Clinical trials: Circulation System
Amnesia, Dementia
Magnetic Resonance Imaging for the Study of Patients With Neurological Disorders
This study is divided into two parts. The first part of the study will use MRI technology to view the brain structure of patients with neurological disorders and normal volunteers.
- Conditions
- Amnesia, Dementia, Healthy, Nervous System Disease
- Trial name
- NCT00001362
- Where
- United States
- Volunteers
- 830 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Prediabetes, Brain Insulin Sensitivity
Long-term Effects of Avocado Consumption on Health in Pre-diabetic Individuals
Primary aim of the study is to assess the effect of 12-week daily avocado consumption on cerebral blood flow and markers of cardio- and vascular health in both, the periphery and the brain, in pre-diabetic individuals with…
- Conditions
- Prediabetes, Brain Insulin Sensitivity, Cerebral Blood Flow, Satiety and Food Intake
- Trial name
- NCT07752225
- Testing
- Avocados
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Maastricht University Medical Center
Bacteremia
T2 and SeptiCyte RAPID Duration Project
Infection with bacteria and other germs in the blood can be deadly. How long germs stay in the blood is important for two reasons.
- Trial name
- NCT04821661
- Where
- 3 sites in Australia
- Volunteers
- 102 people
- Sponsor
- The University of Queensland
Sarcopenia
Exercise Intermittent Isometric Handgrip and Blood Flow Restriction
Isometric handgrip exercises are used to explain the effects of fatigue on the strength and activation of the muscles involved. Blood flow available at the time of exercise can influence this fatigue process, as some studies…
- Trial name
- NCT02384161
- Testing
- Isometric exercise Intermittent
- Where
- Brazil
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Wound Healing Disturbance of Port-A
Using a Thermal Imaging System to Evaluate the Wound of Port-A and the Relationship Between Thermal Images and Infection
Permanently implantable venous ports (Port-A) is very important to patients receiving chemotherapy. It not only provides a reliable route to administrate intravenous drugs, and it also requires minimal care when it is not in use.
- Trial name
- NCT02072265
- Testing
- Infrared thermal images
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Cerebrovascular Disorders
HYPEROXIA Responses and ROS
30 participants (15 males and 15 females) who are ≥18 - ≤ 40 years old and considered healthy will be enrolled into this study to test the role of reactive oxygen species (ROS) in regulating cerebral blood flow (CBF).
- Trial name
- NCT05958303
- Testing
- Antioxidant Cocktail
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Orthostatic Hypotension
Research, Development, and Application of Intelligent Diagnostic System for Orthostatic Hypotension
Orthostatic hypotension (OH) has a high incidence rate of 30%-50% in the elderly and populations with neurodegenerative diseases.
- Trial name
- NCT07309666
- Testing
- Intelligent diagnostic system for orthostatic hypotension
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Idiopathic Membranous Nephropathy
Study on the Therapeutic Effect of TCM Treatment for MDR MN
To evaluate the effectiveness and safety of the Chinese medicine treatment for multiple drug resistance of MN patients with Jianpiyiqi and Huoxuejiedu Recipe.
- Trial name
- NCT02610595
- Testing
- Jianpixiaozhong particles and Wuse Dietotherapy
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Stroke, Acute
Blood Pressure Lowering in Acute Stroke Trial
The investigators hope to show that valsartan can be used safely in the setting of acute stroke to lower elevated blood pressure.
- Trial name
- BLAST (NCT01400256)
- Testing
- Valsartan
- Where
- United States
- Sponsor
- Stanford University
Sarcopenia, Lung Neoplasms
Construction and Effect Evaluation of the Low Load Blood Flow Restriction Training Program for Lung Cancer Patients Complicated With Sarcopenia During Chemotherapy
The goal of this clinical trial is to verify the effectiveness and safety of the low load blood flow restriction training program.
- Trial name
- NCT06347965
- Testing
- Low load blood flow restriction training, Progressive resistance training group
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Xin Wang
Allergy to Fish, Allergy
Anisakis Blastocystis Cryptosporidium Fish Serology
Anisakidae frequently infect fish species that are commonly eaten by humans. Some of them are recognized as zoonotic diseases agents, and have a high impact on human health.
- Conditions
- Allergy to Fish, Allergy, Anisakis
- Trial name
- ABCFish2 (NCT02666092)
- Testing
- Questionnaire, Detection of anti-Anisakis and anti-fish antibodies
- Where
- France
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Ocular Physiology, Optic Disk
Role of Endothelin- and Nitric Oxide-system in the Regulation of Optic Nerve Head Blood Flow During Changes in Ocular Perfusion Pressure
Autoregulation is the ability of a vascular bed to maintain blood flow despite changes in perfusion pressure. The existence of an effective autoregulation in the optic nerve circulation has been shown in animals and humans.
- Conditions
- Ocular Physiology, Optic Disk, Regional Blood Flow
- Trial name
- NCT00406731
- Testing
- NG-monomethyl-L-arginine (L-NMMA), Endothelin-1 (ET-1), Laser Doppler flowmetry
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Heart Disease, Vasodilation
Interaction of Apelin and Angiotensin in the Human Forearm Circulation
The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease.
- Trial name
- NCT00901745
- Testing
- Angiotensin II, Noradrenaline infusion
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Diabetes Mellitus, Type 1, Hypertension
Correlation of Flicker Induced and Flow Mediated Vasodilatation in Patients With Endothelial Dysfunction and Healthy Volunteers.
A couple of studies have shown that illuminating the eye with diffuse flickering light is accompanied by an increase of retinal vessel diameters, optic nerve head blood flow and retinal blood flow.
- Conditions
- Diabetes Mellitus, Type 1, Hypertension, Hypercholesterolemia, Regional Blood Flow
- Trial name
- NCT00432029
- Testing
- Forearm blood flow measurement, Flow mediated dilation (FMD), Zeiss Retinal Vessel Analyzer (RVA), Stimulation with Flicker-light
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Portal Hypertension
The Role of Somatostatin in the Hemodynamics of the Hepatic Circulation in Patients Undergoing Liver Resection
The purpose of the present clinical trial is to study the effect of somatostatin in the regulation of velocity and blood flow of the hepatic circulation in patients undergoing liver resection.
- Trial name
- NCT04010669
- Testing
- Somatostatin
- Volunteers
- 40 people
- Sponsor
- Laikο General Hospital, Athens
Ischemic Stroke
The Effect of Low Intensity With BFR on Stroke Patients
To compare the effects of low-intensity resistance training with blood flow restriction (BFR) versus traditional resistance training on lower limb isokinetic torque and dynamic balance in ischemic stroke survivors.
- Trial name
- NCT07292675
- Testing
- low-intensity resistance training with blood flow restriction, High intensity resistance training
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Delta University for Science and Technology
Coronary Artery Disease, High-risk Percutaneous Coronary Intervention
Early Feasibility Study of the Supira System in Patients Undergoing HRPCI
The objective of this study is to assess the feasibility and safety of the Supira System in providing temporary cardiovascular hemodynamic support in patients undergoing HRPCI.
- Conditions
- Coronary Artery Disease, High-risk Percutaneous Coronary Intervention, Interventional Cardiology
- Trial name
- NCT06087575
- Testing
- Supira System
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- Supira Medical
Alzheimer Disease, Dementia
Aerobic Exercise for Older Adults at Increased Risk of Alzheimer's Disease and Related Dementias
The estimated annual cost of dementia in Canada is $15 billion, with a projected cumulative economic burden of $800 billion by 2038.
- Trial name
- BIMII (NCT03035851)
- Testing
- Aerobic exercise, Stretch and Strength
- Where
- Canada
- Volunteers
- 264 people
- Sponsor
- University of Calgary
Spinal Cord Injury, Insulin Resistance
IR and Microvascular Blood Flow in SCI
Persons with spinal cord injury (SCI) are at an increased risk for metabolic disorders, including that of insulin resistance. As a result of neurological injury, they often have impaired mechanisms that regulate blood vessel…
- Trial name
- NCT02034331
- Testing
- Insulin iontophoresis, Acetylcholine Iontophoresis, Heat application
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Type 2 Diabetes Mellitus
A Clinical Study to Evaluate Renal Hemodynamic Responses to Aliskiren in Patients With Type 2 Diabetes Mellitus
The study objective was to assess the effect of single and multiple doses of aliskiren on renal plasma flow, glomerular filtration rate and to compare the effects of single and multiple doses of aliskiren versus captopril or…
- Trial name
- NCT00660309
- Testing
- Aliskiren, Irbesartan, Captopril
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Novartis