Autonomic Cephalgia, Hemicrania Continua
- Trial name
- PBS (NCT03511846)
- Testing
- Oral capsaicin, Topical capsaicin, Intranasal capsaicin
- Where
- United States
- Volunteers
- 371 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Lacrimal Apparatus Diseases, Dacryocystitis
Follow up of Nasolacrimal Intubation in Adults
For patients with chronic epiphora, Dacryocystorhinostomy is currently the gold standard treatment, with a success rate of 80-90% according to literature.
- Trial name
- NCT00706251
- Testing
- Silicone tube
- Where
- Israel
- Volunteers
- 180 people
- Sponsor
- Shaare Zedek Medical Center
Dacryocystitis, Dacryocystitis; Chronic
Examination of Lacrimal Sac and Nasal Mucosa Preparations Taken in Dacryocystorhinostomy Surgery of Patients With Nasolacrimal Duct Obstruction and Comparison of Clinical Groups With Each Other
The goal of this observational study is to investigate etiology and pathogenesis of nasolacrimal duct obstruction and dacryocystitis in different adult clinic groups.
- Conditions
- Dacryocystitis, Dacryocystitis; Chronic, Dacryocystorhinostomy, Epiphora
- Trial name
- NCT06810089
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Uludag University
Perennial Allergic Rhinitis
Efficacy Study for the Symptomatic Treatment of Perennial Allergic Rhinitis With a 1 Year Safety Extension
Double-blind phase: The objective of the study was to evaluate the efficacy and safety of Bilastine 20 mg, compared to Cetirizine and placebo for the treatment of perennial allergic rhinitis.
- Trial name
- NCT01127620
- Testing
- Bilastine, Cetirizine
- Volunteers
- 650 people
- Sponsor
- Faes Farma, S.A.
Epiphora
Atropine Eye Drops for Watery Eyes (Excessive Tearing)
The goal of this clinical trial is to learn if low-dose atropine eye drops work to reduce excessive watery eyes (epiphora) in adults. It will also learn about the safety of the eye drops.
- Trial name
- NCT07676981
- Testing
- Atropine ophthalmic solution
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Rehan Ahmed