Clinical trials: Cognitive Changes
Proportional Reasoning
Modifying Cognitive Strategies for Comparing Proportions
The goal of this study is to understand the cognitive processes underlying quantitative and relational reasoning, including the understanding of mathematical information (e.g., numbers, proportions, percentages, geometry) and…
- Trial name
- NCT06635577
- Testing
- Verbal Interference Task
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Michelle Hurst, PhD
Post-stroke Dementia, Vascular Mild Cognitive Impairment
The Influence of Sequential Tau Protein and Amyloid Plaque Imaging Changes on Stroke Prognosis and Cognitive Outcome
Amyloid plaques and tau protein are the landmarks of neurodegeneration in Alzheimer's disease (AD). On the other hand, it is reported that cerebral ischemia may induce amyloid plaques and tau protein accumulation.
- Trial name
- NCT04572477
- Testing
- [18F]THK-5351, [18F]AV-45
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Cognitive Change
Effect of a Nootropic on the Cognitive Performance in Young Adults
The main aim of this study is to determine the effect of a nootropic on cognitive performance (i.e., reaction time, inhibitory control, cognitive flexibility, working memory, neuro-psychological outcomes).
- Trial name
- NCT04790188
- Testing
- Nootropic
- Where
- Spain
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Chronic Insomnia Disorder
Modified Suanzaoren Decoction Versus Eszopiclone for the Treatment of Chronic Insomnia Disorder
The purpose of this study is to observe the cognitive function and clinical efficacy of modified Suanzaoren decoction and eszopiclone in the treatment of chronic insomnia disorder patients, and to investigate the possible neural…
- Trial name
- NCT06452953
- Testing
- suanzaoren decoction, Eszopiclone 1 mg
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Central South University
Social Phobia
Social Phobia Intervention Study of Mannheim
Primary objective: The purpose of this study is to examine efficacy and efficiency of a Stepped Care Program (SCP) for patients with Social Phobia in comparison to the standard cognitive therapy for Social Phobia according to…
- Trial name
- NCT00434759
- Testing
- cognitive therapy, stepped care program based on cognitive therapy
- Where
- Germany
- Volunteers
- 89 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Depression
Affective Attentional Bias Training In Depression
Biased attention toward negatively valenced information has been considered as a mechanism for risk and relapse in depression. Those with depression tend to focus their visual attention first, more frequently, and for longer…
- Trial name
- NCT03106883
- Testing
- Affective training
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Queen's University
Multiple Sclerosis
Ocrelizumab Effects on Physiological and Cognitive Changes in Multiple Sclerosis
This is a Phase IV, prospective, open-label, single-center, observational, longitudinal, single blinded study. The investigators will examine the effects of Ocrelizumab on cognitive, patient reported outcomes (PROs), quality of…
- Trial name
- NCT03025269
- Testing
- Ocrelizumab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University at Buffalo
Cognitive Change, Motor Activity
Group Music Practice Enhances Development
This randomized controlled trial shows for the first time that focused musical instrumental practice as compared to traditional sensitization to music provokes multiple transfer effects in the cognitive and sensorimotor domain.
- Trial name
- OC (NCT04200794)
- Testing
- musical instrumental training, sensitization to music
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- School of Health Sciences Geneva
Obesity, Bariatric Surgery Candidate
Examination of Cognitive Function in Obesity and Following Weight Loss
Bariatric surgery is the most effective, long-term treatment for morbid obesity, and consistent with previous findings, individuals who lose significant weight after surgery also have improved cognition or "brain function".
- Conditions
- Obesity, Bariatric Surgery Candidate, Weight Loss
- Trial name
- NCT02994186
- Testing
- Bariatric Surgery, Medical Weight Loss Program
- Sponsor
- Vanderbilt University Medical Center
Diabetes Type 2, Diabetes Type 1
Disentangling the Effect of Brain Insulin Resistance on Brain Health
People with diabetes are at increased risk of developing dementia, including Alzheimer's disease and vascular dementia. In addition, persons with diabetes have more pronounced age-related brain atrophy and cognitive difficulties…
- Trial name
- BIR 1 (NCT07374705)
- Where
- 3 sites in Denmark, Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Henrik Bo Wiberg Larsson
Cardiac Surgery, Post-operative Cognitive Dysfunction
Active Temperature Management After Cardiac Surgery and Its Effect on Postoperative Cognitive Dysfunction
This study will assess the effect of active postoperative temperature management and its effect on the cognitive function in patients following coronary artery bypass graft (CABG) surgery to determine if active postoperative…
- Conditions
- Cardiac Surgery, Post-operative Cognitive Dysfunction, Fever
- Trial name
- NCT03947671
- Testing
- Rapr Rounds Hyper/Hypothermia Wraps, Acetaminophen
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Brain Structure, Cognitive Performance
Effects of Long-Duration Spaceflight on General and Spatial Cognition and Its Neural Basis
This study investigates the effects of extended-duration spaceflight (12-month International Space Station missions) on general cognitive performance (measured with the Cognition test battery), spatial cognition, structural and…
- Trial name
- NCT04856410
- Testing
- Spaceflight, Controls
- Where
- 3 sites in United States, Germany
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Substance Use Disorders
Neurobiological Mechanisms of Chess as an Add-On Treatment Against SUD
Neurobiological and neuropsychological approaches to investigate the potential mechanism of action of chess as an add-on therapy (chess based - cognitive remediation treatment, CB-CRT) to reduce cognitive deficits in individuals…
- Trial name
- Chess_SUD (NCT04057534)
- Testing
- Standard therapy for AUD plus Chess-based cognitive treatment, Standard therapy for AUD, Standard smoking cessation therapy for TUD plus Chess-based cognitive treatment
- Where
- Germany
- Volunteers
- 108 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Neck Pain, Whiplash
PROCO Neck: The Course and Neuroplasticity in Neck Pain-Associated Disorders and Whiplash-Associated Disorders
Neck pain-associated disorders (NAD) and whiplash-associated disorders (WAD) are major health problems. NAD has a lifetime prevalence of 54%.
- Conditions
- Neck Pain, Whiplash, Pain, Acute, Psychosocial Functioning
- Trial name
- NCT05468684
- Testing
- no intervention
- Where
- Switzerland
- Volunteers
- 168 people
- Sponsor
- University of applied sciences
Cognitive Change
Decision Making in Video Games
The purpose of this study is to determine whether anodal transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex induces approach motivation, and whether anodal tDCS applied to the right…
- Trial name
- NCT03869489
- Testing
- Anodal left dorsolateral prefrontal cortex tDCS stimulation, Anodal right dorsolateral prefrontal cortex tDCS stimulation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Tufts University
Cognitive Changes Due to Organic Disorder (Finding), Dementia
Gerontology Research Programme: The Singapore Longitudinal Ageing Studies (SLAS I & II)
The Gerontology Research Programme (GRP) in the National University Singapore's Department of Psychological Medicine, was formed to coordinate and facilitate the conduct of multi-disciplinary research on in a wide range of…
- Conditions
- Cognitive Changes Due to Organic Disorder (Finding), Dementia, Mild Cognitive Impairment, Frailty
- Trial name
- SLAS (NCT03405675)
- Testing
- SLAS 1, SLAS 2
- Where
- Singapore
- Volunteers
- 6,183 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Stroke
Cognitive-motor Exercise for Stroke Patients in Function, Cognition and Related Brain Changes.
The purpose of this study is to evaluate a cognitive-motor exercise on dual-task interference during dual-task ankle movement and the corresponding alterations of brain activity.
- Trial name
- COGMOTION (NCT06362512)
- Testing
- Dual-task training, Single-task training, Upper limb strengthening exercise
- Where
- China
- Volunteers
- 84 people
- Sponsor
- The Hong Kong Polytechnic University
Depression
Mechanisms of Change in Psychotherapy
Background: Major depressive disorder (MDD) is a prevalent psychiatric condition associated with significant disability, mortality and economic burden.
- Trial name
- MOP (NCT03022071)
- Testing
- Cognitive behavior therapy
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Oslo University Hospital
Breast Cancer, Cognitive Change
Computerized Cognitive Training in Breast Cancer Survivors
For millions of cancer survivors, cognitive impairment is a prevalent, severe, and persistent problem that is associated with other symptoms (depressive symptoms, anxiety and fatigue), poorer work ability, and poorer quality of…
- Conditions
- Breast Cancer, Cognitive Change, Cognitive Impairment, Quality of Life
- Trial name
- NCT05570604
- Testing
- Sweep Seeker, Bird Safari, Jewel Diver
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Ohio State University
Postnatal Depression
Online LTP+CaCBT for Treating Depression in British Mothers of African/Caribbean Heritage
The pilot trial aims to test the feasibility, acceptability and cultural appropriateness of online LTP+CaCBT for treating postnatal depression and to improve the mental health and wellbeing of mothers and their children in the UK.
- Trial name
- NCT04820920
- Testing
- LTP, CaCBT, Psychoeducation
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Nottingham Trent University