Clinical trials: Differential Lung Ventilation
Intercostal Nerve Block, Pulmonary Ventilation
EIT Evaluation of Pulmonary Ventilation With Different Ropivacaine Concentrations in Intercostal Nerve Blockade
This study aims to find out how different strengths of the anesthetic drug ropivacaine affect lung breathing function when used in intercostal nerve block (a type of local anesthesia) for breast quadrantectomy surgery.
- Conditions
- Intercostal Nerve Block, Pulmonary Ventilation, Anesthesia, Local, Breast Neoplasms
- Trial name
- EIT (NCT07079436)
- Testing
- 0.25% ropivacaine, 0.375% Ropivacaine, 0.5% Ropivacaine
- Where
- China
- Volunteers
- 67 people
- Sponsor
- Fudan University
Postoperative Pulmonary Dysfunction
Different Modes of Ventilation During Cardiopulmonary Bypass
66 patients divided into 3 groups with different modes of ventilation.
- Trial name
- NCT03824301
- Testing
- Volume controlled ventilation, Pressure controlled ventilation
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Ain Shams University
Acute Respiratory Distress Syndrome
Long Term Outcome on Brain and Lung of Different Oxygen Strategies in ARDS Patients
Acute respiratory distress syndrome (ARDS) is a serious disease with high mortality. In patients who survive ARDS, respiratory, neurological and motor sequelae are frequent, negatively impacting on the patient's quality of life…
- Trial name
- LTO-BLOXY (NCT03621293)
- Testing
- Modulation of Inspired Fraction of Oxygen (FiO2)
- Where
- France
- Volunteers
- 259 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
SARS-CoV Infection, COVID 19
The Efficacy of Different Anti-viral Drugs in COVID 19 Infected Patients
The (World Health Organization) WHO NOR- (Coronavirus infectious disease) COVID 19 study is a multi-centre, adaptive, randomized, open clinical trial to evaluate the safety and efficacy of hydroxychloroquine, remdesivir and…
- Conditions
- SARS-CoV Infection, COVID 19, Acute Respiratory Distress Syndrome ARDS
- Trial name
- NCT04321616
- Testing
- Hydroxychloroquine, Remdesivir, (Standard of Care) SoC
- Where
- Norway
- Volunteers
- 700 people
- Sponsor
- Oslo University Hospital
Coronary Artery Bypass
Noninvasive Ventilation After Coronary Bypass Grafting
This is a prospective, quantitative, randomized, crossover study. Were included in this study 10 people in the Intensive Care Unit at University Hospital in Uberlandia, on the first day of the postoperative coronary artery bypass…
- Trial name
- Physiotherapy (NCT02352376)
- Testing
- Conventional ventilator, Specific ventilator
- Volunteers
- 10 people
- Sponsor
- Federal University of Uberlandia
Ventilator Associated Pneumonia ( VAP)
Impact of Oral Care on Ventilator Associated Pneumonia
The goal of this clinical trial was to find out whether cleaning the mouths of children in the Pediatric Intensive Care Unit (PICU) with toothbrushing and chlorhexidine lowers the chance of getting lung infections in patients on…
- Trial name
- OH-VAP (NCT07287566)
- Testing
- Toothbrushing + Chlorhexidine, Routine oral care + Chlorohexidine
- Where
- Egypt
- Volunteers
- 118 people
- Sponsor
- Ain Shams University
Respiratory Distress, Newborn, Ventilator Induced Lung Injury
Ventilatory Parameters and Inflammatory Responses of Neonates Ventilated by Different Modes of Ventilation
The main purpose of this study is to investigate effects of SIMV+VG (synchronized intermittent mandatory ventilation+volume guarantee) or PSV+VG (pressure support ventilation+volume guarantee) ventilation on vital signs, patient…
- Trial name
- NCT01514331
- Testing
- SIMV+VG mode of ventilation (synchronized intermittent mandatory ventilation+volume guarantee), PSV+VG (pressure support ventilation+volume guarantee)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Gazi University
Respiration, Artificial, Energy Metabolism
Energy Expenditure in Weaning From Mechanical Ventilation
During weaning from mechanical ventilation process, the energy expenditure in T tube is greater than pressure support ventilation.
- Trial name
- NCT00853060
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Lung Cancer, Lung Lobectomy
Effects of Different I:E Ratio on Intrapulmonary Shunt Fraction and Oxygenation During One Lung Ventilation in the Lateral Decubitus Position
The purpose of this study is to investigate effect of increasing inspiratory time (I:E ratio 1:1) on intrapulmonary shunt fraction and oxygenation during one lung ventilation in the lateral decubitus position.
- Trial name
- NCT01499212
- Testing
- I:E ratio
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Yonsei University
Patients Receiving Invasive Mechanical Ventilation
Assessment of A Novel Emergency Transport Ventilator in Mechanically Ventilated Patients
Brief Summary The goal of this clinical trial is to compare whether the novel high-performance emergency transport ventilator (TV80) differs from the intelligent transport ventilator (HAMILTON-T1) in terms of oxygenation…
- Trial name
- NCT07198269
- Testing
- Intelligent emergency ventilator for transport, high-performance emergency ventilator for transport
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Chronic Obstructive Pulmonary Disease
Different Positive Pressure Strategies in COPD Patients.
Chronic obstructive pulmonary disease (COPD) is characterized by a poorly reversible airway obstruction and consequent systemic manifestations.
- Trial name
- NCT03382197
- Testing
- Nebulization, Positive expiratory pressure valve, Nonivasive ventilation
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Universidade Federal de Pernambuco
Obesity
Effectiveness of Two Different Body Positions During Facemask Ventilation in Obese Patients
It is important to provide enough oxygen to the patients who are asleep during surgery. One way to do this is by using a mask placed over the face to help them breathe.
- Trial name
- NCT06305273
- Testing
- Head position for face mask ventilation during induction supine, Head position for face mask ventilation during induction head elevated
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Mount Sinai Hospital, Canada
COPD Exacerbation, Pneumonia
Comparison of Multiple Oxygenation Targets With Different Oximeters in Chronic Obstructive Pulmonary Disease (COPD) and Non-COPD Patients- Impact on Oxygen Flows
The oximeter is an instrument for monitoring patients receiving oxygen therapy. It displays pulse oxygen saturation (SpO2), which is a reflection of arterial oxygen saturation (SaO2).
- Conditions
- COPD Exacerbation, Pneumonia, Hypoxemia, Respiratory Disease
- Trial name
- NCT05819164
- Testing
- Masimo oximeter, Nellcor oximeter, Nonin oximeter
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Laval University
Respiratory Failure, Healthy
Evaluation of Different Interfaces for Noninvasive Positive Pressure Ventilation (NPPV)
In this study the investigators aimed to study the ventilatory performance of different interfaces during NPPV delivering.
- Trial name
- NCT00297986
- Testing
- Helmet
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Policlinico Hospital
COVID-19, Mechanical Ventilation Pressure High
Different PEEP Settings of COVID-19 Induced ARDS
This was a multi-center prospective study. All consecutive severe cases of COVID-19 whose PO2/FiO2<300mmHg with invasive ventilation admitted to 5 fixed-point receive COVID-19 patients hospitals in Wuhan from 5 March to 15 March…
- Conditions
- COVID-19, Mechanical Ventilation Pressure High, Acute Respiratory Distress Syndrome
- Trial name
- NCT04359251
- Testing
- Gas exchanges at different PEEP, lung mechanics at different PEEP, Hemodynamics changes at different PEEP
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Southeast University, China
Prolonged Mechanical Ventilation
Lung Ventilation and Perfusion in Different Phenotypes of Chronic Critical Illness With Prolonged Mechanical Ventilation
This project will conduct a series of analysis of physiological and clinical data on tracheostomy patients who receive prolonged mechanical ventilation, hoping to find out the different manifestations of patients through the…
- Trial name
- NCT05634135
- Where
- Taiwan
- Volunteers
- 103 people
- Sponsor
- National Taiwan University Hospital
Obesity
Effects of Different PEEP Levels on Work of Breathing in Morbidly Obese Patients Prior to and After Extubation
The main purpose of this study is to define at the bedside the "Titrated-PEEP" level for obese patients that increases the likelihood of extubation and ventilator liberation.
- Trial name
- NCT02492113
- Testing
- Positive end-expiratory pressure (PEEP), ZEEP
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Deep Sedation, High Flow Nasal Canula
HFNO Flow Rates and Cerebral Oxygenation During Deep Sedation for Cystoscopy
For Patients and Families This study aims to investigate how high-flow oxygen therapy affects oxygen levels, especially brain oxygenation, during cystoscopy procedures performed under sedation.
- Conditions
- Deep Sedation, High Flow Nasal Canula, Cerebral Oxygenation, PSI
- Trial name
- NCT07630038
- Testing
- High-Flow Nasal Oxygen 40 L/min (HF40), High-Flow Nasal Oxygen 55 L/min (HF55), High-Flow Nasal Oxygen 70 L/min (HF70)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Firat University
Acute Brain Injuries
Effect of Increased Positive End-expiratory Pressure on Intracranial Pressure in Different Respiratory Mechanic in Acute Respiratory Distress Syndrome
There are concerns that the use of positive end-expiratory pressure (PEEP) for the treatment of pulmonary complications in patients with brain injury may potentially elevate intracranial pressure (ICP), and deteriorate…
- Trial name
- NCT02670733
- Testing
- Positive end-expiratory pressure
- Volunteers
- 30 people
- Sponsor
- Capital Medical University
Mechanical Ventilation, Mechanical Power
Investigation of the Optimum PEEP Mechanical Power Relationship
The aim of this study is to compare the effects of standard and optimum positive end expiratory pressures on mechanical power during laparoscopic surgeries.
- Conditions
- Mechanical Ventilation, Mechanical Power, Optimum PEEP, Laparoscopic Abdominal Surgery
- Trial name
- NCT06625099
- Testing
- Mechanical Ventilation (MV) with Low PEEP, Mechanical Ventilation (MV) with Optimum PEEP
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people
- Sponsor
- Kocaeli City Hospital