Substance Use DisordersChess_SUDNCT04057534

Neurobiological Mechanisms of Chess as an Add-On Treatment Against SUD

A study testing Standard therapy for AUD plus Chess-based cognitive treatment, Standard therapy for AUD and Standard smoking cessation therapy for TUD plus Chess-based cognitive treatment in people with Substance Use Disorders, run by Central Institute of Mental Health, Mannheim at 1 site in Germany.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

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Trial summary

Neurobiological and neuropsychological approaches to investigate the potential mechanism of action of chess as an add-on therapy (chess based - cognitive remediation treatment, CB-CRT) to reduce cognitive deficits in individuals with alcohol use disorder (AUD) or tobacco use disorder (TUD). Read more about this study

Who is it for?: Ages 18 to 65 years
Conditions the study is for: Substance Use Disorders
What is being tested?: Standard therapy for AUD plus Chess-based cognitive treatment, Standard therapy for AUD and Standard smoking cessation therapy for TUD plus Chess-based cognitive treatment
Type of treatment: Lifestyle or therapy programme
Could I receive a placebo?: No, everyone receives an active treatment
How many people: 108 participants
Where: 1 siteGermany
Study dates: 1 Apr 2020to 17 Nov 2023
Phase: Interventional
Are there results?: None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 18 to 65 years
All sexes
No healthy volunteers
Adult, Older adult

Who may be able to join

severe alcohol (AUD) or tabacco use disorder (SUD) according to DSM-5
abstinence from alcohol for at least 72 hours (AUD)
sufficient ability to communicate with investigators and answer questions in both written and verbal format
ability to provide fully informed consent and to use self-rating scales
main diagnosis AUD: inpatient or outpatient treatment in our clinic
main diagnosis TUD: participation in 6 weeks smoking cessation treatment
Normal or corrected to normal vision
Signed consents for data security

Who cannot join

severe internal, neurological, and/or psychiatric comorbidities; other Axis I mental disorders other than TUD according to ICD-10 and DSM 5 (except for other substance use disorders - if AUD or TUD is still the main diagnosis -, ADHD, remitted depression, mild or moderate depression, adjustment disorder, generalized anxiety disorder, phobias, panic disorder or other mild or moderate personality disorders) in the last 12 months
Severe withdrawal symptoms (CIWA-Ar > 7; Sullivan et al. 1989)
alcohol intoxication (>0‰)
history of brain injury
severe cognitive impairments
common exclusion criteria for MRI (e.g. metal, claustrophobia, pregnancy)
suicidality or endangerment of others
positive Covid-19 screening

Trial locations and contacts

1 site in 1 country.

Germany1 site

Klinik für Abhängiges Verhalten, Zentralinstitut für Seelische Gesundheit
Mannheim

Other trials in Germany

About this study

Official title: Investigating Neurobiological Mechanisms of Chess as an Add-On Treatment Against Substance Use Disorder

Read the detailed description

The study aims to investigate the potential mechanism of action of chess as a "chess based - cognitive remediation treatment, CB-CRT" to reduce cognitive deficits in individuals with substance use disorder (SUD) seeking treatment using neurobiological and neuropsychological approaches. Furthermore, it will be assessed whether this chess intervention has a generalized positive effect on short-term abstinence. Interestingly, the functional domains and associated underlying neuronal networks observed to be affected in individuals with SUD overlap significantly with those that could be strengthened by chess-based cognitive training or formal chess. Specifically, strengthening of cortical control regions (dorsolateral prefrontal cortex, DLPFC) and brain areas relevant for decision-making (orbitofrontal cortex, OFC) could prevent future relapse. Therefore, chess as an add-on therapy to complement other standard treatments of SUD could lead to improved therapeutic outcomes.

Conditions: Substance Use Disorders
Being tested: Standard therapy for AUD plus Chess-based cognitive treatment, Standard therapy for AUD, Standard smoking cessation therapy for TUD plus Chess-based cognitive treatment, Standard therapy for TUD
Keywords: Alcohol Dependence, Alcoholism, Craving, Cognitive Change, cognitive remediation, Chess based cognitive training, Working Memory, Decision Making, Executive Control, Chess, fMRI, Nicotine use disorder, Tobacco use disorder
Medical subject headings: Substance-Related Disorders, Alcoholism, Tobacco Use Disorder

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Standard therapy for AUD plus Chess-based cognitive treatmentBehavioural
Behavioral: standard AUD Cognitive Behavioral Therapy (CBT) in Clinical setting.
Patients who voluntarily submit to enter a qualified detoxification treatment program will be examined, either in-patient, out-patient, or in a day-clinic setting at the Department of Addictive Behaviour and Addiction Medicine. Additional, the experimental group receives chess based cognitive remediation treatment (CB-CRT) for 1,5 hours three times a week. The tasks of the treatment were created by our cooperation partner, the psychologist Juan Antonio Montero. He is currently successfully applying this battery as an add-on therapy. The training battery is designed to strengthen cognitive functioning in specific domains such as short-term memory, focal attention, selective attention, pattern recognition, visuospatial abilities, metacognition and also inhibition.
Standard therapy for AUDBehavioural
Behavioral: standard AUD Cognitive Behavioral Therapy (CBT) in Clinical setting. Patients who voluntarily submit to enter a qualified detoxification treatment program will be examined, either in-patient, out-patient, or in a day-clinic setting at the Department of Addictive Behaviour and Addiction Medicine.
Standard smoking cessation therapy for TUD plus Chess-based cognitive treatmentBehavioural
Behavioral: standard smoking cessation therapy for TUD in group therapy setting.
Patients who voluntarily submit to enter a qualified smoking cessation program will be examined in an out-patient setting at the Department of Addictive Behaviour and Addiction Medicine. They receive a six-week standard therapy (one 1,5 hours group therapy per week). Additional, the experimental group receives chess based cognitive remediation treatment (CB-CRT) for 1,5 hours three times a week. The tasks of the treatment were created by our cooperation partner, the psychologist Juan Antonio Montero. He is currently successfully applying this battery as an add-on therapy. The training battery is designed to strengthen cognitive functioning in specific domains such as short-term memory, focal attention, selective attention, pattern recognition, visuospatial abilities, metacognition and also inhibition.
Standard therapy for TUDBehavioural
Behavioral: standard smoking cessation therapy for TUD in group therapy setting.
Patients who voluntarily submit to enter a qualified smokind cessation program will be examined in an out-patient setting at the Department of Addictive Behaviour and Addiction Medicine. They receive a six-week standard therapy (one 1,5 hours group therapy per week). Additional, the experimental group receives chess based cognitive remediation treatment (CB-CRT) for 1,5 hours three times a week.

Study groups in NCT04057534
Study group	Role	What they receive
CB-CRT AUD group	Experimental	experimental group AUD: patients receive standard clinical therapy and an add-on chess based - cognitive remediation treatment (CB-CRT) Receives: Behavioral: Standard therapy for AUD plus Chess-based cognitive treatment
Control group AUD	Active comparator	control group: patients with AUD receive standard clinical therapy Receives: Behavioral: Standard therapy for AUD
CB-CRT TUD group	Experimental	experimental group TUD: patients receive standard smoking cessation therapy and an add-on CB-CRT Receives: Behavioral: Standard smoking cessation therapy for TUD plus Chess-based cognitive treatment
Control group TUD	Active comparator	control group: patients with TUD receive standard smoking cessation therapy Receives: Behavioral: Standard therapy for TUD

What is being measured

The primary outcome is the main question the study is designed to answer.

change in neural alcohol cue-reactivity
fMRI alcohol cue-reactivity task (Vollstädt-Klein et al. 2010)
Measured: 2 time points: before and after 6 weeks chess-based cognitive training
change in neural tobacco cue-reactivity
fMRI tobacco cue-reactivity task (Vollstädt-Klein et al. 2011)
Measured: 2 time points: before and after 6 weeks chess-based cognitive training
change in neural correlates of inhibition
fMRI stop-signal task (Whelan et al. 2012)
Measured: 2 time points: before and after 6 weeks chess-based cognitive training
substance use (alcohol consumption and tabacco use)
self-report
Measured: 3 months follow-up after the end of treatment
change in neural working memory processes
fMRI working memory task "N-back" (Charlet et al. 2014)
Measured: 2 time points: before and after 6 weeks chess-based cognitive training
Change in working memory capacity
working memory capacity measured by letter-number sequencing task of the [Wechsler Memory Scale (Kent 2013)]; raw values will be transformed to IQ-like scales (mean 100, SD 15); the higher the value, the higher the working memory capacity
Measured: 2 time points: before and after 6 weeks SCP
Change in impulsivity
impulsivity measured with BIS scale [Barratt impulsiveness scale (Patton et al. 1995)];range 15-60; total score will be used; high values represent high impulsivity
Measured: 3 time points: before and after 6 weeks SCP plus after 3 months
Change in decision-making
[Iowa Gambling Task (Bechara et al. 1994)]
Measured: 2 time points: before and after 6 weeks SCP
Change in mental flexibility
[Dimensional Change Card Sort (Zelazo et al. 2014)]
Measured: 2 time points: before and after 6 weeks SCP
Change in attentional capacity
[d2 Test of Attention (Brickenkamp 2002)].
Measured: 2 time points: before and after 6 weeks SCP

Secondary outcomes (1)

change in functional connectivity within the salience network (SN) and executive control network (ECN)
[measured with fMRI]
Measured: 2 time points: before and after 6 weeks therapy and chess-based cognitive training

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

1 Apr 202017 Nov 2023

First posted15 Aug 2019
Study start1 Apr 2020
Primary completion17 Nov 2023
Study completion17 Nov 2023

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Publications (13)Papers the sponsor has linked to this study.
Other trials for Substance Use DisordersStudies of the same condition, open and under way.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Treatment
Allocation: Randomised
Intervention model: Parallel groups
Masking: None (open label)
Enrolment: 108 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT04057534
Sponsor's protocol ID: Chess_SUD
Acronym: Chess_SUD
Status last verified: Mar 2024
First submitted: 12 Aug 2019
Last updated: 29 Mar 2024
Results posted: No
FDA-regulated drug: No
FDA-regulated device: No
Individual data sharing: Yes: For protection of personal rights, and due to the sensitivity of the clinical and neuroimaging data, data will not be made publicly available. Upon direct request by other researchers and in mutual agreements (e.g., regarding data protection), anonymized data can be made available. Upon request, analysis procedures and codes will be shared with other researchers.

Publications

Adinoff B. Neurobiologic processes in drug reward and addiction. Harv Rev Psychiatry. 2004 Nov-Dec;12(6):305-20. doi: 10.1080/10673220490910844.
PubMed 15764467
Fauth-Buhler M, de Rover M, Rubia K, Garavan H, Abbott S, Clark L, Vollstadt-Klein S, Mann K, Schumann G, Robbins TW. Brain networks subserving fixed versus performance-adjusted delay stop trials in a stop signal task. Behav Brain Res. 2012 Nov 1;235(1):89-97. doi: 10.1016/j.bbr.2012.07.023. Epub 2012 Jul 20.
PubMed 22820235
Amidzic O, Riehle HJ, Fehr T, Wienbruch C, Elbert T. Pattern of focal gamma-bursts in chess players. Nature. 2001 Aug 9;412(6847):603. doi: 10.1038/35088119. No abstract available.
PubMed 11493907
Atherton M, Zhuang J, Bart WM, Hu X, He S. A functional MRI study of high-level cognition. I. The game of chess. Brain Res Cogn Brain Res. 2003 Mar;16(1):26-31. doi: 10.1016/s0926-6410(02)00207-0.
PubMed 12589885
Bates ME, Buckman JF, Nguyen TT. A role for cognitive rehabilitation in increasing the effectiveness of treatment for alcohol use disorders. Neuropsychol Rev. 2013 Mar;23(1):27-47. doi: 10.1007/s11065-013-9228-3. Epub 2013 Feb 15.
PubMed 23412885
Blasco-Fontecilla H, Gonzalez-Perez M, Garcia-Lopez R, Poza-Cano B, Perez-Moreno MR, de Leon-Martinez V, Otero-Perez J. Efficacy of chess training for the treatment of ADHD: A prospective, open label study. Rev Psiquiatr Salud Ment. 2016 Jan-Mar;9(1):13-21. doi: 10.1016/j.rpsm.2015.02.003. Epub 2015 Apr 22. English, Spanish.
PubMed 25911280
Demily C, Cavezian C, Desmurget M, Berquand-Merle M, Chambon V, Franck N. The game of chess enhances cognitive abilities in schizophrenia. Schizophr Res. 2009 Jan;107(1):112-3. doi: 10.1016/j.schres.2008.09.024. Epub 2008 Nov 7. No abstract available.
PubMed 18995990
Fattahi F, Geshani A, Jafari Z, Jalaie S, Salman Mahini M. Auditory memory function in expert chess players. Med J Islam Repub Iran. 2015 Oct 6;29:275. eCollection 2015.
PubMed 26793666
Goncalves PD, Ometto M, Bechara A, Malbergier A, Amaral R, Nicastri S, Martins PA, Beraldo L, dos Santos B, Fuentes D, Andrade AG, Busatto GF, Cunha PJ. Motivational interviewing combined with chess accelerates improvement in executive functions in cocaine dependent patients: a one-month prospective study. Drug Alcohol Depend. 2014 Aug 1;141:79-84. doi: 10.1016/j.drugalcdep.2014.05.006. Epub 2014 May 24.
PubMed 24913200
Onofrj M, Curatola L, Valentini G, Antonelli M, Thomas A, Fulgente T. Non-dominant dorsal-prefrontal activation during chess problem solution evidenced by single photon emission computerized tomography (SPECT). Neurosci Lett. 1995 Oct 6;198(3):169-72. doi: 10.1016/0304-3940(95)11985-6.
PubMed 8552313
Vollstadt-Klein S, Wichert S, Rabinstein J, Buhler M, Klein O, Ende G, Hermann D, Mann K. Initial, habitual and compulsive alcohol use is characterized by a shift of cue processing from ventral to dorsal striatum. Addiction. 2010 Oct;105(10):1741-9. doi: 10.1111/j.1360-0443.2010.03022.x.
PubMed 20670348
Lally N, Huys QJM, Eshel N, Faulkner P, Dayan P, Roiser JP. The Neural Basis of Aversive Pavlovian Guidance during Planning. J Neurosci. 2017 Oct 18;37(42):10215-10229. doi: 10.1523/JNEUROSCI.0085-17.2017. Epub 2017 Sep 18.
PubMed 28924006
Gerhardt S, Lex G, Holzammer J, Karl D, Wieland A, Schmitt R, Recuero AJ, Montero JA, Weber T, Vollstadt-Klein S. Effects of chess-based cognitive remediation training as therapy add-on in alcohol and tobacco use disorders: protocol of a randomised, controlled clinical fMRI trial. BMJ Open. 2022 Sep 6;12(9):e057707. doi: 10.1136/bmjopen-2021-057707.
PubMed 36691127

Want to know more?

The sponsor has not listed a contact. The official record may have more details.

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

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Study at a glance

From the registry record, last updated by the sponsor on 29 Mar 2024. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Investigating Neurobiological Mechanisms of Chess as an Add-On Treatment Against Substance Use Disorder
ClinicalTrials.gov ID: NCT04057534
Acronym / sponsor ID: Chess_SUD / Chess_SUD
Conditions: Substance Use Disorders
Keywords: Alcohol Dependence, Alcoholism, Craving, Cognitive Change, cognitive remediation, Chess based cognitive training, Working Memory, Decision Making
Study type: Interventional
Recruitment status: Completed
Enrolment: 108 participants (actual)
Lead sponsor: Central Institute of Mental Health, MannheimUniversity, hospital or other
Study start: 1 Apr 2020 (actual)
Primary completion: 17 Nov 2023 (actual)
Study completion: 17 Nov 2023 (actual)
First posted: 15 Aug 2019 (actual)
Results: Not posted in the source record

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

Detailed description

Study design

Primary purpose: Treatment
Allocation: Randomised
Intervention model: Parallel groups
Masking: None (open label)
Number of arms: 4

Arm	Type	Receives
CB-CRT AUD group	Experimental	Behavioral: Standard therapy for AUD plus Chess-based cognitive treatmentexperimental group AUD: patients receive standard clinical therapy and an add-on chess based - cognitive remediation treatment (CB-CRT)
Control group AUD	Active comparator	Behavioral: Standard therapy for AUDcontrol group: patients with AUD receive standard clinical therapy
CB-CRT TUD group	Experimental	Behavioral: Standard smoking cessation therapy for TUD plus Chess-based cognitive treatmentexperimental group TUD: patients receive standard smoking cessation therapy and an add-on CB-CRT
Control group TUD	Active comparator	Behavioral: Standard therapy for TUDcontrol group: patients with TUD receive standard smoking cessation therapy

Who may qualify

Ages: 18 to 65 years
Sex: All
Healthy volunteers: Not accepted
Age groups: Adult, Older adult

Key inclusion criteria (8 listed)

severe alcohol (AUD) or tabacco use disorder (SUD) according to DSM-5
abstinence from alcohol for at least 72 hours (AUD)
sufficient ability to communicate with investigators and answer questions in both written and verbal format
ability to provide fully informed consent and to use self-rating scales
main diagnosis AUD: inpatient or outpatient treatment in our clinic

Key exclusion criteria (8 listed)

severe internal, neurological, and/or psychiatric comorbidities; other Axis I mental disorders other than TUD according to ICD-10 and DSM 5 (except for other substance use disorders - if AUD or TUD is still the main diagnosis -, ADHD, remitted depression, mild or moderate depression, adjustment disorder, generalized anxiety disorder, phobias, panic disorder or other mild or moderate personality disorders) in the last 12 months
Severe withdrawal symptoms (CIWA-Ar > 7; Sullivan et al. 1989)
alcohol intoxication (>0‰)
history of brain injury
severe cognitive impairments

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
Standard therapy for AUD plus Chess-based cognitive treatmentBehavioral: standard AUD Cognitive Behavioral Therapy (CBT) in Clinical setting. Patients who voluntarily submit to enter a qualified detoxification treatment program will be examined, either in-patient, out-patient, or in a day-clinic setting at the Department of Addictive Behaviour and Addiction Medicine. Additional, the experimental group receives chess based cognitive remediation treatment (CB-CRT) for 1,5 hours three times a week. The tasks of the treatment were created by our cooperation partner, the psychologist Juan Antonio Montero. He is currently successfully applying this battery as an add-on therapy. The training battery is designed to strengthen cognitive functioning in specific domains such as short-term memory, focal attention, selective attention, pattern recognition, visuospatial abilities, metacognition and also inhibition.	Behavioural	CB-CRT AUD group
Standard therapy for AUDBehavioral: standard AUD Cognitive Behavioral Therapy (CBT) in Clinical setting. Patients who voluntarily submit to enter a qualified detoxification treatment program will be examined, either in-patient, out-patient, or in a day-clinic setting at the Department of Addictive Behaviour and Addiction Medicine.	Behavioural	Control group AUD
Standard smoking cessation therapy for TUD plus Chess-based cognitive treatmentBehavioral: standard smoking cessation therapy for TUD in group therapy setting. Patients who voluntarily submit to enter a qualified smoking cessation program will be examined in an out-patient setting at the Department of Addictive Behaviour and Addiction Medicine. They receive a six-week standard therapy (one 1,5 hours group therapy per week). Additional, the experimental group receives chess based cognitive remediation treatment (CB-CRT) for 1,5 hours three times a week. The tasks of the treatment were created by our cooperation partner, the psychologist Juan Antonio Montero. He is currently successfully applying this battery as an add-on therapy. The training battery is designed to strengthen cognitive functioning in specific domains such as short-term memory, focal attention, selective attention, pattern recognition, visuospatial abilities, metacognition and also inhibition.	Behavioural	CB-CRT TUD group
Standard therapy for TUDBehavioral: standard smoking cessation therapy for TUD in group therapy setting. Patients who voluntarily submit to enter a qualified smokind cessation program will be examined in an out-patient setting at the Department of Addictive Behaviour and Addiction Medicine. They receive a six-week standard therapy (one 1,5 hours group therapy per week). Additional, the experimental group receives chess based cognitive remediation treatment (CB-CRT) for 1,5 hours three times a week.	Behavioural	Control group TUD

Primary outcome

change in neural alcohol cue-reactivity
Time frame: 2 time points: before and after 6 weeks chess-based cognitive training
fMRI alcohol cue-reactivity task (Vollstädt-Klein et al. 2010)
change in neural tobacco cue-reactivity
Time frame: 2 time points: before and after 6 weeks chess-based cognitive training
fMRI tobacco cue-reactivity task (Vollstädt-Klein et al. 2011)
change in neural correlates of inhibition
Time frame: 2 time points: before and after 6 weeks chess-based cognitive training
fMRI stop-signal task (Whelan et al. 2012)
substance use (alcohol consumption and tabacco use)
Time frame: 3 months follow-up after the end of treatment
self-report
change in neural working memory processes
Time frame: 2 time points: before and after 6 weeks chess-based cognitive training
fMRI working memory task "N-back" (Charlet et al. 2014)
Change in working memory capacity
Time frame: 2 time points: before and after 6 weeks SCP
working memory capacity measured by letter-number sequencing task of the [Wechsler Memory Scale (Kent 2013)]; raw values will be transformed to IQ-like scales (mean 100, SD 15); the higher the value, the higher the working memory capacity
Change in impulsivity
Time frame: 3 time points: before and after 6 weeks SCP plus after 3 months
impulsivity measured with BIS scale [Barratt impulsiveness scale (Patton et al. 1995)];range 15-60; total score will be used; high values represent high impulsivity
Change in decision-making
Time frame: 2 time points: before and after 6 weeks SCP
[Iowa Gambling Task (Bechara et al. 1994)]
Change in mental flexibility
Time frame: 2 time points: before and after 6 weeks SCP
[Dimensional Change Card Sort (Zelazo et al. 2014)]
Change in attentional capacity
Time frame: 2 time points: before and after 6 weeks SCP
[d2 Test of Attention (Brickenkamp 2002)].

1 secondary outcome

change in functional connectivity within the salience network (SN) and executive control network (ECN)
Time frame: 2 time points: before and after 6 weeks therapy and chess-based cognitive training

Results and safety

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 29 Mar 2024.
Background: PubMed 15764467Adinoff B. Neurobiologic processes in drug reward and addiction. Harv Rev Psychiatry. 2004 Nov-Dec;12(6):305-20. doi: 10.1080/10673220490910844.
Background: PubMed 22820235Fauth-Buhler M, de Rover M, Rubia K, Garavan H, Abbott S, Clark L, Vollstadt-Klein S, Mann K, Schumann G, Robbins TW. Brain networks subserving fixed versus performance-adjusted delay stop trials in a stop signal task. Behav Brain Res. 2012 Nov 1;235(1):89-97. doi: 10.1016/j.bbr.2012.07.023. Epub 2012 Jul 20.
Results publication: PubMed 11493907Amidzic O, Riehle HJ, Fehr T, Wienbruch C, Elbert T. Pattern of focal gamma-bursts in chess players. Nature. 2001 Aug 9;412(6847):603. doi: 10.1038/35088119. No abstract available.
Results publication: PubMed 12589885Atherton M, Zhuang J, Bart WM, Hu X, He S. A functional MRI study of high-level cognition. I. The game of chess. Brain Res Cogn Brain Res. 2003 Mar;16(1):26-31. doi: 10.1016/s0926-6410(02)00207-0.
Results publication: PubMed 23412885Bates ME, Buckman JF, Nguyen TT. A role for cognitive rehabilitation in increasing the effectiveness of treatment for alcohol use disorders. Neuropsychol Rev. 2013 Mar;23(1):27-47. doi: 10.1007/s11065-013-9228-3. Epub 2013 Feb 15.
Results publication: PubMed 25911280Blasco-Fontecilla H, Gonzalez-Perez M, Garcia-Lopez R, Poza-Cano B, Perez-Moreno MR, de Leon-Martinez V, Otero-Perez J. Efficacy of chess training for the treatment of ADHD: A prospective, open label study. Rev Psiquiatr Salud Ment. 2016 Jan-Mar;9(1):13-21. doi: 10.1016/j.rpsm.2015.02.003. Epub 2015 Apr 22. English, Spanish.
Results publication: PubMed 18995990Demily C, Cavezian C, Desmurget M, Berquand-Merle M, Chambon V, Franck N. The game of chess enhances cognitive abilities in schizophrenia. Schizophr Res. 2009 Jan;107(1):112-3. doi: 10.1016/j.schres.2008.09.024. Epub 2008 Nov 7. No abstract available.
Results publication: PubMed 26793666Fattahi F, Geshani A, Jafari Z, Jalaie S, Salman Mahini M. Auditory memory function in expert chess players. Med J Islam Repub Iran. 2015 Oct 6;29:275. eCollection 2015.
Results publication: PubMed 24913200Goncalves PD, Ometto M, Bechara A, Malbergier A, Amaral R, Nicastri S, Martins PA, Beraldo L, dos Santos B, Fuentes D, Andrade AG, Busatto GF, Cunha PJ. Motivational interviewing combined with chess accelerates improvement in executive functions in cocaine dependent patients: a one-month prospective study. Drug Alcohol Depend. 2014 Aug 1;141:79-84. doi: 10.1016/j.drugalcdep.2014.05.006. Epub 2014 May 24.
Results publication: PubMed 8552313Onofrj M, Curatola L, Valentini G, Antonelli M, Thomas A, Fulgente T. Non-dominant dorsal-prefrontal activation during chess problem solution evidenced by single photon emission computerized tomography (SPECT). Neurosci Lett. 1995 Oct 6;198(3):169-72. doi: 10.1016/0304-3940(95)11985-6.
Results publication: PubMed 20670348Vollstadt-Klein S, Wichert S, Rabinstein J, Buhler M, Klein O, Ende G, Hermann D, Mann K. Initial, habitual and compulsive alcohol use is characterized by a shift of cue processing from ventral to dorsal striatum. Addiction. 2010 Oct;105(10):1741-9. doi: 10.1111/j.1360-0443.2010.03022.x.
Results publication: PubMed 28924006Lally N, Huys QJM, Eshel N, Faulkner P, Dayan P, Roiser JP. The Neural Basis of Aversive Pavlovian Guidance during Planning. J Neurosci. 2017 Oct 18;37(42):10215-10229. doi: 10.1523/JNEUROSCI.0085-17.2017. Epub 2017 Sep 18.
Individual participant dataSharing planned: Yes. For protection of personal rights, and due to the sensitivity of the clinical and neuroimaging data, data will not be made publicly available. Upon direct request by other researchers and in mutual agreements (e.g., regarding data protection), anonymized data can be made available. Upon request, analysis procedures and codes will be shared with other researchers.

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Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.

Sabine Vollstädt-Klein, Prof. Dr. principal investigator

Central Institute of Mental Health, Mannheim

1 site in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 8 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 29 Mar 2024. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Germany. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

change in neural alcohol cue-reactivity (time frame: 2 time points: before and after 6 weeks chess-based cognitive training). The study lists 10 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT04057534, which also lists 13 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Mar 2024.