Clinical trials: Critically Ill
Critical Illness
Alternative Substrates in the Critically Ill Subject
The over-arching aim of this study is to investigate the feasibility of administrating alternative substrates to intensive care unit (ICU) patients.
- Trial name
- ASICS (NCT04101071)
- Testing
- Modular ketogenic feed, Standard feed
- Where
- 2 sites in United Kingdom
- Volunteers
- 29 people
- Sponsor
- Barts & The London NHS Trust
Respiratory Insufficiency Requiring Mechanical Ventilation
Effects of Neuromuscular Electrical Stimulation on Critically Ill Patients With Mechanical Ventilation
Up to 25% of patients who require mechanical ventilation (MV) more than seven days in the intensive care unit (ICU) develop muscle weakness, which comprises deep muscle weakness , including the respiratory muscles.Early active…
- Trial name
- NCT05217511
- Testing
- Neuromuscular Electrical Stimulation
- Where
- China
- Volunteers
- 47 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Lupus Nephritis, Diastolic Dysfunction
Diastolic Dysfunction and Inflammatory Biomarkers in Lupus Nephritis
This cross-sectional observational study aims to investigate the correlation between echocardiographic parameters of left ventricular diastolic dysfunction (E/A ratio, e', E/e' ratio, LAVI, and LVEF) and systemic inflammatory…
- Conditions
- Lupus Nephritis, Diastolic Dysfunction, Systemic Lupus Erythematosus, Heart Failure, Diastolic
- Trial name
- NCT07837544
- Volunteers
- 90 people
- Sponsor
- Assiut University
Intensive Care
The Feasibility of Measuring Energy Expenditure During Physical Rehabilitation In Critically Ill Patients
Many patients who are admitted to the intensive care unit (ICU) experience muscle weakness. This muscle weakness occurs whilst patients are unconscious, immobile in bed and on a breathing machine (ventilator).
- Trial name
- ENERGY-ICU (NCT02754622)
- Testing
- Observational Group
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Muscle Weakness, Critical Illness
Systematic Team Approach to Guide Early Mobilization in Surgical Intensive Care Unit Patients
The investigators hypothesize that by applying a validated algorithm to accomplish early mobilization in surgical intensive care unit (ICU) patients, these patients will achieve a higher level of mobility which translates to…
- Conditions
- Muscle Weakness, Critical Illness, Respiratory Insufficiency
- Trial name
- mSOMS (NCT01363102)
- Testing
- SOMS
- Where
- 5 sites in United States, Austria and 1 more
- Volunteers
- 200 people
- Sponsor
- Massachusetts General Hospital
Circulatory Shock, Hemodynamic Instability
Peripheral pULSe Assessment and Arterial pRessure (PULSAR)
This prospective multicenter observational study aims to investigate the relationship between palpable peripheral pulses and simultaneously measured arterial blood pressure in adult patients with circulatory shock or impending…
- Conditions
- Circulatory Shock, Hemodynamic Instability, Hypotension, Shock
- Trial name
- PULSAR (NCT07609095)
- Testing
- Peripheral Pulse Palpation
- Where
- Sweden
- Volunteers
- 5,000 people
- Sponsor
- Region Stockholm
Critically Ill, Mechanically Ventilated
Treatment of Invasively Ventilated Adults With Early Activity and Mobilisation
The aim of this study is to evaluate the effect of early activity and mobilisation during prolonged IMV on the composite outcome "days alive and out of hospital to day 180".
- Trial name
- TEAM(III) (NCT03133377)
- Testing
- Early activity and mobilisation
- Where
- 49 sites in Australia, Germany and 3 more
- Volunteers
- 750 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Respiratory Insufficiency
VivaSight-SL™ Versus Bronchoscopy for Percutaneous Tracheotomy
Optical guidance for percutaneous tracheotomy in intensive care is usually performed by bronchoscopy. Recently, an endotracheal tube with a camera mounted at its tip (VivaSight-SL) has been introduced that allows for endotracheal…
- Trial name
- VivaPDT (NCT02861001)
- Testing
- conventional bronchoscopy, VivaSight-SL tube
- Where
- Germany
- Volunteers
- 56 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Gastric Residual Volume, Abdominal Distension
Abdominal Massage for Gastric Residual Volume in Surgical Patients
This randomized controlled trial aimed to evaluate the effect of abdominal massage on gastric residual volume (GRV) and abdominal distension in surgical intensive care patients receiving enteral nutrition.
- Conditions
- Gastric Residual Volume, Abdominal Distension, Enteral Nutrition, Massage Therapy
- Trial name
- NCT07018414
- Testing
- Abdominal Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Marmara University
Acute Kidney Injury, VExUS
VExUS Score and AKI in Critically Ill Adult patients-a Prospective Observational Study.
Introduction Renal perfusion is dependent on the renal perfusion pressure across the renal capillaries. Venous congestion due to excess fluid therapy can drastically reduce the renal perfusion pressure in spite of a normal mean…
- Trial name
- NCT06889116
- Where
- Nepal
- Volunteers
- 52 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Cardiogenic Shock
ECMOsorb Trial - Impact of a VA-ECMO in Combination With CytoSorb in Critically Ill Patients With Cardiogenic Shock
In the ECMOsorb study the impact of a veno-arterial -ECMO in combination with an extracorporeal cytokine hemadsorption system in critically ill patients with cardiogenic shock is to be examined
- Trial name
- ECMOsorb (NCT05027529)
- Testing
- CytoSorb, VA-ECMO only
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- Christian Schulze
Septic Shock, Critically Ill
Resuscitation Strategies in Septic Shock
The purpose of this study, in mechanically ventilated septic shock patients, is to determine whether a fluid loading strategy based on parameters derived from the transpulmonary thermodilution technique may lead to more…
- Trial name
- ReSSeS (NCT02150512)
- Testing
- Transpulmonary Thermodilution, Surviving Sepsis Guidelines (SSG)
- Where
- Netherlands
- Volunteers
- 170 people
- Sponsor
- Medisch Spectrum Twente
Systemic Inflammatory Response Syndrome, Sepsis
Impact of Vitamin D Supplementation on Hepcidin Levels and Transfusion Requirements in Surgical and Septic Patients
Acute inflammation induced by surgery and sepsis is complicated by the development of iron-restricted anemia due to the up-regulation of hepcidin.
- Conditions
- Systemic Inflammatory Response Syndrome, Sepsis, Surgical Injuries
- Trial name
- DEHEPTRA (NCT03001687)
- Testing
- enteral supplementation with vitamin D, blood collection 3mL
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Intra-Abdominal Hypertension, Abdominal Compartment Syndrome
Intra-abdominal Hypertension in Critically Ill Patients
The aim of the proposed study is to determine the incidence and prevalence of intra-abdominal hypertension and abdominal compartment syndrome in consecutive intensive care admissions using broad inclusion criteria.
- Trial name
- NCT02514135
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 286 people
- Sponsor
- Western University, Canada
Critical Illness
Single Dose Omeprazole Versus High Dose in High-risk Critically Ill Patients.
Upper gastrointestinal (GIT) bleeding is common in high risk critically ill patients. Hyperacidity has been identified as one of the main reasons for bleeding.1 2 Antacids with different treatment modalities have been studied to…
- Trial name
- NCT03388463
- Testing
- Omeprazole
- Volunteers
- 110 people
- Sponsor
- Menoufia University
Acute Kidney Injury, Severe Sepsis
Acute Kidney Injury in Septic Critically Ill Patients : Are Aminoglycosides Really Harmful?
The purpose of the present study is to determine whether administration of aminoglycosides in septic critically ill patient is a risk factor for acute kidney injury
- Trial name
- REAMICHOC (NCT01932814)
- Where
- France
- Volunteers
- 317 people
- Sponsor
- Université Victor Segalen Bordeaux 2
Anemia, Critical Illness
Practical Anemia Bundle for SusTained Blood Recovery
The purpose of this study is to test a multi-faceted anemia treatment plan to reduce the severity of anemia and to promote hemoglobin and functional recovery in adults who have been in the intensive care unit (ICU).
- Trial name
- PABST-BR (NCT05167734)
- Testing
- Iron Dextran, Erythropoietin (EPO)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Intracranial Pressure
Study of Intracranial Pressure (ICP) Monitoring in Critically Ill
The SIM City study seeks to explore for the variance in practice that is associated with nursing and medical care of patients with brain pressure (ICP) monitors.
- Trial name
- SIM City (NCT01330264)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Upper Gastrointestinal Bleeding
Safety & Efficacy of Omeprazole Sodium Bicarbonate for the Prevention of Upper GI Bleeding in the Critically Ill
Critically ill patients are at an increased risk of having upper gastrointestinal (GI) bleeding due to stress related mucosal damage.
- Trial name
- NCT00045799
- Testing
- Omeprazole sodium bicarbonate immediate release PWD/FS, Cimetidine IV
- Where
- 58 sites in United States
- Volunteers
- 354 people
- Sponsor
- Bausch Health Americas, Inc.
Healthcare Associated Infections
Daily Chlorhexidine Bathing and Infection Rates in Critically-ill Patients
Healthcare-associated infections are a major cause of morbidity among critically ill patients. Bathing critically ill patients with cloths impregnated with the broad-spectrum antimicrobial agent chlorhexidine-gluconate may…
- Trial name
- NCT02033187
- Testing
- Chlorhexidine bathing, Non-chlorhexidine bathing
- Where
- United States
- Volunteers
- 12,000 people
- Sponsor
- Vanderbilt University
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