Clinical trials: Cognitive Flexibility, active
Alcohol Use Disorder, Cognition Disorders
Influence of Individual Traits on Adaptation Processes in Individuals With Alcohol Use Disorder
Alcohol Use Disorder (AUD) is a chronic condition that affects behavior, decision-making, and the ability to adapt to changing situations.
- Trial name
- TIPA (NCT07468825)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Depression, Anxiety
Novel and Conventional Interventions for Cognitive and Emotional Flexibility in Patient Trauma
This study is testing whether combining a rapid form of transcranial magnetic stimulation (TMS), an oral medication called d-cycloserine (DCS), and therapy can improve brain flexibility and emotional control in adults…
- Conditions
- Depression, Anxiety, Trauma Patients
- Trial name
- NOCICEPT (NCT07868627)
- Testing
- D-Cycloserine (DCS), Transcranial Magnetic Stimulation, Unified Protocol
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Mclean Hospital
Menopause, Stress, Psychological
Fascial Yoga in Menopausal Women
Aim: The aim of this study is to evaluate the effects of a structured fascial yoga-based behavioral intervention on perceived stress, cognitive control, and cognitive flexibility in menopausal women.
- Conditions
- Menopause, Stress, Psychological, Cognitive Flexibility, Nonpharmacological Interventions
- Trial name
- FascialYogaM (NCT07401810)
- Testing
- Fascial Yoga Program
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Marmara University
Spastic Diplegic Cerebral Palsy
Effects of Transcranial Direct Current Stimulation Combined With Virtual Reality on Balance and Executive Functions in Children With Spastic Diplegic Cerebral Palsy
Children with spastic diplegic cerebral palsy commonly experience difficulties with balance and may also have challenges involving attention, working memory, cognitive flexibility, and inhibitory control.
- Trial name
- NCT07829770
- Testing
- Active Transcranial Direct Current Stimulation, Virtual Reality Rehabilitation, Conventional Physical Therapy
- Where
- 2 sites in Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Obsessive Compulsive Disorder (OCD)
Priming CBT With rTMS for OCD
Cognitive behavioural therapy (CBT), incorporating exposure/response prevention (ERP) and cognitive therapy, is considered the gold-standard first-line treatment for obsessive-compulsive disorder (OCD).
- Trial name
- NCT06840951
- Testing
- rTMS, CBT
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sunnybrook Health Sciences Centre
Chronic Cancer-related Pain
An N-of-1 Trial of an Internet-delivered CBT Program Based on the Psychological Flexibility Model of Chronic Pain for Cancer-related Difficulties
Chronic pain is a commonly occurring complication of cancer and can have negatively impact day-to-day functioning and well-being. The recommended treatment for all forms of chronic pain is cognitive behavioral therapy (CBT).
- Trial name
- NCT06749964
- Testing
- Internet-delivered, therapist-assisted, pain-focused CBT based on the psychological flexibility model for chronic pain
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Lund University
Schizophrenia, Attention Deficit Disorder With Hyperactivity (ADHD)
Investigating Mediodorsal Thalamus Representations Underlying Human Cognitive Flexibility
The goal of this basic experimental research study is to examine how the human thalamus supports flexible thinking and behavior.
- Trial name
- NCT07217652
- Testing
- High-resolution fMRI during working memory, cognitive control, and decision-making tasks
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kai Hwang
Dementia, Memory, Short-Term
Evaluation of the Effect of Memory-based Reminiscence Therapy
The main objective of this study is to examine the effects of memory-based recall therapy applied to elderly adults diagnosed with Stage 0, 1, and 2 dementia on their mental state, psychological flexibility, and cognitive…
- Trial name
- NCT07073443
- Testing
- Experimental: Memory Therapy Group
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people
- Sponsor
- Kahramanmaraş İstiklal University
Healthy
Investigating Cognitive Flexibility Training
The investigators' previous research identified two distinct subtypes of Cognitive Flexibility (CF), termed CF1 (shifting flexibility) and CF2 (strategy flexibility).
- Trial name
- NCT07556250
- Testing
- Experimental (Implicit Training): Structure Learning Training, Active Control (Explicit Training): 'All You Can E.T.'
- Where
- Singapore
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Nanyang Technological University
Cognitive Impairment, Cognitive Flexibility
Beta-1 Band Functional Connectivity Mediates the Effects of Acute Exercise on Cognitive Flexibility in Older Adults With Cognitive Impairment: A Randomized Controlled Trial
Objective: The effects of different exercise modalities (mind-body, aerobic, and resistance training) on cognitive flexibility and brain functional connectivity in cognitively impaired older adults are unknown, and the…
- Conditions
- Cognitive Impairment, Cognitive Flexibility, Brain Functional Connectivity
- Trial name
- NCT07854444
- Testing
- Baduanjin, Brisk walking, Resistance band
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai University of Sport
Anxiety Disorders
Effects of tDCS on Fear Reversal in Patients With Anxiety Disorders
This study evaluates the effects of single-session Transcranial Direct Current Stimulation (tDCS) on fear reversal learning in patients with anxiety disorders.
- Trial name
- NCT07405463
- Testing
- Cathodal tDCS (rDLPFC), Anodal tDCS (vmPFC), Anodal tDCS (lDLPFC)
- Where
- China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Jingchu Hu
Post Traumatic Stress Disorder
rTMS-augmented Written Exposure Therapy for PTSD
Post-traumatic stress disorder (PTSD) is prevalent and represents a high healthcare burden among Veterans. Repetitive transcranial magnetic stimulation (rTMS) is a brain-based therapy that may be effective for treating PTSD.
- Trial name
- NCT05149534
- Testing
- Written Exposure Therapy, repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- VA Office of Research and Development
Chronic Non-Malignant Pain (Chronic Musculoskeletal Pain, Chronic Widespread Pain)
Effectiveness of Acceptance and Commitment Therapy for Chronic Non-Malignant Pain: A Randomized Controlled Trial
This study is evaluating whether Acceptance and Commitment Therapy (ACT) helps adults with chronic non-malignant pain (pain lasting 3 months or longer that is not caused by cancer).
- Trial name
- NCT07709572
- Testing
- Acceptance and Commitment Therapy (ACT), Cognitive Behavioral Therapy (CBT)
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- GIFT University
ARFID, Anorexia Nervosa
Cognitive Evaluation of Patients With Eating Disorders
The goal of this cross - sectional observational study is to improve understanding of the psychological and cognitive characteristics of Feeding and Eating Disorders (FEDs), a group of conditions that represent a growing public…
- Conditions
- ARFID, Anorexia Nervosa, Bulimia Nervosa, Cognitive Flexibility
- Trial name
- DNA_ARFID (NCT07478510)
- Testing
- Go/No-go, IAT, WCST
- Where
- 3 sites in Italy
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Cognition Improvement
Tinkering to Flex Ur Brain (Tinker-FUN): A Cognitive Flexibility Pilot Program for Community Dwelling Older Adults
The Tinker-FUN program is a cognitive flexibility intervention designed to help older adults adapt to aging and live independently.
- Trial name
- NCT07128498
- Testing
- Tinker-Fun
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Florida
Obsessive-Compulsive Disorder, Virtual Reality Exposure Therapy
Virtual Reality Exposure Therapy for Obsessive-Compulsive Disorder: A Randomized Controlled Trial in Inpatients
The aim of this study is to evaluate the efficacy of virtual reality exposure therapy (VRET) as a treatment for obsessive-compulsive disorder (OCD).
- Conditions
- Obsessive-Compulsive Disorder, Virtual Reality Exposure Therapy, Virtual Reality Cognitive Training, Cognitive Behavior Therapy
- Trial name
- OCD-VRET1 (NCT07245134)
- Testing
- Exposure Therapy (Virtual Reality), Cognitive flexibility training, Standard CBT program without VR interventions
- Where
- Czechia
- Volunteers
- 62 people
- Sponsor
- National Institute of Mental Health, Czech Republic
Exhaustion Disorder, Stress-Related Disorders
Step by Step Back - A Feasibility Study of a Physical Activity Intervention for Adults With Stress-related Exhaustion
The goal of this clinical study is to learn whether a psychologist- or psychotherapist-guided physical activity program can be delivered and used as part of regular care for adults experiencing stress-related exhaustion.
- Trial name
- NCT07407829
- Testing
- CBT/ACT-based psychologist-delivered physical activity program
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- The Swedish School of Sport and Health Sciences
Executive Function
Comparison Between Plyometrics and Calisthenics on Executive Function in School Going Children
The goal of this clinical trial is to compare the effects of calisthenics and plyometric exercises on executive functions in school-going children.
- Trial name
- NCT06770192
- Testing
- Calisthenics, Plyometric, Control
- Where
- Pakistan
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Autism Spectrum Disorder
Flexibility and the Predictive Brain in Autistic Males and Females
The goal of this study is to compare the neural correlates of predictive brain mechanisms during high-level social and non-social flexibility tasks, between autistic and non-autistic males and females.
- Trial name
- FLEX-PREAU (NCT06391684)
- Testing
- Social/non social; predictable vs unpredictable
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Anxiety Disorders, Depressive Disorder
Study on Mental Health Promoting Effects of Natural Psychotherapy for Adolescents
This randomized controlled trial aims to evaluate the efficacy of a universal intervention based on Natural Psychotherapy in reducing anxiety and depressive symptoms among primary and middle school students.
- Conditions
- Anxiety Disorders, Depressive Disorder, Mental Health
- Trial name
- NP-A-MHP (NCT07639476)
- Testing
- Multi-modal Nature-based Meditation, Intervention diary
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Beijing HuiLongGuan Hospital