Clinical trials: Critically Ill
Obesity, Critical Illness
Levofloxacin Pharmacokinetics (PK) in the Severely Obese
Obesity is known to affect the concentrations of certain medications in the body. Levofloxacin is a commonly used antibiotic. Based on what the investigators know about levofloxacin and how it moves through the body, obesity may…
- Trial name
- NCT00176306
- Testing
- Levofloxacin 750 mg IV
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Joel Thompson, PhD
Cirrhosis, Liver, Acute-On-Chronic Liver Failure
20% Albumin vs. Balanced Salt Solution as Resuscitation Fluid in Cirrhosis With Sepsis Induced Hypotension
Patients with cirrhosis patients have a high incidence of sepsis which can trigger decompensation and may result in prolonged hospital stay and increased mortality.
- Conditions
- Cirrhosis, Liver, Acute-On-Chronic Liver Failure, Shock, Septic, Shock Hypovolemic
- Trial name
- NCT05441878
- Testing
- 20% albumin, Balanced salt solution
- Where
- India
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
ICU, Comfort
Comfort Care Bundle
Intensive care units (ICUs) are specialized units where numerous complex treatment and care procedures are applied. In these units, critically ill patients are exposed to stressful conditions and experience significant pain and…
- Conditions
- ICU, Comfort, Bundle Care, Nursing Care
- Trial name
- NCT07366021
- Testing
- Comfort Care Bundle
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Blood Stream Infection
Central and Peripheral Venous Catheters Associated Blood Stream Infection in ICU in Assiut University
Catheter related infections (CRIs) were found to be associated with several risk factors, including patient related risk factors such as age, gender, clinical status and catheter related risk factors such as the vascular access…
- Trial name
- NCT03379948
- Testing
- blood culture
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
PTSD, Critical Illness
The Experiences of Children and Caregivers Given PICU Storybooks
1. To assess the acceptability and feasibility of a study design aimed at evaluating the efficacy of a newly developed intervention for children and their caregivers following discharge from PICU 2.
- Conditions
- PTSD, Critical Illness, Depression, Anxiety
- Trial name
- NCT04041401
- Testing
- PICU storybook
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Critical Illness
Family Presence on Multidisciplinary Patient Care Rounds in ICU
Family presence on patient care rounds in adult intensive care units remains the least studied area of family-centered care. Despite support from professional organizations and critical care experts, very few critical care units…
- Trial name
- NCT05449990
- Testing
- Participation in PFCC-IR
- Where
- United States
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Delirium
Dexmedetomidine Versus Propofol for Prolonged Sedation in Critically Ill Trauma and Surgical Patients
The purpose of this study is to assess the efficacy of dexmedetomidine versus propofol for prolonged sedation in trauma and surgical patients.
- Trial name
- NCT02548923
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Tennessee Graduate School of Medicine
Child, Only, Infant, Newborn, Diseases
Capnography Monitoring in Ventilated Children
End-tidal CO2 measurements in children will be assessed for their accuracy with arterial CO2 measurements.
- Conditions
- Child, Only, Infant, Newborn, Diseases, Critical Illness, ARDS, Human
- Trial name
- NCT04354220
- Testing
- capnography monitoring, arterial blood gas
- Where
- Switzerland
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Vincenzo Cannizzaro
Pediatric ALL, Critical Illness
Singapore's Health Outcomes After Critical Illness in Kids
What is the problem? Every year about 2.5 million children are affected by critical illness and require admission to the pediatric intensive care unit (PICU).
- Conditions
- Pediatric ALL, Critical Illness, Post Intensive Care Unit Syndrome
- Trial name
- SHACK (NCT04637113)
- Testing
- This is a non-interventional study
- Where
- Singapore
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Critical Illness, Death, Sudden
Critical Health Assessment and Outcomes Score/Study
CHAOS is based on the investigator's new and exciting results from pre-clinical and large longitudinal multi-center observational clinical studies of critically ill patients and asymptomatic community-based adults with little or…
- Trial name
- CHAOS (NCT02766166)
- Where
- 3 sites in United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Intensive Care Unit Syndrome, Prediction
Machine Learning-based Longitudinal Study of Post-ICU Syndrome Development Trajectory in Critically Ill Patients and Construction of Clinical Early Warning Models: a Research Protocol for Longitudinal Study
This project intends to track and evaluate whether post-ICU syndrome will occur 7 days, 1 month, 3 months and 6 months after ICU patients are transferred out of the ICU through a longitudinal study, apply the latent category…
- Conditions
- Intensive Care Unit Syndrome, Prediction, Cognitive Impairment, Sleep Disorder
- Trial name
- NCT06427265
- Where
- China
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital Of Guizhou Medical University
Diaphragm Disease, Covid19
Effects of COVID-19 Infection and Critical Illness on Diaphragm Tissue Characteristics and Movement, Visualized With MRI
COVID-19-infection has a large impact on the respiratory system and possibly on the diaphragm, the main respiratory muscle. In ICU-patients, diaphragm weakness is associated with prolonged ICU-stay, difficult weaning and…
- Trial name
- NCT04735757
- Testing
- Contrast-enhanced MRI, Measurement of respiratory muscle force
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Sleep Disorders
Protocol For Sleep for Critically Ill Patients
Sleep is essential for health and well-being. The quality of sleep impacts physical and cognitive aspects, including memory, immune system, and neuroendocrine function, with abnormalities associated with cardiovascular changes…
- Trial name
- NCT05996861
- Testing
- ICU sleep protocol
- Where
- 2 sites in Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital Moinhos de Vento
Anxiety, Depression
PARTNER II: Improving Patient and Family Centered Care in Advanced Critical Illness
This is a stepped wedged randomized controlled trial comparing the PARTNER intervention with usual care in 5 Intensive Care Units.
- Trial name
- NCT02445937
- Testing
- PARTNER II
- Where
- 2 sites in United States
- Volunteers
- 848 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Sepsis, Critical Illness
Provider Perspectives on Beta-lactam Therapeutic Drug Monitoring Programs in the Critically Ill
The purpose of the study is to characterize various healthcare practitioners' perspectives on implementation of beta-lactam therapeutic drug monitoring in critical care practice.
- Trial name
- NCT04755777
- Where
- 3 sites in United States, Australia
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Critical Illness Polyneuropathy, Critical Illness Myopathy
Evaluation of the NeuroMuscular Junction Using the Single Fiber Electromyography and Reliability of Train-Of-Four in Critically Ill Patients.
Patients suffering from critical illnesses who are admitted to the Intensive Care Unit (ICU) are often affected by multiple organ failure.
- Conditions
- Critical Illness Polyneuropathy, Critical Illness Myopathy, Weakness Due to Disease, Neuromuscular Blockade
- Trial name
- NCT03893058
- Where
- Italy
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Respiration, Artificial, Critical Illness
Medical Gas Humidification During Noninvasive Mechanical Ventilation
In this study, the investigators aimed to study the role of medical gas humidification during noninvasive mechanical ventilation.
- Trial name
- NCT00124345
- Testing
- MR730
- Where
- Italy
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Policlinico Hospital
Major Injury
Perioperative Research Into Memory: Cognitive Outcome Following Major Burns
The long term survival of patients who require admission to critical care (CC) following a major burn injury (MBI) continues to improve with advanced clinical management.
- Trial name
- PRiMe (NCT03470844)
- Testing
- Face-to-face neurocognitive tests, Psychological screening, fMRI
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Cardiogenic Shock,, With ECMO or IABP Support,
The Analysis of Heart Rate Variability With 24hrs Holter ECG and Serum Cardiac Fibrosis Markers in Critical Illness Patients Who Are With Cardiogenic Shock, With ECMO or IABP Support, or With APACH II Score >25)
The study is to show the prognostic factor of HRV parameter and cardiac fibrosis markers in critical illness patients
- Conditions
- Cardiogenic Shock,, With ECMO or IABP Support,, With APACH II Score >25)
- Trial name
- NCT01993745
- Where
- Taiwan
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Mechanical Ventilation, Critically Ill
Family Preparation Study For Withdrawal of Mechanical Ventilation From Their Family Member
Using the self-regulation theory, an intervention to prepare families for that experience was developed. This study will assess the impact of the intervention on a family's evaluation of their preparation and their short-term…
- Trial name
- NCT00214344
- Testing
- family preparation for withdrawing life support
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison