Clinical trials: Current Smoker, open to volunteers
COPD, Lung Cancer (NSCLC)
Tumors and Respiratory System Diseases Due to Air Pollution: New Biomarkers of Exposure and Effects
This study aims to examine the exposure to atmospheric pollutants in a group of non-smoking patients suffering from lung cancer, chronic obstructive pulmonary disease (COPD), and leukemia.
- Conditions
- COPD, Lung Cancer (NSCLC), Leukemia
- Trial name
- RECAP (NCT06800586)
- Where
- 3 sites in Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Cigarette Smoker, Current Smoker
Beating Lung Cancer in Ohio Protocol in Improving Survival in Patients With Stage IV Non-Small Cell Lung Cancer
This randomized clinical trial studies the Beating Lung Cancer in Ohio protocol in improving survival in patients with stage IV non-small cell lung cancer.
- Conditions
- Cigarette Smoker, Current Smoker, Lung Adenocarcinoma, Squamous Cell Lung Carcinoma
- Trial name
- BLCIO (NCT03199651)
- Testing
- Best Practice, Biospecimen Collection, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 3,584 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Lazertinib
A Randomized Phase II Study of LAZE rtiNib Alone Versus Lazertinib Plus bevaCizumab for NSCLC With EGFR + & Smoker
Using gefitinib or Osimertinib, an EGFR tyrosine kinase inhibitor (TKI), in patients with active mutations in epithelial cell growth factor receptors (EGFR), 70% response rate (CR+PR) and 90% disease control rate (CR+PR+SD)…
- Trial name
- NCT06156527
- Testing
- Lazertinib, Bevacizumab Injectable Product
- Where
- 5 sites in South Korea
- Volunteers
- 120 people
- Sponsor
- National Cancer Center, Korea
Healthy, Healthy Smoker
Inhaled RB042 in Healthy Adult Volunteers, Healthy Adult Smokers and Patients With Chronic Obstructive Pulmonary Disease
This is a 4-part, randomised, double-blind, placebo-controlled, first in human study evaluating the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of inhaled RB042.
- Conditions
- Healthy, Healthy Smoker, COPD (Chronic Obstructive Pulmonary Disease), COPD
- Trial name
- NCT07285122
- Testing
- RB042
- Where
- Australia
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Atisama Therapeutics
Lung Carcinoma
Home-Based Respiratory Muscle Training and Aerobic Exercise Programs to Improve Lung Health in Current and Former Cigarette Smokers
This clinical trial studies whether home-based respiratory muscle training (RMT) and aerobic exercise (AE) programs can be used to improve lung health in current and former cigarette smokers.
- Trial name
- NCT07553819
- Testing
- Accelerometry, Aerobic Exercise, Biospecimen Collection
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Lung Cancer
Collection of Sputum and Labeling for Lung Cancer
The primary objective of this study is to compare Assay results to diagnoses determined by currently accepted standards for lung cancer detection.
- Trial name
- NCT03457415
- Where
- 3 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- bioAffinity Technologies Inc.
Smoking Cessation
Impact of a Counseling Consultation in the Workplace for Smoker Health Professionals
Smoking is still a major cause of premature death in France (75,000 deaths a year). Health professionals also seem to be affected by smoking, but few studies have been carried out on this population of smokers.
- Trial name
- PSYTaB (NCT06988644)
- Testing
- exhaled carbon monoxyde measurement
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Groupe Hospitalier Mutualiste de Grenoble
Smoking
Evaluation of Lung Cancer CT Screening Performance Among Former and Current Smokers
Diagnostic performance of low-dose chest CT scan combined with lung-RADS classification (version 1.1) for lung cancer screening among former and current smokers.
- Trial name
- NCT05486455
- Testing
- Low-dose chest CT scan
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Hospital St. Joseph, Marseille, France
Smoking Prevention and Control
Impact of Cigarette and E-cigarette Menthol Regulation on Current Smokers of Menthol Cigarettes
In a 2x2 design, current menthol smokers (N=240) will complete a baseline period before being assigned to a cigarette (menthol or non-menthol) and e-cigarette condition (menthol or tobacco-flavored e-liquid) and receiving a…
- Trial name
- NCT05896033
- Testing
- Non-Menthol Cigarettes, Tobacco Flavored E-cigarettes, Menthol Cigarettes
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Smoking History, Current Smoker
Increasing Lung Cancer Screening Among Emergency Department Patients - LCS R01
This randomized clinical trial evaluates the effectiveness of text messaging and facilitated referral strategies to increase lung cancer screening uptake among emergency department patients who meet lung cancer screening…
- Conditions
- Smoking History, Current Smoker, Lung Cancer Screening
- Trial name
- NCT07566221
- Testing
- Basic Referral, Facilitated Referral, Text Messaging
- Volunteers
- 1,036 people
- Sponsor
- University of Rochester
Smoking, Cigarette
Dyadic Financial Incentive Treatments for Dual Smoker Couples
Smokers partnered with other smokers (i.e., dual-smoker couples) represent ~2/3 of all smokers. Dual-smoker couples (DSCs) are less likely to try to quit smoking and more likely to relapse during a quit attempt, reducing overall…
- Trial name
- NCT06296849
- Testing
- Financial Incentive Treatment (FIT)
- Where
- 2 sites in United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
High-risk Lung Nodules
Immunoprevention for High-risk Lung Lesions
The main purpose of this study is to assess nadunolimab as an immunoprevention strategy for high-risk lung nodules in participants who are current or former tobacco smokers. The study may last up to 5 years for each participant.
- Trial name
- NCT07284485
- Testing
- Nadunolimab
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Robert Samstein
Cancer of Head and Neck
Discontinuation of Tobacco Dependence in Smoking Patients With Squamous Cell Carcinoma of the Head-neck District: Multicenter Prospective Observational Study
The primary objective of our study is to evaluate the effectiveness of a standardized clinical practice counseling strategy for promoting post-diagnosis smoking cessation among patients with SCCHN.
- Trial name
- STOP-HNC (NCT06995417)
- Testing
- Smoking counseling
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Smoking, Tobacco
A Multi-Site Study to Assess the Effect of Availability of a Heated Tobacco Product on Smoking Abstinence Among Current Primary Cigarette Smokers
The goal of this study is to evaluate the rate of end of study complete cigarette reduction in health adult consumers of cigarettes when given access to a heated tobacco product (HTP).
- Trial name
- NCT07710820
- Testing
- 31237616, 31237617, 31237571
- Where
- 9 sites in United States
- Volunteers
- 1,060 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Smoker, Smoking Cessation
The Options 2 Study
The goal of this clinical trial is to investigate how well nicotine pouches and nicotine mini lozenges serve as substitutes for cigarettes when people try to switch from smoking to using these alternate nicotine products.
- Trial name
- NCT06595459
- Testing
- Nicotine Pouches, Mini Nicotine lozenges
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Wisconsin, Madison
Pulmonary Disease, Chronic Obstructive
A Study to Assess the Efficacy and Safety of Co-administration of GSK3862995B With GSK5784283 in Adult Participants With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
This study is for adult participants with moderate to severe Chronic Obstructive Pulmonary Disease (COPD) who continue to experience exacerbations despite standard of care triple therapy treatment.
- Trial name
- ALARMONY (NCT07915791)
- Testing
- GSK3862995B, GSK5784283
- Volunteers
- 279 people
- Sponsor
- GlaxoSmithKline
Former Smoker, Non-Smoker
Vaped Phenanthrene
Some people who used to smoke cigarettes continue to be at higher risk of developing lung cancer, even years after quitting. This study will look to see if a specific chemical, phenanthrene, is broken down in the lungs of former…
- Trial name
- NCT07134426
- Testing
- D10-phenanthrene
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Adenocarcinoma of Lung, Carcinoma, Non-Small-Cell Lung
A Study of LP-300 With Carboplatin and Pemetrexed in Never Smokers With Advanced Lung Adenocarcinoma
The goal of this clinical trial is to determine clinical advantages for LP-300 in combination with carboplatin and pemetrexed in the never smoker patient population.
- Trial name
- HARMONIC (NCT05456256)
- Testing
- LP-300, Pemetrexed, Carboplatin
- Where
- 16 sites in United States, Japan and 1 more
- Volunteers
- 90 people
- Sponsor
- Lantern Pharma Inc.
Periodontal Disease, Periodontitis (Stage 3)
Omega-3 Plus Low-Dose Aspirin in Smokers With Stage III Periodontitis
This randomized double-blind placebo-controlled clinical trial aims to evaluate the clinical and biochemical effects of omega-3 fatty acids combined with low-dose aspirin as an adjunct to scaling and root planing (SRP) in smoker…
- Conditions
- Periodontal Disease, Periodontitis (Stage 3), Smoking Behaviors
- Trial name
- OASP (NCT07673185)
- Testing
- Omega-3 Fatty Acids (EPA plus DHA) plus low dose aspirin
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Azhar University
Periodontitis, Smoking ( Cigarette)
Effect of Non-Surgical Periodontal Therapy on Salivary Biomarkers in Smokers and Non-Smokers With Periodontitis
This study evaluates the effect of non-surgical periodontal therapy on salivary biomarkers (Dkk-1, Sclerostin, and PLAP-1) and clinical periodontal parameters in patients with periodontitis.
- Trial name
- NSPT-Biomarker (NCT07547202)
- Testing
- Non-surgical periodontal therapy (Scaling and root planing)
- Where
- 2 sites in Iraq
- Volunteers
- 44 people
- Sponsor
- Al-Mustansiriyah University