Clinical trials: Chronic Coronary Occlusion
Atherosclerotic Cardiovascular Disease, Heart Failure
Focus on Levels of Awareness and Perceptions Regarding hsCRP in Identifying Systemic Inflammation in ASCVD, CKD and Heart Failure Management
This is a survey-based study conducted among cardiologists and nephrologists treating people with Atherosclerotic Cardiovascular Disease (ASCVD), Heart Failure (HF) and Chronic Kidney Disease (CKD).
- Conditions
- Atherosclerotic Cardiovascular Disease, Heart Failure, Chronic Kidney Disease
- Trial name
- FLARE (NCT07160829)
- Testing
- No treatment given
- Where
- 4 sites in Australia, India and 2 more
- Volunteers
- 608 people
- Sponsor
- Novo Nordisk A/S
Coronary Arteriosclerosis
P2Y12 Inhibitors Utilization in Bifurcation and Chronic Total Occlusion PCI
Prasugrel and ticagrelor were both associated with a significant reduction in the risk of MACE in patients undergoing PCI for an ACS, mostly through a reduced stent thrombosis.
- Trial name
- P2BiTO (NCT01967615)
- Volunteers
- 4,500 people
- Sponsor
- G. d'Annunzio University
Percutaneous Coronary Revascularisation, Complex Coronary Lesion
Use of Physiology to Evaluate Procedural Result After PCI CTO
ULTRA-CTO is a prospective multicentre non-randomised investigator-initiated trial designed to enrol 200 subjects with an indication for percutaneous coronary intervention (PCI) of chronic total occluded (CTO) coronary artery.
- Trial name
- ULTRA-CTO (NCT04780971)
- Testing
- post-PCI Pd/Pa
- Where
- 2 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- Isala
Chronic Total Occlusion of Coronary Artery
Evaluating the Use of the CapBuster System for the Crossing of CTO's in Coronary Arteries
Evaluate the safety and effectiveness of the CapBuster System medical device in crossing de novo or restenotic chronic total occlusions in coronary arteries
- Trial name
- NCT05733481
- Testing
- CapBuster System Medical Device for the Crossing of Chronic Total Occlusions in Coronary Arteries
- Volunteers
- 26 people
- Sponsor
- Praxis Medical Devices Ltd
Coronary Artery Disease, Coronary Occlusion
Safety and Efficacy of Drug-Coated Balloon Angioplasty for the Treatment of Chronic Total Occlusions
The purpose of this study is to investigate the safety and efficacy of drug-coated balloon angioplasty for the treatment of chronic total occlusions patients with chronic total occlusion (CTO) lesion.
- Conditions
- Coronary Artery Disease, Coronary Occlusion, Percutaneous Coronary Intervention, Chronic Total Occlusion of Coronary Artery
- Trial name
- NCT04744571
- Testing
- aspirin, betaloc, atorvastatin, rosuvastatin, clopidogrel, ticagrelor, coronary wires. or coronary balloons, drug-coated balloon
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Anzhen Hospital
Angina Pectoris, Coronary Artery Disease
A Study on the Effects of Ranolazine on Exercise Duration in Subjects With Chronic Stable Angina and Coronary Artery Disease (CAD) With Type 2 Diabetes Mellitus (T2DM)
This study will evaluate the efficacy of ranolazine compared to placebo on duration of exercise assessed by exercise tolerance testing (ETT) at anticipated peak ranolazine plasma concentration after 12 weeks of treatment in…
- Conditions
- Angina Pectoris, Coronary Artery Disease, Type 2 Diabetes Mellitus
- Trial name
- NCT01334203
- Testing
- Ranolazine
- Sponsor
- Gilead Sciences
Coronary Artery Disease
A Trial to Evaluate Efficacy of Heart-protecting Musk Pill
Title: A randomized, double-blind, multi-centered, placebo-controlled trial to examine effects of of Heart-protecting Musk Pill on clinical outcomes in patients with chronic stable coronary artery disease Objective: To examine…
- Trial name
- NCT01897805
- Testing
- Heart-protecting Musk Pill
- Where
- 98 sites in China
- Volunteers
- 2,700 people
- Sponsor
- Shanghai Hutchison Pharmaceuticals Limited
Coronary Artery Disease, Congestive Heart Failure
Prognostic Indicators as Provided by the EPIC ClearView
The objective of this study is to determine whether the finger tip images captured by the EPIC ClearView device, when analyzed via the ClearView software, produce a Response Scale that characterizes trends consistent with known…
- Conditions
- Coronary Artery Disease, Congestive Heart Failure, Valvular Heart Disease, Atrial Fibrillation
- Trial name
- GBMC (NCT01476995)
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Epic Research & Diagnostics, Inc.
Erector Spinae Plane Block, Pain Control
Intravenous(IV) vs. Erector Spinae Plane Blocks in Cardiac Surgery
Interfascial plane blocks have been developed for analgesia, among which the erector spinae plane (ESP) has gained popularity. The ESP block has been hypothesized to provide truncal analgesia by spread of local anesthetic into…
- Conditions
- Erector Spinae Plane Block, Pain Control, Post-Operative Pain, Chronic
- Trial name
- NCT04995497
- Testing
- Intravenous Administration of Lidocaine Post Cardiac Surgery, Administration of Lidocaine Post Cardiac Surgery via ESP Catheter
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Archit Sharma
Cardiovascular Diseases, Heart Diseases
The Jackson Heart Study of Cardiovascular Disease Among African Americans
This is a prospective study of the environmental and genetic factors that influence the development of cardiovascular disease (CVD) in African American adults.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Coronary Disease
- Trial name
- JHS (NCT00005485)
- Where
- United States
- Volunteers
- 5,306 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
68Ga-NODAGA-RGD PET in Patients With an Occluded Coronary Artery
Background: In patients with coronary artery disease, acute or chronic coronary artery occlusion is associated with various degrees of ischemic myocardial injury and left ventricle dysfunction.
- Trial name
- RGDHeart (NCT04871217)
- Testing
- 68Ga-NODAGA-RGD PET-imaging
- Where
- 3 sites in Finland, Netherlands and 1 more
- Volunteers
- 60 people
- Sponsor
- Turku University Hospital
Congenital Complete Atrioventricular Heart Block, High Grade Atrioventricular Block
Effects of Chronic Right Ventricular Pacing in Children With Advanced Atrioventricular Block
Recent studies have shown that chronic stimulation of the right ventricle can cause deleterious effects to cardiac function and synchronicity.
- Conditions
- Congenital Complete Atrioventricular Heart Block, High Grade Atrioventricular Block, Postoperative Complete Heart Block
- Trial name
- NCT01477658
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- University of Sao Paulo
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Peripheral Artery Disease
REGistry of Long-term AnTithrombotic TherApy-1
To assess the rates of ischemic and hemorrhagic complications of long-term antithrombotic therapy in patients with chronic coronary syndromes
- Trial name
- REGATTA-1 (NCT04347200)
- Testing
- Antiplatelet Drug
- Where
- Russia
- Volunteers
- 2,000 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Chronic Total Occlusion of Coronary Artery
Safety and Efficacy Study of the SoundBite™ Crossing System With ACTIVE Wire in Coronary CTOs.
The objective of this study is to evaluate the safety and efficacy of the SoundBite™ Crossing System - Coronary (SCS-C) in a subject population with chronic coronary artery disease including Chronic Total Occlusion (CTO).
- Trial name
- ACTIVE (NCT03521804)
- Testing
- SoundBite™ Crossing System Active Wire 14
- Where
- 5 sites in United States, Canada
- Volunteers
- 35 people
- Sponsor
- SoundBite Medical Solutions, Inc.
Coronary Occlusions
AngiographiC Evaluation of the Everolimus-Eluting Stent in Chronic Total Occlusions - the ACE-CTO Study
Chronically total occlusions (CTO) are difficult to treat and have high risk for restenosis. Although everolimus-eluting stents (EES) [(Xience, Abbott Vascular) or Promus (Boston Scientific)] are very promising for the treatment…
- Trial name
- ACE-CTO (NCT01012869)
- Testing
- everolimus-eluting stent
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- North Texas Veterans Healthcare System
Chronic Total Occlusion of Coronary Artery
EvaLuAtion On the cHaracteristics of the True/False lUmen and Its Prognostic Value for cOronary CTO Patients Just Before Stent Implantation
IVUS will be used to evaluate the ratio of false lumen to occluded segment, the ratio of false lumen to stent length, the location characteristics of false lumen and its prognostic value for perioperative complications, 1-year…
- Trial name
- NCT04965207
- Volunteers
- 1,000 people
- Sponsor
- Shanghai 10th People's Hospital
Chronic Heart Failure
Splanchnic Nerve Block for Therapy of Chronic Heart Failure (Splanchnic III)
Splanchnic vasoconstriction may contribute to decompensation of chronic heart failure (HF) via volume redistribution from the splanchnic vascular bed to the central compartment.
- Trial name
- NCT04575428
- Testing
- Splanchnic nerve block
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Duke University
Coronary Artery Disease, Ischemia and No Obstructive Coronary Arteries
Coronary Microcirculatory Disease and Inflammation in Patients With Chronic Coronary Syndrome and no Significant Coronary Artery Stenosis
Patients with chronic coronary syndromes (CCS) diagnosed without significant lesions in invasive coronary angiography (ischemia non-obstructive coronary artery disease - INOCA) represent approximately 50% of all patients with…
- Conditions
- Coronary Artery Disease, Ischemia and No Obstructive Coronary Arteries, Ischemic Heart Disease, Microvascular Angina
- Trial name
- MOSAIC-COR (NCT05313919)
- Testing
- Comprehensive functional diagnostics of coronary circulation
- Where
- Poland
- Volunteers
- 160 people
- Sponsor
- Bartlomiej Guzik
Coronary Artery Disease, Chronic Coronary Syndrome
Very Long Versus Overlapping Stents in Long Coronary Lesions
This study is performed to compare the angiographic and clinical outcomes of the use of single long stent versus overlapping stents in the treatment of long coronary lesions in patients with chronic coronary syndrome.
- Conditions
- Coronary Artery Disease, Chronic Coronary Syndrome, Drug Eluting Stents
- Trial name
- NCT04738344
- Testing
- Percutaneous Coronary Intervention and Stent Implantation
- Where
- 2 sites in Egypt
- Sponsor
- The Young Investigator Group of Cardiovascular Research
Insomnia, Insomnia Chronic
SHADES Mechanistic Trial
Cardiovascular disease (CVD) is common, deadly, and costly, and adults with insomnia represent a large group of people at elevated risk of developing CVD in the future.
- Conditions
- Insomnia, Insomnia Chronic, Insomnia, Primary, Sleep Disturbance
- Trial name
- SHADES (NCT06041581)
- Testing
- Sleep Healthy Using The Internet (SHUTi), Telephonic CBT-I, Face-to-Face CBT-I
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Indiana University