Clinical trials: Chronic Low Back Pain (CLBP)
Chronic Low-back Pain (cLBP)
Core Muscle Training in Patients With Chronic Mechanical Low Back Pain
The goal of this study is to train core muscles in patients with chronic low back pain, the researchers will compar between the effect of suspension exercise core muscle training and pressure biofeed back core muscle training
- Trial name
- NCT07448766
- Testing
- suspension execises, pressure biofeedback training, advices
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Cairo University
Chronic Low Back Pain (CLBP)
Empowering Pain Psychology Access and Collaboration (EPPAC) to Improve Treatment Engagement Among Medicaid-insured Adults With Chronic Low Back Pain
Chronic low back pain (cLBP) is a leading cause of disability, with socioeconomically disadvantaged populations experiencing worse outcomes and lower rates of treatment initiation for evidence-based pain psychology services.
- Trial name
- NCT07843706
- Testing
- Empowering Pain Psychology Access and Collaboration (EPPAC), Usual Care Pain Psychology Evaluation
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Johns Hopkins University
Acute Low Back Pain, Chronic Low Back Pain (CLBP)
Exploring Multidimensional Trajectories in People With Low Back Pain
Low back pain (LBP) is a major health problem in Switzerland and worldwide. Globally, LBP remains the leading cause of years lived with disability and its incidence and associated socioeconomic consequences are predicted to…
- Trial name
- NCT07176845
- Testing
- Observational
- Where
- Switzerland
- Volunteers
- 600 people
- Sponsor
- Bern University of Applied Sciences
Chronic Low Back Pain (CLBP), Nociplastic Pain
PRT for Chronic Low Back Pain
The goal of this clinical trial is to learn whether Pain Reprocessing Therapy (PRT) is a feasible and acceptable treatment to complete for working-age adults (ages 18-65) with chronic low back pain.
- Trial name
- NCT07696741
- Testing
- Pain Reprocessing Therapy, Monitoring and Education
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Chronic Low-back Pain (cLBP)
Therapeutic Exercise Plus Pain Neuroscience Education for Chronic Low Back Pain
### What is this study about? This study looked at whether adding pain neuroscience education (PNE) to standard therapeutic exercise helps people with chronic low back pain who are afraid of moving (a condition called…
- Trial name
- NCT07856992
- Testing
- Therapeutic exercise, Pain Neuroscience Education
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Qingdao Municipal Hospital
Chronic Low-back Pain (cLBP), Myofacial Pain
Treatment Validation for Myofascial Pain
The goal of this clinical trial is to see if a body test called the NUN biomarker can track changes in chronic low back pain after dry needling and predict who will feel better.
- Trial name
- NCT07133139
- Testing
- Dry Needling, NUN Biomarker
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Ajay Wasan, MD, Msc
Chronic Low-back Pain (cLBP)
Pain Assessment Through Integrated Neurophysiology and Multidimensional Profiling
This observational case-control study aims to investigate the central neurophysiological mechanisms underlying non-specific chronic low back pain (CLBP) with neural mechanosensitivity, with wearable Optically Pumped Magnetometers…
- Trial name
- PAIN-MAP (NCT07846163)
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Obesity, Overweight
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain
The main purpose of this study is to evaluate the efficacy and safety of retatrutide in relieving chronic low back pain in participants who have obesity or overweight. Participation in the study will last about 80 weeks.
- Conditions
- Obesity, Overweight, Chronic Low Back Pain (CLBP)
- Trial name
- TRIUMPH-7 (NCT07035093)
- Testing
- Retatrutide
- Where
- 40 sites in United States, Argentina and 2 more
- Volunteers
- 586 people
- Sponsor
- Eli Lilly and Company
Chronic Low Back Pain, Chronic Low Back Pain (CLBP)
Bowen Therapy and McGill Stabilization Exercises in Chronic Low Back Pain
This randomized controlled trial aims to compare the effectiveness of Bowen Therapy combined with McGill stabilization exercises versus Bowen Therapy alone in individuals with chronic nonspecific low back pain.
- Trial name
- NCT07694219
- Testing
- Bowen Therapy + McGill Stabilization Exercise, Bowen Therapy
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Sehat Medical Complex
Chronic Low-back Pain (cLBP)
Pain Science Education and Graded Exposure for Chronic Low Back Pain
Chronic low back pain can affect daily activities and may be influenced by how people understand pain, their fear of movement, and their responses to stressful or uncertain physical activities.
- Trial name
- PSE-GEM (NCT07836946)
- Testing
- Pain Science Education Plus Graded Exposure, Usual Physical Therapy
- Volunteers
- 82 people
- Sponsor
- University of Chile
Low Back Pain, Recurrent, Chronic Low Back Pain (CLBP)
Magnetic Resonance Elastography Of Chronic Low Back Pain Before And After Therapy
The purpose of this study is to quantify Magnetic Resonance Elastography (MRE)-derived mechanical property biomarkers of the lumbar paraspinal musculature and associated myofascial tissue regions before and after the intervention.
- Trial name
- NCT07712458
- Testing
- EMMA (Expert Manipulative Massage Automation)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Mayo Clinic
Chronic Low-back Pain (cLBP), Non Specific Chronic Low Back Pain
TECAR Therapy in Chronic Back Pain
The goal of this clinical trial is to learn whether adding high-intensity electromyostimulation (Hi-EMS) to capacitive and resistive electric transfer (TECAR) therapy improves pain and functional performance in adults with…
- Trial name
- NCT07821021
- Testing
- TECAR Therapy plus Hi-EMS, Tecar therapy alone
- Volunteers
- 37 people
- Sponsor
- University of Hartford
MSK Conditions, Chronic Low Back Pain (CLBP)
Efficacy of Antibiotic Treatment for Patients With Chronic Low Back Pain and Modic Type I Changes - Randomized Placebo-controlled Trial
The goal of this clinical trial is to learn if antibiotics (amoxicillin) work to treat chronic low back pain in adults. In some patients, this type of back pain may be caused by bacteria in the vertebrae, resulting in a condition…
- Conditions
- MSK Conditions, Chronic Low Back Pain (CLBP), Modic Changes
- Trial name
- ABBA (NCT06771492)
- Testing
- Amoxicillin
- Where
- Netherlands
- Volunteers
- 144 people
- Sponsor
- Bart Koes
Chronic Low Back Pain (cLBP)
Integration of Virtual Reality and Traditional Acupuncture: From Education to Clinical Practice.
This research project aims to develop and validate whether a "VR-assisted traditional acupuncture therapy model" provides superior pain relief and functional improvement compared to acupuncture alone.
- Trial name
- NCT07816796
- Testing
- VR-Assisted Acupuncture Group, Traditional Acupuncture Group, Conventional Care / Outcome Assessment Only
- Volunteers
- 90 people
- Sponsor
- China Medical University Hospital
Chronic Low-back Pain (cLBP)
Melatonin for Patients With Chronic Low Back Pain
Low back pain is one of the conditions causing more disability worldwide. The use of pain medications is substantial in patients with chronic LBP. But the efficacy of commonly used analgesics is modest.
- Trial name
- MELBACK (NCT06859957)
- Testing
- Melatonin 10 mg
- Where
- Netherlands
- Volunteers
- 222 people
- Sponsor
- Bart Koes
Chronic Low Back Pain (CLBP)
Comparative Study on SNAG From Different Positions Low Back Pain Treatment
Objectives: To compare the effects of lumbar sustained natural apophyseal glides (SNAGs) applied in loaded versus unloaded positions on pain, disability, and function in individuals with chronic nonspecific LBP.
- Trial name
- NCT07215286
- Testing
- Loaded-SNAG, Unloaded-SNAG
- Where
- Saudi Arabia
- Volunteers
- 59 people
- Sponsor
- University of Hail
Chronic Low Back Pain (CLBP)
Study of Correlation Between Serum BDNF Levels and Pfirmann Grading and IL- 1β
Brain-derived neurotrophic factor (BDNF) is a protein belonging to the neurotrophin family, known to be involved in neuronal survival, growth, and synaptic plasticity.
- Trial name
- NCT07807839
- Testing
- blood sampling for ELISA
- Where
- South Korea
- Volunteers
- 59 people
- Sponsor
- Keimyung University Dongsan Medical Center
Chronic Low Back Pain (CLBP)
SENECA - Smart Therapies for Chronic Pain
This will be a randomized controlled prospective pilot study: The feasibility and usability of VIVO 2nd GEN therapy + Standard-of-Care (SoC) vs. Standard-of-Care alone will be evaluated.
- Trial name
- SENECA (NCT07628179)
- Testing
- VIVO 2nd GEN, Standard-of-Care Multimodal Pain Therapy
- Where
- Austria
- Volunteers
- 44 people
- Sponsor
- Aurimod GmbH
Chronic Low Back Pain (CLBP), Physical Therapy
Psilocybin-Assisted Physical Therapy in Chronic Low Back Pain
The purpose of this research study is to investigate whether a single administration of psilocybin can improve interoceptive awareness (awareness of bodily sensations) in individuals with chronic low back pain undergoing physical…
- Conditions
- Chronic Low Back Pain (CLBP), Physical Therapy, Psilocybin
- Trial name
- NCT07306364
- Testing
- Psilocybin 10 mg, Psilocybin 25 mg, Niacin 100 mg
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Yale University
Chronic Low Back Pain (CLBP)
Neuroimmune Responses to Exercise in Chronic Back Pain
The goal of this mechanistic clinical trial is to learn how physical exercise affects the body and brain in people with chronic low back pain.
- Trial name
- eCLBP (NCT07497425)
- Testing
- Physical Exercise
- Where
- Canada
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- McGill University