Clinical trials: Cognitive Dysfunction
Mild Cognitive Impairment, Cognitive Impairment
SNIFF Multi-Device Study 2
The SNIFF Device study will involve using one of three devices to administer insulin through each participant's nose or intra-nasally, accompanied by a lumbar puncture.
- Trial name
- NCT04199767
- Testing
- 20 IU Humulin® R U-100 (NDC: 0002-8215, Eli Lilly & Company), 40 IU Humulin® R U-100 (NDC: 0002-8215, Eli Lilly & Company)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Mild Cognitive Impairment, Cognitive Impairment
SNIFF - Combo INI+EMPA Trial
The proposed pilot study will provide safety and efficacy preliminary data regarding singular and combined effects of two therapeutic approaches, intranasal insulin and treatment with the sodium-glucose cotransporter type 2…
- Conditions
- Mild Cognitive Impairment, Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT05081219
- Testing
- Insulin (Humulin® R U-100), Empagliflozin 10 MG, Aptar Pharma CPS Intranasal Delivery Device
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Mild Cognitive Impairment
MCI Speech in Noise
The purpose of this study is to determine whether people with MCI (Mild Cognitive Impairment) and healthy comparison subjects differ with respect to their ability to hear soft sounds and how their brain understands and processes…
- Trial name
- NCT06102486
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Alzheimer's Disease, Mild Cognitive Impairment
Wake Forest Alzheimer's Disease Clinical Core
Efforts to find treatments for AD have yielded only modest benefits, likely because longstanding AD pathological processes induce irreversible neurological compromise.
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Prediabetic State
- Trial name
- ADCC (NCT03140865)
- Where
- United States
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Cognitive Disorders
Prospective Monocentric Study of Taste in Patients With Minor or Major Cognitive Disorders Such as Alzheimer's, Through the Analysis of Gustatory Evoked Potentials.
Approximately 24 million people worldwide suffer from dementia, with Alzheimer's disease being the most common cause. Alzheimer's disease typically progresses in three stages: presymptomatic, prodromal ("early onset" or minor…
- Trial name
- MAPEG (NCT04860414)
- Testing
- Blood sampling, Cognitive Assessment, Subjective taste tests
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Epilepsy, Seizures
Pharmacological Modulation of Brain Oscillations in Memory Processing
The goal of this study is to learn about the effects of scopolamine (an anticholinergic drug) on areas of the brain involved in memory, and changes it may have on brain activity.
- Conditions
- Epilepsy, Seizures, Cognitive Impairment, Mild, Memory Disorders
- Trial name
- NCT05594017
- Testing
- Scopolamine (0.4mg)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Alzheimer Disease, Mild Cognitive Impairment
A Scalable Nutrition Adherence Intervention
Objective 1: To scale-up the nutrition adherence intervention for testing in racially diverse rural communities in North Florida. The investigators hypothesize that: 1.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Adherence
- Trial name
- NCT06121986
- Testing
- Improving Cognitive Aging through Nutrition (ICAN) Adherence Program, Improving Cognitive Aging through Nutrition, Mediterranean diet
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Florida State University
Quality of Life, Surgery
Determination of the Effect of Puzzle Use in Elderly Patients
The aim of this study is to determine the effects of the use of a simple, reliable and cost-effective puzzle on post-operative cognitive function changes, postoperative recovery, and quality of life using questionnaires and…
- Conditions
- Quality of Life, Surgery, Postoperative Confusion, Cognitive Dysfunction
- Trial name
- NCT05796830
- Testing
- Puzzle application
- Volunteers
- healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Mild Cognitive Impairment Due to Alzheimer's Disease, Subjective Cognitive Decline (SCD)
Autophagy-Enhancers to Reduce Sleep Disturbances
This clinical trial investigates the effects of spermidine supplementation on sleep quality and sleep-dependent memory consolidation in older adults with Subjective Cognitive Decline (SCD) or Mild Cognitive Impairment (MCI), two…
- Trial name
- SpSleep (NCT07383311)
- Testing
- Spermidine Supplementation
- Where
- Germany
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Schizophrenia, Schizoaffective Disorder
NEURO-COGS: Neurometabolic Mechanisms of Cognitive Training in Schizophrenia
This study will examine brain metabolic and excitatory/inhibitory mechanisms related to cognitive and visual functioning in adults with schizophrenia and healthy control participants.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Cognitive Impairment, Visual Impairment
- Trial name
- NCT07788755
- Testing
- Perceptual Discrimination Training, Cognitive Control Training
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Healthy Control Subjects, Schizophrenia Diagnosis
Understanding Lifespan Trajectories of Social Cognition, Brain Microstructure and Iron Dysregulation in Schizophrenia
This study aims to better understand how schizophrenia may affect social thinking, emotion regulation, brain function, and biological processes over time. Two groups will take part in the study: 1.
- Trial name
- NCT07856381
- Where
- Austria
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Hypertension, Cognitive Decline
Implementation of Multifaceted Patient-Centered Treatment Strategies for Intensive Blood Pressure Control in Minimize Cognitive Decline
The study will test a multifaceted strategy for implementing an intensive blood pressure intervention protocol targeting systolic BP <120 mmHg on cognitive decline in racial minority and low-income hypertensive patients in…
- Trial name
- IMPACTS-MIND (NCT04797403)
- Testing
- Stepped-care protocol adapted from the SPRINT intensive-treatment algorithm
- Where
- United States
- Volunteers
- 1,306 people, healthy volunteers welcome
- Sponsor
- Tulane University
Fall, Mild Cognitive Impairment (MCI)
Digital STEADI Efficacy
The aging of the U.S. population, combined with health care workforce shortages and insufficient access to effective fall prevention and exercise programs, has contributed to a high burden of fall-related injuries in older…
- Conditions
- Fall, Mild Cognitive Impairment (MCI), Aging
- Trial name
- NCT07852650
- Testing
- Digital STEADI-1, STEADI Standard of Care, Digital STEADI-2
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Friendi.fi Corporation
Perioperative/Postoperative Complications, Postoperative Cognitive Dysfunction
CEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm State
The goal of this observational study is to learn the how to determine the mean arterial pressure(MAP) or blood pressure level to be maintained during non-cardiac surgery for optimal brain health in patients above the age of 60…
- Conditions
- Perioperative/Postoperative Complications, Postoperative Cognitive Dysfunction, Postoperative Delirium, EEG With Periodic Abnormalities
- Trial name
- CERBERUS (NCT06133842)
- Testing
- Intra-op EEG and CO data collection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Mild Cognitive Impairment, Alzheimer Disease
Alzheimer's Disease Neuroimaging Initiative 4
The Alzheimer's Disease Neuroimaging Initiative 4 (ADNI4) is a non-randomized, longitudinal, natural history study designed to validate biomarkers, improve clinical trial design, and advance understanding of Alzheimer's disease…
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Dementia
- Trial name
- ADNI4 (NCT05617014)
- Testing
- Neuraceq, Amyvid, Tauvid
- Where
- 65 sites in United States, Canada
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Cognitive Impairment, Alzheimer Blood Biomarkers
Impact of a Multimodal Lifestyle Intervention on Dementia Risk Factors and Attitude Related to Dementia Risk: A Logistical Pilot Study
Many individuals develop dementia, and dementia has multiple causes, yet we currently have limited treatment options. A critical observation of the effectiveness of the available dementia treatments is that they tend to be more…
- Conditions
- Cognitive Impairment, Alzheimer Blood Biomarkers, Alzheimer Disease (AD), Mild Cognitive Impairment (MCI)
- Trial name
- NCT07146412
- Testing
- Multimodal Lifestyle Intervention
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- HudsonAlpha Institute for Biotechnology
Cancer, Breast, Age-related Cognitive Decline
Older Breast Cancer Patients: Risk for Cognitive Decline
The goal of this study is to evaluate the impact of systemic therapy on cognition in older breast cancer patients, explore change in APE, LM and Cognition domains, measure associations between cognitive decline and QOL, and…
- Conditions
- Cancer, Breast, Age-related Cognitive Decline, Cognitive Decline
- Trial name
- TLC (NCT03451383)
- Where
- United States
- Volunteers
- 1,700 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Mild Cognitive Impairment, Cognitive Decline
Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging
The study will examine whether 5mg melatonin (over the counter, OTC) over a 9-month period improves Alzheimer's disease (AD) biomarkers and cognitive function in two groups of individuals: those with mild cognitive impairment…
- Conditions
- Mild Cognitive Impairment, Cognitive Decline, Healthy Aging
- Trial name
- NCT03954899
- Testing
- melatonin
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Natalie Denburg
Silent Cerebral Infarct, Biomarkers / Blood
Biomarkers as Prognostic Factors of Silent, Cerebral Infarctions in Patients Undergoing High-thromboembolic-risk Transcatheter Interventions
Background: The transcatheter interventions with high thromboembolic risk, as transcatheter carotid angioplasty or transcatheter ablation of cardiac arrhythmias are associated with asymptomatic strokes- silent strokes.
- Conditions
- Silent Cerebral Infarct, Biomarkers / Blood, Cardiac Ablation, Cognitive Impairment
- Trial name
- PRINCESS (NCT07844850)
- Testing
- High-thromboembolic-risk transcatheter interventions
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Cognitive Disorders
Single-center Prospective Longitudinal Study of Taste in Patients With Cognitive Disorders at Different Stages of Severity (Isolated Cognitive Complaint, Minor or Major Neurocognitive Alzheimer-type Disorders) by Analysis of Gustatory Evoked Potentials
The aim of the MAPEG 2 study is to explore gustatory function and to follow its evolution in the 4 following groups of participants: Healthy subjects Participants with isolated cognitive complaint Participants with minor…
- Trial name
- MAPEG 2 (NCT05888961)
- Testing
- Blood samples, Interviewing the subject and scales, Neurocognitive evaluation
- Where
- France
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon