Clinical trials: Dissociation, active
Coma, Cardiac Arrest
Combined Whole-brain Structural and Functional MRI for the Prediction of Neurological Recovery After Cardiac Arrest
To assess the performance of a predictive model resulting from the analysis of sMRI/fMRI/contrast-enhanced MRI-derived personalized connectomic data, as compared with standard predictors (clinical examination, electrophysiology…
- Conditions
- Coma, Cardiac Arrest, Disorder of Consciousness, Neurologic Disorder
- Trial name
- ARISE (NCT06617377)
- Testing
- advanced whole-brain sMRI/fMRI/contrast-enhanced MRI scan
- Where
- France
- Volunteers
- 263 people
- Sponsor
- University Hospital, Toulouse
Traumatic Brain Injury (TBI) Patients, Intracerebral Hemorrhage (ICH)
Sleep to Predict Recovery In Unconscious Patients With Acute Brain Injury
Severe brain injuries can leave people in states where they are unconscious or only partly aware, such as a coma. These conditions are common after injuries like head trauma or bleeding in the brain.
- Trial name
- SPRINT (NCT07794605)
- Where
- 2 sites in United States
- Volunteers
- 230 people
- Sponsor
- Columbia University
Posttraumatic Stress Disorders, Dissociative Identity Disorder
Evaluating the Neurobiological Basis of Traumatic Dissociation in Women With Histories of Abuse and Neglect
This study aims to evaluate the neurobiological basis of traumatic dissociation in a cross-diagnostic sample of women who have histories of childhood abuse and neglect.
- Trial name
- NCT02757339
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Scapholunate Dissociation
Diagnosing Dynamic Scapholunate Instability with Computer Tomography
Scapholunate instability can result in debilitating pain, dysfunction, and secondary arthritis. If treatment is required, the instability should ideally be addressed in the dynamic stage, before non-reducible non-repairable…
- Trial name
- stressct (NCT06695260)
- Testing
- CT scan
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Regionaal Ziekenhuis Heilig Hart Tienen
Traumatic Brain Injury (TBI) Patients, Intracerebral Hemorrhage
Smartphone Enabled Detection of Cognitive Motor Dissociation in the ICU
The purpose of this research study is to evaluate whether a smartphone-enabled EEG (electroencephalography) system can be used to detect Cognitive Motor Dissociation (CMD) in patients with acute neurological injuries who appear…
- Conditions
- Traumatic Brain Injury (TBI) Patients, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Cardiac Arrest (CA)
- Trial name
- SMART-CMD (NCT07917728)
- Where
- 9 sites in United States, Brazil and 3 more
- Volunteers
- 240 people
- Sponsor
- Columbia University
Well-Being, Psychological, Mood Disturbance
Neurofeedback and Well-Being Among People With Co-Occurring Obsessive Compulsive Disorder and Post-traumatic Stress Symptoms
The proposed study will collect novel data evaluating the feasibility of a neurofeedback training program delivered to prospective clients with a history of clinically concerning trauma-related mental health symptoms who are on a…
- Conditions
- Well-Being, Psychological, Mood Disturbance, Emotional Regulation, Dissociation
- Trial name
- NCT07217925
- Testing
- Neuroptimal (Zengar, Inc.) Neurofeedback
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Wayne State University
Dissociative Symptoms
Clinical Hypnosis Versus Guided Imagery for Dissociative Symptoms in Adults
This randomized controlled trial aims to investigate whether a brief clinical hypnosis intervention can reduce dissociative symptoms more effectively than guided imagery in adults receiving psychiatric care.
- Trial name
- HYDRA (NCT07895875)
- Testing
- Clinical Hypnosis, Non-Hypnotic Guided Imagery
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- University of Rome Foro Italico
Depression
Cognitive and Affective Processes Online
This study will provide data for evaluating the psychometric characteristics of the tests assessing cognitive flexibility, including their (1) internal consistency, (2) feasibility and tolerability, their (3) convergent and…
- Trial name
- NCT05736471
- Testing
- Computational dissociation of the causes of cognitive rigidity in depression
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Treatment-resistant Depression (TRD)
Esketamine With or Without Integration Therapy for Treatment-Resistant Depression
This study will explore the effects of esketamine (Spravato®), an FDA-approved nasal spray, on adults diagnosed with treatment-resistant depression (TRD).
- Trial name
- KIND-PR (NCT07369102)
- Testing
- Esketamine hydrochloride (intranasal), Integration Therapy
- Where
- 2 sites in Puerto Rico
- Volunteers
- 20 people
- Sponsor
- University of Puerto Rico
Consciousness Disorders, Persistent Vegetative State
Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)
After a severe brain injury some patients survive but cannot communicate, and deciding early which of them are likely to recover consciousness remains one of the hardest problems in neurocritical care.
- Conditions
- Consciousness Disorders, Persistent Vegetative State, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- CyDoC-MAP (NCT07736820)
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Nicosia General Hospital
Traumatic Brain Injury (TBI) Patients, Severe Traumatic Brain Injury
SeeMe: Using Automated Facial Tracking to Detect Voluntary Behavior in Brain Injury
Objective: This prospective interventional study introduces "SeeMe," an automated, high-resolution computer vision platform designed to objectively quantify microscopic, auditory command-evoked movements in patients with…
- Trial name
- NCT07560631
- Testing
- SeeMe Multimodal Auditory Command Protocol
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Functional Neurological Symptom Disorder
Cognitive Disengagement Syndrome in Functional Neurological Symptom Disorder
This cross-sectional observational case-control study aims to investigate symptoms of sluggish cognitive tempo (SCT), also known as cognitive disengagement syndrome (CDS), in adults diagnosed with Functional Neurological Symptom…
- Trial name
- NCT07451821
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Elazığ Mental Health and Diseases Hospital
Bradycardia, Conduction Block, Atrioventricular
LLL vs. SDL for LBBP: A Non-inferiority RCT
Left Bundle Branch Pacing (LBBP) has emerged as one of the most commonly used physiological pacing modalities in clinical practice.
- Trial name
- NCT07378124
- Testing
- SDL implantation, LLL implantation
- Where
- China
- Volunteers
- 288 people
- Sponsor
- Ningbo No.2 Hospital
Sacral Fractures, Traumatic Unstable Sacral Fractures
Open Versus Minimally Invasive Fixation for Unstable Sacral Fractures in Adults
Severe injuries to the lower spine and pelvis, known as traumatic unstable sacral fractures, are complex injuries that often require surgery to stabilize the bones and prevent long-term disability.
- Conditions
- Sacral Fractures, Traumatic Unstable Sacral Fractures, Spinopelvic Dissociation, Pelvic Ring Injuries
- Trial name
- NCT07534579
- Volunteers
- 60 people
- Sponsor
- Assiut University
Scapholunate Dissociation, Scapholunate Ligament Rupture
Scapholunate Ligament Reconstruction Using Modified Flexor Carpi Radialis Tenodesis
Retrospective study of patients who underwent a modified flexor carpi radialis (FCR) tenodesis for scapholunate ligament injury at Waldfriede Hospital during the period 2016-2026.
- Trial name
- NCT07667114
- Testing
- modified flexor carpi radialis tenodesis
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Waldfriede Hospital
Dissociative Disorder
Evaluation of the Efficacy of Dissociation-Focused Cognitive Behavior Therapy
Dissociative symptoms and disorders are particularly prevalent in the general population and among people suffering from psychiatric disorders. To date, no treatment has proven effective for this type of problem.
- Trial name
- TCC-DISSO (NCT06917209)
- Testing
- CBT-CD psychotherapy
- Where
- 8 sites in France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Tours
Burn, Pain
Low-Dose Ketamine Infusion During Burn Wound Care
The current standard of care (SOC) (i.e. fentanyl and midazolam) offers limited efficacy for preventing or relieving pain. Ketamine infusions may provide the benefits of analgesia, minimize adverse events, and reduce opioid use.
- Conditions
- Burn, Pain, Dissociation, Opioid
- Trial name
- IMPROVE (NCT06506565)
- Testing
- Ketamine, 0.9% NaCl
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Tennessee
PTSD - Post Traumatic Stress Disorder, Depression
Feasibility of a Web-based Single-session Intervention Combined With Ecological Momentary Assessment and Intervention for Patients With Complex Posttraumatic Stress Disorder Awaiting Inpatient Treatment
This clinical trial examines whether a self-administered web-based single-session intervention named AWARE OUT, combined with Ecological Momentary Assessments (EMA) and Ecological Momentary Interventions (EMI), can be feasibly…
- Conditions
- PTSD - Post Traumatic Stress Disorder, Depression, Anxiety, Complex Post-Traumatic Stress Disorder (CPTSD)
- Trial name
- NCT07920107
- Testing
- Digital self-administered web-based single-session intervention, While Waiting application: Ecological momentary assessments and interventions
- Volunteers
- 30 people
- Sponsor
- University of Oslo
Scapholunate Interosseous Ligament Injury, Scaphoid-Lunate Instability
Comparison of Strength, Weight Bearing, Proprioception, Reaction Time and Function in Scapholunate Instability
Scapholunate (SL) instability is the most common type of instability seen in the wrist, resulting from SLI injury or excessive mobility [1,2].
- Conditions
- Scapholunate Interosseous Ligament Injury, Scaphoid-Lunate Instability, Scapholunate Dissociation
- Trial name
- NCT07134452
- Testing
- Baseline Assessments
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Alcohol Use Disorder (AUD), Alcohol-Related Disorders
Body-Focused Mindfulness as an Add-on Intervention in Inpatient Alcohol Use Disorder Treatment (MBI-AUD-PL)
The goal of this clinical trial is to learn if a body-focused mindfulness program can help people with alcohol use disorder (AUD) feel more connected to their bodies and manage their emotions better.
- Trial name
- MBI-AUD-PL (NCT07706660)
- Testing
- Body-Focused Mindfulness Intervention, Standard Psychoeducation
- Where
- Poland
- Volunteers
- 240 people
- Sponsor
- Medical University of Warsaw