Clinical trials: Chronic Low Back Pain (CLBP), active
Overweight or Obesity, Chronic Low-back Pain
Lifestyle Intervention in Overweight/Obese Chronic Low Back Pain (CLBP) Patients: an International Multi-center RCT
Chronic low back pain (CLBP) is the most expensive cause of workrelated disability: it causes the highest number of years lived with disability.
- Trial name
- BO2WL (NCT05811624)
- Testing
- Physiotherapy intervention, including behavioral weight reduction program combined with pain neuroscience education and cognition-targeted exercise therapy., Physiotherapy intervention, including pain neuroscience education and cognition-targeted exercise therapy alone.
- Where
- 2 sites in Belgium, Switzerland
- Volunteers
- 252 people
- Sponsor
- Vrije Universiteit Brussel
Low Back Pain, Chronic Low-back Pain (cLBP)
Virtual Tai Chi for Chronic Low Back Pain (Spine 2027)
This study tests whether a virtually delivered integrated tai chi, qigong, and meditation program, added to usual care, improves chronic low back pain, disability, quality of life, and healthcare costs compared with usual care…
- Trial name
- NCT07772154
- Testing
- Virtually Delivered Integrated Tai Chi, Qigong, and Meditation (VDTQM)
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- New York Medical College
Chronic Low-back Pain (cLBP)
Melatonin for Patients With Chronic Low Back Pain
Low back pain is one of the conditions causing more disability worldwide. The use of pain medications is substantial in patients with chronic LBP. But the efficacy of commonly used analgesics is modest.
- Trial name
- MELBACK (NCT06859957)
- Testing
- Melatonin 10 mg
- Where
- Netherlands
- Volunteers
- 222 people
- Sponsor
- Bart Koes
Chronic Low-back Pain (cLBP)
Effects of Vertebral Axial Loading Walking Combined With Core Stabilization Exercises in Individuals With Chronic Low Back Pain
Chronic low back pain is a common musculoskeletal condition persisting for more than three months and is associated with pain, functional limitations, impaired balance, altered proprioception, reduced trunk muscle performance…
- Trial name
- NCT07334782
- Testing
- Exercise - Core Stabilization Exercise Program, Core Stabilization Exercises Plus Vertebral Axial Loading Walking Training
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Hacettepe University
Chronic Low Back Pain (CLBP), Low Back Pain
Chronic Low Back Pain and Osteopathic Manipulation Treatment
The goal of this clinical trial is to learn if adding Osteopathic Manipulative Therapy (OMT) to the usual medical care provided at the VA (usual VA care) improves treatment outcomes in individuals with chronic low back pain…
- Trial name
- NCT07161661
- Testing
- Usual VA Care, Osteopathic manipulative treatment
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Edward Hines Jr. VA Hospital
Chronic Low Back Pain (CLBP), Sacroiliac Joint Dysfunction
Connective Tissue Dry Needling for Low Back Pain Related to Local Posterior Superior Iliac Spine Pain
This single-blind randomized controlled trial will aim to determine the effectiveness of a connective tissue dry needling (CTDN) technique, in reducing pain and improving function in individuals with chronic mechanical low back…
- Conditions
- Chronic Low Back Pain (CLBP), Sacroiliac Joint Dysfunction, Mechanical Low Back Pain
- Trial name
- NCT07345871
- Testing
- Connective tissue dry needling, Exercise therapy
- Volunteers
- 42 people
- Sponsor
- University of Social Welfare and Rehabilitation Science
Chronic Low Back Pain (CLBP)
A Superiority Trial of Radiofrequency Ablation for Low Back Pain
The purpose of the ASTRAL Study is to evaluate the effectiveness of LRFA (Lumbar radiofrequency ablation) against a control procedure.
- Trial name
- ASTRAL (NCT07222462)
- Testing
- Lumbar radiofrequency ablation with conventional electrodes (LRFA-C), Lumbar radiofrequency ablation with multi-tined electrodes (LRFA-M), Simulated lumbar radiofrequency ablation
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Washington
Chronic Low-back Pain (cLBP), Myofacial Pain
Treatment Validation for Myofascial Pain
The goal of this clinical trial is to see if a body test called the NUN biomarker can track changes in chronic low back pain after dry needling and predict who will feel better.
- Trial name
- NCT07133139
- Testing
- Dry Needling, NUN Biomarker
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Ajay Wasan, MD, Msc
Chronic Low Back Pain (CLBP)
Comparison Between Lumbar Stabilization Exercises and Lumbar Manipulation on Multifidus Muscle in Chronic Low Back Pain This Study Will Investigate and Compare the Effect of Lumbar Stabilization Exercises and Manipulation on Multifidus Muscle in Chronic Low Back Pain
Histological and morphological changes of multifidus muscle have been reported in lumbar disc herniation (LDH), but there is scarce research comparing the efficacy of different treatment programs that can correct multifidus…
- Trial name
- NCT06796023
- Testing
- Stretching and strengthening exercises for back muscles, Lumbar stabilization Exercises, Lumbar Manipulation
- Volunteers
- 60 people
- Sponsor
- Cairo University
Chronic Pain, Chronic Back Pain
Virtual Reality Treatment for Adults With Chronic Back Pain (VRNT)
Participants with chronic back pain will complete an online Qualtrics eligibility survey. After signing a consent form, eligible participants enter a two-week baseline period ("Baseline Period"), during which they complete two…
- Conditions
- Chronic Pain, Chronic Back Pain, Chronic Lower Back Pain (CLBP)
- Trial name
- NCT07033195
- Testing
- Skills-based Virtual Reality Therapy, Distraction-based Virtual Reality Therapy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- CognifiSense Inc.
Chronic Low-back Pain
DBS of the SCC for the Treatment of Medically Refractory CLBP
The purpose of this study is to evaluate the feasibility and preliminary efficacy of deep brain stimulation of the subgenual cingulate cortex for the treatment of chronic medically-refractory low back pain using a randomized…
- Trial name
- NCT04085406
- Testing
- Deep Brain Stimulation of the Subgenus Cingulate Cortex
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- University of California, Los Angeles
Chronic Low Back Pain (CLBP)
Clinical Research on the Comparative Effectiveness and Safety of JHG002 Therapy for Chronic Low Back Pain: A Multicenter Randomized Controlled Trial
A multicenter randomized controlled trial
- Trial name
- NCT07304076
- Testing
- Hominis placental pharmacopuncture, Tanscutaneous electrical nerve stimulation (TENS)
- Where
- 4 sites in South Korea
- Volunteers
- 96 people
- Sponsor
- Jaseng Medical Foundation
Chronic Lower Back Pain (CLBP)
Mechanistic Evaluation of Polypharmacy Effects for Pain
This is a single-group, within-subject, double-blind, double-dummy, placebo-controlled study evaluating whether gabapentin (Neurontin) changes the analgesic, safety, and subjective effects of the opioid hydromorphone (Dilaudid)…
- Trial name
- PAT (NCT07846020)
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Maryland, Baltimore
Chronic Low Back Pain (CLBP), Acute Low Back Pain
Multimodal Imaging and Biospecimen Collection for Low Back Pain (LBPB)
This prospective cohort study investigates the neurobiological, genetic, and psychosocial mechanisms underlying acute and chronic low back pain (LBP).
- Conditions
- Chronic Low Back Pain (CLBP), Acute Low Back Pain, Low Back Pain, Chronic Pain
- Trial name
- LBPB (NCT06967363)
- Testing
- Nerve Block, endoscopic spinal disecetomy, Medication
- Where
- 2 sites in China
- Volunteers
- 360 people
- Sponsor
- Peking University Third Hospital
Chronic Low Back Pain (CLBP)
SENECA - Smart Therapies for Chronic Pain
This will be a randomized controlled prospective pilot study: The feasibility and usability of VIVO 2nd GEN therapy + Standard-of-Care (SoC) vs. Standard-of-Care alone will be evaluated.
- Trial name
- SENECA (NCT07628179)
- Testing
- VIVO 2nd GEN, Standard-of-Care Multimodal Pain Therapy
- Where
- Austria
- Volunteers
- 44 people
- Sponsor
- Aurimod GmbH
Chronic Low-back Pain (cLBP), Non Specific Chronic Low Back Pain
TECAR Therapy in Chronic Back Pain
The goal of this clinical trial is to learn whether adding high-intensity electromyostimulation (Hi-EMS) to capacitive and resistive electric transfer (TECAR) therapy improves pain and functional performance in adults with…
- Trial name
- NCT07821021
- Testing
- TECAR Therapy plus Hi-EMS, Tecar therapy alone
- Volunteers
- 37 people
- Sponsor
- University of Hartford
Nonspecific Low Back Pain, Low Back Pain
A Novel Treatment for Chronic Low Back Pain Using Multi Angular Isometric Lumbar Exercise: Randomized Clinical Trial.
The study aims to evaluate the effectiveness of Multi Angular Isometric Lumbar Exercise (MAILE) in comparison to traditional lumbar stabilization and core stability treatments for managing nonspecific chronic low back pain…
- Conditions
- Nonspecific Low Back Pain, Low Back Pain, Chronic Low-back Pain (cLBP)
- Trial name
- MAILE (NCT07908693)
- Testing
- MAILE (Multi Angular Isometric Exercise)
- Where
- Qatar
- Volunteers
- 98 people
- Sponsor
- Hamad Medical Corporation
Chronic Low-back Pain (cLBP), High-Impact Chronic Pain (HICP)
Comparing Non-Medicine Strategies for Improving Low Back Pain
The goal of this clinical trial is to help veterans manage high-impact chronic pain (HICP) in the lower back. The trial will use a program, ENCompaSS (Education, Navigated Care, and Supported Self-Management) designed to reduce…
- Trial name
- NCT07679178
- Testing
- ENCompaSS (Education, Navigated Care, and Supported Self-Management) with VA Stepped Usual Care
- Where
- United States
- Volunteers
- 530 people
- Sponsor
- Duke University
Low Back Pain, Kinesiophobia (Fear of Movement)
Impact of the Receptive Music Intervention Tool (MUSIC CARE©) on Changes in the Functional Abilities of Patients With Chronic Low Back Pain
Brief Summary The goal of this clinical trial is to learn if MUSIC CARE©, a music-based therapy tool, can improve the physical abilities of people with chronic low back pain (back pain that lasts more than 3 months).
- Conditions
- Low Back Pain, Kinesiophobia (Fear of Movement), Chronic Low-back Pain (cLBP)
- Trial name
- LOMBALZIC' (NCT07731204)
- Testing
- Receptive Music Therapy
- Where
- France
- Volunteers
- 34 people
- Sponsor
- LNA SANTE
Chronic Low Back Pain (CLBP)
Empowering Pain Psychology Access and Collaboration (EPPAC) to Improve Treatment Engagement Among Medicaid-insured Adults With Chronic Low Back Pain
Chronic low back pain (cLBP) is a leading cause of disability, with socioeconomically disadvantaged populations experiencing worse outcomes and lower rates of treatment initiation for evidence-based pain psychology services.
- Trial name
- NCT07843706
- Testing
- Empowering Pain Psychology Access and Collaboration (EPPAC), Usual Care Pain Psychology Evaluation
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Johns Hopkins University