Clinical trials: Chronic Obstructive Pulmonary Disease Exacerbation
COPD Exacerbation, COPD Exacerbation Acute
Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease
The STOP-COPD trial is a randomized, patient-blinded, prehospital clinical trial designed to evaluate the effect of titrated oxygen therapy compared to standard oxygen treatment in patients with suspected acute exacerbation of…
- Trial name
- STOP-COPD (NCT05703919)
- Testing
- Titrated Oxygen, Standard Oxygen
- Where
- Denmark
- Volunteers
- 1,888 people
- Sponsor
- Central Denmark Region
COPD (Chronic Obstructive Pulmonary Disease), Rhinovirus Infection
Using Multiomics to Define Mechanisms of Rhinovirus-induced Chronic Obstructive Pulmonary Disease Exacerbations to Develop Novel Therapies and Therapeutic Targets
The goal of this study is to examine exacerbations of chronic obstructive pulmonary disease (COPD) caused by a common cold virus called rhinovirus, to identify new treatments.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Rhinovirus Infection, Exacerbation of COPD
- Trial name
- MRVCOPD (NCT07112235)
- Testing
- Rhinovirus-A16
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Imperial College London
COPD
Effects of Lysozyme on Acute Exacerbation of Chronic Obstructive Pulmonary Disease : A Randomised Placebo-Controlled Study
The aim of this study is to assess the effectiveness in preventing exacerbation of 52 weeks lysozyme administration in patients with COPD.
- Trial name
- NCT01645800
- Testing
- Lysozyme hydrochloride
- Where
- 25 sites in Japan
- Volunteers
- 408 people
- Sponsor
- Eisai Co., Ltd.
Lung Cancer (Diagnosis), Chronic Obstructive Pulmonary Disease (COPD)
Muco-active Agent Use and Clinical Outcomes After Lung Cancer Diagnosis in Chronic Obstructive Pulmonary Disease
The Target Trial Emulation of Muco-active Agent Use and Clinical Outcomes After Lung Cancer Diagnosis Among Patients With Chronic Obstructive Pulmonary Disease (TAME-CLC) study is a retrospective observational cohort study using…
- Trial name
- TAME-CLC (NCT07712016)
- Testing
- Muco-active agents, No muco-active agent use
- Where
- 2 sites in South Korea
- Volunteers
- 27,000 people
- Sponsor
- Seoul National University
Chronic Obstructive Pulmonary Disease (COPD), Exacerbation Copd
Determinants of Lower Limb Muscle Atrophy Induced During an Hospitalization for Exacerbation of COPD
Chronic Obstructive Pulmonary Disease (COPD) is characterized by persistent airway obstruction and inflammatory response of the lungs and bronchi.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Exacerbation Copd, Muscle Atrophy
- Trial name
- AMI-EX-BPCO (NCT03153826)
- Testing
- Comparison of clinical and biological characteristics of patients
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Montpellier
Copd, Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The Individualized Accurate Diagnosis and Treatment of Chronic Objective Pulmonary Disease(COPD) Patients Based on Multidimensional Data
Chronic obstructive pulmonary disease (COPD) is known as progressive lung disease and the fourth leading cause of death worldwide.
- Trial name
- COPD (NCT04183530)
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
COPD Exacerbation Acute
Airway Inflammation, Small Airways Dysfunction, and Frequency of Exacerbations in COPD
Chronic Obstructive Pulmonary Disease (COPD) is a common, preventable, and treatable disease that is characterized by persistent respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities…
- Trial name
- NCT06040931
- Testing
- Bronchoscopy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mansoura University Hospital
Chronic Obstructive Pulmonary Disease
Compliance of Long-term Home Non-invasive Ventilation for Patients With Chronic Obstructive Pulmonary Disease
Background : Long-term home non-invasive ventilation (NIV) can be proposed as treatment for acute respiratory failure with severe alveolar hypoventilation.
- Trial name
- NCT04333901
- Where
- 8 sites in France
- Volunteers
- 25 people
- Sponsor
- Vivisol
Chronic Obstructive Pulmonary Disease
Two Different Dosages of Nebulized Steroid Versus Parenteral Steroid in the Management of COPD Exacerbations
Chronic obstructive pulmonary disease (COPD) is a common disease that has a chronic and progressive course. Patients with COPD may have exacerbations one to four times in a year.
- Trial name
- NCT01865500
- Testing
- Budesonide 4 mg, Budesonide 8 mg, Metil prednisolone
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ataturk University
COPD, Muscle Weakness
Feasibility of Strength Training in Patients Hospitalized Due to COPD
To examine the feasibility of progressive unilateral knee-extension strength training using ankle weight cuffs in patients hospitalized due to acute exacerbation in COPD
- Trial name
- NCT01981200
- Testing
- Resistance training in AECOPD
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Frederikssunds Hospital, Denmark
Acute Exacerbation of COPD, Lung Diseases
Antibiotic Stewardship in AECOPD Through CRP-Guided Management
Objectives: To determine whether CRP-guided antibiotic treatment for managing AECOPD in adult patients attending Emergency Departments leads to reduced antibiotic duration, without non-inferior COPD health status with usual care.
- Conditions
- Acute Exacerbation of COPD, Lung Diseases, Lung Diseases, Obstructive, Pulmonary Disease, Chronic Obstructive
- Trial name
- NCT05286918
- Testing
- The intervention (CRP-guided) group
- Where
- Hong Kong
- Volunteers
- 1,184 people
- Sponsor
- The University of Hong Kong
Asthma
Mechanism(s) of Airflow Limitation During Exacerbation of Asthma
The purpose of this study is to evaluate the site and mechanisms responsible for expiratory airflow limitation in chronic, treated, non-smoking, stable asthmatics with moderate to severe persistent expiratory airflow obstruction.
- Trial name
- NCT01225913
- Testing
- fluticasone/salmeterol in all asthmatics, budesonide/formoterol or fluticasone/salmeterol in all asthmatics
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Gelb, Arthur F., M.D.
Chronic Obstructive Pulmonary Disease
BACE Trial Substudy 1 - PROactive Substudy
A first sub-analysis of the BACE trial will address physical activity levels in a subgroup of the intervention study with portable validated activity monitors.
- Trial name
- PROactive (NCT02205242)
- Testing
- Azithromycin, Dynaport®
- Where
- 6 sites in Belgium
- Volunteers
- 60 people
- Sponsor
- Wim Janssens
Pulmonary Disease, Chronic Obstructive
ICS/LABA Adherence and COPD Exacerbation
The purpose of this retrospective, non-interventional sutdy is to compare the effectiveness of ICS/LABA combination therapy in the reduction of COPD exacerbations during the 12 months after initiation of therapy between COPD…
- Trial name
- NCT02446041
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
Transcutaneous Electrical Muscle Stimulation In Chronic Obstructive Pulmonary Disease (COPD)
Transcutaneous electrical muscle stimulation (TCEMS) is well established intervention for rehabilitation of clinically stable patients with chronic obstructive pulmonary disease.
- Trial name
- NCT01226342
- Testing
- Transcutaneous electrical muscle stimulation
- Where
- Slovenia
- Volunteers
- 19 people
- Sponsor
- The University Clinic of Pulmonary and Allergic Diseases Golnik
COPD
Predicting Exacerbation of COPD With Wireless Telemonitoring
This is an open-label single-center 6-month prospective clinical trial predicting exacerbation of COPD with wireless telemonitoring of respiratory rate, heart rate and sleep in patients admitted to the pulmonary ward of the Turku…
- Trial name
- NCT02791451
- Testing
- telemonitoring
- Volunteers
- 6 people
- Sponsor
- Turku University Hospital
COPD
High Flow Nasal Cannula and Hypercapnia
In the present investigation, in 50 COPD with persistent hypercapnia after an acute exacerbation, the investigators want to assess the acceptability of HFNC and its effectiveness in further reducing the level of PaCO2, and to…
- Trial name
- NCT03759457
- Testing
- High Flow Nasal Cannula (AIRVO2)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Pulmonary Disease, Chronic Obstructive, Acute Exacerbation
Effects of Traditional Chinese Medicine on AECOPD Patients
This is a multi-center, randomized, double-blind, controlled trial to compare the efficacy of two therapies for patients with AECOPD.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Acute Exacerbation, Medicine, Chinese Traditional
- Trial name
- NCT03428412
- Testing
- TCM and conventional drug
- Volunteers
- 378 people
- Sponsor
- Henan University of Traditional Chinese Medicine
COPD (Chronic Obstructive Pulmonary Disease)
The Effectiveness of Tele-pulmonary Rehabilitation Program on People With Chronic Obstructive Pulmonary Disease (COPD) After Hospitalization for Acute Exacerbation
Introduction: There are great impacts of chronic obstructive pulmonary disease (COPD) over healthcare and economic systems globally.
- Trial name
- NCT07762157
- Testing
- Tele-pulmonary rehabilitation
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- North District Hospital
Chronic Bronchitis
A Trial To Evaluate Two Antibiotics For The Treatment Of Acute Exacerbation Of Chronic Bronchitis (AECB)
This trial is a research drug study to compare the effects of two antibiotics for the treatment of acute exacerbation of chronic bronchitis
- Trial name
- NCT00254566
- Testing
- Moxifloxacin, Azithromycin SR
- Where
- 34 sites in China, Malaysia and 4 more
- Volunteers
- 398 people
- Sponsor
- Pfizer