Clinical trials: Delirium in the Intensive Care Unit, active
Delirium, Intensive Care Unit Delirium
Family-partnered Delirium Prevention, Detection, and Management in the ICU
Almost half of critically ill patients experience delirium. Delirium is associated with impaired cognition, mortality, and increased healthcare costs.
- Conditions
- Delirium, Intensive Care Unit Delirium, Post Intensive Care Unit Syndrome, Post Intensive Care Unit Syndrome Family
- Trial name
- ACTIVATE (NCT07896356)
- Testing
- Standard of Care, Delirium Education, Prevention, and Management
- Where
- Canada
- Volunteers
- 1,344 people
- Sponsor
- University of Calgary
Sleep, Circadian Dysregulation
reALIGNing Circadian Rhythm and Promoting Sleep in the Intensive Care Unit
The goal of this pilot clinical trial is to learn whether a program to support sleep and the body's daily rhythms can be delivered safely and consistently to critically ill adults in intensive care units (ICUs).
- Conditions
- Sleep, Circadian Dysregulation, ICU, Delirium in Intensive Care Unit
- Trial name
- ALIGN ICU (NCT07886567)
- Testing
- Sleep chronobundle, Control
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Delirium in the Intensive Care Unit
Impact on Delirium of the Use of DEXmedetomidine as First-line Sedation in PEDIAtric Intensive Care
The goal of this clinical trial is to learn if dexmedetomidine can reduce delirium in critically ill children, needing mechanical ventilation for more than 12 hours.
- Trial name
- PEDIADEX (NCT07542990)
- Testing
- Dexmedetomidine, Midazolam
- Where
- 7 sites in France
- Volunteers
- 266 people
- Sponsor
- University Hospital, Tours
Delirium in the Intensive Care Unit
Virtual Reality-based Sensory Stimulation for Delirium Prevention in Intensive Care Units
The goal of this clinical trial is to evaluate whether virtual reality (VR)-based sensory stimulation can help prevent delirium in adult intensive care unit (ICU) patients, compared with an active control condition delivering the…
- Trial name
- NCT07806422
- Testing
- immersive VR group, Active control group
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chinese University of Hong Kong
Delirium in Intensive Care Unit, Acute Heart Failure (AHF)
Intravenous Infusion of Low Dose Ketamine Versus Dexmedetomedine for Delirium Treatment in Acute Heart Failure
Delirium is an acute, fluctuating disturbance in attention and cognition that commonly complicates the course of critically ill patients, particularly those admitted with acute heart failure (AHF).
- Trial name
- NCT07781462
- Testing
- Low dose ketamine infusion, Dexmedetomidine infusion
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Alexandria University
Delirium in Old Age, Delirium in the Intensive Care Unit
Multi-Component Delirium Prevention Bundle in Older Cardiac Intensive Care Unit Patients
The goal of this randomized controlled clinical trial is to learn whether a structured delirium prevention protocol can reduce the occurrence of delirium in older adults admitted to the cardiac intensive care unit (CICU).
- Conditions
- Delirium in Old Age, Delirium in the Intensive Care Unit, Delirium Confusional State, Delirium
- Trial name
- CICUDEL (NCT07776184)
- Testing
- Multicomponent Delirium Prevention Bundle, Control Group
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Tel Aviv Medical Center
Patients in ICU, Delirium in the Intensive Care Unit
A Prospective Observational Study Using the FAM-CAM
The goal of this observational study is to learn whether family members can help identify signs of delirium in adult patients who are staying in the intensive care unit.
- Conditions
- Patients in ICU, Delirium in the Intensive Care Unit, Family
- Trial name
- NCT07694687
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Shanghai Zhongshan Hospital
Delirium in the Intensive Care Unit
Ceribell Delirium Monitor Outcomes Pilot Study
This pilot study is designed as a pre- and post-delirium monitor cohort study, with a prospective intervention cohort and a retrospective control cohort.
- Trial name
- DOM (NCT07449416)
- Testing
- Ceribell Delirium Monitoring System
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Ceribell Inc.
Critical Illness, Delirium in the Intensive Care Unit
Digital and Plasma Biomarkers in Delirium
The goal of this observational study is to learn if there are potential digital and plasma-based biomarkers that could help detect, predict, and prognosticate delirium in older adult patients who are admitted to the intensive…
- Conditions
- Critical Illness, Delirium in the Intensive Care Unit, Sleep Quality
- Trial name
- DELTA (NCT07694206)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Scripps Health
Delirium in the Intensive Care Unit, Sleep Quality
Precision ICU Care: Evaluating an AI-Driven Nursing Decision Support System for Delirium Prevention
Delirium affects up to 83% of mechanically ventilated patients in the Intensive Care Unit (ICU), often leading to longer hospital stays and long-term memory or cognitive problems.
- Trial name
- NCT07631494
- Testing
- MLP-based Clinical Decision Support System (MLP-CDSS), VR-based Cognitive Intervention, VR-assisted Early Mobility Exercise
- Where
- Taiwan
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Intensive Care Unit Delirium
Prevention of Delirium in ICU Using Multimodal Interventions
This study was designed to evaluate the impact of non-pharmacological multimodal interventions including ongoing orientation, sensory correction, setting of familiar circumstance and promotion of sleep enviromnet for prevention…
- Trial name
- NCT05950958
- Testing
- Multimodal therapy for prevention of delirium
- Where
- South Korea
- Volunteers
- 196 people
- Sponsor
- Seoul National University Hospital
Pain, Delirium in the Intensive Care Unit
Therapeutic Cuddling in Critically Ill Children
2.1 CONTEXT Pain and agitation are common comorbidities of pediatric critical illness due to both underlying disease processes and ICU related therapies.
- Trial name
- THE ChICKS (NCT07562048)
- Testing
- Therapeutic cuddling, Standard of care
- Where
- Canada
- Volunteers
- 112 people
- Sponsor
- University of Calgary
Delirium in the Intensive Care Unit
EEG Abnormalities in Adult ICU Patients With High Risk of Delirium
The purpose of this study is to assess the prevalence of EEG abnormalities on Ceribell POC EEG in adult medical, surgical, and cardiovascular ICU patients with high risk of delirium
- Trial name
- NCT07485244
- Testing
- Ceribell EEG System
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ceribell Inc.
Intensive Care Unit Delirium, Intensive Care Acquired Cognitive Impairment
Virtual Reality Cognitive Intervention for Critically Ill Delirium Survivors (VR-Cog)
The purpose of this study is to measure the feasibility, acceptability of virtual reality (VR) brain games and estimate their effect on memory, attention, and mood for ICU survivors.
- Conditions
- Intensive Care Unit Delirium, Intensive Care Acquired Cognitive Impairment, Post Intensive Care Unit Syndrome, Virtual Reality Cognitive Training
- Trial name
- NCT07496255
- Testing
- VR-based cognitive training program, VR-based attention control
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Indiana University
Intensive Care Unit Delirium, Encephalopathy
Automating Delirium Severity in the ICU
The goal of this observational study is to develop a passive digital marker (PDM) for delirium severity and examine its performance in comparison to validated delirium severity tools in ICU patients >50 years of age.
- Conditions
- Intensive Care Unit Delirium, Encephalopathy, Delirium
- Trial name
- ADS-ICU (NCT06172491)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Mayo Clinic
Critical Illness, Intensive Care Unit Delirium
Bringing to Light the Risk Factors And Incidence of Neuropsychological Dysfunction in ICU Survivors, 2nd Study
This BRAIN-ICU-2 study [Bringing to light the Risk factors And Incidence of Neuropsychological dysfunction (dementia) in ICU Survivors, 2nd Study] is in direct response to PAR-17-038 and will determine ICU patients' main paths to…
- Trial name
- BRAIN-2 (NCT04305600)
- Where
- 2 sites in United States
- Volunteers
- 567 people
- Sponsor
- Vanderbilt University Medical Center
Critical Illness, Cognitive Impairment
Optimal Timing of Computerized Cognitive Training for Older Intensive Care Unit Survivors
More than 60% of intensive care unit (ICU) patients are adults ages 60 and older, who are at high risk for ICU-acquired cognitive impairment.
- Conditions
- Critical Illness, Cognitive Impairment, Circadian Dysrhythmia, Intensive Care Unit Delirium
- Trial name
- OPTIMIZE (NCT05467410)
- Testing
- COG-AM, COG-PM
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Washington
Immersive Virtual Reality, Discomfort
Effect of a Virtual Reality Program on Patient Comfort in the Surgical Intensive Care Unit
Admission to a surgical intensive care unit (ICU) following major surgery is associated with a number of discomforts, not only related to the disease itself, but also to the care provided or the ICU environment itself (lights…
- Conditions
- Immersive Virtual Reality, Discomfort, IPREA, Intensive Care Unit
- Trial name
- ZION (NCT06830369)
- Testing
- HypnoVR, usual health care
- Where
- France
- Volunteers
- 194 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Delirium, Anxiety and Depression
Effects of Artificial Intelligence Nurse Orientation Program on Psychological Outcomes and Length of Hospital Stay in Intensive Care Unit
Artificial intelligence (AI), now an integral part of healthcare services and presents numerous opportunities. Customized treatment plans, clinical decision support systems, predictive analysis for disease prevention, patient…
- Conditions
- Delirium, Anxiety and Depression, Intensive Care Units (ICUs), Artificial Intelligence (AI)
- Trial name
- AINURSE-OP (NCT07171944)
- Testing
- Structured orientation program, Human Nurse
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- Koç University
Aged, Intensive Care Units
Dexmedetomidine-Esketamine Combination for Sedation and Analgesia in ICU Patients
Patients with mechanical ventilation in the intensive care unit (ICU) often develop anxiety and agitation, sleep distuebances, and delirium. Delirium occurrence is associated with worse early and long-term outcomes.
- Conditions
- Aged, Intensive Care Units, Ventilators, Mechanical, Dexmedetomidine
- Trial name
- NCT06468436
- Testing
- Dexmedetomidine-Esketamine Combination, Dexmedetomidine
- Where
- 3 sites in China
- Volunteers
- 1,508 people
- Sponsor
- Peking University First Hospital