Clinical trials: Critical Illness Recovery
Surgery, Critical Illness
Measuring the Recovery of Barts Health Patients With Electronic Follow-up
More and more people are surviving emergency, life-threatening illnesses. However, survival often comes at a cost to patients' wellbeing. Many suffer from being so ill in ways not necessarily related to their original illness.
- Conditions
- Surgery, Critical Illness, Trauma
- Trial name
- PROSPER (NCT06038045)
- Where
- United Kingdom
- Volunteers
- 314 people
- Sponsor
- Queen Mary University of London
AKI - Acute Kidney Injury
Parameters of the Recovery Time of Acute Kidney Injury in Critically Ill Patients
the primary objective of this study is to identify and analyze parametrers affecting the time of recovery of AKI in critical ill patient ,Specifically, the study aims to: 1.
- Trial name
- NCT06114693
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assiut University
Critical Illness, Sarcopenia
Effect of Protein, Mobility Therapy and Electric Stimulation on Recovery in Older ICU Survivors
Older ICU survivors with ICU acquired weakness (ICUAW) are malnourished, sarcopenic, and functionally debilitated as a consequence of the high burden of comorbidities common in the elderly.
- Conditions
- Critical Illness, Sarcopenia, ICU Acquired Weakness
- Trial name
- ProMoTE (NCT05326633)
- Testing
- MRP and High Protein Supplement (HPRO) and Neuromuscular Electric Stimulation (NMES)
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Maryland, Baltimore
Acute Kidney Disease, Acute Kidney Injury
Impact of Different CRRT Modalities, Dosing Strategies, and Timing on Kidney Recovery and Prolonged Kidney Dysfunction
KARMA study is a hospital-based research study looking at how different ways of delivering kidney support therapy (CRRT) affect patients who are critically ill.
- Trial name
- KARMA (NCT07052617)
- Testing
- Continuos renal replacement therapy
- Volunteers
- 2,500 people
- Sponsor
- Croatian Society for Organ Support
Critical Illness, Children
Functional Recovery in Critically Ill Children
Intensive Care Unit-acquired weakness (ICU-AW) is a well-recognized, important and preventable sequelae of critical illness, affecting up to 60% of adult ICU patient.
- Trial name
- NCT01724593
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Karen Choong
Critical Illness, Post Intensive Care Syndrome (PICS)
Effectiveness of a Structured Multidimensional Tele-rehabilitation Intervention in Cardiac Patients With Post-Intensive Care Syndrome (CARDIO-PICS)
This two-arm, parallel-group randomized clinical trial investigates the effectiveness of an additional telerehabilitation program compared with standard care in patients with Post-Intensive Care Syndrome (PICS).
- Conditions
- Critical Illness, Post Intensive Care Syndrome (PICS), Cardiopathy
- Trial name
- CARDIO-PICS (NCT07599306)
- Testing
- Tele-rehabilitation, Standard of Care
- Where
- Italy
- Volunteers
- 326 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Critical Illness, Intensive Care Unit Acquired Weakness
PRotEin Provision in Critical IllneSs
Rapid skeletal muscle wasting during critical illness had a detrimental impact on both short and long term outcomes following ICU admission.
- Trial name
- PRECISe (NCT04633421)
- Testing
- PRECISe protocol EN 8g protein/100kcal, PRECISe protocol EN 5g protein/100kcal
- Where
- 10 sites in Belgium, Netherlands
- Volunteers
- 935 people
- Sponsor
- Maastricht University Medical Center
Post-Intensive Care Syndrome
Collaborative Assessment of ICU Recovery Needs
The primary purpose of this study is to better understand the impact of the Society of Critical Care Medicine (SCCM) THRIVE Collaboratives on patients, their families and clinicians.
- Trial name
- CAIRN (NCT03513289)
- Testing
- Patient, Carer, and Clinician Interviews
- Where
- 2 sites in United States, Australia
- Volunteers
- 66 people
- Sponsor
- Vanderbilt University Medical Center
Critical Illness, Mechanical Ventilation Complication
A Problem Solving Intervention for Post-ICU Cognitive Impairment in Older Adults
This study will apply an evidence based program to assist ICU survivors to overcome cognitive problems as a result of their critical illness.
- Conditions
- Critical Illness, Mechanical Ventilation Complication, Delirium, Cognitive Impairment
- Trial name
- PIC-UPS (NCT03972384)
- Testing
- Post-ICU Problem Solving
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Ohio State University
Acute Kidney Injury, Chronic Kidney Disease
Evaluating the Role of Cystatin C and Creatinine as Markers of Renal Recovery in Critically Ill Patients After Acute Kidney Injury.
This is a cohort study in which patients who survive Acute Kidney Injury (AKI) during intensive care unit (ICU) admission are recalled at 3-6 months and renal function tests are performed.
- Conditions
- Acute Kidney Injury, Chronic Kidney Disease, Acute Kidney Disease
- Trial name
- NCT02894164
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 336 people
- Sponsor
- Karolinska Institutet
Anemia, Post ICU Syndrome
Iron Deficiency at ICU Discharge
IRON-RECOVERY is a prospective, multicenter, observational cohort study designed to determine the prevalence of iron deficiency at intensive care unit (ICU) discharge and to evaluate its association with post-ICU clinical…
- Conditions
- Anemia, Post ICU Syndrome, Red Blood Cell Transfusions, Iron Deficiencies
- Trial name
- IRON-ICU (NCT07781540)
- Testing
- transferrin saturation
- Where
- 4 sites in Belgium, Italy
- Volunteers
- 462 people
- Sponsor
- Università degli Studi di Ferrara
Critically Ill
Towards RECOVER: Outcomes and Needs Assessment in Intensive Care Unit (ICU) Survivors of Prolonged Mechanical Ventilation and Their Caregivers
Advances in critical care medicine have dramatically improved the survival of critically ill patients requiring prolonged mechanical ventilation.
- Trial name
- RECOVER (NCT00896220)
- Where
- 5 sites in Canada
- Volunteers
- 500 people
- Sponsor
- University Health Network, Toronto
Critical Illness Recovery, Behavioral Health Concerns
Behavioral Health Collaborative Care Model in Post-ICU Clinic Family Pilot
This pilot study evaluates the feasibility and acceptability of implementing a Behavioral Health Collaborative Care Model (BH CoCM) for family members of ICU survivors.
- Conditions
- Critical Illness Recovery, Behavioral Health Concerns, Anxiety, Depression - Major Depressive Disorder
- Trial name
- NCT07390786
- Testing
- Behavioral Treatment
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Medical University of South Carolina
Acute Respiratory Distress Syndrome, Critical Illness
Acetaminophen and Ascorbate in Sepsis: Targeted Therapy to Enhance Recovery
Prospective multi-center phase 2b randomized placebo-controlled double-blinded interventional platform trial of two different pharmacologic therapies (intravenous Vitamin C or intravenous Acetaminophen) for patients with…
- Conditions
- Acute Respiratory Distress Syndrome, Critical Illness, Respiratory Failure, Sepsis
- Trial name
- ASTER (NCT04291508)
- Testing
- Intravenous Acetaminophen (room temperature), Intravenous Vitamin C (refrigerated), 5% Dextrose (room temperature)
- Where
- 41 sites in United States
- Volunteers
- 488 people
- Sponsor
- Massachusetts General Hospital
ICU Acquired Weakness, Post Intensive Care Unit Syndrome
Muscle Recovery After Critical Illness
The overarching goal of the proposed study is to determine the trajectories of physical recovery and cellular markers involved with the underlying failure to recover muscle after critical illness, while exploring which…
- Conditions
- ICU Acquired Weakness, Post Intensive Care Unit Syndrome, Muscle Weakness, Critical Illness
- Trial name
- TRACER (NCT05537298)
- Where
- 3 sites in United States
- Volunteers
- 209 people
- Sponsor
- Esther Dupont-Versteegden
Acute Renal Failure
Furosemide in Early Acute Kidney Injury
Acute renal failure, now referred to as acute kidney injury, is common in intensive care unit patients, contributes to high morbidity and mortality, and has no proven interventions with benefit once established.
- Trial name
- SPARK (NCT00978354)
- Testing
- Furosemide, Normal Saline
- Where
- 4 sites in Australia, Canada
- Volunteers
- 72 people
- Sponsor
- University of Alberta
Critical Illness
Wake Forest Post-ICU Telehealth (WFIT) Program
Wake Forest Post-Intensive Care Unit Telehealth (WFIT) program consists of a nurse practitioner who has access to daily activity data as well as telehealth capabilities for 6 months post-hospital discharge in order to improve the…
- Trial name
- WFIT (NCT04576065)
- Testing
- WFIT
- Where
- United States
- Volunteers
- 413 people
- Sponsor
- Wake Forest University Health Sciences
Post Intensive Care Syndrome
On the Road to Recovery After Critical Illness
Spending time on intensive care can affect people in many different ways. Ability to move, walk, concentrate and remember events can all be affected.
- Trial name
- ORRCI (NCT04272684)
- Testing
- Driving Assessment
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Acute Kidney Injury, Critical Illness Myopathy
Critical Illness Myopathy and Trajectory of Recovery in AKI Requiring CRRT
The purpose of this study is to determine whether patients with acute kidney injury requiring renal replacement therapy have a higher incidence of muscle wasting than controls and whether the course of recovery is longer compared…
- Conditions
- Acute Kidney Injury, Critical Illness Myopathy, Dialysis; Complications
- Trial name
- NCT05287204
- Testing
- Musculoskeletal ultrasound, Assessments of muscle strength and physical function, Metabolomics
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Iowa
Intensive Care Unit Syndrome, Intensive Care Neuropathy
Recovery From ICUAW Following Severe Respiratory and Cardiac Failure
To observe and identify determinants of recovery from intensive care unit-acquired weakness (ICUAW) following a severe cardiorespiratory failure requiring extra-corporeal membrane oxygenation (ECMO).
- Conditions
- Intensive Care Unit Syndrome, Intensive Care Neuropathy, Intensive Care (ICU) Myopathy, Acute Respiratory Distress Syndrome
- Trial name
- CLEVERER (NCT03753412)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Barts & The London NHS Trust