Clinical trials: Disc, Herniated
Degenerative Disc Disease, Degenerative Spondylolisthesis
The Five-repetition Sit-to-stand Test for Lower Back Pain or Radiculopathy
The five-repetition sit-to-stand test (5R-STS) has been used in many medical disciplines, but has never been correlated with or validated in regard to degenerative spinal diseases.
- Conditions
- Degenerative Disc Disease, Degenerative Spondylolisthesis, Herniated Disc, Stenosis, Spinal
- Trial name
- 5R-STS (NCT03303300)
- Where
- Netherlands
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- Marc Schröder
Low Back Pain and Core Muscle, Disc Herniation
Neural Control and Mechanosensation in Spine Muscle
Low back pain (LBP) is a condition that affects a majority of the US population and is responsible for a significant proportion of health care costs and utilization.
- Trial name
- NCT07003802
- Testing
- Resistance exercise
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Lumbar Disc Herniation
Brain Connectomic Mechanisms of Spinal Manipulative Therapy on LDH Analgesia Based on Multimodal MRI
Low back and leg pain caused by lumbar disc herniation (LDH) is common. Lever positioning manipulation (LPM) is a spinal manual therapy used to relieve this pain, but how it affects the brain is unclear.
- Trial name
- NCT07728149
- Testing
- Active Lever Positioning Manipulation
- Where
- China
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Lumbar Disc Herniation
Effects of Whole-Body Electromyostimulation Application in Individuals With Lumbar Disc Hernia
To determine the effects of WB-EMS application on balance, pain, muscle strength, muscle endurance, flexibility, muscle shortening and quality of life in individuals with Lumbar Disc Hernia and compare it with individuals who…
- Trial name
- NCT04329598
- Testing
- Whole-Body Electromyostimulation Group, Exercise Group
- Where
- 2 sites in Cyprus
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Transforaminal Epidural Injection, Dorsal Root Ganglion Stimulation
The Effect of Adding a Local Anesthetic to Transforaminal Epidural Injection in Cervical Disc Herniation.
The study is designed as a double-blind, prospective, randomized controlled trial. Blindness is ensured by having different researchers performing the interventional procedures and monitoring the pain diaries, thus preventing…
- Conditions
- Transforaminal Epidural Injection, Dorsal Root Ganglion Stimulation, Servical Disc Herniation
- Trial name
- NCT07397286
- Testing
- servical transforaminal epidural steroid injection with local anaesthetic, servical transforaminal epidural steroid injection without local anaesthetic
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Cervical Pain, Postural Balance
Balance Performance in Dual Task in Patients With Cervical Disc Herniation Related Chronic Neck Pain:a Comparative Study
Intense pain and moderate disability are seen most patients with symptomatic cervical disc herniation (CDH). Since neck motion and motor control are associated with changes in neck pain and disability, it is highly likely that…
- Trial name
- NCT05338788
- Testing
- neck pain and dual task
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Bozyaka Training and Research Hospital
Paresis, Lumbar Disc Herniation
Validation of a Methodology Using Isometric Dynamometer for Ankle STrength Assessment to Quantify LDH-induced Paresis
Lumbar disc herniation (LDH) is a common condition that may cause lower limb motor weakness (paresis), particularly affecting ankle dorsiflexion and plantarflexion.
- Trial name
- VAST-LDH (NCT07763522)
- Testing
- Strength test validity and reliability
- Where
- Finland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Type 2 Diabetes, Neuropathy, Painful
Methylglyoxal Evaluation in Humans
The investigators will test the hypothesis that patients with low back pain associated with lumbar disc aberrancy will have elevated MGO-protein levels circulating in the blood that are comparable to patients with painful…
- Conditions
- Type 2 Diabetes, Neuropathy, Painful, Chronic Low-back Pain, Lumbar Disc Herniation
- Trial name
- MEH (NCT05350553)
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Low Back Pain, Disc, Herniated
Motor Control Mechanisms by CNS of Tuina in Patients With Lumbar Disk Herniation
Lumbar disk herniation (LDH)is a prevalent health problem around the world. It can cause symptoms of low back pain, numbness or weakness.The understanding of low back pain in traditional Chinese medicine(TCM) theory"unbalanced…
- Trial name
- NCT03475095
- Testing
- Tuina
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
Lumbar Disc Herniation, Radiculopathy Lumbar
The Effect of Ultrasound Guidance on Radiation Dose and Procedure Time in Lumbar Transforaminal Epidural Injection
Low back pain is one of the leading causes of disability, and its social burden and economic cost are quite high. Although there are many causes that can lead to low back pain, radicular pain, which develops mostly secondary to…
- Trial name
- NCT05793528
- Testing
- Fluoroscopy Guided Transforaminal Epidural Steroid Injection, Ultrasound Guided Transforaminal Epidural Steroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Marmara University
Stenosis, Herniated Nucleus Pulposus
Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion
Neural injury is a well-known complication following extreme lateral lumbar interbody fusion (XLIF). It has been found that up to 9.4% of patients will have either temporary or persistent neurologic deficit.
- Conditions
- Stenosis, Herniated Nucleus Pulposus, Degenerative Disc Disease, Spondylosis
- Trial name
- NCT03327272
- Testing
- Methylprednisolone, Saline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Lumbar Disc Herniation
Impact of Transforaminal Epidural Steroid Injection in Lumbar Disc Prolpse on Micro RNA-155 Serum Level
Chronic pain could be considered a brain disease as it can affect multiple aspects of brain function, chemistry, neural networks and structure. Pain is associated with impaired cognitive function (1).
- Trial name
- NCT05626283
- Testing
- transforaminal epidural injection., micro RNA-155 serum level
- Where
- Egypt
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Lumbar Disc Herniation
Brain Effect Mechanism of Spinal Manipulative Therapy on LDH Analgesia Based on Multimodal MRI
The clinical symptoms of Lumbar Disc Herniation (LDH) can be effectively ameliorated through Spinal Manipulative Therapy (SMT), which is closely linked to the brain's pain-regulating mechanisms.
- Trial name
- NCT06277739
- Testing
- Spinal Manipulative Therapy
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zhou Xingchen
Opioid Consumption, Postoperative, ESPB
Evaluation of the Postoperative Efficacy of Bilateral Lumbar Erector Spinae Plane Block (ESPB) in Patients Undergoing Lumbar Disc Herniation Repair Surgery
This prospective observational study aims to evaluate the efficacy of bilateral lumbar erector spinae plane (ESP) block in providing effective postoperative analgesia and its potential impact on early mobilization and length of…
- Conditions
- Opioid Consumption, Postoperative, ESPB, Postoperative Pain, Plane Blocks
- Trial name
- NCT07403734
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Lumbar Disc Herniation, Pain, Postoperative
mTLIP vs. ITP Blocks in Lumbar Disc Surgery
to compare ultrasonography (USG)-guided intertransverse process block and modified thoracolumbar interfascial plan (mTLIP) block in the treatment of postoperative pain in patients undergoing lumbar disc herniation surgery under…
- Conditions
- Lumbar Disc Herniation, Pain, Postoperative, Regional Aneshesia
- Trial name
- NCT06391541
- Testing
- modified thoracolumbar interfacial plan block (mTLIP), Intertransverse process block (ITP)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Low Back Pain
Serum Cytokine Levels in Patients with Lumbal Disc Herniation and Effectiveness of Exercise
The aim of the study is to investigate serum cytokine levels and the efficacy of lumbar stabilization exercises in patients with lumbar disc herniation with and without neurological deficits.
- Trial name
- NCT04912388
- Testing
- Lumbal stabilization excercises, Conventional exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Spinal Manipulation, Chiropractic
Comparison of the Effectiveness of Chiropractic Manipulation Applied to the Lumbar Sacroiliac Region in Patients With Lumbar Disc Herniation
This study aims to compare the effectiveness of chiropractic manipulation applied to the lumbar and sacroiliac regions in patients with lumbar disc herniation.
- Conditions
- Spinal Manipulation, Chiropractic, Lumbal Disc Herniation
- Trial name
- CLuSH (NCT07037641)
- Testing
- Lumbar Spine Manipulation, Sacroiliac Joint Manipulation, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- SEFA HAKTAN HATIK
Vibration, Lumbar Disc Herniation
IASTM and Vibration Effects on Pain, Functionality, and Kinesiophobia in Lumbar Disc Herniation
The aim of this study is to investigate the effects of Instrument-Assisted Soft Tissue Mobilization and vibration massage therapy on pain, functionality, and kinesiophobia in individuals with lumbar disc herniation.
- Conditions
- Vibration, Lumbar Disc Herniation, Soft Tissue Mobilization
- Trial name
- NCT07293676
- Testing
- Exercise, IASTM, Percussion massage therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Lumbar Disc Herniation, Surgery
The Effect of Ney Music on Patients Undergoing Lumbar Disc Surgery
This randomized controlled study aims to investigate the effects of ney music listening, a traditional Turkish wind instrument, on pain, anxiety, sleep quality, and vital signs in patients undergoing lumbar disc herniation…
- Conditions
- Lumbar Disc Herniation, Surgery, Nurse's Role
- Trial name
- NCT07171008
- Testing
- Ney music
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Niran Çoban
Disc Herniation
Caudal Neuroplasty Using Epidural Catheter Combined with Pulsed Radiofrequency (versus Pulsed Radiofrequency Alone
Evaluating the superiority of caudal neuroplasty using epidural catheter (Perifix® Complete Set 16 G) combined with Pulsed Radiofrequency (PRF) versus Pulsed Radiofrequency (PRF) alone targeting the dorsal root ganglion In…
- Trial name
- NCT06711419
- Testing
- f caudal neuroplasty using epidural catheter combined with Pulsed Radiofrequency (PRF) versus Pulsed Radiofrequency (PRF) alone
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Assiut University