Clinical trials: Current Smoker
Lung Cancer, Non-small Cell Lung Cancer
Phase II Trial to Correlate Radiographic Response Induced By Gefitinib With Mutations in the Protein-Tyrosine Kinase Domain of the EGF Receptor Gene
The purpose of this research study is to: see if gefitinib pills can shrink Stage 1 or 2 non-small cell lung cancers before surgery see if your non-small cell lung cancer has a mutation in a certain part of the EGFR gene see if…
- Conditions
- Lung Cancer, Non-small Cell Lung Cancer, Bronchioloalveolar Cancer
- Trial name
- NCT00588445
- Testing
- Gefitinib
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cancer
A Web Site and Print Materials Intervention for Smoking Intervention for Childhood and Young Adult Cancer Survivors
The purpose of this study was to compare two different ways of helping people who have had childhood cancer, leukemia, tumors or similar illnesses learn health information and information about trying to quit smoking.
- Trial name
- PFH2 (NCT00588107)
- Testing
- Web Intervention, print materials
- Where
- United States
- Volunteers
- 374 people
- Sponsor
- Dana-Farber Cancer Institute
Healthy Subject, Tobacco Use Disorder
Effect of Black Raspberry Phytochemicals on Oral Microbiome in Current Smokers and Non-smokers
This randomized clinical trial studies the effects of black raspberry compounds (phytochemicals) on the bacteria in the mouth (oral microbiome) of current smokers and non-smokers.
- Trial name
- NCT02439255
- Testing
- Laboratory Biomarker Analysis, Phytochemical, Screening Questionnaire Administration
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Lung Cancer
S0002 - A Program to Quit Smoking With or Without Bupropion in Treating Patients With Stage I or II Non-Small Cell Lung Cancer Who Have Undergone Surgery
RATIONALE: A program that includes bupropion may be more effective in helping early-stage lung cancer patients to quit smoking. It is not yet known if a program to quit smoking is more effective with or without bupropion.
- Trial name
- NCT00032084
- Testing
- smoking cessation intervention, bupropion hydrochloride, nicotine
- Where
- 176 sites in United States, Puerto Rico
- Volunteers
- 10 people
- Sponsor
- SWOG Cancer Research Network
Smoking Cessation
Safety and Pharmacodynamics of SEL-068 Vaccine in Smokers and Non-Smokers
The purpose of this study is to evaluate the safety and pharmacodynamics of SEL-068. Increasing subcutaneous doses of SEL-068 will be administered to healthy non-smoker and smoker volunteers.
- Trial name
- NCT01478893
- Testing
- SEL-068, Saline
- Where
- Belgium
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Selecta Biosciences, Inc.
Current Every Day Smoker
Smartphone-Delivered Attentional Bias Modification Training in Helping Patients Quit Smoking
This randomized clinical trial studies how well a smartphone-delivered attentional bias modification training works in helping patients quit smoking.
- Trial name
- NCT02224391
- Testing
- Computer-Assisted Smoking Cessation Intervention, Laboratory Biomarker Analysis, Nicotine Patch
- Where
- United States
- Volunteers
- 311 people
- Sponsor
- M.D. Anderson Cancer Center
Healthy, Cigarette Smoking
A Study of Inhalation of 20,000 EU CCRE and Mucociliary Clearance (MCC) in Otherwise Healthy Individuals Who Are Current Cigarette Smokers
The purpose of this Phase 1 research study is to identify a dose of inhaled endotoxin that is safe (does not cause prolonged cough, shortness of breath or other problems), but causes changes in sputum cell samples that the…
- Trial name
- IRB 09-0259 (NCT00924768)
- Testing
- 20K EU CCRE
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
COPD, Smoking
Modulation of Genes Responsible for Cilia Length by Exposure to Cigarette Smoke
Cigarette smoking is the major risk factor for developing chronic obstructive pulmonary disease (COPD). Patients with COPD have difficulty clearing mucus and debris from their airways.
- Trial name
- NCT02168673
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Tobacco Smoking
Potential Impact of Menthol Ban in Cigarettes and E-cigarettes
Menthol cigarette use remains a major public health problem and the FDA has proposed to ban menthol in cigarettes. However, additional evidence is needed to understand whether menthol flavor in e-cigarettes is important for harm…
- Trial name
- NCT05259566
- Testing
- menthol ban in cigarettes only, total menthol ban
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- Yale University
Periodontitis, Periodontal Diseases
Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers
The purpose of this study is to determine in current and non-smokers the clinical and microbiological effects of 3 therapies: scaling and root planing (SRP) alone; SRP in combination with the orally administered antibiotic…
- Trial name
- NCT00066066
- Testing
- Scaling and root planing, Metronidazole, Amoxicillin
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- The Forsyth Institute
Transcranial Direct Current Stimulation, Smoking, Cigarette
tDCS and Cognitive Training Intervention for Chronic Smokers With Schizophrenia
This study is being done to develop new methods to help smokers with schizophrenia to successfully reduce their smoking and/or quit. This is not a treatment study, but will help find new techniques to create better treatments.
- Conditions
- Transcranial Direct Current Stimulation, Smoking, Cigarette, Schizophrenia
- Trial name
- TACTICSS (NCT03588728)
- Testing
- Transcranial Direct Current Stimulation, Cognitive Remediation (CR)
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Pittsburgh
Chronic Obstructive Pulmonary Disease (COPD), Smoking
Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies
The purpose of this study is to obtain biologic materials from the blood, airways and/or urine of normal individuals and individuals with lung disease.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Smoking, Smoking Cessation, Idiopathic Pulmonary Fibrosis (IPF)
- Trial name
- NCT01776398
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Lung Cancer, Precancerous Condition
Screening for Lung Cancer in Current or Past Smokers With Chronic Obstructive Pulmonary Disease
RATIONALE: Screening tests or exams may help doctors find lung cancer sooner, when it may be easier to treat. PURPOSE: This randomized clinical trial is studying screening tests or exams to see how well they work compared to…
- Trial name
- NCT00512746
- Testing
- cytology and cytometry specimen collection procedure, Chest x ray, Autofluorescence bronchoscopy
- Where
- 10 sites in United Kingdom
- Volunteers
- 1,569 people
- Sponsor
- University College, London
Lung Cancer, Adenocarcinoma
Phase II Trial of Sunitinib in BAC or Never-Smokers With Any Lung Adenocarcinoma
This is an open-label study of a new oral drug for advanced stage (IIIB or IV) lung cancer. The cancer must be EITHER bronchoalveolar carcinoma (BAC) type, or if the patient is a never-smoker (less than 100 cigarettes lifetime)…
- Trial name
- NCT00430261
- Testing
- sunitinib
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Swedish Medical Center
Smoking, Tobacco
CSD201204 An Actual Use Study of P12 Electronic Nicotine Delivery System Among U.S. Adult Smokers
The purpose of this Actual Use Study (AUS) is to investigate how United States (US) adult tobacco consumers 21 to 60 years of age, inclusive, who are regular smokers (≥5 cigarettes/day on at least 20 of the past 30 days) will use…
- Trial name
- NCT05960305
- Testing
- P1213416, P1213422, P1213716
- Where
- 12 sites in United States
- Volunteers
- 1,845 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
COPD
The Effect of Inhaled PUL-042 on Rhinovirus-induced Symptoms in Smokers With GOLD Stage 0 COPD
This is a study examining the effect of inhaled PUL-042 on peak lower respiratory symptoms as measured by subject diary in early stage COPD subjects who are experimentally infected with rhinovirus.
- Trial name
- NCT03794557
- Testing
- Sterile Water Injection, PUL-042 Inhalation Solution
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Pulmotect, Inc.
Vascular Disease
Tobacco's Impact on Postoperative Complications in Acute Surgery
The purpose of the study is to see whether intensive smoking intervention on the day of operation can reduce per- and postoperative complications in patients operated for acute ischaemic disease compared to control group with no…
- Trial name
- ROC (NCT01469091)
- Testing
- Smoking intervention.
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cigarette Smoking, Current Smoker
Quit4Health Intervention in Supporting Smoking Cessation and Preventing Smoking Initiation in Young Adults
This trial studies how well Quit4Health intervention works in supporting smoking cessation and preventing smoking initiation in young adults.
- Trial name
- NCT04009590
- Testing
- Educational Intervention, Questionnaire Administration, Smoking Cessation Intervention
- Where
- United States
- Volunteers
- 579 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Smoking
Feasibility and Smokers' Reactions to DNA Feedback
The purpose of the study is to explore how feedback of cellular DNA (Deoxyribonucleic Acid) damage, as a marker of exposure to the genotoxic agents of tobacco smoke, promotes cessation.
- Trial name
- NCT02922790
- Testing
- standard health information, standard health information plus info. on DNA damage, Subjects will review standard health information and information on DNA damage, plus pictures of their DNA damage
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Duke University
Periodontitis, Diabete Mellitus
Omega-3 Pufa and Aspirin as Adjunctive Therapy in Treatment of Smoker Patients With Stage Iii Periodontitis
Background: Smoking reduces the effect of non-surgical periodontal therapy, a host modulation regimen consisting of omega-3 polyunsaturated fatty acids (ω-3 PUFA) supplementation with low-dose aspirin (ASA) with or without…
- Trial name
- NCT07385300
- Testing
- Omega-3 PUFA and Aspirin as adjunctive therapy to (SRP), Omega-3 PUFA and Aspirin and doxycycline as adjunctive therapy to (SRP), scaling and root planning (SRP)
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Alexandria University