Clinical trials: Chronic Sinusitis With Nasal Polyps
Rhinosinusitis
Laser Assisted Treatment of Chronic Sinusitis With and Without Light Activated Agents
Chronic rhinosinusitis (CRS) is common disorder which affects up to 13% of the US population. CRS affects numerous Quality of Life (QOL) factors including smell, sleep and communication.
- Trial name
- NCT00948519
- Testing
- Laser + ICG, Laser only
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- New York Head & Neck Institute
Chronic Sinusitis, Nasal Polyps
A Clinical Study of TQC2731 Injection in the Treatment of Chronic Rhinosinusitis With Nasal Polyps
This is a multicenter, randomized, double-blind, placebo-controlled Phase II clinical trial to evaluate the efficacy, safety and pharmacokinetics of TQC2731 injection in the treatment of Chronic Sinusitis with Nasal Polyps.
- Trial name
- NCT06036927
- Testing
- TQC2731 injection
- Where
- 16 sites in China
- Volunteers
- 80 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Nasal Polyps, Sinusitis
Study to Compare Resection Versus Preservation of the Middle Turbinate in Surgery for Nasal Polyps
Endoscopic sinus surgery (ESS) has become the standard of care for patients suffering of chronic rhinosinusitis with nasal polyposis (CRSwP) who have failed medical therapy.
- Trial name
- NCT02855931
- Testing
- Middle turbinate resection
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Chronic Sinusitis, Nasal Polyps
Steroid-Releasing S8 Sinus Implant for Recurrent Nasal Polyps
The RESOLVE Study is a randomized controlled trial with the S8 Sinus Implant in 100 chronic sinusitis patients with recurrent nasal polyps.
- Trial name
- RESOLVE (NCT01732536)
- Testing
- S8 Sinus Implant, Mometasone furoate nasal spray
- Where
- 19 sites in United States
- Volunteers
- 100 people
- Sponsor
- Intersect ENT
Chronic Sinusitis, Nasal Polyposis
Safety Evaluation of Repeat Placement of the S8 Sinus Implant in Chronic Sinusitis Patients With Nasal Polyps (ENCORE)
The ENCORE Study is designed to evaluate the repeat administration of the S8 Sinus Implant in chronic sinusitis (CS) patients with recurrent nasal polyps.
- Trial name
- NCT03358329
- Testing
- S8 Sinus Implant
- Where
- 9 sites in United States
- Volunteers
- 50 people
- Sponsor
- Intersect ENT
Sinusitis, Nasal Polyps
A Study to Evaluate 611 in Patients With Chronic Rhinosinusitis With Nasal Polyps
This study will evaluate the effect and safety of 611 in patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)
- Trial name
- NCT06639295
- Testing
- 611
- Where
- China
- Volunteers
- 243 people
- Sponsor
- Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.
Chronic Rhinosinusitis With Nasal Polyps
A Study of GR1802 in Participants With Chronic Sinusitis With Nasal Polyps
The goal of this clinical trial is to learn if GR1802 works to treat severe chronic rhinosinusitis with nasal polyps (CRSwNP) in adults. It will also learn about the safety of GR1802. The main questions it aims to answer are: 1.
- Trial name
- NCT06516302
- Testing
- GR1802
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Genrix (Shanghai) Biopharmaceutical Co., Ltd.
Sinusitis, Chronic
Effect of Postoperative Additive Systemic Steroids in CRSwNP
This study investigate the additive effect of systemic postoperative steroids in patients with chronic rhinosinusitis (CRSwNP). All patients receive a functional endoscopic sinus surgery (FESS) followed by topical steroid spray…
- Trial name
- NCT04915456
- Testing
- Systemic Steroid (Prednisolone)
- Volunteers
- 106 people
- Sponsor
- Friedrich-Alexander-Universität Erlangen-Nürnberg
Sinusitis, Nasal Polyps
Pilot Study of The EPIC Trial
Chronic sinusitis is one of the most common chronic diseases in North America, with over 5% of the Canadian population affected by the disease. Until now, treatment with surgery has been performed only in the operating room.
- Trial name
- NCT02533206
- Testing
- Endoscopic Polypectomy Performed in Clinic, Functional Endoscopic Sinus Surgery (FESS)
- Where
- 5 sites in Canada
- Volunteers
- 20 people
- Sponsor
- Ottawa Hospital Research Institute
Chronic Sinusitis, Nasal Polyposis
FESS With or Without Intranasal Desmopressin in Chronic Rhinosinusitis With Nasal Polyps
Chronic rhinosinusitis with nasal polyps is a condition that causes long-lasting inflammation and swelling in the nose and sinuses and may lead to nasal blockage, nasal discharge, facial pressure, and reduced sense of smell.
- Trial name
- NCT07855315
- Testing
- Desmopressin Acetate Nasal, 10 μg/0.1 ml per spray, Functional Endoscopic Sinus Surgery
- Volunteers
- 174 people
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Chronic Rhinosinusitis With Nasal Polyps
Evaluation of Patient Satisfaction During Treatment With Dupilumab in Severe and Recurrent Nasosinusal Polyposis Despite Appropriate Medical and Surgical Treatment.
Chronic rhinosinusitis with nasal polyps (CRSwNP) or nasal polyposis is a frequent disease leading to a decreased quality of life.
- Trial name
- Dupi-PNS (NCT06017427)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 32 people
- Sponsor
- IHU Strasbourg
Chronic Sinusitis
Efficacy of Dupilumab for Patients With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)
The overarching objective of this study is to determine the clinical effectiveness of dupilumab for the treatment of CRS that includes several potential disease endotypes with the exclusion of the nasal polyp cluster that has…
- Trial name
- NCT04362501
- Testing
- dupilumab
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Johns Hopkins University
Rhinosinusitis, Chronic Polyposis
Buparid/PARI SINUS Versus Budes® Nasal Spray in the Therapy of Chronic Rhinosinusitis With Polyposis Nasi
The study should create data for the selection of a clinically relevant primary endpoint to assess the efficacy and safety of Buparid/PARI SINUS as compared to Budes Nasal Spray in the therapy of chronic rhinosinusitis (CRS) with…
- Trial name
- NCT01946711
- Testing
- Budesonide
- Where
- 4 sites in Germany
- Volunteers
- 14 people
- Sponsor
- Pari Pharma GmbH
Chronic Sinusitis
Roflumilust in Chronic Rhinosinusitis With Nasal Polyposis.
The current study will be a pilot study for a randomized controlled trial conducted on 60 patients recruited from the outpatient clinic of the Otorhinolaryngology Department, Menoufia Faculty of Medicine after approval of the…
- Trial name
- NCT05369039
- Testing
- Roflumilust, Prednisolone
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Menoufia University
Chronic Rhinosinusitis (Diagnosis)
Adrenaline Solution Irrigation and Bleeding During Sinus Surgery
Intranasal irrigation with normal saline is routinely used in sinus surgery to clean the tip of the nasal endoscope and clear the surgical field from blood.
- Trial name
- NCT04551703
- Testing
- Adrenaline saline irrigation
- Volunteers
- 60 people
- Sponsor
- Jordan University of Science and Technology
Chronic Sinusitis, Nasal Polyposis
The Efficacy of MEDIHONEY® for Chronic Rhinosinusitis With Nasal Polyposis After Functional Endoscopic Sinus Surgery
This study will assess the effectiveness of MEDIHONEY® sinus rinses (alone or in combination with intranasal corticosteroids) vs.
- Trial name
- NCT02562924
- Testing
- MEDIHONEY®, Budesonide, Normal saline sinus rinse
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Vermont Medical Center
Chronic Sinusitis, Endoscopic Sinus Surgery
The Effect of Modified Radical Endoscopic Sinus Surgery on Eosinopilic Chronic Rhinosinusitus With Nasal Polyps
Functional endoscopic sinus surgery (FESS) is the pimary surgical treatment of CRS, characterized with the preservation of nasal structure and function.But the control of disease by surgery has been unsatisfactory.
- Conditions
- Chronic Sinusitis, Endoscopic Sinus Surgery, Nasal Polyps
- Trial name
- EMRESSECRS (NCT04852562)
- Testing
- Modified radical endoscopic sinus surgery, functional endoscopic sinus surgery
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Zheng Liu
Disorder of Maxillary Sinus, Aspirin-sensitive Asthma With Nasal Polyps
The Role of Canine Fossa Trephination in the Severely Diseased Maxillary Sinus
The hypothesis of this study is that canine fossa trephination (CFT) improves surgical outcomes for patients with a severely diseased maxillary sinus.
- Conditions
- Disorder of Maxillary Sinus, Aspirin-sensitive Asthma With Nasal Polyps, Rhinosinusitis
- Trial name
- CFT (NCT01615536)
- Testing
- Canine fossa trephine technique, Standard Endoscopic Sinus Surgery
- Where
- Canada
- Sponsor
- IWitterick
Chronic Sinusitis
Vitamin D Supplementation in Chronic Rhinosinusitis With Nasal Polyps
The purpose of this study is to determine if Vitamin D supplementation improves clinical and immunologic parameters in chronic rhinosinusitis with nasal polyps.
- Trial name
- VDinCRS (NCT01185808)
- Testing
- Vitamin D
- Where
- United States
- Sponsor
- Medical University of South Carolina
Chronic Rhinosinusitis With Nasal Polyps
A Extension Clinical Study of TQC2731 Injection in the Treatment of Chronic Sinusitis With Nasal Polyps
This study aims to evaluate the efficacy and safety of TQC2731 injection in the treatment of chronic sinusitis with nasal polyps.
- Trial name
- NCT06451640
- Testing
- 210mg of TQC2731 injection, 420mg of TQC2731 injection
- Where
- 16 sites in China
- Volunteers
- 59 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.