Clinical trials: Endstage Kidney Disease
Renal Impairment
A Phase l Study to Evaluate the Pharmacokinetics and Safety Pasireotide in Subjects With Varying Degrees of Renal Impairment Compared to Healthy Volunteers
The purpose of this study is to assess the effect of renal impairment on the pharmacokinetics (PK) of pasireotide,the PK of pasireotide in subjects with different degrees of renal impairment.
- Trial name
- NCT01578928
- Testing
- SOM230
- Where
- 2 sites in Germany, South Africa
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Endstage Renal Disease
Parathyroidectomy in Endstage Renal Disease
To test the hypothesis that total parathyroidectomy retards cardiovascular calcification, improves bone mineral density, reduces cardiac hypertrophy and arterial stiffening in end-stage renal disease patients on maintenance…
- Trial name
- NCT00745719
- Testing
- parathyroidectomy
- Where
- Hong Kong
- Volunteers
- 122 people
- Sponsor
- The University of Hong Kong
End Stage Renal Disease, Renal Failure
Homocysteine Study (HOST)
The primary objective of this study is to test the hypothesis that administration of folate, pyridoxine (vitamin B6) and cyanocobalamin (vitamin B12) in high doses to patients with advanced chronic renal failure or end stage…
- Trial name
- NCT00032435
- Testing
- PAL-40 Active
- Where
- 37 sites in United States, Puerto Rico
- Volunteers
- 2,003 people
- Sponsor
- US Department of Veterans Affairs
Diabetes
Interactive Studies of Endstage Diabetic Dialysis Patients
The purpose of this study is to document relevant and related clinical changes associated with different hemoglobin concentrations in diabetic hemodialysis patients.
- Trial name
- NCT00175734
- Testing
- High Hemoglobin Concentration, Low Hemoglobin Concentration
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of British Columbia
Vitamin K Supplementation, Endstage Renal Disease
Effect of Vitamin K2 (MK7) on Cardiovascular and Bone Disease in Dialysis Patients
Cardiovascular disease (CVD) is the most frequent cause of death in patients (ptt.) with chronic kidney disease (CKD). Compared to the general population death due to CVD is 10-20 times higher in CKD ptt.
- Conditions
- Vitamin K Supplementation, Endstage Renal Disease, Cardiovascular Disease, Bone Disease
- Trial name
- RenaKvit (NCT02976246)
- Testing
- Vitamin K2 (MK7)
- Where
- Denmark
- Volunteers
- 123 people
- Sponsor
- Zealand University Hospital
Endstage Renal Disease
The Effect of Increasing Dialysate Magnesium on Calcification Propensity in Subjects on Haemodialysis
The purpose of this trial is to examine the effect of increasing dialyse magnesium on serum calcification propensity in subjects with end-stage renal disease treated with haemodialysis.
- Trial name
- NCT02977117
- Testing
- Dialysate magnesium (1.0 mmol/L), Dialysate magnesium (0.5 mmol/L)
- Where
- Denmark
- Volunteers
- 59 people
- Sponsor
- Iain Bressendorff
Endstage Renal Disease
Randomized Multicenter Cross-over Study to Compare the Effect of Physioneal 35 to 40 on the Protein Metabolism
The purpose of this study is to demonstrate an increase in protein metabolism during treatment with Physioneal 35® (containing lactate 10 mmol/l, calcium 1.75 mmol/l) compared to treatment with Physioneal 40® (containing lactate…
- Trial name
- NephropaedPD01 (NCT00776191)
- Testing
- Physioneal 35, Physioneal 40
- Where
- 5 sites in Germany
- Volunteers
- 5 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Renal Failure
Pilot Study of Wearable Artificial Kidney
This is a pilot study of a wearable type of kidney dialysis machine to treat patients with chronic kidney disease.
- Trial name
- WAK (NCT00454974)
- Testing
- Wearable artificial kidney
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Royal Free Hampstead NHS Trust
Endstage Renal Disease
Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease
Individuals receiving dialysis are at risk of heart failure and heart related death. There is an urgent need for treatments that reduce the risk of these problems in patients that require dialysis.
- Trial name
- ACHIEVE (NCT03020303)
- Testing
- Spironolactone 25Mg Tablet
- Where
- 141 sites in Australia, Brazil and 10 more
- Volunteers
- 2,538 people
- Sponsor
- Hamilton Health Sciences Corporation
Kidney Failure, Chronic, Diabetes Mellitus, Type 1
Vascular Reactivity in Kidney Disease Patients
Dialysis patients suffer from many problems with blood vessels and this is even more so for patients with the added complication of diabetes.
- Conditions
- Kidney Failure, Chronic, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT00226902
- Testing
- Changing hemoglobin concentration
- Where
- Australia
- Volunteers
- 15 people
- Sponsor
- Melbourne Health
End-Stage Renal Disease
Role of Extrarenal 1-Alpha-Hydroxylase in Patients With End Stage Renal Disease
The goal of this study is to evaluate the role of nutritional Vitamin D deficiency as a potential contributor to the morbidity witnessed in patients with end-stage renal disease
- Trial name
- NCT00677534
- Testing
- Cholecalciferol
- Volunteers
- 7 people
- Sponsor
- University of Kansas
Kidney Disease, Chronic
Oral Findings in a Group of Egyptian Pediatric Patients at Endstage Renal Disease
In Egypt, the prevalence of end stage renal disease in pediatric population has never been estimated on a national scale. The patients at end stage renal disease encounter oral and dental problems that emphasize regular and…
- Trial name
- NCT03590067
- Testing
- Questionnaire
- Volunteers
- 150 people
- Sponsor
- Cairo University
Endstage Kidney Disease
Implementing "Explore Transplant"- A Pilot Study
Patients with End Stage Kidney Disease (ESKD) require Renal Replacement Therapy (RRT) in order to survive, be it dialysis or kidney transplantation (KT).
- Trial name
- NCT03046732
- Testing
- Implementing "Explore Transplant" Education
- Where
- 2 sites in Canada
- Volunteers
- 227 people
- Sponsor
- University Health Network, Toronto
Diabetes Mellitus, Endstage Renal Disease
A Podiatry Led MDT Intervention to Reduce the Burden of Foot Disease in Patients With End Stage Kidney Failure
Observational studies clearly show that people with diabetes and end-stage kidney failure have an increased risk of foot ulceration and leg amputation. However, there is very little evidence on addressing this problem.
- Trial name
- NCT03054454
- Testing
- Podiatry
- Volunteers
- 32 people
- Sponsor
- South Tees Hospitals NHS Foundation Trust
Endstage Renal Disease
LMWH Infusion as Anticoagulation for Home HD
There is a lack of data in the literature about the use of low-molecular weight heparin (LMWH) as anticoagulation for nocturnal home hemodialysis (NHHD).
- Trial name
- NCT02957877
- Testing
- Nadroparin, Unfractionated heparin
- Where
- Hong Kong
- Volunteers
- 12 people
- Sponsor
- Alice Ho Miu Ling Nethersole Hospital
Microalbuminuria, Cardiovascular Diseases
Prevention of Renal and Vascular Endstage Disease Intervention Trial
The Prevention of Renal and Vascular Endstage Disease Intervention Trial (PREVEND IT) was designed to determine whether intervention with the angiotensin-converting enzyme (ACE) inhibitor fosinopril and/or the…
- Conditions
- Microalbuminuria, Cardiovascular Diseases, Renal Disease
- Trial name
- PREVEND-IT (NCT03073018)
- Testing
- Fosinopril, Pravastatin
- Volunteers
- 864 people
- Sponsor
- University Medical Center Groningen
Endstage Renal Disease, Direct Oral Anticoagulants (DOACs)
Effect of Apiban Therapy on AVF Maturation in ESRD Patients
End-stage renal disease (ESRD) is a growing global health burden, and the creation of a native arteriovenous fistula (AVF) is the gold standard for vascular access in patients requiring hemodialysis [1].
- Conditions
- Endstage Renal Disease, Direct Oral Anticoagulants (DOACs), Arteriovenous Fistula, Arteriovenous Fistula Occlusion
- Trial name
- NCT07559942
- Testing
- Apixaban
- Where
- Pakistan
- Volunteers
- 190 people
- Sponsor
- Combined military hospital lahore
Endothelial Dysfunction, Endstage Renal Disease
Effect of Febuxostat on Endothelial Dysfunction in Hemodialysis Patients.
The Purpose of this study is to determine if the Febuxostat has an effect on endothelial dysfunction on hemodialysis patients.
- Trial name
- NCT02866214
- Testing
- Febuxostat
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Endstage Renal Disease
Data Collection for Next Generation Ultrasound Technology Development
The study is designed to collect data from a ultrasound device being used to evaluate feasibility of next generation algorithms for ultrasound data processing and does not test any health outcome.
- Trial name
- NCT02946229
- Testing
- Ultrasound scan
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- GE Healthcare
Hyperphosphatemia, Inflammation
An Open Label Trial to Evaluate the Effects of a Novel Renal Multivitamin on Inflammation and Other Biomarkers in Endstage Renal Disease Patients
The purpose of the study is to determine whether an ingestion of a new renal multivitamin supplement can have a beneficial effect on bone and mineral adn inflammation issues related to patients on dialysis.
- Conditions
- Hyperphosphatemia, Inflammation, Renal Disease
- Trial name
- NCT00834301
- Testing
- Oral Multivitamin
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Nephrian