Clinical trials: Drug Use
Human Immunodeficiency Virus Exposure, Alcohol; Harmful Use
Game Plan for PrEP
This small pilot randomized controlled trial will test whether a brief, web-based intervention inspired by the principles of motivational interviewing helps high-risk men who take pre-exposure prophylaxis (PrEP) moderate their…
- Trial name
- NCT04973267
- Testing
- Game Plan for PrEP, Attention-Matched Control Lifestyle Habits Videos
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Brown University
Smoking
Reduced Exposure Study in Smokers Using THS 2.2 With 5 Days in a Confinement Setting.
The overall goal of the study is to evaluate if the ad libitum use of the Tobacco Heating System 2.2 (THS 2.2) for 5 days by adult healthy smokers results in a reduction in the levels of biomarkers of exposure (BoExp) for…
- Trial name
- NCT01959932
- Testing
- Tobacco Heating System (THS 2.2), Smoking abstinence (SA), Conventional cigarette (CC)
- Where
- Poland
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Substance Use Disorders, HIV
Implementing Technology-Assisted Drug Treatment and Relapse Prevention in Federally Qualified Health Centers (FQHCs)
Implementing a mobile-phone based system for drug use disorders in primary care settings.
- Trial name
- Seva (NCT01963234)
- Testing
- Seva
- Where
- 3 sites in United States
- Volunteers
- 439 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Drug Abuse
A First Study in Healthy Volunteers of a New Mobile Phone Application Measuring the Eyes Before and After Medication
This is a pre-market, explorative, early feasibility, pilot, controlled clinical investigation designed to collect initial clinical data on the medical device Previct Drugs.
- Trial name
- NCT05731999
- Testing
- Previct Drugs
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Kontigo Care AB
Schizophrenia, Dual Diagnosis
Cannabis, Schizophrenia and Reward: Self-Medication and Agonist Treatment?
In this translational research proposal, based on our formulation, we seek to confirm and expand upon data obtained in our pilot study suggesting that cannabis and the cannabinoid agonist dronabinol, given in low dose to patients…
- Conditions
- Schizophrenia, Dual Diagnosis, Psychotic Disorder, Cannabis Use Disorder
- Trial name
- NCT01964404
- Testing
- Marijuana, Dronabinol
- Where
- 2 sites in United States
- Volunteers
- 263 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Opioid Use Disorder, HIV Infections
Combination Primary Care and Prevention Services for Women Who Inject Drugs and Exchange Sex in Seattle, Washington
The investigators will implement a non-randomized observational clinical trial that will include a pop-up clinic for women who inject drugs (WWID) near venues for exchange sex and drug use in north Seattle.
- Conditions
- Opioid Use Disorder, HIV Infections, Chlamydia, Gonorrhea
- Trial name
- NCT06187064
- Testing
- Mobile Van Clinic
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Washington
Smoking, Cigarette
The Impact of Standardized Tobacco Product Packaging on Young Adults in the Retail Environment
The overall aim of this research is to experimentally evaluate the extent to which partially standardizing the color of tobacco packaging influences tobacco use intentions among young adults who have varying levels of tobacco use…
- Trial name
- NCT05973981
- Testing
- Package standardization
- Where
- United States
- Volunteers
- 433 people, healthy volunteers welcome
- Sponsor
- RAND
HIV/AIDS
Packaging PrEP to Prevent HIV Among WWID
Evidence suggests women who inject drugs (WWID) are disproportionately vulnerable to HIV. If HIV incidence continues unchecked, 1 in 23 WWID in the United States will acquire HIV.
- Trial name
- NCT03304912
- Testing
- PrEP Education and option to accept a PrEP prescription
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Drexel University
Pain, Cannabis
Enhancing Medication-based Analgesia in Humans- STUDY 2
This is a single-group, within-subject, double-blind, double-dummy, placebo and active-controlled study evaluated whether the FDA-approved cannabinoid cannabidiol (CBD; Epidiolex) would enhance analgesia, subjective reports, and…
- Conditions
- Pain, Cannabis, Opioid Use
- Trial name
- NCT04036968
- Testing
- Within-subject test of blinded study medications
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Diabetes, Hypertension
A Mixed Methods Approach to the Development and Testing of the Measure of Drug Self-Management (MeDS)
The study objective is to develop and test a Measure of Drug Self-Management for use in clinical settings among patients with hypertension and diabetes.
- Trial name
- MeDS (NCT01998269)
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Drug Use Disorders, Hepatitis C
Community-Based, Client-Centered Prevention Homes to Address the Rural Opioid Epidemic- Aim 3
The goal of this study was to effectively use a client-centered community-based intervention to engage people who inject drugs (PWIDs) in healthcare that helps reduce risky behaviors and lower infectious disease risks.
- Conditions
- Drug Use Disorders, Hepatitis C, Harm Reduction, Opioid-use Disorder
- Trial name
- NCT04268173
- Testing
- Community-Based, Client-Centered Prevention Home
- Where
- 6 sites in United States
- Volunteers
- 343 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Heartburn
Comparison of Two Omeprazole-Containing Products for Relief of Frequent Heartburn (MK-0764A-036)
This study will evaluate a single ingredient product (omeprazole 20 mg) with a combination product capsule (omeprazole 20 mg + sodium bicarbonate 1100 mg) in participants with frequent heartburn.
- Trial name
- NCT01587885
- Testing
- Omeprazole 20 mg + Sodium Bicarbonate 1100 mg, Omeprazole 20 mg
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bayer
Schizophrenia
Pharmacologically-augmented Cognitive Therapies (PACTs) for Schizophrenia.
This application seeks renewed support for MH59803, "Dopaminergic substrates of startle gating across species," to extend a clear path of "bench-to-bedside" progress towards a critical paradigm shift in therapeutic models for…
- Trial name
- NCT02634684
- Testing
- Dextroamphetamine
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Tobacco Use
The Abuse Liability of a Novel Heated Tobacco Product (IQOS) and Its Feasibility as a Menthol Cigarette Substitute
This project examines the influence of flavor availability on switching to an MRTP known as IQOS, part of the Heated Tobacco Product (HTP) class, among menthol smokers using clinical lab and naturalistic evaluations of abuse…
- Trial name
- NCT05499377
- Testing
- Tobacco product administration and assessment
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cannabis Use
Cannabis Edibles Packaging Imagery Experiment
The purpose of this study is to assess differences in perceptions of product appeal, harm, and subsequent willingness to try cannabis edibles products with/without packaging imagery.
- Trial name
- NCT06358144
- Testing
- Packaging imagery, No Imagery (Control)
- Where
- United States
- Volunteers
- 1,260 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Tobacco Use Disorder
Efficacy of Oral Tobacco Products Compared to a Medicinal Nicotine
For the primary goals, we hypothesize that 1) the oral tobacco product will be more efficacious than the medicinal nicotine product in substituting for smoking cigarettes; 2) among non-abstainers, the oral tobacco product will…
- Trial name
- NCT00710034
- Testing
- Oral tobacco, Nicotine Gum
- Where
- 2 sites in United States
- Volunteers
- 391 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Sex, Unsafe, Drug Use
Addressing Substance Use Through CVCT
The proposed study developed and tested two adjunct components for use in Couples HIV Testing and Counseling (CHTC) with gay-male couples: a communication skills training video and a substance use agreement module.
- Trial name
- NCT03125915
- Testing
- Communication skills training video, substance use module, Couples HIV Testing and Counseling
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Hunter College of City University of New York
Smoking Cessation, Smoking, Tobacco
Helping Poor Smokers Quit
Using a 2x2 randomized factorial design, we will conduct a statewide field trial in Missouri to compare the relative and combined effects of these two strategies for augmenting an existing, evidence-based tobacco quitline…
- Conditions
- Smoking Cessation, Smoking, Tobacco, Smoking, Cigarette, Smoking, Pipe
- Trial name
- NCT03194958
- Testing
- Specialized Quitline, Basic Needs Navigator
- Where
- United States
- Volunteers
- 1,944 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Cocaine Use Disorder
Cocaine and Zolmitriptan
Cocaine potently inhibits the reuptake of serotonin (5-HT). Increased synaptic 5-HT resulting from this reuptake inhibition activates multiple 5-HT receptor subtypes.
- Trial name
- NCT05019430
- Testing
- Cocaine, Zolmitriptan
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- William Stoops
Post-operative Pain, Colon Cancer
The Effect of Exparel on Post Operative Pain and Narcotic Use After Colon Surgery
The purpose of the study is to evaluate the effect of Exparel on pain control and patient outcome after colon resection. The investigators will evaluate the clinical course of the patients who receive exparel as compared to the…
- Conditions
- Post-operative Pain, Colon Cancer, Diverticulitis
- Trial name
- NCT02052557
- Testing
- Bupivacaine, Bupivacaine liposome suspension
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Des Moines University