Clinical trials: Diagnostic Decision Making
Breast Cancer
Understanding Decision Making Processes for Undergoing Genetic Testing Among Women With Newly Diagnosed Breast Cancer
Genes are the "blueprints" for our bodies. Some people are born with an abnormal copy ("mutation") of a gene. These people may have a higher chance of getting a disease.
- Trial name
- NCT01386411
- Testing
- BRCA testing and questionnaire assessments
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Sepsis
The Clinical and Pharmacoeconomic Impact of Rapid Diagnostic Test (Multiplex PCR FilmArray) on Antimicrobial Decision Making Compared to Conventional Decision Making Among Critically Ill Patients
We will show in this study the impact of use the rapid diagnostic method (multiplex PCR filmArray) on clinical and pharmacoeconomic aspects among Critically Ill Patients.
- Trial name
- NCT05759494
- Testing
- rapid diagnostic test (multiplex PCR filmArray)
- Volunteers
- 100 people
- Sponsor
- Cairo University
Healthy
Methylphenidate in Healthy Young Adults
Background: There is a paucity of data as to the effect of methylphenidate (MPH) on young adults who do not have attention deficit hyperactivity disorder (ADHD).
- Trial name
- NCT00815841
- Testing
- METHYLPHENIDATE
- Volunteers
- 50 people
- Sponsor
- Shaare Zedek Medical Center
Normal Labor
Generative AI-Powered Intrapartum Clinical Decision Support Among Healthcare Providers
Pregnancy and childbirth are uniquely important events in women's lives because they are accompanied by major physical, emotional, and psychological changes.
- Trial name
- NCT07720531
- Testing
- Generative AI-Powered Intrapartum Chatbot
- Where
- Egypt
- Volunteers
- 427 people, healthy volunteers welcome
- Sponsor
- Delta University for Science and Technology
Epilepsy
The Clinical Utility of BioEP in Diagnostic Decision Making in Epilepsy
Neuronostics plan a prospective multisite trial to determine the clinical utility of BioEP in the context of diagnostic decision making.
- Trial name
- CITADEL (NCT06097195)
- Testing
- BioEP
- Where
- 2 sites in United Kingdom
- Volunteers
- 559 people
- Sponsor
- Neuronostics Ltd
Obstructive Sleep Apnea Syndrome
Diagnosis of Patients With Low or Intermediate Suspicion of SAHS or With Comorbidity: Standard Laboratory Polysomnography Compared With Three Nights of Home Respiratory Polygraphy.
Study Objectives: Obstructive sleep apnea (OSA) diagnosis using simplified methods such as home respiratory polygraphy (HRP) is only recommended in patients with a high pre-test probability.
- Trial name
- NCT01820156
- Testing
- Home Respiratory Polygraphy, Standard Polysomnography
- Where
- Spain
- Volunteers
- 56 people
- Sponsor
- Hospital Clinic of Barcelona
Prostate Cancer
Interactive Decision Aid for Men Diagnosed With Prostate Cancer
Prostate cancer is the second leading cause of cancer related deaths in the western world (National Cancer Institute, 2011). Prostate cancer diagnosis relates to significant psychological distress (Roesch et al, 2005; Hervouet et…
- Trial name
- NCT04260737
- Testing
- Decision Aid for Men with Localized Prostate Cancer
- Where
- Iceland
- Volunteers
- 163 people
- Sponsor
- Reykjavik University
Localised Prostate Cancer
BeSpoke Decision Support for Patients With Newly Diagnosed Localised Prostate Cancer
The goal of this randomised clinical trial is to assess whether personalised treatment counselling can improve the decision-making experience in patients with a new diagnosis of localised prostate cancer.
- Trial name
- BeSpoke (NCT07135271)
- Testing
- Bespoke Decision Support tool, Standard of Care (SOC) decision support material
- Where
- United Kingdom
- Volunteers
- 346 people
- Sponsor
- University College, London
Epilepsy
A Prospective Diagnostic Belief Updating Study to verIfy the Utility of BioEP in First Seizure Clinics.
The goal of this belief updating study is to assess the utility of BioEP as a complementary support tool in aiding clinical decision making in adults in first seizure clinics.
- Trial name
- PRISTINE (NCT05764252)
- Testing
- BioEP
- Where
- United Kingdom
- Volunteers
- 88 people
- Sponsor
- Neuronostics Ltd
Medical Malpractice, Artificial Intelligence in Medicine
The Impact of AI-Assisted Diagnosis and Treatment on Physicians' Potential Legal Liability: An Expert Perspective
The goal of this randomized vignette-based experiment is to investigate how AI-related contextual factors influence expert assessment of physician negligence in AI-assisted diagnosis and treatment scenarios among experts in…
- Conditions
- Medical Malpractice, Artificial Intelligence in Medicine, Clinical Decision-Making
- Trial name
- NCT07869303
- Testing
- General AI With a Standard-of-Care Recommendation, General AI With a Non-Standard-of-Care Recommendation, Expert AI With a Standard-of-Care Recommendation
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Xie Xiaoyun
Respiratory Infection
Unclogging the Pediatric Emergency Room: Impact of Rapid Viral Diagnostics
Acute respiratory tract infections are among the most common problems of childhood, particularly among infants and children younger than 3 years, and account for most antibiotic prescriptions to children.
- Trial name
- NCT00278759
- Testing
- Nasopharyngeal washing for viral antigen detection by immunofluorescence initiated early in ED visit.
- Where
- Canada
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Artificial Intelligence (AI) in Diagnosis, Decision Support Systems, Clinical
Comparing Artificial Intelligence and Physicians: A Vignette-Based Study in Pediatric Clinical Decision-Making
This study evaluates how well anonymized artificial-intelligence (AI) tools perform on standardized pediatric case vignettes and whether showing AI suggestions can improve clinicians' answers.
- Conditions
- Artificial Intelligence (AI) in Diagnosis, Decision Support Systems, Clinical, Clinical Decision-making, Pediatrics
- Trial name
- NCT07179861
- Testing
- AI Suggestions (Anonymized 5-tool panel), Confidence Rating Task (1-10 Likert)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Haseki Training and Research Hospital
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Treatment Decision Making in African American Women Diagnosed With Triple Negative Breast Cancer
This study evaluates what influences treatment decision-making in African American women with triple negative breast cancer. The study also aims to learn about the influence of information sources that support this…
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- NCT05071677
- Testing
- Discussion, Interview, Survey Administration
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer, Satisfaction, Patient
Shared Decision Making and Satisfaction With the Diagnostic-therapeutic Process in the Shared Decision Making and Satisfaction With Colorectal Cancer Screening. The CyDESA Study
A cross sectional multicenter study (3 centers) to know the participation in decision making and the experience and satisfaction of participants with a positive immunological fecal test (FIT) result in relation to the screening…
- Trial name
- CyDESA (NCT04610086)
- Where
- Spain
- Volunteers
- 846 people
- Sponsor
- Corporacion Parc Tauli
Metastatic Breast Cancer
Patient-Centric Study to Assess the Impact of Genomic Profiling on the Treatment of Patients With Metastatic Breast Cancer in Spain
HOPE Focus is an observational study that aims at promoting research against metastatic breast cancer by means of collective research led by patients (patient-centric trial).
- Trial name
- HOPE-Focus (NCT06991946)
- Testing
- Liquid Biopsy, Archival Tumor DNA
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- SOLTI Breast Cancer Research Group
Prostate Cancer, Risk Assessment
PROstate Cancer Risk Calculator for ACTionable Clinical Decision-making in Nigeria
This study is a pilot trial that builds on findings from the validation of prostate cancer risk calculators in Nigerian men. The goal of the overall study is to improve the early detection of prostate cancer in a high-risk…
- Conditions
- Prostate Cancer, Risk Assessment, Clinical Decision Support Systems, Predictive Value of Tests
- Trial name
- PROACT (NCT07733440)
- Testing
- (a) Training and (b) Supported risk assessment
- Where
- Nigeria
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Ahmadu Bello University
Non Small Cell Lung Cancer
Real-Time Imaging to Improve Lung Cancer Diagnosis : Comparing Confocal Laser Endomicroscopy (CLE) With Standard Biopsy for Quicker and Safer Detection of Non-Small Cell Lung Cancer
The goal of this observational study is to evaluate whether confocal laser endomicroscopy (CLE) can improve the real-time diagnosis of non-small cell lung cancer (NSCLC) in patients undergoing bronchoscopic biopsy for suspected…
- Trial name
- SCORACLE (NCT07538947)
- Testing
- bronchoscopic navigation with CLE
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Central Hospital, Nancy, France
Schizophrenia
Bizarreness and Anomalous Self Experiences in Schizophrenia
Several authors suggest that the specific experience felt in clinical encounter, called Praecox Feeling, is directly linked to the psychopathology of Schizophrenia.
- Trial name
- BASES (NCT05966610)
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Toulouse
Infectious Diseases, Immunocompromised Host
Metagenomic Sequencing Across the Infectious Disease Risk and Care Continuum
The AXIS Network is a prospective, multicenter observational registry designed to generate real-world evidence on the use of metagenomic sequencing in clinical practice across a broad range of patient populations, infectious…
- Conditions
- Infectious Diseases, Immunocompromised Host, Opportunistic Infections
- Trial name
- AXIS (NCT07825714)
- Volunteers
- 10,000 people
- Sponsor
- Karius, Inc.
Low Back Pain, Neck Pain
Pre-Visit AI Symptom-Checking and Shared Decision-Making in Spine Physical Therapy
Artificial intelligence (AI) symptom-checking tools, including large language models such as ChatGPT, are increasingly used by patients before they seek care.
- Conditions
- Low Back Pain, Neck Pain, Radiculopathy
- Trial name
- NCT07733752
- Testing
- re-visit AI symptom-checker use
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Assiut University