Ischemic StrokeNCT07292675
The Effect of Low Intensity With BFR on Stroke Patients
A study testing low-intensity resistance training with blood flow restriction and High intensity resistance training in people with Ischemic Stroke, run by Delta University for Science and Technology at 1 site in Egypt.
Trial summary
To compare the effects of low-intensity resistance training with blood flow restriction (BFR) versus traditional resistance training on lower limb isokinetic torque and dynamic balance in ischemic stroke survivors. Read more about this study
- Who is it for?
- Ages 30 to 50 years
- Conditions the study is for
- Ischemic Stroke
- What is being tested?
- low-intensity resistance training with blood flow restriction and High intensity resistance training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteEgypt
- Study dates
- 13 Jul 2025to 13 Sep 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 50 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- • First-ever ischemic stroke (3-12 months post-stroke)
- Aged 30-40 years
- Can walk independently or with an aid
- Medically stable and able to follow instructions
Who cannot join
- •Hemorrhagic stroke
- Deep vein thrombosis or peripheral vascular disease
- Orthopedic conditions affecting lower limb
- Severe cognitive impairment or uncontrolled hypertension
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Effect of Low Intensity Training With Blood Flow Restriction Versus Traditional Resistance Exercise on Lower Extermity Isokinetic Torque and Balance in Ischemic Stroke Patients
To compare the effects of low-intensity resistance training with blood flow restriction (BFR) versus traditional resistance training on lower limb isokinetic torque and dynamic balance in ischemic stroke survivors.
Read the detailed description
Ischemic stroke commonly results in reduced lower extremity muscle torque and impaired balance, affecting mobility and fall risk.
Traditional resistance training improves muscle function but may not be suitable for all patients due to the need for high mechanical loads.
Low-intensity resistance training with blood flow restriction (BFR) has emerged as an alternative that enhances muscular adaptation at lower loads. However, limited data exists on its effect on isokinetic torque and functional balance in stroke patients. This study aims to fill this gap using objective isokinetic measurements and validated balance scales.
- Conditions
- Ischemic Stroke
- Being tested
- low-intensity resistance training with blood flow restriction, High intensity resistance training
- Keywords
- BFR , Stroke
- Medical subject headings
- Ischemic Stroke, Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
low-intensity resistance training with blood flow restrictionOther
"Low-Intensity" BFR Means (for Quads)
It involves resistance 20-30% 1RM combined with partial arterial + full venous restriction using a cuff placed on the proximal thigh.
High intensity resistance trainingOther
High-intensity quadriceps training in stroke patients focuses on using 60-80% of 1RM to improve strength, motor unit recruitment, and functional mobility. Exercises such as loaded sit-to-stand, leg press, and step-ups are commonly used to target the quadriceps safely. Training intensity is guided by a perceived exertion of 7-9/10 while maintaining proper supervision to prevent falls. This approach enhances knee stability, gait efficiency, and overall functional independence.
| Study group | Role | What they receive |
|---|---|---|
| Study group | Experimental | Study group will receive low-intensity BFR resistance training Receives: Other: low-intensity resistance training with blood flow restriction |
| Control group | Active comparator | Control group will receive high intensity resistance training Receives: Other: High intensity resistance training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Isokinetic torque
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Dec 2025
- Study start13 Jul 2025
- Primary completion13 Sep 2025
- Study completion13 Sep 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Ischemic StrokeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Model description
- Groups: * Group A: Low-intensity BFR resistance training * Group B: Traditional resistance training
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 40 participants (actual)
Sponsor and investigators
- Lead sponsor
- Delta University for Science and Technology
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ibrahim Ahmed Ibrahim Abu Ella, Delta University for Science and Technology
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07292675
- Sponsor's protocol ID
- P.T.REC/012/005961
- Status last verified
- Jun 2025
- First submitted
- 6 Dec 2025
- Last updated
- 13 Aug 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 13 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Low Intensity Training With Blood Flow Restriction Versus Traditional Resistance Exercise on Lower Extermity Isokinetic Torque and Balance in Ischemic Stroke Patients
- ClinicalTrials.gov ID
- NCT07292675
- Acronym / sponsor ID
- P.T.REC/012/005961
- Conditions
- Ischemic Stroke
- Keywords
- BFR , Stroke
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 40 participants (actual)
- Lead sponsor
- Delta University for Science and TechnologyUniversity, hospital or other
- Study start
- 13 Jul 2025 (actual)
- Primary completion
- 13 Sep 2025 (actual)
- Study completion
- 13 Sep 2025 (actual)
- First posted
- 18 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To compare the effects of low-intensity resistance training with blood flow restriction (BFR) versus traditional resistance training on lower limb isokinetic torque and dynamic balance in ischemic stroke survivors.
Detailed description
Ischemic stroke commonly results in reduced lower extremity muscle torque and impaired balance, affecting mobility and fall risk.
Traditional resistance training improves muscle function but may not be suitable for all patients due to the need for high mechanical loads.
Low-intensity resistance training with blood flow restriction (BFR) has emerged as an alternative that enhances muscular adaptation at lower loads. However, limited data exists on its effect on isokinetic torque and functional balance in stroke patients. This study aims to fill this gap using objective isokinetic measurements and validated balance scales.
Study design
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
- Model description
- Groups: * Group A: Low-intensity BFR resistance training * Group B: Traditional resistance training
| Arm | Type | Receives |
|---|---|---|
| Study group | Experimental | Other: low-intensity resistance training with blood flow restrictionStudy group will receive low-intensity BFR resistance training |
| Control group | Active comparator | Other: High intensity resistance trainingControl group will receive high intensity resistance training |
Who may qualify
- Ages
- 30 to 50 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- • First-ever ischemic stroke (3-12 months post-stroke)
Key exclusion criteria (4 listed)
- •Hemorrhagic stroke
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| low-intensity resistance training with blood flow restriction"Low-Intensity" BFR Means (for Quads) It involves resistance 20-30% 1RM combined with partial arterial + full venous restriction using a cuff placed on the proximal thigh. | Other | Study group |
| High intensity resistance trainingHigh-intensity quadriceps training in stroke patients focuses on using 60-80% of 1RM to improve strength, motor unit recruitment, and functional mobility. Exercises such as loaded sit-to-stand, leg press, and step-ups are commonly used to target the quadriceps safely. Training intensity is guided by a perceived exertion of 7-9/10 while maintaining proper supervision to prevent falls. This approach enhances knee stability, gait efficiency, and overall functional independence. | Other | Control group |
Primary outcome
Isokinetic torque
Time frame: Baseline
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Aug 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing low-intensity resistance training with blood flow restriction and High intensity resistance training in people with Ischemic Stroke, run by Delta University for Science and Technology at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Isokinetic torque (time frame: Baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Aug 2026.