Clinical trials: Diagnostic Reasoning
Diagnosis
Automation Bias in Physician-LLM Diagnostic Reasoning
This study aims to systematically measure the extent and patterns of automation bias among physicians when utilizing ChatGPT-4o in clinical decision-making.
- Trial name
- NCT06963957
- Testing
- ChatGPT-4o Recommendations with Hallucinations
- Where
- Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Lahore University of Management Sciences
Diagnosis, Educational Problems
Examining Clinical Reasoning With Eye-tracking
The process of medical information intake, interpretation and diagnosis, commonly referred to as clinical reasoning, involves a complex interaction between visual perception and multiple cognitive processes.
- Trial name
- NCT06470269
- Testing
- Eye tracking
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Large Language Models
Physician Response Evaluation With Contextual Insights vs. Standard Engines - Artificial Intelligence RAG vs LLM Clinical Decision Support
Clinical decision support tools powered by artificial intelligence (AI) are being rapidly integrated into medical practice. Two leading systems currently available to clinicians are OpenEvidence, which uses retrieval-augmented…
- Trial name
- PRECISE (NCT07037940)
- Testing
- OpenEvidence, GPT-4
- Where
- 2 sites in United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Clinical Decision Support Systems, Diagnostic Reasoning
Effects of Agent-assisted, LLM-assisted and Traditional Workflows on Diagnosis and Management Planning at Admission
The goal of this clinical trial is to evaluate whether AI-assisted workflows improve physicians' admission diagnosis and management planning performance on standardized simulated inpatient cases, among practicing internal…
- Conditions
- Clinical Decision Support Systems, Diagnostic Reasoning, Artificial Intelligence (AI)
- Trial name
- NCT07760051
- Testing
- Agent-assisted workflow, LLM-assisted workflow, Traditional Workflow
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Diagnosis
Physician Reasoning on Diagnostic Cases With Large Language Models
This study will evaluate the effect of providing access to GPT-4, a large language model, compared to traditional diagnostic decision support tools on performance on case-based diagnostic reasoning tasks.
- Trial name
- NCT06157944
- Testing
- GPT-4
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Stanford University
Fragile X Syndrome (FXS), Creatine Transporter Deficiency
Optical Imaging in X-linked Disorders.
Fragile X syndrome (FXS, OMIM #300624) and Creatine Transporter Deficiency (CTD, #300352) are the two most common causes of X-linked intellectual disability.
- Trial name
- IMAGINER (NCT06868979)
- Testing
- Clinical assessment, Parental questionnaires, Cognitive assessment
- Where
- France
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Nursing Students, Decision-Making
The Effect of an Artificial Intelligence-Supported Virtual Reality Simulation on Nursing Students' Holistic Care Skills
This study aims to evaluate the effect of artificial intelligence (AI)-supported virtual reality (VR) simulation on nursing students' holistic care skills.
- Conditions
- Nursing Students, Decision-Making, Diagnostic Reasoning
- Trial name
- AI-VRS (NCT07518199)
- Testing
- AI-VRS, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Gazi University
Artificial Intelligence (AI), Clinical Reasoning
Learning Diagnostic Reasoning Through AI
This experiment aims to determine the effect of AI-generated questions and feedback on diagnostic reasoning in preclinical medical students.
- Conditions
- Artificial Intelligence (AI), Clinical Reasoning, Medical Education, Feedback
- Trial name
- NCT06754826
- Testing
- AI-generated questions and feedback as a spaced repetition
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Gazi University
Rheumatic Diseases
Al to Improve the Diagnosis of Rare Rheumatic Diseases
This trial aims to assess the impact of providing medical students with access to ChatGPT, a state-of-the-art large language model, in comparison to conventional diagnostic decision support tools, on their diagnostic accuracy for…
- Trial name
- AIDRARER (NCT06748170)
- Testing
- ChatGPT
- Where
- Germany
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Pulmonary Embolism, Diagnostic Uncertainty
The Visualization of Uncertainty in Clinical Diagnostic Reasoning for Pulmonary Embolism
Medical reasoning is a form of inquiry that examines the thought processes involved in making medical decisions. When physicians are faced with patients' symptoms or signs, their thought processes follow either direct shortcuts…
- Conditions
- Pulmonary Embolism, Diagnostic Uncertainty, Clinical Reasoning, Evidence Based Medicine
- Trial name
- NCT01752673
- Testing
- Visualized pulmonary embolism computer task model, Didactic review lecture
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Paranoia in People With Schizophrenia-spectrum Diagnosis
Computerised Interventions for Thinking and Anxiety in Delusions (CITADEL) Trial
People with a schizophrenia spectrum diagnosis often experience distressing worries or beliefs about others intending to cause them harm (also known as paranoia).
- Trial name
- CITADEL (NCT01920685)
- Testing
- Anxiety intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 25 people
- Sponsor
- King's College London
Diagnosis
Mitigating Automation Bias in Physician-LLM Diagnostic Reasoning Using Behavioral Nudges
The goal of this randomized controlled trial is to evaluate whether behavioral nudges can reduce automation bias, the uncritical acceptance of automated output, in physicians using large language models (LLM) like ChatGPT-5.1 for…
- Trial name
- NCT07328815
- Testing
- Behavioral Nudge Intervention
- Where
- Pakistan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Lahore University of Management Sciences
Clinical Reasoning, Medical Education
Simulation-Based Learning on Clinical Reasoning, Knowledge Retention, and Transfer in Undergraduate Medical Education
This randomized controlled trial evaluates whether a digital, video-based clinical-reasoning simulation improves clinical-reasoning performance compared with conventional lecture-based teaching across multiple clinical…
- Conditions
- Clinical Reasoning, Medical Education, Simulation Training
- Trial name
- SIMCORE (NCT07679672)
- Testing
- Behavioral, Lecture
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Altinbas University
Differential Diagnosis, Diagnostic Accuracy
Evaluation of One-Shot Vision Differential Diagnosis (OSVDE) and Multi-Step Conversational Non-Inferiority (MSCNE) in AI Medical Interviewing
This study evaluates the diagnostic performance of a multimodal artificial intelligence (AI) system (AIMD.1) using de-identified medical images and semi-synthetic patient simulations.
- Trial name
- OSVDE-MSCNE (NCT07470463)
- Testing
- AI Diagnostic System (AIMD.1)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Magic Health Inc. (d.b.a. Nolla Health)
Health Diagnosis Skills, CORE
The Effectiveness of the Web-Based CORE on Nursing Students' Health Diagnosis Skills
Health diagnosis is an essential part of the professional nursing role and the holistic nursing approach. The goal of the health diagnosis process is to establish a baseline database for the care plan, encompassing the patient's…
- Conditions
- Health Diagnosis Skills, CORE, Nursing Students, Clinical Oriented Reasoning Exam
- Trial name
- NCT07105696
- Testing
- Web-Based CORE
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Diagnosis
Evaluation of a Retrieval Augmented Large Language Model as a Diagnostic Copilot in Rheumatology
This trial evaluates whether providing physicians with access to Prof. Valmed, a clinical decision support medical product, improves identification of rheumatic diseases and formulation of differential diagnoses compared with…
- Trial name
- ALLIANCE (NCT07166692)
- Testing
- Prof. Valmed
- Where
- Germany
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Pathologic Processes, Disease
Diagnostic Reasoning With Customized GPT-4 Model
This study will assess the impact of immediate access to a customized version of GPT-4, a large language model, on performance in case-based diagnostic reasoning tasks.
- Trial name
- NCT06911645
- Testing
- Immediate access to customized version of GPT-4, Access to customized version of GPT-4 following use of conventional resources
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Stanford University
Diagnosis
The Impact of Large Language Models on Diagnostic Reasoning Among LLM-Trained Medical Doctors
This study aims to evaluate whether large language model-trained medical doctors demonstrate enhanced diagnostic reasoning performance when utilizing ChatGPT-4o alongside conventional resources compared to using conventional…
- Trial name
- NCT06774612
- Testing
- ChatGPT-4o
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lahore University of Management Sciences
Chest Pain, Dyspnea
Diagnostic Reasoning and Sense of Alarm at Dyspnoea and / or Chest Pain
Dyspnea and chest pain represent 1.5% of general practice consultations. They may be a sign of many diseases, potentially serious. The concept of Gut Feelings brings a sense of alarm and reinsurance.
- Trial name
- RaisDiag (NCT02932982)
- Where
- 11 sites in France
- Volunteers
- 241 people
- Sponsor
- University Hospital, Brest
Diagnosis, Clinical Decision-making
Reasoning Enrichment With Feedback From IA in NEphrology Trial
The goal of this clinical trial is to learn how artificial intelligence (AI) may help doctors make diagnoses in kidney medicine.
- Conditions
- Diagnosis, Clinical Decision-making, Artificial Intelligence (AI) in Diagnosis, Decision Support Systems, Clinical
- Trial name
- REFINe (NCT07352475)
- Testing
- AI suggestion
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille