Clinical trials: Digestive Inflammation
HIV, Hepatitis C
A Prospective, Longitudinal Study of Endothelial Function in HIV/HCV Coinfected Subjects
The CTSI-PLACE Study is a study for men and women with HIV/hepatitis C co-infection or HIV only. The study looks at the impact of having hepatitis C virus in addition to HIV on risk for cardiovascular disease.
- Trial name
- CTSI-PLACE (NCT02597790)
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of California, Los Angeles
Crohn Disease, Absorption; Disorder, Protein
Impact of an Oligomeric Diet in Intestinal Absorption and Inflammatory Markers in Patients With Crohn Disease
This is a randomized, multicenter, translational, triple-blind, clinical trial in patients with Crohn's disease, who will be prescribed an oral nutritional supplement to control symptoms in the acute phase and to recover in the…
- Conditions
- Crohn Disease, Absorption; Disorder, Protein, Absorption; Disorder, Absorption; Disorder, Fat
- Trial name
- NCT04305535
- Testing
- Peptidic+Probiotic
- Where
- Spain
- Volunteers
- 162 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Alcoholic Hepatitis
The Effect of Gut Sterilisation on Macrophage Activation in Patients With Alcoholic Hepatitis.
Alcoholic hepatitis (AH) is a severe alcohol induced hepatic inflammation that leads to jaundice and liver failure. Gut derived bacterial translocation to the liver is currently thought to be one of the main inflammatory drivers…
- Trial name
- NCT03157388
- Testing
- Combined Vancomycin and Gentamycin and Meropenem
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- University of Aarhus
Inflammatory Bowel Disease
The EDICT Trial - Therapy for Inflammatory Bowel Disease Flares
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory conditions of the gastrointestinal tract that affect millions of people in the United States of America.
- Trial name
- EDICT (NCT07143188)
- Testing
- elemental diet (ED)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Wake Forest University Health Sciences
Acute Appendicitis, Abscess
Water And Saline Head-to-head In The Blinded Evaluation Study Trial
Patients who are diagnosed with acute appendicitis consented and then randomized into two arms of the trial. In one arm, patients receive irrigation of the abdomen during surgery with normal saline, or salt water.
- Trial name
- WASHITBEST (NCT02714023)
- Testing
- Normal Saline, Sterile Water
- Where
- United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Gallbaldder Cancer
Initial Study of Gallbladder Cancer in Chile
Background: Chile has the highest diagnosis and death rates of gallbladder cancer in the world. Gallbladder cancer is also the leading cause of cancer death in Chilean women.
- Trial name
- NCT01520259
- Where
- 4 sites in Chile
- Volunteers
- 446 people
- Sponsor
- National Cancer Institute (NCI)
Intra-Abdominal Infections
Abdominal SepsiS Study: Epidemiology of Etiology and Outcome
The aim of the project is to perform a multinational, prospective, observational study on IAIs (IntraAbdominal Infections) in critically ill patients; special emphasis will be given to epidemiology and outcomes.
- Trial name
- AbSeS (NCT02442596)
- Where
- Belgium
- Volunteers
- 2,200 people
- Sponsor
- European Society of Intensive Care Medicine
Gastroesophageal Reflux, Asthma
Elucidation of Acid-Induced Pulmonary Inflammation
This study will evaluate how heartburn may lead to different types of inflammation in one's airways. Additionally, the study will determine whether aggressive treatment of heartburn results in improvement in both symptoms of…
- Trial name
- NCT00361972
- Testing
- lansoprazole
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Utah
NAFLD, NASH
Validation of the LiverFASt Test and the Associated Fibrosis Staging Scores Compared to Liver Tissue Pathology Via Liver Biopsy
This study is to assess the diagnostic performance of the LiverFASt Test for assessing fibrosis staging scores compared to the assessment of liver tissue pathology from liver biopsy.
- Trial name
- NCT03980912
- Testing
- LiverFASt
- Where
- United States
- Sponsor
- Fibronostics USA, Inc
Diverticulitis
Italian Study Group on Complicated Diverticulosis
Patients were recruited over a four year period from 1996 to 1999. Those admitted in the years 1996 and 1997 were retrospectively accrued from the clinical records, while patients treated between 1998 and 1999 patients were…
- Trial name
- GISDIC (NCT01276886)
- Testing
- antibiotic, Colonic resection with or without stoma
- Where
- Italy
- Sponsor
- Gruppo Italiano per lo Studio della Diverticolite Complicata
Cancer, Solid Tumor
Exploring Cancer-Associated Thromboembolism Prognosis Biomarkers and Polymorphisms
This study aims to assess biomarkers and their related polymorphisms in the context of cancer-associated thromboembolism, with a particular focus on their interaction with the immune system.
- Conditions
- Cancer, Solid Tumor, Thromboembolism, Cardiovascular Diseases
- Trial name
- CAT_PB (NCT06065592)
- Testing
- Palbociclib, Rivaroxaban, SNP
- Where
- 2 sites in Lebanon
- Volunteers
- 500 people
- Sponsor
- Lebanese University
Morbid Obesity, Non Alcoholic Steatohepatitis
Non Invasive Measurements of Fibrosis, Inflammation and Steatohepatitis in Morbidly Obese Patients
Abstract: Fatty liver most frequently corresponds to a fat overload of the liver. It is usually classified as alcoholic steatosis or non-alcoholic steatosis.
- Trial name
- FIRM (NCT01695083)
- Where
- France
- Volunteers
- 186 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Autoimmune Hepatitis
Mindfulness - Based Stress Reduction and the Relationship on Inflammation in Autoimmune Hepatitis
The study is a 'pilot study' to assess the effect of a mindfulness-based stress reduction (MBSR) intervention on patients with autoimmune liver disease specifically autoimmune hepatitis type I.
- Trial name
- NCT02950077
- Testing
- mindfulness based stress reduction
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
Hepatitis C
Inflammation, Stress & Social Behavior: Using Ecological Assessments & Model Systems to Enhance Relevance to Health Outcomes
The current study has been designed to identify behavioral and physiological mechanisms through which positive social connectivity (PCS) and negative social processes (NSP) interact with psychosocial stress to promote resilience…
- Trial name
- NCT01625793
- Testing
- Interferon-alpha
- Where
- 2 sites in United States
- Sponsor
- University of Arizona
Rheumatoid Arthritis, Ankylosing Spondylitis
Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases
TRANSREG will assess the safety and biological efficacy of low-dose IL2 as a Treg inducer in a set of 14 autoimmune and auto-inflammatory diseases, with the aim to select diseases in which further therapeutic development will be…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Systemic Lupus Erythematosus, Psoriasis
- Trial name
- TRANSREG (NCT01988506)
- Testing
- Interleukin 2
- Where
- 11 sites in France
- Volunteers
- 81 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Fibrosis
Development of Non-Invasive MRI Applications for Liver Fibrosis and Inflammation
Chronic liver disease is a major healthcare problem in Hong Kong and worldwide. The diagnosis of liver fibrosis and inflammation in patients with chronic liver disease has important prognostic and therapeutic implications.
- Trial name
- NCT05168982
- Where
- Hong Kong
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Crohn Disease, Resection Margins
Cellvizio to Evaluate Margins in Crohn's Ileal Disease
Crohn disease is an inflammatory bowel disease. A surgical procedure is required in about 80% of cases. Surgery doesn't cure from Crohn's disease but the type of surgery remains important as there are several intraoperative risk…
- Conditions
- Crohn Disease, Resection Margins, Recurrence
- Trial name
- CELLVICROHN (NCT05805020)
- Testing
- cellvizio
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Inflammatory Bowel Disease
Non-invasive Imaging of GI Inflammation Using Microbubble Contrast Enhanced Ultrasonography
Inflammatory bowel disease (IBD) is a common chronic inflammatory disorder, but a noninvasive method of assessing disease location, severity, and extent is currently not available.
- Trial name
- NCT00591669
- Testing
- Definity
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Virginia
Gall Stone, Gallbladder Inflammation
Benchmarks in Elective Laparoscopic Cholecystectomy
The aim of this observational cohort study is to define peri- and postoperative reference values for elective laparoscopic cholecystectomy, using the achievable benchmarks of care methodology (ABC™).
- Conditions
- Gall Stone, Gallbladder Inflammation, Gall Bladder Pain, Gallstone
- Trial name
- NCT06692517
- Testing
- Laparoscopic cholecystectomy
- Volunteers
- 60,000 people
- Sponsor
- Region Östergötland
Renal Disease, Liver Diseases
Outcomes of Children After Hospitalization in Intensive Care Unit
More than 10,000 children are hospitalized in an PICU every year in Canada. While most of them will survive their PICU hospitalization and their critical illness, some children will not recover to their pre-illness level.
- Conditions
- Renal Disease, Liver Diseases, Heart Diseases, Trauma Injury
- Trial name
- APCI (NCT06124092)
- Testing
- neurocognitive tests
- Where
- 8 sites in Canada
- Volunteers
- 690 people
- Sponsor
- St. Justine's Hospital