Clinical trials: Embryo Disorder
Infertility, Female
Effect of Colony Stimulating Factor on Poor Endometrial Development During IVF
The purpose of this study is to investigate the effect of G-CSF on endometrial thickness in women who have failed reaching minimal endometrial thickness by standard treatments, to assess how many reach embryo transfer and what…
- Trial name
- NCT01202643
- Testing
- G-CSF, Saline
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Infertility, Implantation Rate
Hyaluronan-enriched Medium and Euploid Blastocyst Transfers
It has been proposed that enriching transfer media with hyaluronan (EmbryoGlue medium) improves pregnancy outcomes compared with media containing lower concentrations of this molecule.
- Conditions
- Infertility, Implantation Rate, Clinical Pregnancy Rate, Live Birth Rate
- Trial name
- GluePloid (NCT06165367)
- Testing
- EmbryoGlue Medium
- Where
- United Arab Emirates
- Volunteers
- 783 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Infertility, Female, IVF
Effect of Intrauterine Administration of Autologous PBMC Modulated With IFNt on IVF Outcome
The goal of this clinical trial is to test the effect of modulated specialised immune cells isolated from the patients' own blood when administered to the uterus before embryo transfer on the IVF outcome (implantation, pregnancy…
- Trial name
- NCT05775198
- Testing
- PBMC immunomodulated with IFNt
- Where
- Bulgaria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Nadezhda Women's Health Hospital
Infertility
Impact of Sequential Double Embryo Transfer on Live Birth Rates: A Case-Control Study.
The main aim of this study is to evaluate the impact and identify potential indications for sequential double embryo transfer (SEQ-ET) in couples undergoing assisted reproductive technology (ART).
- Trial name
- SEQ-ET (NCT07499453)
- Where
- France
- Volunteers
- 778 people, healthy volunteers welcome
- Sponsor
- Hopital Pierre Rouques - Les Bluets
Recurrent Implantation Failure
Platelet Rich Plasma and Recurrent Implantation Failure
This study is a randomized controlled clinical trial to compare the pregnancy outcomes of infertile women with recurrent implantation failure.
- Trial name
- NCT03996837
- Testing
- Intra uterine infusion of platelet rich plasma
- Where
- Iran
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Royan Institute
Fertility Disorders
Data Collection and Professional Simulated Use Study to Develop an Embryo Quality Artificial Intelligence (AI) Model
This protocol supports the reliable development and improvement of Artificial Intelligence (AI)-based applications by enabling training, verification, and validation using high-quality real clinical data.
- Trial name
- NCT07017972
- Testing
- AI evaluation of embryos
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Fairtility
Infertility
The Effectiveness of Endometrial Injury in IVF
Many studies have demonstrated that endometrial scratch significantly increase pregnancy rate in patients undergoing in vitro fertilization and embryo transfer.
- Trial name
- NCT02409745
- Testing
- endometrial scratch
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Infertility
Vitrification Versus Slow Cooling of Human Cleavage Stage Embryos
Human embryos can be preserved for later transfers by freezing. Traditionally the slow cooling method has been used. About 70% of the embryos remain fully intact after thawing.
- Trial name
- NCT00886431
- Testing
- embryo vitrification
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Infertility, Male
Sperm Selection Using Microfluidic Technology
This clinical study has been organised to investigate whether microfluidic technology may be considered as a new procedure for routine sperm preparation during assisted reproduction.
- Trial name
- MSS (NCT04997070)
- Where
- Belgium
- Volunteers
- 1,038 people, healthy volunteers welcome
- Sponsor
- CRG UZ Brussel
Pregnancy
The Effect of Acupuncture on Pregnancy Rates in Women Undergoing Embryo Transfer
The present study is designed to test the hypothesis that acupuncture, before and after embryo transfer, significantly improves pregnancy rates, compared to embryo transfer with sham acupuncture and no acupuncture at all.
- Trial name
- AcuIVF (NCT00722462)
- Testing
- Active acupuncture
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ottawa Fertility Centre
Infertility, Female
Impact of Serum Progesterone in Modified Natural Cycles and Stimulated Cycles on Ongoing Pregnancy Rate
Prospective cohort unicentric study including infertile patients undergoing an embryo transfer in the context of natural or stimulated cycles and receiving luteal phase support with vaginal natural progesterone following the…
- Trial name
- CORPUS-LUTEUM (NCT04259996)
- Testing
- PROGESTERONE AND ESTRADIOL SERUM CONCENTRATION MEASUREMENT
- Where
- Spain
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Infertility
Morphometrics and Morphokinetics of Thawed Oocytes and Embryos
The aim of this observational study is to describe for the first time a complete set of morphometric and morphokinetic parameters of frozen-thawed human embryos in order to select the embryo with the highest implantation…
- Trial name
- NCT02639715
- Volunteers
- 1,272 people, healthy volunteers welcome
- Sponsor
- Sophie Debrock
Infertility
Novel Approach for Embryo Transfer Medium by Adding Cytokine to Hyaluronan Enriched Embryo Transfer Medium (Embryo Glue)
It was proven that the Cytokine granulocyte-Macrophage clony stimulating factor had been found naturally in reproductive tract so our target is to test its effect if added to embryo transfer medium.
- Trial name
- NCT02422134
- Testing
- Cytokine group
- Where
- 2 sites in Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Ibn Sina Hospital
Infertility, Subfertility
Effect of hCG on Receptivity of the Human Endometrium
Worldwide, 1 in 12 couples experience difficulty in getting pregnant and seek the help of assisted reproductive technologies (ART) such as in vitro fertilization (IVF-egg is fertilized by sperm outside the body), ovarian…
- Trial name
- NCT01786252
- Testing
- human chorionic gonadotropin (hCG)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Infertility, Female
Impact of Serum Progesterone Levels on the Day of β-hCG Test in Artificial Cycles on the Ongoing Pregnancy Rate.
Prospective cohort multicentric study including infertile patients undergoing a pregnancy test on βhCG day (around ET +11), after an ET in the context of an artificial cycle and receiving LPS with vaginal natural progesterone…
- Trial name
- P4-BETA (NCT05750849)
- Testing
- BLOOD COLLECTION FOR P4 DETERMINATION
- Where
- Spain
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Infertility, IVF
Addition of Dydrogesterone to the Luteal Phase Support After Fresh Embryo Transfer
Randomized controlled study, open label to compare effectiveness of addition of dydrogesterone 20mg to the standard luteal phase support treatment after fresh embryos transfer.
- Trial name
- NCT04408144
- Testing
- Dydrogesterone 10mg Oral Tablet
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Laniado Hospital
Coronary Artery Disease
The Association Between Very Small Embryonic-like Stem Cells and the Prognosis of Coronary Artery Disease Patients
Hypothesis: Peripheral blood Very Small Embryonic-like Stem Cells (VSELs) are different in coronary artery disease (CAD) patients from those without CAD, which might account for the benefits of Atorvastatin in CAD patients.
- Trial name
- VSEL-CAD (NCT01633359)
- Testing
- Intensive statin, Routine statin
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ji Huang
Healthy People, Diabetes Mellitus, Type 2
The Effects of Mixed Grain on Blood Glucose and Insulin in Healthy Male
This study was an open, 4-treatment, 5-sequence, 5-day cross-over randomized design clinical trial to evaluate the efficacy of mixed grain on blood glucose, insulin and Glycemic index(GI) in healthy males.
- Trial name
- NCT01840982
- Testing
- Mixed grain 1, Mixed grain 2, White rice
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Infertility
Oestradiol Supplementation in Luteal Long Agonist Fresh In Vitro Fertilization/Intra Cytoplasmic Sperm Injection ( IVF/ICSI) Cycle .
Whether oestradiol administration affects the pregnancy rate in long agonist fresh IVF/ICSI cycles. Oestradiol level will be measured the day of HCG trigger to assess whether oestradiol level affects cycle outcome results.
- Trial name
- NCT03832894
- Testing
- Estradiol Valerate
- Where
- Egypt
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Cairo University
Infertility, Hereditary Diseases
Embryo Health Study
This study intends to determine the patients' perception and motivation to obtain additional information on their preimplantation embryos' risks of polygenic disorders.
- Trial name
- EHS (NCT04528498)
- Testing
- Preimplantation Genetic Testing
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Genomic Prediction Inc.