Clinical trials: Embryo Disorder
Recurrent Implantation Failure, Endometrial Receptivity Disorders
Experimental Study on the Use of Intrauterine Infusion of Autologous Platelet-rich Plasma (PRGF-IUI) in Patients With Recurrent Implantation Failure and/or Refractory Thin Endometrium
Endometrial receptivity is a key determinant of success in assisted reproductive technology (ART). A significant proportion of patients experience repeated implantation failure despite euploid embryos and adequate laboratory…
- Conditions
- Recurrent Implantation Failure, Endometrial Receptivity Disorders, Embryo Implantation, Platelet-Rich Plasma
- Trial name
- PMA_PREPAIRE (NCT07455773)
- Testing
- Intrauterine Platelet-Rich Plasma (PRP) Infusion, Hormone Replacement Therapy (HRT)
- Volunteers
- 80 people
- Sponsor
- Azienda Sanitaria Locale di Asti
Severe Oligoasthenoteratozoospermia, Sperm Quality
PRP Improves Blastocyst Formation in ICSI Cycles
The goal of this clinical trial is to learn if platelet rich plasma (PRP) works to improve embryo development rates and embryo quality in IVF cycles, involving male adult patients with severe sperm disorders.
- Conditions
- Severe Oligoasthenoteratozoospermia, Sperm Quality, Spermatazoa Disorders, Sperm Parameters in Fertile and Infertile Men
- Trial name
- PRP ICSI SOAT (NCT07579858)
- Testing
- Platelet Rich Plasma
- Where
- Indonesia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Stella Maris Women and Children Hospital
IVF, Infertility Treatment
Biomarkers of Endometrial Receptivity
Analysis of proteins from cervical mucus will be done in patients undergoing infertility treatment (fresh or frozen embryo transfer). Cervical mucus will be analysed for potential new biomarkers of endometrium receptivity.
- Conditions
- IVF, Infertility Treatment, Fertility Disorders, Embryo Transfer
- Trial name
- BIOMER (NCT04619524)
- Testing
- Cervical mucus will be collected from patients undergoing IVF, Cervical mucus will be collected from patients undergoing transfer of cryopreserved embryos
- Where
- 3 sites in Czechia
- Volunteers
- 476 people
- Sponsor
- The Institute of Molecular and Translational Medicine, Czech Republic
Sperm DNA Fragmentation, Embryo Quality
Sperm Selection by Microfluidic Separation Improves Embryo Quality
This is a randomized controlled trial of couples with a history of poor embryo quality undergoing a repeat in vitro fertilization (IVF) cycle for unexplained infertility.
- Conditions
- Sperm DNA Fragmentation, Embryo Quality, Fertility Disorders, Infertility
- Trial name
- SPERM (NCT03085433)
- Testing
- Microfluidic Sperm Sorting, in vitro fertilization
- Where
- United States
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Embryo Disorder
DFI and Aneuploidies
IVF is the most commonly employed form of assisted reproductive technologies (ART) for the 10-15% of couples who face difficulties becoming pregnant.
- Trial name
- NCT06279715
- Testing
- Preimplantation Genetic Testing for Aneuploidy
- Where
- Canada
- Volunteers
- 537 people
- Sponsor
- Clinique Ovo
Infertility, Poor Ovarian Reserve
Ovarian PRP Injections for Improved Embryo Quality Using Embryo Quality Score
Patients will have ovarian PRP treatments and embryo development will be observed using time-lapse imaging and AI software.
- Conditions
- Infertility, Poor Ovarian Reserve, Embryo Growth Disorder, in Vitro Fertilization
- Trial name
- NCT07020546
- Testing
- Ovarian Platelet-rich plasma (PRP) injections
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Generation Next Fertility
Anxiety, Assisted Reproductive Treatments
Virtual Reality for Anxiety Relief in Infertile Women
This study examines the impact of virtual reality (VR) applications on anxiety levels before and after embryo transfer procedures.
- Conditions
- Anxiety, Assisted Reproductive Treatments, Women, VR
- Trial name
- NCT07020975
- Testing
- VR Glasses
- Where
- Cyprus
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cyprus Aydin University
Being Diagnosed With Primary Infertility, Having Had an Embryo Transfer for the First Time
Effects of Virtual Reality Glasses and Meditation Music on Anxiety, Pain, Vital Signs, Satisfaction and Pregnancy Outcomes in Embryo Transfer Procedure
The aim of this study is to determine the effects of virtual reality glasses (VRG) and meditation music on anxiety, pain, vital signs, satisfaction and pregnancy outcomes during the embryo transfer (ET) procedure.
- Trial name
- NCT06802692
- Testing
- VR glasses and meditation music group, Meditation music group
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Nuh Naci Yazgan University
Embryo Growth Disorder, Humans
Impact of PH Values of the Embryo Culture Medium on Success of in Vitro Fertilization (IVF)
The objective of this study is to compare, through a multicentric randomized trial, the impact of two pH values in the embryo culture medium on the clinical results of In Vitro Fertilization (IVF) process and especially the…
- Conditions
- Embryo Growth Disorder, Humans, Pregnancy
- Trial name
- ACIDOFIV (NCT04456478)
- Testing
- pH at 7.38 ± 0.02, pH at 7.22 ± 0.02
- Where
- 3 sites in France
- Volunteers
- 429 people
- Sponsor
- University Hospital, Toulouse
Embryo, Embryo Disorder
Genetic Screening and Assisted Oocyte Activation in Couples with Diminished/aberrant Embryonic Development.
This is an interventional comparative study at the Department of Reproductive Medicine at Ghent University Hospital. Patients with previous embryo developmental problems are eligible for the study.
- Conditions
- Embryo, Embryo Disorder, Genetic Disease
- Trial name
- AOA (NCT03354013)
- Testing
- AOA, Genetic screening, Calcium pattern analysis
- Where
- Belgium
- Volunteers
- 42 people
- Sponsor
- University Hospital, Ghent
REPRODUCTIVE TECHNIQUES, Embryo Transfer
Music for Anxiety in Embryo Transfers
The goal of this clinical trial is to compare if playing music before and during an embryo transfer can make a difference for women who are going through a frozen embryo transfer as part of a medical procedure called assisted…
- Conditions
- REPRODUCTIVE TECHNIQUES, Embryo Transfer, Music, Test Anxiety
- Trial name
- MUSIC-ET (NCT06084793)
- Testing
- Music
- Where
- Argentina
- Volunteers
- 146 people
- Sponsor
- Centro de Estudios en Genetica y Reproduccion
Embryo Disorder
Pilot Study: hCG Secreted by Blastocyst as Potential Marker of Embryo Quality
hCG is a hormone produced very early by the pre-embryo, but not by the oocyte. It has a pivotal role in the trophoblast differentiation, and embryo implantation as well as the corpus luteum support.
- Trial name
- NCT04736160
- Testing
- collect data
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- IVI Vigo
Embryo Disorder
Embryos With Preimplantation Genetic Testing for Aneuploidies (PGT-A) Inconclusive Result: Clinical Implications
One of the most remarkable improvements in trophoectoderm cells biopsy is the robustness of diagnosis as result of analyzing multiple cells.
- Trial name
- NCT04734769
- Testing
- Collect retrospectively clinical data on reproductive outcomes
- Volunteers
- 600 people
- Sponsor
- IVI Vigo
Embryo Disorder
Does the Air-bubble Location Influence on the Implantation Rate
The main objective of the study is to evaluate whether there is any association between the location into the uterine cavity, where the air bubbles containing the pre-embryos were placed, and the implantation rate.
- Trial name
- TRANSFER (NCT04574310)
- Testing
- Collect retrospectively data on embryo implantation rate
- Volunteers
- 400 people
- Sponsor
- IVI Vigo