Clinical trials: Dehiscence, open to volunteers
Cleft Lip, Cleft Palate +/- Lip
Comparative Study of Regional Nerve Blocks in Primary Cleft Palate Repair
This study will evaluate whether adding a suprazygomatic maxillary nerve block to the standard palatal nerve block improves pain control after cleft palate repair surgery in children.
- Conditions
- Cleft Lip, Cleft Palate +/- Lip, Pain Management, Wound Dehiscence, Surgical
- Trial name
- NCT07892963
- Testing
- Palatal Nerve Block, Suprazygomatic Maxillary Nerve Block
- Volunteers
- 144 people
- Sponsor
- Children's National Research Institute
Dehiscence, Tooth Extraction
Effect of Collagen Membrane on Ridge Preservation
This study will evaluate whether adding a resorbable collagen membrane to an anorganic bone-collagen composite (ABCC) graft improves ridge preservation after tooth extraction.
- Conditions
- Dehiscence, Tooth Extraction, Alveolar Bone Loss
- Trial name
- NCT07580495
- Testing
- Minimally Invasive tooth extraction, Alveolar ridge preservation with ABCC, Resorbable collagen membrane (InterCollagen® Guide)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Debora Dias
Pelvic Floor Dysfunction, Perineal Laceration
Perineal Protection Device for Reducing Perineal Trauma During Vaginal Delivery in First-time Mothers: a Multicenter Randomized Controlled Trial
The goal of this clinical trial is to determine whether using a soft perineal protection device (BabySlide®) in addition to standard manual perineal support during vaginal delivery can reduce the risk of perineal trauma in…
- Conditions
- Pelvic Floor Dysfunction, Perineal Laceration, Wound Dehiscence, Anal Incontinence
- Trial name
- PeriPROTECT (NCT07862660)
- Testing
- Perineal protection device, BabySlide, Standard manual perineal support
- Where
- Sweden
- Volunteers
- 4,226 people
- Sponsor
- Region Skane
Cesarean Section, Surgical Wound Infection
Timing of Cesarean Wound Dressing Removal on Wound Healing in Women With BMI ≥ 30 kg/m²
Cesarean delivery is one of the most common surgical procedures in obstetric care. Women with obesity (body mass index [BMI] of 30 kg/m² or higher) are at increased risk for postoperative wound complications, including surgical…
- Conditions
- Cesarean Section, Surgical Wound Infection, Wound Healing, Obesity
- Trial name
- NCT07846930
- Volunteers
- 726 people
- Sponsor
- Assiut University
Abdominal Wound Dehiscence, Burst Abdomen
Vacuum-Assisted Closure Versus Graduated Primary Skin Closure for Postoperative Burst Abdomen
Burst abdomen, or complete abdominal wound dehiscence, is a severe postoperative complication characterized by the separation of the musculo-aponeurotic layer of the abdominal wall.
- Conditions
- Abdominal Wound Dehiscence, Burst Abdomen, Surgical Wound Dehiscence
- Trial name
- NCT07797868
- Testing
- Vacuum-Assisted Closure (VAC) Therapy, Graduated Primary Skin Closure
- Volunteers
- 50 people
- Sponsor
- Assiut University
Abdominal Wound Dehiscence, Necrotizing Soft Tissue Infection
Myriad™ Augmented Soft Tissue Reconstruction Registry
This is an observational study designed to evaluate the safety and clinical outcomes of Myriad™ in soft tissue reconstruction procedures.
- Conditions
- Abdominal Wound Dehiscence, Necrotizing Soft Tissue Infection, Lower Extremity Wound, Pilonidal Sinus
- Trial name
- MASTRR (NCT05243966)
- Testing
- Myriad Matrix™ and Myriad Morcells™
- Where
- 15 sites in United States
- Volunteers
- 800 people
- Sponsor
- Aroa Biosurgery Limited
Cesarean Section; Complications, Wound, Dehiscence
Effect of Bioptron Light Therapy on Wound Healing After Caesarean Section
The purpose of this study is to investigate the effect of Bioptron light therapy on wound healing after caesarean section.
- Trial name
- NCT07693478
- Testing
- Standard Postoperative Medical Care, Bioptron Light Therapy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Surgical Incision, Wound Dehiscence
Treating Emergency Laparotomy Incisions With Negative Pressure Wound Therapy
The goal of this clinical trial is to investigate Negative Pressure Wound Therapy (NPWT) in adults undergoing emergency laparotomy.
- Conditions
- Surgical Incision, Wound Dehiscence, Surgical Site Infection, Incisional Hernia
- Trial name
- TELIN (NCT07003906)
- Testing
- Negative pressure wound therapy, Standard postoperative dressing
- Where
- 6 sites in Sweden
- Volunteers
- 720 people
- Sponsor
- Uppsala University
Cesarean Section, Surgical Site Infection
Steri-Strip Application Versus Standard Wound Closure for Cesarean Section Incisions
This study is evaluating whether Steri-Strips® provide additional benefits when used after cesarean section (C-section) surgery.
- Conditions
- Cesarean Section, Surgical Site Infection, Wound Dehiscence, Seroma
- Trial name
- STRIP-CS (NCT07686913)
- Testing
- Steri-Strip™ Skin Closures, Standard Cesarean Wound Closure
- Where
- United States
- Volunteers
- 610 people
- Sponsor
- Riverside University Health System Medical Center
Gynecologic Cancers, Vaginal Cuff Dehiscence
Comparison of Self-Locking Versus Traditional Sutures in Double-Layer Laparoscopic Vaginal Vault Closure After Hysterectomy (BI-SURE Trial)
Vaginal vault closure after laparoscopic or robotic hysterectomy may be associated with postoperative complications such as vaginal cuff dehiscence, infection, and bleeding.
- Conditions
- Gynecologic Cancers, Vaginal Cuff Dehiscence, Postoperative Complications
- Trial name
- BI-SURE (NCT07313839)
- Testing
- Double-Layer Vaginal Vault Closure with Self-Locking Suture, Double-Layer Vaginal Vault Closure with Polyglactin 910
- Where
- 5 sites in Italy
- Volunteers
- 310 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Surgical Site Infection (SSI), Wound Healing Complication
Prophylactic Use of ciNPWT in Gynecologic Laparotomy
This is a prospective, open-label, non-randomized interventional feasibility study with a nested qualitative analysis. The study exploratively verifies the feasibility of targeted prophylactic closed incision negative pressure…
- Conditions
- Surgical Site Infection (SSI), Wound Healing Complication, Seroma, Hematoma
- Trial name
- NCT07645547
- Testing
- closed incision negative pressure wound therapy (ciNPWT)
- Volunteers
- 30 people
- Sponsor
- University Hospital Hradec Kralove
Fracture of Tibia, Wound Heal
Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk Fractures
This is a multi-center, pragmatic, parallel arm randomized controlled trial (RCT) of 352 patients with high-risk open or closed tibial plateau fracture, high-risk open or closed tibial pilon fracture, or open tibial shaft…
- Conditions
- Fracture of Tibia, Wound Heal, Infected Wound, Wound Complication
- Trial name
- iVAC (NCT06337292)
- Testing
- Incisional Negative Pressure Wound Therapy (NPWT)
- Where
- 6 sites in United States
- Volunteers
- 352 people
- Sponsor
- Major Extremity Trauma Research Consortium
Obesity, Obesity, Morbid
Luso-Cor Stent Compared to Other Endoscopic Techniques for Management of Fistulas and Anastomotic Dehiscences(ES-LCCE-UDFM)
The global prevalence of obesity has prompted an increase in bariatric surgery, which is the only management strategy that provides long-term weight loss and improvement of obesity-related diseases.
- Conditions
- Obesity, Obesity, Morbid, Esophageal Cancer, Esophageal Neoplasms
- Trial name
- ES-LCCE-UDFM (NCT06862479)
- Testing
- Endoscopic management of fistulas with stents or vacum therapy
- Where
- Portugal
- Volunteers
- 180 people
- Sponsor
- Unidade Local de Saúde Santa Maria
Cesarean Section; Dehiscence
Comparison of the Therapeutic Effects of Vaginal Repair With Leuprorelin and Vaginal Repair in the Treatment of Cesarean Section Scar Defect
GnRH-a will be used to postpone period after vaginal repair for Cesarean Section Scar Defect（CSD） patients with adenomyosis which will be compared with CSD patients with adenomyosis who receive transvaginal surgery without…
- Trial name
- NCT05206682
- Testing
- Leuprorelin
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Alveolar Buccal Bone Dehiscences, Socket Type 3 Subclass B
Evaluation Of The Success Rate of NOVAMag® SHIELD
This study hypothesizes that the SHIELD technique, when combined with a suitable bone graft material, enables successful immediate implant placement in Type 3 extraction sockets with buccal bone dehiscence, regardless of the…
- Conditions
- Alveolar Buccal Bone Dehiscences, Socket Type 3 Subclass B, Socket Type 3 Subclass C
- Trial name
- NOVASHIELD-RCT (NCT07533110)
- Testing
- SHIELD technique with NOVAMag membrane
- Where
- Portugal
- Volunteers
- 40 people
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Diabetic Foot Ulcer (DFU), Pressure Ulcer (PU)
PAW-Hydrogel for Chronic Wound Healing
The goal of this randomized controlled trial is to evaluate the efficacy and safety of a novel hydrogel made of Carbopol® 940 functionalized with Plasma-Activated Water (PAW) in patients with chronic wounds (diabetic foot ulcers…
- Conditions
- Diabetic Foot Ulcer (DFU), Pressure Ulcer (PU), Wound Dehiscence, Venous Leg Ulcer
- Trial name
- NCT07541196
- Testing
- PAW-Functionalized Carbopol® 940 Hydrogel, Standard Advanced Wound Care
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- Benjamín Gonzalo Rodríguez Méndez
Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia
Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging.
Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Feasibility Study on Nitropaste Using Intraoperative SPY Imaging.
- Conditions
- Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia, Tibial Plateau Fracture, Ankle Fracture (Bimalleolar Equivalent, Bimalleolar, or Trimalleolar)
- Trial name
- SPY NITROPASTE (NCT07004764)
- Testing
- Nitroglycerin Ointment 2%
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Wound Breakdown, Breast Reduction
CO2Lift and T-Junction Breakdown Rates Evaluation After Breast Reduction Surgery Pilot Trial
The goal of this pilot study is to determine the feasibility of a larger randomized controlled trial evaluating CO₂Lift® Pro Carboxy Gel to reduce wound breakdown after bilateral breast reduction in adult female patients…
- Conditions
- Wound Breakdown, Breast Reduction, Surgical Wound, Breast Surgery
- Trial name
- CO2-BREAST (NCT07408960)
- Testing
- Carboxygel, Vaseline
- Volunteers
- 10 people
- Sponsor
- University of Calgary
Superior Canal Dehiscence Syndrome, Autophony
The Diagnostic Accuracy of Ankle Audiometry Performed With the B250 for Superior Canal Dehiscence Syndrome in Patients Affected by Pulsatile Tinnitus and/or Autophony Disorders
The goal of this clinical trial is to learn if the ankle audiometry test performed with the B250 bone conduction transducer can identify patients with superior canal dehiscence syndrome from those without among subjects…
- Conditions
- Superior Canal Dehiscence Syndrome, Autophony, Pulsatile Tinnitus
- Trial name
- AA by B250 (NCT07384091)
- Testing
- Ankle audiometry performed with the B250 transducer
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Region Stockholm
Pilonidal Sinus Disorder
Factors Affecting Wound Dehiscence in Pilonidal Sinus Surgery (ORIPIS)
The goal of this multicenter, prospective, observational study is to investigate factors associated with wound dehiscence following pilonidal sinus surgery.
- Trial name
- NCT07370714
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Ankara Etlik City Hospital