Clinical trials: Early Pregnancy Failure
Acute Kidney Injury, Fluid Overload
Early Deresuscitation Strategy Driven by Tissue Perfusion in Renal Replacement Therapy in Patients With Acute Renal Failure
In Intensive Care Unit (ICU) patients with acute kidney injury (AKI) and treated with renal replacement therapy (RRT) often present a fluid overload which is associated with morbidity (mechanical ventilation duration increase…
- Trial name
- EarlyDry (NCT05817539)
- Testing
- Fluid balance negativation, Body weight Stabilization
- Where
- 14 sites in France
- Volunteers
- 250 people
- Sponsor
- Hospices Civils de Lyon
Chronic Kidney Failure
Belatacept as a Replacement for CNIs 3 to 12 Months Post-transplantation in Patients With Early Graft Dysfunction
Calcineurin inhibitors (CNI) remain the standard treatment in renal transplantation to prevent rejection. Currently the main limitation of kidney transplantation is the occurrence of chronic graft dysfunction due to the CNI…
- Trial name
- BELASBRIDGE (NCT05562869)
- Testing
- Belatacept 250 Milligram Intravenous Powder for Solution
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Acute Renal Failure
Vasodilators and Anti-Oxidant Therapy in Early ATN
Patients developing kidney failure after open heart surgery experience an abrupt decrease in blood flow to the kidney. The investigators hypothesize that administration of fenoldopam mesylate (a drug that increases blood flow to…
- Trial name
- NCT00286403
- Testing
- Fenoldopam Mesylate and/or MESNA
- Where
- 2 sites in United States
- Sponsor
- Southeast Renal Research Institute
Septic Shock and Acute Kidney Injury
Early Versus Late CRRT in ACLF Patients With Septic Shock and AKI
Consecutive patients with ACLF (Acute on Chronic Liver Failure) and septic shock with AKI (Acute Kidney Injury) who give written informed consent will be included in this prospective trial at ILBS.
- Trial name
- NCT03343340
- Testing
- Early CRRT, Late CRRT, Standard Medical Therapy
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Prematurity; Extreme, Feeding Disorder Neonatal
Early Protein Supplementation in Extremely Preterm Infants Fed Human Milk
The central hypothesis of this clinical trial is that, in extremely preterm infants, protein-enriched human milk diets compared to usual human milk diets during the first 2 weeks after birth increase fat-free mass (FFM)-for-age Z…
- Conditions
- Prematurity; Extreme, Feeding Disorder Neonatal, Breast Milk Expression, Growth Failure
- Trial name
- NCT04325308
- Testing
- Protein-enriched human milk diet, Usual human milk diet
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Alabama at Birmingham
Kidney Failure, Chronic
Creation of Arteriovenous Ante-brachial Fistula Under Axillary Block Versus Local Anesthesia : Impact on Early Complications
Recommended by the KDOQI vascular access guidelines, antebrachial arteriovenous fistula is the best primary vascular access for hemodialysis in patients with end stage renal disease.
- Trial name
- FAV ss ALR (NCT02722096)
- Testing
- Axillary block anesthesia with Ropivacaine and Lidocaine, Local anesthesia with Ropivacaine and Lidocaine
- Where
- France
- Volunteers
- 78 people
- Sponsor
- Hospices Civils de Lyon
Anembryonic Pregnancy, Gestation Abnormality
Mifepristone and Misoprostol for Fetal Demise
This is a pilot clinical trial to evaluate whether the medical management of early pregnancy failure with mifepristone and misoprostol is an effective and acceptable treatment.
- Conditions
- Anembryonic Pregnancy, Gestation Abnormality, Intrauterine Fetal Demise Term
- Trial name
- MIMID (NCT00177372)
- Testing
- mifepristone/misoprostol
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Acute Kidney Injury
Early Versus Late Renal Replacement Therapy After Cardiac Surgery
The question of timing of initiation of renal replacement therapy (RRT), "early" versus "late", has seldom been the focus of high-quality or rigorous evaluation.
- Trial name
- NCT01961999
- Testing
- Early RRT, Late RRT
- Where
- Italy
- Volunteers
- 1,800 people
- Sponsor
- Ospedali Riuniti Ancona
Calciphylaxis, Renal Insufficiency, Chronic
The Early Administration of Sodium Thiosulfate Should Help to Reduce the Mortality of Dialysis Patients With Calciphylaxis, From a National Cohort
The national drug safety agency authorizes nominatively the use of sodium thiosulfate in dialysis patients with calciphylaxis. To date, it is the largest global cohort (more 600 patients from 2012 to 2016).
- Trial name
- NCT03146793
- Testing
- Sodium Thiosulfate
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Centre Hospitalier St Esprit
Renal Disease, Kidney Failure
The Boston Scientific ACCESS Trial
The Boston Scientific ACCESS trial seeks to study the safety and to evaluate the success of the Fusion™ Vascular Access Graft for patients in need of early vascular access for hemodialysis.
- Trial name
- ACCESS (NCT00260728)
- Testing
- vascular access graft implantation
- Where
- 8 sites in United States
- Volunteers
- 149 people
- Sponsor
- Maquet Cardiovascular
Kidney Failure, Acute, Renal Insufficiency, Acute
Impact of Early Renal Involvement on the Development of Severe In-hospital Renal Failure
The purpose of this study is to determine whether renal team involvement early at the onset of kidney injury will prevent further developement of more severe renal failure and worse hospitalization outcomes.
- Conditions
- Kidney Failure, Acute, Renal Insufficiency, Acute, Kidney Failure, Renal Insufficiency
- Trial name
- EARLI (NCT00806039)
- Testing
- Early Renal Involvement
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Saint Louis VA Medical Center
Infant, Very Low Birth Weight, Growth Failure
Preterm Infants on Early Solid Foods
Introduction: Preterm infants with a birth weight less than 1500 grams have special nutritional needs in comparison to full-term neonates.
- Trial name
- PIES-Project (NCT01809548)
- Testing
- Early intervention group, Late intervention group
- Where
- Austria
- Volunteers
- 177 people
- Sponsor
- Medical University of Vienna
Shock, Septic, Renal Failure, Acute
Haemofiltration Study : IVOIRE (hIgh VOlume in Intensive Care)
Sepsis and septic shock are still important causes of mortality in intensive care medicine. Renal replacement therapy by standard volume haemofiltration is currently used, but a higher-volume haemofiltration may improve the…
- Trial name
- IVOIRE (NCT00241228)
- Testing
- Venovenous haemofiltration (renal replacement therapy)
- Where
- 16 sites in Belgium, France and 1 more
- Volunteers
- 139 people
- Sponsor
- University Hospital, Bordeaux
Early Pregnancy Failure, Miscarriage
MiMi: A Randomized Trial of Mifepristone and Misoprostol for Treatment of Early Pregnancy Failure
The purpose of this study is to compare two combinations of drugs (mifepristone and misoprostol versus placebo and misoprostol) used for medical treatment for early pregnancy failure.
- Conditions
- Early Pregnancy Failure, Miscarriage, Fetal Demise, Anembryonic Pregnancy
- Trial name
- MiMi (NCT00468299)
- Testing
- Mifepristone and misoprostol
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Boston University
Kidney Failure
Treatment of Early Stage Renal Failure With Active Vitamin D or a Phosphate Binder.
Patients with reduced renal function normally develop hyperparathyroidism, which in turn is associated with increased cardiovascular risk and de-calcification.
- Trial name
- NCT01231438
- Testing
- Renvela, Etalpha
- Where
- 2 sites in Norway
- Volunteers
- 21 people
- Sponsor
- Helse Stavanger HF
Trehalase Levels, Acute Kidney Injury
Early Diagnosis of Acute Renal Failure by Urine Trehalase Levels.
We think that in surgical patients requiring hypotensive anesthesia, acute kidney injury, which may occur due to intraoperative renal hypoperfusion, can be diagnosed early by evaluating the urine trehalase value using the ELISA…
- Trial name
- NCT06505655
- Testing
- trehalase levels
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istinye University
Burns, Multiple Organ Failure
Early Haemadsorption in Major Burns
Major deep burns (>20% body surface, involving deep skin layers) and associated severe inflammatory reaction and their complication are one of the biggest challenge of intensive care.
- Conditions
- Burns, Multiple Organ Failure, Shock, Organ Dysfunction Syndrome, Multiple
- Trial name
- NCT04195126
- Testing
- CytoSorb haemadsorption device
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- University of Pecs
Acute Kidney Injury
Development of an Innovative Clinico-biological Score for the Early Detection of Acute Renal Failure Associated With Cardiac Surgery.
The prediction and early detection of acute renal failure associated with cardiac surgery (ARF-CS) are desirable in order to try to reduce its magnitude.
- Trial name
- DETECT-AKI (NCT05283213)
- Testing
- Early biomarkers of acute kidney injury
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Nantes University Hospital
END STAGE RENAL DISEASE
ESTEROID WITHDRAWAL STUDY, SAFETY AND EFFICACY IN RENAL TRANPLANTATION
BACKGROUND: Non-steroid maintenance immunosuppression after transplantation can improve long-term lipid and hemodynamic profiles without severe acute rejection (AR) events that alter graft function or survival.
- Trial name
- ESWMEX001 (NCT02328222)
- Testing
- ESW group
- Where
- Mexico
- Volunteers
- 71 people
- Sponsor
- Unidad de Investigacion Medica en Enfermedades Renales
Cancer, Drug Toxicity
Tc-99m Renography and Cisplatin-induced Nephrotoxicity
Cisplatin is a heavy-metal complex widely used in the treatment of a variety of malignancies, including small cell and non-small cell lung cancer, ovarian, bladder, head and neck, esophageal, cervical and germ cell tumors.
- Conditions
- Cancer, Drug Toxicity, Kidney Failure
- Trial name
- NCT00213642
- Volunteers
- 20 people
- Sponsor
- University Hospital, Rouen