Clinical trials: Critical Illness Recovery
Anemia, Critical Illness
Practical Anemia Bundle for SusTained Blood Recovery
The purpose of this study is to test a multi-faceted anemia treatment plan to reduce the severity of anemia and to promote hemoglobin and functional recovery in adults who have been in the intensive care unit (ICU).
- Trial name
- PABST-BR (NCT05167734)
- Testing
- Iron Dextran, Erythropoietin (EPO)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Post Intensive Care Unit Syndrome, Intensive Care Unit Acquired Weakness
Intensive Care Unit Recovery
Survival rates of patients with critical illness have increased due to improved facilities and treatment methods in the intensive care unit (ICU).
- Conditions
- Post Intensive Care Unit Syndrome, Intensive Care Unit Acquired Weakness, Critical Illness
- Trial name
- ICU-RE (NCT04154995)
- Testing
- Venipuncture, Ultrasound Quadriceps Muscles
- Where
- Netherlands
- Volunteers
- 81 people
- Sponsor
- Frisius Medisch Centrum
ICU Survivors
Integrated Recovery Program for Critical Illness
This study aims to investigate the effects of the Integrated Critical Illness Aftercare and Recovery Enhancement (I-CARE) program on reducing healthcare burden and improving functional outcomes in ICU survivors.
- Trial name
- iCARE (NCT06997822)
- Testing
- LINE Bot-Based Remote Care Combined with In-Person Post-ICU Clinic
- Where
- Taiwan
- Volunteers
- 240 people
- Sponsor
- National Taiwan University Hospital
Critical Illness
SC2i VIPER: EnVenomation Investigation Pilot to Evaluate Recovery
The purpose of this study is to pilot data for a systematic molecular characterization of pathophysiologic perturbations incurred by snake envenomation and compare this to other inflammatory physiologic states such as trauma and…
- Trial name
- VIPER (NCT03170297)
- Testing
- Research interventions of blood sampling and data collection
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Acute Respiratory Distress Syndrome, Critical Illness
A Study Promoting Critical Illness Recovery in the Elderly
This proposal will test the hypothesis that EARLY application of a novel early rehabilitation therapy in critically ill patients will improve functional outcomes, and change the functional trajectory of this population.
- Conditions
- Acute Respiratory Distress Syndrome, Critical Illness, Critical Care
- Trial name
- ASPIRE (NCT02963558)
- Testing
- cycle ergometry
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Wake Forest University Health Sciences
Muscle Weakness, Critical Illness
Development of the Italian Version of the ICU Mobility Scale (IMS). Cross-cultural Adaptation, Italian Translation, and Validation Study.
Early mobilisation of the patient admitted to intensive care units (ICUs) is essential to prevent Intensive Care Unit Acquired Weakness (ICUAW).
- Conditions
- Muscle Weakness, Critical Illness, Critical Illness Recovery, Acquired Weakness
- Trial name
- NCT07195942
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Istituto Clinico Humanitas
Corona Virus Disease 19 (COVID-19), COVID
Rehabilitation for People With COVID-19 in ICU
COVID-19 DISEASE Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by a newly emergent coronavirus, severe acute respiratory syndrome from COVID-19, that was first recognized in Wuhan, China, in December…
- Conditions
- Corona Virus Disease 19 (COVID-19), COVID, Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Critical Illness
- Trial name
- COVID_REHAB (NCT04381338)
- Testing
- Pulmonary and Motor Rehabilitation
- Where
- 2 sites in Italy
- Volunteers
- 96 people
- Sponsor
- University of Padova
Post Traumatic Stress Disorder, Critical Illness
Eye Movement Desensitisation and Reprocessing (EMDR) to Improve Mental Health Following Intensive Care Admission
The goal of this multi-centre, randomised, pilot feasibility study is to assess the feasibility of recruiting intensive care survivors, with symptoms of traumatic stress, to a study evaluating the use of eye movement…
- Conditions
- Post Traumatic Stress Disorder, Critical Illness, Eye Movement Desensitisation and Reprocessing, Depression, Anxiety
- Trial name
- EMERALD (NCT05591625)
- Testing
- Eye Movement Desensitisation and Reprocessing
- Where
- 2 sites in United Kingdom
- Volunteers
- 160 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Critical Illness
KetAmine and Recovery After Mechanical VentilAtion ( KARMA )
Invasive mechanical ventilation of critically ill patients in the intensive care unit (ICU) is associated with significant morbidity and mortality, as well as a severe prognosis in survivors, in terms of functional…
- Trial name
- KARMA (NCT07590687)
- Testing
- Intervention Group
- Where
- France
- Volunteers
- 640 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Post-Intensive Care Syndrome (PICS), Critical Illness Recovery
Virtual Reality for Recovery After Intensive Care (PICS)
The goal of this clinical trial is to learn if virtual reality (VR) helps improve thinking and memory skills in adults who have stayed in the intensive care unit (ICU).
- Conditions
- Post-Intensive Care Syndrome (PICS), Critical Illness Recovery, Rehabilitation After Critical Illness, Rehabilitation Exercise of ICU Patients
- Trial name
- VR4ICU (NCT07585500)
- Testing
- Immersive VR Multi-Domain Rehabilitation, Tablet-Based Multi-Domain Training
- Where
- Portugal
- Volunteers
- 51 people
- Sponsor
- University of Minho
Post-Intensive Care Syndrome (PICS)
Long-Term Outcomes and Post-Intensive Care Syndrome: Investigating the Associations Between Metabolic Signatures and Physical Functioning in Critically Ill Patients
Despite being young, healthy, and physically fit, some intensive care unit (ICU) patients experience significantly worse functional recovery after critical illness than older patients with multiple comorbidities although a poor…
- Trial name
- TOPICS (NCT07170527)
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- ARH van Zanten, MD PhD
Critical Illness
The Use of Sugammadex in the Critically Ill
Moderate and Deep neuromuscular blockade (rocuronium administered to a train of four count 0 and post-tetanic count of 1-2) in critically ill patients needing intubation or procedures can be reversed immediately and effectively…
- Trial name
- NCT03791801
- Testing
- Sugammadex, Neostigmine, Rocuronium
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Inflammation, Acute Illness
Nicotinamide Riboside in Hospitalized Patients
Patients will receive oral nicotinamide riboside or placebo and clinical and paraclinical outcome will be determined
- Trial name
- NCT04110028
- Testing
- Nicotinamide riboside
- Where
- Norway
- Volunteers
- 57 people
- Sponsor
- Oslo University Hospital
Sepsis
Adapting a Sepsis Transition and Recovery Program for Optimal Scale Up
The Adapting a Sepsis Transition and Recovery Program for Optimal Scale Up (ASTROS) study is an effectiveness-implementation hybrid design.
- Trial name
- ASTROS (NCT05997420)
- Testing
- STAR Program, Usual Care
- Where
- United States
- Volunteers
- 1,820 people
- Sponsor
- Wake Forest University Health Sciences
Delirium, Critical Illness
Recovery After ICU Treatment: A Prospective Cohort Study
This project aims to investigate the physical, mental and cognitive recovery after admission to the Intensive Care Unit (ICU). This will be done by a three and 12 month follow up after discharge.
- Conditions
- Delirium, Critical Illness, Quality of Life
- Trial name
- NCT02599428
- Where
- Denmark
- Volunteers
- 161 people
- Sponsor
- Zealand University Hospital
Malnutrition in Pregnancy, Malnutrition; Protein
Value of Early Postoperative Peptide-based Formula in Critically Ill Obstetrics on Recovery Enhancement
This is the first trial to assess the early semi-elemental postoperative formula load to meet the protein requirements in the first and second day postoperative to enhance the recovery of critically ill parturient (value on ERAS…
- Conditions
- Malnutrition in Pregnancy, Malnutrition; Protein, Postpartum Disorder, Patient Satisfaction
- Trial name
- NCT06164301
- Testing
- Elemental amino-acids
- Where
- Egypt
- Volunteers
- 83 people
- Sponsor
- Ain Shams University
Shock, Critical Illness
Enteral Versus Parenteral Nutrition During Recovery After Shock
This study compares enteral nutrition and parenteral nutrition in critically ill adult patients recovering from shock while receiving decreasing doses of vasopressors in the intensive care unit.
- Conditions
- Shock, Critical Illness, Nutritional Support, Vasopressor Therapy
- Trial name
- NCT07411014
- Testing
- enteral nutrition, Parenteral Nutrition
- Where
- South Korea
- Volunteers
- 1,150 people
- Sponsor
- Samsung Medical Center
Frailty, Critical Illness
Frailty, Outcomes, Recovery and Care Steps of Critically Ill Patients (FORECAST) Study Multi-Center Study
A prospective observational study of critically ill patients over the age of 50, studying the occurrence of frailty as measured by a variety of frailty measures, processes of care and long term outcomes.
- Trial name
- FORECAST (NCT05509036)
- Testing
- No interventions
- Where
- 11 sites in Canada
- Volunteers
- 700 people
- Sponsor
- Dr. John Muscedere
Delirium Risk, Critical Illness in Coronary ICU Patients
THE EFFECTS OF VIRTUAL ART THERAPY ON PHYSIOLOGICAL PARAMETERS, DELIRIUM RISK, ANGER, ANXIETY, AND MENTAL AND SPIRITUAL RECOVERY IN INTENSIVE CARE PATIENTS.
Patients in intensive care units experience significant physiological and psychological stress due to life-threatening conditions and invasive treatments.
- Conditions
- Delirium Risk, Critical Illness in Coronary ICU Patients, Mental and Spiritual Recovery, Effects of Virtual Art Therapy
- Trial name
- NCT07562802
- Testing
- Virtual Art Therapy
- Volunteers
- 62 people
- Sponsor
- Inonu University
Post-Intensive Care Syndrome (PICS), Critical Illness
Inflammatory and Genetic Predictors of Cognitive and Emotional Recovery After Critical Illness
Survivors of critical illness frequently develop persistent cognitive and emotional impairments, known as post-intensive care syndrome (PICS), which substantially impact quality of life and long-term recovery.
- Trial name
- CORE-ICU (NCT07659431)
- Volunteers
- 114 people
- Sponsor
- Corporacion Parc Tauli