Clinical trials: Deprescription
Hypothyroidism
REduction of LEvothyroxine in Adults; a SElf Controlled Study
Many older persons use the thyroid hormone levothyroxine which is often continued for life. Scientifically, there is much uncertainty whether simple continuation is the optimal approach.
- Trial name
- RELEASE (NCT05821881)
- Testing
- Discontinuation of levothyroxine treatment
- Where
- Netherlands
- Volunteers
- 513 people
- Sponsor
- Leiden University Medical Center
Dementia
Optimal Medication Management in Alzheimer's Disease and Dementia
The study objective is to conduct a pragmatic deprescribing intervention for people with Alzheimer's Disease or Related Dementia with Multiple Chronic Conditions (ADRD-MCC) so that these patients are on 'just right' medication…
- Trial name
- Optimize (NCT03984396)
- Testing
- Educational Materials - Patient & Clinician
- Where
- United States
- Volunteers
- 7,398 people
- Sponsor
- Kaiser Permanente
Fall, Congestive Heart Failure
Reducing High-Risk Geriatric Polypharmacy Via EHR Nudges: Pilot Phase
Polypharmacy is common among older adults in the United States and is associated with harms such as adverse drug reactions and higher costs of care.
- Conditions
- Fall, Congestive Heart Failure, Chronic Kidney Failure, Adverse Drug Event
- Trial name
- NCT03791580
- Testing
- Commitment nudge, Justification nudge
- Where
- United States
- Sponsor
- RAND
Medical Overuse, Inappropriate Prescribing
Engaging Patients to Promote Deprescribing
One mechanism to reduce potentially inappropriate medications is through deprescribing, a deimplementation-based approach to thoughtfully discontinue a medication a patient is currently prescribed.
- Conditions
- Medical Overuse, Inappropriate Prescribing, Deprescriptions
- Trial name
- NCT04294901
- Testing
- Direct to patient medication brochure
- Where
- 4 sites in United States
- Volunteers
- 5,946 people
- Sponsor
- VA Office of Research and Development
Terminal Cancer
Towards Cancer Patient Empowerment for Optimal Use of Antithrombotic Therapy at the End of Life
Despite the fact that antithrombotic therapy (ATT) has little or even negative effects on the well-being of cancer patients during their last year of life, stopping ATT is rare in clinical practice.
- Trial name
- SERENITY (NCT05706740)
- Testing
- Physician survey on antithrombotic medication during end-of-life care in cancer patients
- Where
- 12 sites in Denmark, France and 6 more
- Volunteers
- 467 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Proton Pump Inhibitors, Deprescription
Efficacy of a Multi-faceted Intervention Combining an Educational Outreach Visit to General Practitioners and Patient Education Material to Deprescribe Proton Pump Inhibitors (PPI): a Population-based, Pragmatic, Cluster-randomized Controlled Trial
Deprescribing is defined as "the process of withdrawal of an inappropriate medication, supervised by a health care professional with the goal of managing the polypharmacy and improving outcomes".
- Trial name
- DeprescrIPPDAM (NCT04513834)
- Testing
- GP will receive the educational outreach visit by a DAM (healthcare representative)., Patient education material on PPI deprescribing will be sent to the patients
- Where
- France
- Volunteers
- 25,000 people
- Sponsor
- Nantes University Hospital
Fall, Fall Injury
A Clinical Decision Support System and Patient Portal for Preventing Medication-related Falls in Older Patients
Falls in older adults represents a growing public health challenge. The use of certain medication is recognized as an important modifiable risk factor for falls.
- Conditions
- Fall, Fall Injury, Fall Patients, Accidental Fall
- Trial name
- ADFICE_IT (NCT05449470)
- Testing
- CDSS, Patient Portal
- Where
- 10 sites in Netherlands
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Benzodiazepine Withdrawal
Brief Motivational Intervention (BMI) on the Deprescription of Benzodiazepines and Related Substances in Adult Chronic Drug Users
We hypothesise that a short-term intervention by dispensing pharmacists is feasible and relatively easy to implement, and that it could have an impact on the deprescribing of BZD/Z in adult patients.
- Trial name
- BENZ_HALTE (NCT06446349)
- Testing
- Brief motivational intervention
- Where
- 20 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Grenoble
Deprescription, Benzodiazepine (BZD) and Related Drugs
Multimodal Educative Data Feedback for Deprescribing BZD and Related Drugs in Outpatients: a Cluster RCT
Benzodiazepine (BZD) and related drugs are sedative anxiolytics and hypnotics that should be avoided especially in people aged 65 years and older, given the high risk of falling, fracture, dependence, respiratory depression and…
- Trial name
- NCT05859555
- Testing
- Thematic quality circles - Deprescription
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- Réseau de soins Delta
Schizophenia Disorder, Schizoaffective Disorder
Reduction of Anticholinergic Medications Among Persons With Schizophrenia or Other Psychiatric Disorders
The goal of this study is to reduce Anticholinergic Medication (ACM) in persons with psychoses or serious mental illness, when these medications are no longer needed.
- Conditions
- Schizophenia Disorder, Schizoaffective Disorder, Bipolar Disorder, Psychiatric Disorders
- Trial name
- RAMP (NCT07043803)
- Testing
- Reduction of anticholinergic medication
- Where
- 4 sites in United States
- Volunteers
- 53 people
- Sponsor
- University of Pittsburgh
Multiple Chronic Conditions, End Stage Disease
Optimising Drug Therapy in Polymedicated Patients According to the Person-centered Care Model
Introduction: In recent years, multi-aging has increased by 25%. This is related to plutipatology, frailty, polymedications, elevated sanitary cost, low quality of life, adverse events and mortality.
- Trial name
- NCT04188470
- Testing
- person-centered care model
- Where
- 2 sites in Spain
- Volunteers
- 208 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Deprescriptions, Antidepressive Agents
Patient-centred Deprescribing of Psychotropic, Sedative and Anticholinergic Medication in Elderly Patients With Polypharmacy
The PARTNER study is a multicentre, two-arm, pragmatic cluster-randomised trial evaluating the impact of a focused and patient-centred cooperation between general practitioners (GPs) and community pharmacists (PARTNER…
- Conditions
- Deprescriptions, Antidepressive Agents, Antipsychotic Agents, Analgesics, Opioid
- Trial name
- PARTNER (NCT05842928)
- Testing
- PARTNER intervention, Control intervention
- Where
- 3 sites in Germany
- Volunteers
- 352 people
- Sponsor
- Ludwig-Maximilians - University of Munich
End-Of-Life, Inappropriate Prescribing
Effectiveness of a Person-centred Prescription Model at the End of Life
This study's main objective is to investigate whether the application of an adapted person-centred prescription model during a hospital stay would reduce the use of inappropriate or futile regular medications in older people at…
- Conditions
- End-Of-Life, Inappropriate Prescribing, Deprescriptions, Palliative Medicine
- Trial name
- NCT05454644
- Testing
- Person-Centred Prescription Model
- Where
- Spain
- Volunteers
- 114 people
- Sponsor
- Matia Foundation
Anxiety, Insomnia
Augmenting Benzodiazepine Receptor Agonist Deprescribing With Acupuncture and Yoga Among Older Adults
The main purpose of this 12-week study is to see if a new combination of treatments can help older adults reduce benzodiazepine or related medication use.
- Conditions
- Anxiety, Insomnia, Benzodiazepine, Deprescription
- Trial name
- NCT06197243
- Testing
- Acupuncture, Yoga, Deprescribing
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Drug-Related Side Effects and Adverse Reaction, Digoxin Overdose
Introducing Electronic Alerts to Reduce Inappropriate Digoxin Prescribing in Older Adults
The intervention consists of introducing computerized alerts into the electronic medical record of the CSAPG (MIRA software), which are triggered when a physician prescribes digoxin at a dose higher than the recommended amount…
- Trial name
- Aldigo (NCT07008144)
- Testing
- Digoxin alarm
- Where
- 2 sites in Spain
- Volunteers
- 5,954 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Polypharmacy, Gabapentin
Deprescription of Gabapentinoids in Medical Inpatients
In this trial, investigators will distribute educational brochures with information about the deprescription of gabapentinoids (gabapentin and pregabalin) to inpatients in five medical wards spread across two tertiary-care…
- Conditions
- Polypharmacy, Gabapentin, Pregabalin
- Trial name
- GABA-WHY (NCT04855578)
- Testing
- In-Hopsital Patient Educational Brochure, Physician Education about Gabapentinoid Prescription
- Where
- 2 sites in Canada
- Volunteers
- 160 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Benzodiazepine-Related Disorders
Informative Exhibition for Deprescribing Benzodiazepines
The goal of this trial is to determine if an interactive and informative exhibition in the waiting room of a Primary Care Clinic can reduce the use of benzodiazepines in adults.
- Trial name
- ESUB (NCT06467019)
- Testing
- Informative Session
- Where
- Spain
- Volunteers
- 6,410 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Deprescriptions, Polypharmacy
Optimising Medication With Focus on Deprescribing in Frail Older People With Multidose Drug Dispensing Systems
Overuse is common in frail older people with polypharmacy, especially in frail older users of multidose drug dispensing (MDD) systems.
- Conditions
- Deprescriptions, Polypharmacy, Primary Health Care, Community Pharmacy Services
- Trial name
- NCT05609981
- Testing
- Clinical medication review focused on deprescribing
- Where
- Netherlands
- Volunteers
- 318 people
- Sponsor
- SIR Institute for Pharmacy Practice and Policy
Hospices, Poly Pharmacy
Standardized Patient-Centered Medication Review in Home Hospice
This is a pilot cluster randomized trial that tests the effect of a novel intervention that trains hospice staff to 1. regularly review, simplify, and align patients' prescribed medications with their goals of care as their…
- Conditions
- Hospices, Poly Pharmacy, Deprescriptions, Caregivers
- Trial name
- SPECTORx (NCT03972163)
- Testing
- NIA Medication Management - Active Comparator, STOPPFrail (Screening Tool of Older Persons Prescriptions), "Discontinuing Medication Appropriately" and "Understanding the Art of Communication about Deprescribing"
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Massachusetts, Worcester
Deprescription, Antidepressants
Deprescription of Antidepressants in Primary Care (DAPriCare)
Introduction The consumption of antidepressants has increased considerably worldwide, including in Spain. Despite their effectiveness in cases of moderate to severe depression, their long-term use in mild cases is questioned.
- Trial name
- DAPriCare (NCT06796946)
- Testing
- Deprescription of Antidepressants (fluoxetine, citalopram, sertraline, paroxetine, and escitalopram)
- Where
- Spain
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- University of Huelva