Clinical trials: ENT Surgery
ENT Disease, Tonsil Disease
Bizact Tonsillectomy: Postoperative Pain, Bleeding and Cost-effectiveness (Randomized Study)
Randomized trial assessing Bizact-instrument in tonsillectomy and it's impact on postoperative recovery (pain, hemorrhage)
- Conditions
- ENT Disease, Tonsil Disease, Surgery
- Trial name
- NCT07842419
- Testing
- Tonsillectomy
- Where
- Finland
- Volunteers
- 224 people
- Sponsor
- Helsinki University Central Hospital
Hypotension, ENT Disease
Influence of the "Hypotension Probability Index" on Intraoperative and Postoperative Hypotension in ENT- and OM-Surgery
The aim of the project is to investigate whether the use of the HPI can reduce the number and duration of intra- and postoperative hypotension in ventilated patients during and two hours after extensive surgery in the head and…
- Conditions
- Hypotension, ENT Disease, Acute Kidney Injury, Anesthesia
- Trial name
- NCT04151264
- Testing
- Hypotension probability index (HPI)
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- University of Giessen
ENT Surgery, Gynecological Surgery
Medico-economic Evaluation of Subcutaneous Automatic Resorbable Staples Device
A surgery made by an external incision requires to stitch the subcutaneous plans, usually performed using absorbable synthetic sutures hold on wire needle.
- Conditions
- ENT Surgery, Gynecological Surgery, Plastic Surgery
- Trial name
- S2CARA (NCT01546272)
- Testing
- Insorb resorbable staples, Monocryl resorbable wire
- Where
- 24 sites in France
- Volunteers
- 664 people
- Sponsor
- Nantes University Hospital
Frailty
SCM Muscle as a Marker for Frailty in Patients Undergoing ENT Surgery
This study focuses on evaluating the relationship between physical frailty and measurements of the muscles of the neck in patients undergoing non-cancer Head and Neck surgery.
- Trial name
- NCT06704256
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Tonsillitis, Tonsillar Hypertrophy, Tonsillitis
Comparing Two Agents Used to Stop Bleeding During Tonsil Removal Surgery: Adrenaline Versus Hydrogen Peroxide
The goal of this quasi-experimental study is to compare the effectiveness of topical adrenaline and 3% hydrogen peroxide for controlling bleeding (hemostasis) during tonsil removal surgery in patients aged 5 to 18 years.
- Conditions
- Chronic Tonsillitis, Tonsillar Hypertrophy, Tonsillitis, Tonsillectomy
- Trial name
- NCT07675278
- Testing
- Adrenaline, Hydrogen Peroxide
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- Rawalpindi Medical College
Otorhinolaryngologic Diseases
Reconstruction Implant Bone After Removal Using Porous Titanium Prosthesis
This trial will study the reconstruction of the anterior part of the mandible and the adjacent soft tissue parts by a mandibular prosthesis made in porous titanium, associated or not, to a latissimus dorsi or pectoral flap, to…
- Trial name
- NCT00213837
- Testing
- Mandibular prosthesis made of a new highly biointegratable material
- Where
- France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Strasbourg, France
Anesthesia; Functional
Neuromuscular Blockade Reversal Agent Effect on Postoperative Cognitive Function and Behaviour in Children
The aim of this prospective randomized study is to investigate comparatively the effect of neostigmine-atropine versus sugammadex on speed and quality of recovery and on postoperative cognitive function \& behavior in children…
- Trial name
- NCT02455921
- Testing
- neostigmine - atropine, Sugammadex
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- Attikon Hospital
Otorhinolaryngologic Neoplasms
Support Pathway for ENT Cancer Patients in a Support Care Day Hospital
Cancers of the upper respiratory / digestive tract are a major public health problem, ranking 5th among the most common cancers. Surgery plays a central role in the recommended treatments for this type of pathology.
- Trial name
- PAKO-HDJ (NCT06512662)
- Testing
- Consultations with paramedics
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Clinique Pasteur Lanroze
Emergence Delirium
Emergence Agitation of Sevoflurane in Pediatric
Low dose nalbuphine versus dexmedetomidine on prevention of emergence agitation in children
- Trial name
- NCT06830564
- Testing
- we will give the patient 0.1 mg nalbuphine 15 min before the end of the procedure, we will give the patient 0.5 mg dexmedetomidine 15 min before the end of the procedure
- Where
- Egypt
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Anesthesia, General
The Effect of BIS-guided Propofol Induction on Hemodynamic Response in Patients With Cardiac Risk.
Anesthesia induction will be started by monitoring ECG, non-invasive artery monitoring, peripheral oxygen saturation and BIS for all patients who are taken to the operating room without sedation.
- Trial name
- NCT04729465
- Testing
- Propofol, Bispectral Index Monitor
- Volunteers
- 60 people
- Sponsor
- Istanbul University - Cerrahpasa
Adenotonsillectomy, Analgesia
Post-operative Course of Dexamethasone to Reduce Tonsillectomy Morbidity
The goal of this study is determine if an oral systemic course of steroids is a safe and effective option in lowering pain and complications following adenotonsillectomy in various pediatric age groups.
- Conditions
- Adenotonsillectomy, Analgesia, Surgery
- Trial name
- NCT04879823
- Testing
- Dexamethasone, Ibuprofen, Acetaminophen
- Where
- 2 sites in United States
- Volunteers
- 222 people
- Sponsor
- David Chi, MD
Mucopolysaccharidosis (MPS)
Mucopolysaccharidosis (MPS) I, II, and VI Screening in a High-Risk Population With Previous Surgical Repair or Presence of Inguinal and/or Umbilical Hernia in Combination With Pediatric ENT Surgery (The HATT Project)
Mucopolysaccharidosis (MPS) type II (MPS II; Hunter syndrome) is a rare, X-linked disease caused by a deficiency of the lysosomal enzyme iduronate-2-sulfatase (I2S) and occurs almost exclusively in boys, with an incidence of…
- Trial name
- NCT02095015
- Where
- 14 sites in United States, Canada and 5 more
- Volunteers
- 159 people
- Sponsor
- Shire
Cervical Surgery, Endonasal Surgery
Effect of Passive Music Therapy Via an App on Anxiety Prevention in ENT Surgery
Music therapy is a controlled method of listening to music, utilizing its physiological, psychological, and emotional effects on humans during the treatment of illness or trauma.
- Conditions
- Cervical Surgery, Endonasal Surgery, Otologic Disease, Oropharyngeal Disease
- Trial name
- MUSICORL (NCT06600919)
- Testing
- Preoperative Music Therapy Session
- Where
- Reunion
- Volunteers
- 500 people
- Sponsor
- Clinique Saint-Vincent
ENT Cancers
Evaluation of the Superficial Cervical Plexus Block in Oncological Throat and Neck Surgery
This national, prospective, multicenter, randomized study aims to reduce the amount of intravenous morphine (titration + PCA morphine) during the first 24 postoperative hours via a locoregional anesthesia technique in patients…
- Trial name
- BCS-ORL (NCT07110857)
- Testing
- Cervical plexus block with 0.2 % Naropeine
- Where
- 7 sites in France
- Volunteers
- 346 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Head and Neck Surgery, Chronic Sinusitis
Sugammadex v.s. Neostigmine/Glycopyrrolate
The aim of study is to clarify the role of sugammadex in ENT surgery patients with a prior history of postoperative urinary retention, benign prostatic hypertrophy, or a history of prostate cancer, to prevent postoperative…
- Conditions
- Head and Neck Surgery, Chronic Sinusitis, Chronic Otitis Media, Laryngeal Disease
- Trial name
- NCT06398899
- Testing
- Group S: sugammadex injection, Group N: neostigmine/glycopyrrolate
- Where
- Taiwan
- Volunteers
- 124 people
- Sponsor
- National Taiwan University Hospital
Cervico-Facial Surgery ENT Academic Medical and Surgical Training in France, Cervico-Facial Surgery ENT Medical Residency (Auvergne-Rhône-Alpes, Grand Est, Ile de France, Nouvelle Aquitaine and Provence-Alpes-Côte d'Azur Areas)
Impact of Covid-19 on Training for ENT and Cervico-Facial Surgery Residents in France
The impact of the Covid-19 pandemic on medical education is real but little known. ENT interns were directly affected by the management of Covid-19 patients (performing surgical tracheostomies), many conferences and trainings…
- Trial name
- NCT05158790
- Testing
- Questionnaire
- Where
- 6 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Head Neck Cancer, Mouth Cancer
CApecitabine Prior to TUmor Resection in Ent Oncology (CAPTURE)
head and neck squamous cell carcinoma (HNSCC) is a type of cancer that affects areas such as the mouth, throat, and voice box. Despite medical progress, little has changed in the care for patients with HPV-negative cancer.
- Conditions
- Head Neck Cancer, Mouth Cancer, Throat Cancer, Larynx Cancer
- Trial name
- CAPTURE (NCT07254962)
- Testing
- Capecitabine, Standard of Care (SOC)
- Volunteers
- 75 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Patients Undergoing ENT Surgery With Cuffed ETT
The Relationship Between Patients' Head Position and ETT Intracuff Pressure
This study is designed to investigate the relationship between patients' position and endotracheal tube intracuff pressure in the pediatric population.
- Trial name
- NCT01851317
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Nationwide Children's Hospital
Reaction; Anesthesia
Clinically Relevant Asymmetry of Bispectral Index
BIS for monitoring depth of anesthesia is usually obtained unilaterally. Obtaining BIS bilaterally revealed side differences in previous studies.
- Trial name
- NCT01289613
- Where
- Germany
- Volunteers
- 88 people
- Sponsor
- University Hospital Schleswig-Holstein
Rehabilitation, Neck Cancer
Rehabilitation Nursing Program in Otolaryngology
The European Commission's current political guidelines demonstrate into a joint plan aimed at improving and controlling cancer disease. Head and neck cancer (HNC) are the sixth most common cancer worldwide.
- Conditions
- Rehabilitation, Neck Cancer, Otorhinolaryngologic Neoplasms
- Trial name
- NCT05246891
- Testing
- rehabilitation nursing
- Where
- Portugal
- Volunteers
- 151 people
- Sponsor
- University of Évora