Clinical trials: Delirium in the Intensive Care Unit
Delirium in the Intensive Care Unit, Sleep Quality in Adult ICU Patients
Virtual Reality to Reduce Anxiety, Agitation and Delirium in Critically Ill Patients
This is a pilot feasibility study examining the use of immersive virtual reality (VR) in adult intensive care unit (ICU) patients.
- Conditions
- Delirium in the Intensive Care Unit, Sleep Quality in Adult ICU Patients, Agitation Associated With Critical Illness, Anxiety Acute
- Trial name
- NCT07649876
- Testing
- Virtual reality (VR) therapy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Sleep, Circadian Dysregulation
reALIGNing Circadian Rhythm and Promoting Sleep in the Intensive Care Unit
The goal of this pilot clinical trial is to learn whether a program to support sleep and the body's daily rhythms can be delivered safely and consistently to critically ill adults in intensive care units (ICUs).
- Conditions
- Sleep, Circadian Dysregulation, ICU, Delirium in Intensive Care Unit
- Trial name
- ALIGN ICU (NCT07886567)
- Testing
- Sleep chronobundle, Control
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Child, Intensive Care Unit Acquired Weakness
Clinical Effectiveness of the "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children
While mortality in U.S. pediatric intensive care units (PICUs) is improving, surviving children frequently develop persistent physical, cognitive, and psychological impairments.
- Conditions
- Child, Intensive Care Unit Acquired Weakness, Critical Illness, Hospital Acquired Pressure Ulcer
- Trial name
- PICU Up! (NCT04989790)
- Testing
- PICU Up!
- Where
- 11 sites in United States
- Volunteers
- 1,470 people
- Sponsor
- Johns Hopkins University
Delirium in the Intensive Care Unit
Impact on Delirium of the Use of DEXmedetomidine as First-line Sedation in PEDIAtric Intensive Care
The goal of this clinical trial is to learn if dexmedetomidine can reduce delirium in critically ill children, needing mechanical ventilation for more than 12 hours.
- Trial name
- PEDIADEX (NCT07542990)
- Testing
- Dexmedetomidine, Midazolam
- Where
- 7 sites in France
- Volunteers
- 266 people
- Sponsor
- University Hospital, Tours
Critical Illness, Post Intensive Care Unit Syndrome
pEEG Monitoring Effect on Delirium, Ventilator Days, and PICS
The goal of this multi-site observational study is to compare delirium rates, days on mechanical ventilation, and Post Intensive Care Syndrome (PICS) rates in adult Intensive Care Unit (ICU) patients.
- Conditions
- Critical Illness, Post Intensive Care Unit Syndrome, Post Intensive Care Syndrome, Mechanical Ventilation Complication
- Trial name
- NCT06019078
- Testing
- SedLine
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Fraser Health
Delirium in the Intensive Care Unit
Virtual Reality-based Sensory Stimulation for Delirium Prevention in Intensive Care Units
The goal of this clinical trial is to evaluate whether virtual reality (VR)-based sensory stimulation can help prevent delirium in adult intensive care unit (ICU) patients, compared with an active control condition delivering the…
- Trial name
- NCT07806422
- Testing
- immersive VR group, Active control group
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chinese University of Hong Kong
Delirium in Intensive Care Unit, Acute Heart Failure (AHF)
Intravenous Infusion of Low Dose Ketamine Versus Dexmedetomedine for Delirium Treatment in Acute Heart Failure
Delirium is an acute, fluctuating disturbance in attention and cognition that commonly complicates the course of critically ill patients, particularly those admitted with acute heart failure (AHF).
- Trial name
- NCT07781462
- Testing
- Low dose ketamine infusion, Dexmedetomidine infusion
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Alexandria University
Delirium in Old Age, Delirium in the Intensive Care Unit
Multi-Component Delirium Prevention Bundle in Older Cardiac Intensive Care Unit Patients
The goal of this randomized controlled clinical trial is to learn whether a structured delirium prevention protocol can reduce the occurrence of delirium in older adults admitted to the cardiac intensive care unit (CICU).
- Conditions
- Delirium in Old Age, Delirium in the Intensive Care Unit, Delirium Confusional State, Delirium
- Trial name
- CICUDEL (NCT07776184)
- Testing
- Multicomponent Delirium Prevention Bundle, Control Group
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Tel Aviv Medical Center
Patients in ICU, Delirium in the Intensive Care Unit
A Prospective Observational Study Using the FAM-CAM
The goal of this observational study is to learn whether family members can help identify signs of delirium in adult patients who are staying in the intensive care unit.
- Conditions
- Patients in ICU, Delirium in the Intensive Care Unit, Family
- Trial name
- NCT07694687
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Shanghai Zhongshan Hospital
Delirium in the Intensive Care Unit
Ceribell Delirium Monitor Outcomes Pilot Study
This pilot study is designed as a pre- and post-delirium monitor cohort study, with a prospective intervention cohort and a retrospective control cohort.
- Trial name
- DOM (NCT07449416)
- Testing
- Ceribell Delirium Monitoring System
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Ceribell Inc.
Delirium in the Intensive Care Unit, Burnout, Healthcare Workers
A Study of Silent Alarm Delivery Versus Standard Audible Alarm Delivery in Intensive Care and High Dependency Units
The goal of the trial is to learn if a strategy to eliminate audible alarm noise in intensive care and high dependency units can reduce overall noise levels, patient delirium, staff alarm fatigue, and staff burnout.
- Conditions
- Delirium in the Intensive Care Unit, Burnout, Healthcare Workers, Noise in the ICU, Alarm Fatigue
- Trial name
- DECIBEL (NCT07364097)
- Testing
- Silent alarm strategy
- Where
- India
- Volunteers
- 311 people
- Sponsor
- MindWave Medical Inc
Critically Ill, Intensive Care Unit Delirium
Physical Restraints in Intensive Care Unit Patients
The use of physical restraints is common practice in Intensive Care Units (ICU). This medically prescribed procedure requires full attention of medical and paramedical teams for its implementation, monitoring and ending, as a…
- Conditions
- Critically Ill, Intensive Care Unit Delirium, Delirium Confusional State, Agitation,Psychomotor
- Trial name
- ARBORéa (NCT04957238)
- Testing
- ARBORea decision-making tool
- Where
- 19 sites in France
- Volunteers
- 4,000 people
- Sponsor
- University Hospital, Clermont-Ferrand
Critical Illness, Delirium in the Intensive Care Unit
Digital and Plasma Biomarkers in Delirium
The goal of this observational study is to learn if there are potential digital and plasma-based biomarkers that could help detect, predict, and prognosticate delirium in older adult patients who are admitted to the intensive…
- Conditions
- Critical Illness, Delirium in the Intensive Care Unit, Sleep Quality
- Trial name
- DELTA (NCT07694206)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Scripps Health
Older Patients, Postoperative Care
Sedation With Dexmedetomidine-esketamine Combination and Delirium in ICU Patients
Patients in the intensive care unit (ICU) often develop anxiety and agitation, sleep disturbances, and delirium. Delirium occurrence is associated with worse early and long-term outcomes.
- Conditions
- Older Patients, Postoperative Care, Intensive Care Unit, Dexmedetomidine
- Trial name
- NCT07151716
- Testing
- Dexmedetomidine, Dexmedetomidine-esketamine combination
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University First Hospital
Myocardial Infarction (MI), Delirium, Intensive Care Unit, Randomised Controlled Trial
Mannitol Administration for Delerium Prevention
The aim of the study is to evaluate the efficacy of adjuvant administration of mannitol for the prevention of delirium in patients with myocardial infarction.
- Trial name
- MAD (NCT06759259)
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Delirium in the Intensive Care Unit, Sleep Quality
Precision ICU Care: Evaluating an AI-Driven Nursing Decision Support System for Delirium Prevention
Delirium affects up to 83% of mechanically ventilated patients in the Intensive Care Unit (ICU), often leading to longer hospital stays and long-term memory or cognitive problems.
- Trial name
- NCT07631494
- Testing
- MLP-based Clinical Decision Support System (MLP-CDSS), VR-based Cognitive Intervention, VR-assisted Early Mobility Exercise
- Where
- Taiwan
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Intensive Care Unit Delirium
Prevention of Delirium in ICU Using Multimodal Interventions
This study was designed to evaluate the impact of non-pharmacological multimodal interventions including ongoing orientation, sensory correction, setting of familiar circumstance and promotion of sleep enviromnet for prevention…
- Trial name
- NCT05950958
- Testing
- Multimodal therapy for prevention of delirium
- Where
- South Korea
- Volunteers
- 196 people
- Sponsor
- Seoul National University Hospital
Pain, Delirium in the Intensive Care Unit
Therapeutic Cuddling in Critically Ill Children
2.1 CONTEXT Pain and agitation are common comorbidities of pediatric critical illness due to both underlying disease processes and ICU related therapies.
- Trial name
- THE ChICKS (NCT07562048)
- Testing
- Therapeutic cuddling, Standard of care
- Where
- Canada
- Volunteers
- 112 people
- Sponsor
- University of Calgary
Agitated Delirium, Delirium Confusional State
Phenobarbital for Agitated Delirium
The goal of this clinical trial is to test whether the medication phenobarbital is as effective for treating agitated delirium among adult patients admitted to the intensive care unit.
- Conditions
- Agitated Delirium, Delirium Confusional State, Delirium in the Intensive Care Unit, Hyperactive Delirium
- Trial name
- NCT07548489
- Testing
- Phenobarbital, Conventional therapy group
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Duke University
Delirium in the Intensive Care Unit
EEG Abnormalities in Adult ICU Patients With High Risk of Delirium
The purpose of this study is to assess the prevalence of EEG abnormalities on Ceribell POC EEG in adult medical, surgical, and cardiovascular ICU patients with high risk of delirium
- Trial name
- NCT07485244
- Testing
- Ceribell EEG System
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ceribell Inc.