Clinical trials: Deprescription, active
Deprescription, Antidepressants
Deprescription of Antidepressants in Primary Care (DAPriCare)
Introduction The consumption of antidepressants has increased considerably worldwide, including in Spain. Despite their effectiveness in cases of moderate to severe depression, their long-term use in mild cases is questioned.
- Trial name
- DAPriCare (NCT06796946)
- Testing
- Deprescription of Antidepressants (fluoxetine, citalopram, sertraline, paroxetine, and escitalopram)
- Where
- Spain
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- University of Huelva
Drug-Related Side Effects and Adverse Reaction, Digoxin Overdose
Introducing Electronic Alerts to Reduce Inappropriate Digoxin Prescribing in Older Adults
The intervention consists of introducing computerized alerts into the electronic medical record of the CSAPG (MIRA software), which are triggered when a physician prescribes digoxin at a dose higher than the recommended amount…
- Trial name
- Aldigo (NCT07008144)
- Testing
- Digoxin alarm
- Where
- 2 sites in Spain
- Volunteers
- 5,954 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Essential Hypertension
REMIDEP-HTA Program for Hypertension Remission and Medication Deprescription
The REMIDEP-HTA trial is a multicenter randomized controlled study designed to evaluate whether a structured approach combining an intensive lifestyle intervention with a systematic deprescribing algorithm can achieve clinical…
- Trial name
- REMIDEP-HTA (NCT07424118)
- Testing
- Intensive Lifestyle Intervention, Pharmacological Deprescribing Algorithm, Standard Medical Care
- Where
- Argentina
- Volunteers
- 240 people
- Sponsor
- Evelyn Vanina Re
Benzodiazepine Withdrawal
Brief Motivational Intervention (BMI) on the Deprescription of Benzodiazepines and Related Substances in Adult Chronic Drug Users
We hypothesise that a short-term intervention by dispensing pharmacists is feasible and relatively easy to implement, and that it could have an impact on the deprescribing of BZD/Z in adult patients.
- Trial name
- BENZ_HALTE (NCT06446349)
- Testing
- Brief motivational intervention
- Where
- 20 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Grenoble
Deprescriptions, Antidepressive Agents
Patient-centred Deprescribing of Psychotropic, Sedative and Anticholinergic Medication in Elderly Patients With Polypharmacy
The PARTNER study is a multicentre, two-arm, pragmatic cluster-randomised trial evaluating the impact of a focused and patient-centred cooperation between general practitioners (GPs) and community pharmacists (PARTNER…
- Conditions
- Deprescriptions, Antidepressive Agents, Antipsychotic Agents, Analgesics, Opioid
- Trial name
- PARTNER (NCT05842928)
- Testing
- PARTNER intervention, Control intervention
- Where
- 3 sites in Germany
- Volunteers
- 352 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Medication Overuse, Deprescriptions
Prescribing Outcomes of a GP-Targeted Deprescribing Educational Intervention: A Cluster Randomized Trial
Polypharmacy is a common and growing public health concern across healthcare settings worldwide and is associated with an increased risk of inappropriate prescribing and adverse drug events.
- Conditions
- Medication Overuse, Deprescriptions, Polypharmacy, Frailty Syndrome
- Trial name
- NCT06470308
- Testing
- Medication Reviews and Deprescribing
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- University of Crete
Schizophrenia, Schizoaffective Disorder
Anticholinergic Deprescription in Schizophrenia
In this study, the investigators will examine whether a deprescription of unnecessary anticholinergic drugs (benztropine or trihexyphenidyl) can augment quality of life, functioning, and neurocognition in individuals who with…
- Trial name
- NCT06562608
- Testing
- Anticholinergic Deprescription, No Anticholinergic Deprescription
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Deepak K. Sarpal, M.D.
Benzodiazepine-Related Disorders
Informative Exhibition for Deprescribing Benzodiazepines
The goal of this trial is to determine if an interactive and informative exhibition in the waiting room of a Primary Care Clinic can reduce the use of benzodiazepines in adults.
- Trial name
- ESUB (NCT06467019)
- Testing
- Informative Session
- Where
- Spain
- Volunteers
- 6,410 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf