Clinical trials: Contracture
Dupuytren's Contracture
Effects of Steroid Injection With Percutaneous Needle Aponeurotomy in Dupuytren's Contracture
Background: Dupuytren's contracture is a common hand problem that causes certain fingers to bend towards the palm. Patients with this condition cannot perform daily activities and many are unable to work.
- Trial name
- NCT00565019
- Testing
- Triamcinolone Acetonide
- Where
- Canada
- Volunteers
- 51 people
- Sponsor
- Sunnybrook Health Sciences Centre
Ankle Equinus, Ankle Contracture
Ankle Equinus Contracture Treated With Dynamic Splinting
The purpose of this study is to determine if the Ankle Dorsiflexion Dynasplint System (DS) is effective in treating contracture for patients with Ankle Equinus secondary to diabetes mellitus.
- Conditions
- Ankle Equinus, Ankle Contracture, Diabetes Mellitus
- Trial name
- NCT01238484
- Testing
- Standard of care, Dynasplint
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Dynasplint Systems, Inc.
Facial Scarring, Facial Trauma
Tools for Return of Facial Function
This study will evaluate novel intraoral (inside-the-mouth) splints designed to gently stretch facial tissues that have become tight or scarred following facial trauma, including burn injuries and gunshot wounds.
- Conditions
- Facial Scarring, Facial Trauma, Burn, Orofacial Contracture
- Trial name
- NCT07825844
- Testing
- Intraoral Stretching Splints
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Pronation Contracture
Dynamic Splinting for Excessive Pronation Following CVA
The purpose of this study is to examine range of motion and lasting effects of Botox injections along with the use of the Supination Dynasplint.
- Trial name
- SupPro Botox (NCT00900692)
- Testing
- Dynasplint
- Where
- United States
- Sponsor
- Dynasplint Systems, Inc.
Dupuytren's Disease
Efficacy of Aponeurectomy on the 2-year Recurrence Rate of Dupuytren's Disease
Dupuytren's disease is a frequent hereditary disease in Northern Europe. It is a degenerative disease affecting the palmar aponeurosis of the hand.
- Trial name
- REMEDY (NCT05067764)
- Testing
- Aponeurectomy with grafting, Aponeurectomy alone
- Where
- 2 sites in France
- Volunteers
- 172 people
- Sponsor
- Elsan
Children, Adult
Effects of Battle Rope Training on ROM and Pain in Children With Post Traumatic Elbow Contractures.
The primary objective of this study is to assess the effectiveness of battle rope training in improving ROM, reducing pain, and enhancing overall elbow function in children with post-traumatic elbow contracture.
- Trial name
- NCT07248475
- Testing
- Battle Rope Training, Stretching and Heat Therapy
- Where
- Pakistan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Dupuytren's Disease
Nodular Shrinking in Dupuytren Disease
Dupuytren disease (DD) is a common hand disorder with disabling finger contractures that may require surgery to restore function.
- Trial name
- Echo (NCT06321991)
- Testing
- Ultrasound measurement
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hamstring Contractures
Comparison of Dry Needling and IASTM on Hamstring Tightness in Posterior Pelvic Tilt
The purpose of the study is to compare the effects of dry needling (DN) and instrument-assisted soft tissue mobilization (IASTM) on pain, range of motion, lower extremity functional status on hamstring tightness in patients with…
- Trial name
- NCT05931120
- Testing
- Dry needling, IASTM
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Dupuytren's Disease
Splinting for Dupuytren's Contracture Release
This study is comparing two different kinds of splints for patients who have had a surgical contracture release of dupuytren's disease. It compares a static splint and a dynamic splint.
- Trial name
- NCT00575458
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Carcinoma, Non-Small-Cell Lung
A Study of MM-121 Combination Therapy in Patients With Advanced Non-Small Cell Lung Cancer
A Phase 1-2 study of MM-121 in combination with standard therapy for non-small cell lung cancer (NSCLC).
- Trial name
- NCT00994123
- Testing
- MM-121, Erlotinib
- Where
- 38 sites in United States, Canada and 4 more
- Volunteers
- 162 people
- Sponsor
- Merrimack Pharmaceuticals
Internal Rotation Contracture-shoulder
Glenohumeral Rotation After Throwing: RCT Comparing the Sleeper Stretch to the 90/90 Hip Lift With Balloon Blow Exercise
The primary purpose of this study is to determine if the loss of internal rotation following a throwing session is best restored through soft tissue stretching with the sleeper stretch or with scapular repositioning with the…
- Trial name
- NCT03091530
- Testing
- Sleeper Stretch, 90/90 Hip Lift with Balloon Blow Exercise
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Duke University
Flexion Contracture of Proximal Interphalangeal Joint, Joint Deformities, Acquired
Rationale and Analysis of the Use of ETDNO in the Treatment of PIPJ Flexion Contracture:
Introduction: Flexion contracture is one of the most frequent complications in finger trauma. The use of orthoses to obtain the best total end range time (TERT) is the most popular method to treat this pathology .
- Trial name
- NCT05465603
- Testing
- ETDNO (Elastic Tension digital neoprene orthosis)
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Vicenç Punsola Izard
Joint Contracture
Joint Stiffness Following Knee Replacement Surgery
Our primary research question is to find out whether there is a genetic component to the development of joint contractures following knee surgery, through the application of lab techniques.
- Trial name
- NCT00664651
- Where
- Canada
- Sponsor
- Ottawa Hospital Research Institute
Dupuytren's Disease
MiniFlo for Advanced Dupuytren's Disease
The aim of this study is to investigate the potential use of the MiniFlo (CitiEffe) progressive distraction external fixator in the treatment of advanced Dupuytren's disease.
- Trial name
- NCT07505563
- Testing
- MiniFlo
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Dupuytren's Disease
Registry of Dupuytren's Contracture Treatment Outcomes
Experience with Microbial Collagenase (trade name Xiapex) in Europe currently is limited to randomised controlled studies.While such studies are essential to determine efficacy and safety of the product (usually compared to…
- Trial name
- ReDuCTO (NCT01567397)
- Where
- 4 sites in Germany
- Volunteers
- 87 people
- Sponsor
- Technische Universität Dresden
Dupuytren's Disease
MRI Results in Dupuytren's Contracture Before and After Injection With Xiaflex
The purpose of this study is to determine the effects of XIAFLEX on your finger through MRI.
- Trial name
- NCT01450397
- Testing
- XIAFLEX
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Hospital for Special Surgery, New York
Breast Implant; Complications, Breast Implant Infection
Comparative Analysis of Two Animal-derived ADMs in Irradiated Implant-based Reconstruction
The goal of this retrospective observational trial is to compare two different devices, used in implant-based breast reconstruction, called acellular dermal matrices, which are a sort of collagen patch that integrates with the…
- Conditions
- Breast Implant; Complications, Breast Implant Infection, Implant Capsular Contracture, Breast Seroma
- Trial name
- RTADM (NCT06139588)
- Testing
- acellular dermal matrix implant for breast reconstruction
- Where
- Italy
- Volunteers
- 146 people
- Sponsor
- European Institute of Oncology
Management of Postburn Neck Contracture
Pre-expanded Flap Versus Free Flap for Postburn Neck Contracture
This prospective, randomized, parallel-group trial was conducted at two tertiary care centers in Egypt between April 2022 and October 2024.
- Trial name
- SCAIP (NCT07865689)
- Testing
- surgery (any volume) and / or pharmaceuticals treatment initiated or planned or only dynamic observation, in accordance with current clinical guidelines
- Where
- Egypt
- Volunteers
- 2 people
- Sponsor
- South Valley University
Bladder Cancer, Triple Negative Breast Cancer
A Phase I/IIa Trial of HMBD-001 in Advanced HER3 Positive Solid Tumours
This clinical trial is evaluating a drug called HMBD-001 (an anti-HER3 monoclonal antibody) in participants with advanced HER3 positive solid tumours.
- Conditions
- Bladder Cancer, Triple Negative Breast Cancer, Castration-resistant Prostate Cancer, Cervical Cancer
- Trial name
- NCT05057013
- Testing
- HMBD-001, HMBD-001 and enzalutamide
- Where
- 4 sites in United Kingdom
- Volunteers
- 81 people
- Sponsor
- Cancer Research UK
Hallux Limitus
Contracture Reduction Following Bunionectomy: a Longitudinal, Controlled Trial
To determine the efficacy of Metatarsal Dynasplint Sytem (MTP) in reducing contracture of hallux limitus secondary to Bunionectomy, in a longitudinal, controlled trial.
- Trial name
- Bunionectomy (NCT01589679)
- Testing
- standard of care, Metarsal Dynasplint
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Dynasplint Systems, Inc.