Clinical trials: Dysglycemia, active
Gestatiaonl Diabetes Mellitus, GDM
Study to Prevent Dysglycemia in Women With GDM
Women with a history of gestational diabetes mellitus (GDM) have a 7-fold increased risk of type 2 diabetes (T2D), with the risk at its highest during the 3-6 years postpartum.
- Trial name
- NCT07269405
- Testing
- Intervention, Conventional care
- Where
- Hong Kong
- Volunteers
- 800 people
- Sponsor
- Chinese University of Hong Kong
Gestational Diabetes
Pilot Study of Continuous Glucose Monitoring for Postpartum Glucose Screening
The oral glucose tolerance test (OGTT) is the standard of care in the postpartum period to screen patients with gestational diabetes mellitus (GDM) for persistent dysglycemia.
- Trial name
- NCT07332416
- Testing
- Continuous glucose monitoring for 14 days using the Freestyle LibrePro by Abbott
- Where
- United States
- Volunteers
- 1,300 people
- Sponsor
- Wake Forest University Health Sciences
Dysglycemia
Effect of a Food Supplement on Blood Glucose Levels in Patients With Impaired Glucose Values
The primary objective is to evaluate the efficacy of Euglycem® plus recommended standard diet on reducing FPG compared to baseline and to recommended standard diet alone after 3 months
- Trial name
- EUGLYCARE (NCT07263789)
- Testing
- Nutraceutical supplements
- Where
- 2 sites in Italy
- Volunteers
- 108 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Diabetes, Prediabetes
Meta-Analyses of the Effect of Plant Protein Versus Animal Protein on Cardiometabolic Risk
Vegetarian diets have been associated with a reduced risk of preventable diseases such as type 2 diabetes and cardiovascular disease. These effects may be mediated through direct or indirect pathways.
- Conditions
- Diabetes, Prediabetes, Metabolic Syndrome, Dysglycemia
- Trial name
- NCT02037321
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper
Dyslipidemias, Cardiovascular Risk Factor
Meta-analyses of Soy Protein and Its Food Sources for Cholesterol Reduction
Although soy protein has approved health claims in Canada and the US, and is recognized by major cardiovascular clinical practice guidelines for the reduction of cholesterol and risk of coronary heart disease (CHD), these claims…
- Conditions
- Dyslipidemias, Cardiovascular Risk Factor, Dysglycemia
- Trial name
- NCT04861545
- Testing
- Soy
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- John Sievenpiper
Gestational Diabetes, Diagnosis
Outcomes After Unified Versus Standard GDM Diagnosis
Gestational diabetes mellitus (GDM) is a condition that can affect pregnant women during pregnancy and may cause complications for the mother and the baby.
- Conditions
- Gestational Diabetes, Diagnosis, Pregnancy
- Trial name
- UPDATE-GDM (NCT06401629)
- Testing
- NPRP criteria, IADPSG criteria
- Volunteers
- 2,650 people
- Sponsor
- Qatar University
Cystic Fibrosis, Cystic Fibrosis-related Diabetes
The Effects of a Low Glycemic Load Diet on Dysglycemia and Body Composition in Adults With Cystic Fibrosis-Related Diabetes
This study will evalute the effect of a low glycemic load (LGL diet on dysglycemia, insulin requirements, DXA-derived body composition, gastrointestinal symptoms and quality of life measures in adults with cystic fibrosis-related…
- Conditions
- Cystic Fibrosis, Cystic Fibrosis-related Diabetes, Cystic Fibrosis With Intestinal Manifestations
- Trial name
- DINE (NCT05723445)
- Testing
- Low Glycemic Load Diet
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Rhode Island Hospital
Impaired Fasting Glucose (IFG), Impaired Glucose Tolerance (Prediabetes)
Effect of a Food Supplement on Glycemic Parameters in Patients With Impaired Glucose Metabolism
The primary objective will be to evaluate the efficacy of GlycoDual in reducing fasting plasma glucose (FPG) and post-prandial plasma glucose (PPG) levels compared to placebo after 90 days of treatment.
- Trial name
- NCT07263802
- Testing
- GlycoDual
- Volunteers
- 90 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Dysglycemia
Glucose Evaluation Through Continuous Glucose Monitors in Polycystic Ovary Syndrome
PCOS is the most common endocrine disorder of reproductive aged women. In addition to menstrual and endocrine abnormalities, PCOS is characterized by insulin resistance and glycemic dysregulation.
- Conditions
- PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Dysglycemia, Insulin Resistance
- Trial name
- GEMS-PCOS (NCT06050265)
- Testing
- DEXCOM Continuous Glucose Monitor (CGM)
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cystic Fibrosis
Identification of Dysglycemia With Continuous Glucose Monitoring to Assess Clinical Evolution in Cystic Fibrosis
Cystic fibrosis (CF)-related diabetes (CFRD) is the most important emerging complication after pulmonary complications. This specific form of diabetes is associated with an increased morbidity and mortality.
- Trial name
- ProspeC-F (NCT05099939)
- Where
- 4 sites in Canada, France
- Volunteers
- 121 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Chronic Underhydration, Thirst; Due to Deprivation of Water
Effects of Habitual Water Intake on Thirst in Healthy Young Adults Explained by Osmoadaptive Metabolism, Brain and Kidney Function (Adapt-Thirst)
Social relevance: For 30 years, people have been confused about how much plain water to drink. Over 30 years, health professionals have criticized media advice to drink 8 glasses of water per day, citing lack of evidence (Valtin…
- Conditions
- Chronic Underhydration, Thirst; Due to Deprivation of Water, Aestivation Metabolism, Warburg Effect
- Trial name
- Adapt-Thirst (NCT07464002)
- Testing
- Drinking water to dilute urine
- Volunteers
- 120 people
- Sponsor
- Jodi Stookey
Gestational Diabetes, Prediabetes; Complicating Pregnancy
Predicting Dysglycemia in Individuals With Gestational Diabetes Immediately Postpartum Using Continuous Glucose Monitoring
Gestational diabetes is one of the most common medical disorders in pregnancy and is a major risk factor for the postpartum development of dysglycemia.
- Conditions
- Gestational Diabetes, Prediabetes; Complicating Pregnancy, Type 2 Diabetes, Pregnancy Related
- Trial name
- PREDISPOSE (NCT04972955)
- Testing
- Freestyle Libre 2
- Where
- 4 sites in Canada
- Volunteers
- 240 people
- Sponsor
- University of Manitoba
Type 1 Diabetes (T1D)
Platform Trial in Stage 1 Diabetes: Comparing Golimumab vs Placebo
The goal of this clinical trial is to learn if golimumab is effective at preventing progression to Stage 2 diabetes in participants with presymptomatic Type 1 Diabetes.
- Trial name
- NCT07683026
- Testing
- Golimumab
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Dysglycemia
Perioperative Use of Continuous Glucose Monitoring for Scheduled Cesarean Deliveries (PERUSE)
This prospective pilot study is exploratory in nature and is designed to evaluate the validity of continuous glucose monitor (CGM) use for perioperative glucose surveillance during scheduled Cesarean delivery for nondiabetic…
- Trial name
- PERUSE (NCT07671599)
- Testing
- Continuous Glucose Monitor
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cystic Fibrosis Related Diabetes, Cystic Fibrosis (CF)
Verapamil Effect in Cystic Fibrosis-related Dysglycemia
The investigators are conducting a pilot open-label pre/post interventional trial in adolescents and adults with cystic fibrosis (CF) and abnormal glucose tolerance or early CF-related diabetes mellitus (CFRD) to assess the…
- Conditions
- Cystic Fibrosis Related Diabetes, Cystic Fibrosis (CF), Abnormal Glucose Tolerance
- Trial name
- NCT07688070
- Testing
- Verapamil Hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Rhode Island Hospital
Gestational Diabetes Mellitus (GDM)
Screening for Dysglycemia During Postpartum Period in Women With GDM
Gestational diabetes mellitus (GDM) is one of the most common clinical conditions in pregnancy, with an increasing incidence due to the rise in overweight women and the postponement of motherhood.
- Trial name
- NCT07489456
- Testing
- Whatsapp message
- Where
- Brazil
- Volunteers
- 182 people
- Sponsor
- University of Sao Paulo General Hospital
Diabetes, Obesity
Polish Registry of Diabetes (PolReD)
The aim of this project is to create a registry of diabetic patients, containing a detailed clinical profile of each patient, along with omics data, which will be analyzed using artificial intelligence algorithms, and their…
- Conditions
- Diabetes, Obesity, PreDiabetes, Dysglycemia
- Trial name
- PolReD (NCT04657367)
- Testing
- Observational study - registry
- Where
- Poland
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Gestational Diabetes
Continuous Glucose Monitoring to Detect Postpartum Dysglycemia in Patients With Gestational Diabetes
The aim of this study is to determine the ability of postpartum continuous glucose monitoring (CGM) for subjects with gestational diabetes (GDM) to predict dysglycemia on 4-12 week postpartum oral glucose tolerance test (OGTT).
- Trial name
- NCT07034261
- Testing
- Blinded Continuous Glucose Monitoring Device
- Volunteers
- 50 people
- Sponsor
- University of Chicago
Type2 Diabetes, Type 2 Diabetes Mellitus in Obese
Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)
Investigators propose to study youth across the spectrum of body mass index (BMI) and dysglycemia. This approach will allow investigators to disentangle the relationship of key features of type 2 diabetes (T2D) risk (e.g.
- Conditions
- Type2 Diabetes, Type 2 Diabetes Mellitus in Obese, Dysglycemia, Microvascular Complications
- Trial name
- Metabrain (NCT05277558)
- Testing
- Observational
- Where
- 2 sites in United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine