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Cardiovascular DiseasesJHSNCT00005485

The Jackson Heart Study of Cardiovascular Disease Among African Americans

An observational study of Cardiovascular Diseases and Heart Diseases, run by National Heart, Lung, and Blood Institute (NHLBI) at 1 site in United States.

Active, not recruiting

Under way, not looking for participants. Everyone needed has enrolled. The study is still running.

Official record
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Trial summary

This is a prospective study of the environmental and genetic factors that influence the development of cardiovascular disease (CVD) in African American adults. The cohort is a collaboration among multiple institutions (Jackson State University, Mississippi State Department of Health, Tougaloo College, and the… Read more about this study

Who is it for?
Ages 35 to 84 yearsHealthy volunteers can take part
How many people
5,306 participants
Where
1 siteUnited States
Study dates
19 Sep 2000to 12 Aug 2025
Phase
Observational
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 35 to 84 years
  • All sexes
  • Healthy volunteers accepted
  • Adult, Older adult

Study population: African-American adult residents of metropolitan Jackson, Mississippi

Who may be able to join

  • African American
  • Residents of Jackson, Mississippi

Who cannot join

  • Institutionalization

Trial locations and contacts

1 site in 1 country.

United States1 site

  • UMMC, JSU, Tougaloo College, MSDH

    Jackson, Mississippi, 39213

Other trials in United States

About this study

This is a prospective study of the environmental and genetic factors that influence the development of cardiovascular disease (CVD) in African American adults. The cohort is a collaboration among multiple institutions (Jackson State University, Mississippi State Department of Health, Tougaloo College, and the University of Mississippi Medical Center), NIMHD, and NHLBI.

Read the detailed description

The Jackson Heart Study (JHS) initiated in 1998, is a longitudinal investigation of genetic and environmental risk factors associated with the disproportionate burden of cardiovascular disease (CVD) in African American adults. In addition, the JHS conducts community education and outreach activities to promote healthy lifestyles and reduce disease risk burden, undergraduate- and graduate-level research training programs, and high school science and math enrichment programs to prepare and encourage students to pursue biomedical careers. The study recruited 5306 African American adults living in the Jackson, MS area (Hinds, Madison, and Rankin Counties). Participants were enrolled from each of 4 recruitment pools: random, 17%; volunteer, 30%; currently enrolled in the Atherosclerosis Risk in Communities (ARIC) Study, 31% (shared JHS/ARIC cohort); and secondary family members, 22%. Recruitment was limited to non-institutionalized African American adults aged 35-84 years, except in a nested family cohort where those aged 21+ years were also eligible. Among those enrolled, approximately 3,700 gave consent that allows genetic research and deposition of data into dbGaP. JHS participants have completed four clinical examinations (Exam 1, 2000-04; Exam 2, 2005-08; Exam 3, 2009-13; Exam 4, 2021-2025) that have generated extensive longitudinal data on traditional and putative CVD risk factors, socioeconomic and sociocultural factors, biochemical analytes, and measures of subclinical disease from echocardiography, cardiac magnetic resonance imaging (MRI), and computed tomography (CT) scans of the heart, aorta, and abdomen. Stored biological samples have been assayed for putative biochemical risk factors and stored for future research. DNA has been extracted and lymphocytes cryopreserved for study of candidate genes, genome-wide scanning, expression, and other -omics investigations. Participants have been contacted annually to update information, confirm vital status, document interim medical events, hospitalizations, and functional status, and obtain additional sociocultural information. Ongoing cohort surveillance includes abstraction of medical records and death certificates for relevant International Classification of Diseases (ICD) codes and adjudication of nonfatal events and deaths. The JHS serves as a resource to the scientific community for novel research, promotes cardiovascular health in the local community, and encourages students and fellows to pursue biomedical careers.

Keywords
Cardiovascular diseases, Heart failure, Stroke, Coronary heart disease, Diabetes, Hypertension, Chronic kidney disease
Medical subject headings
Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Coronary Disease, Hypertension, Cerebrovascular Disorders, Heart Failure, Stroke

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Cardiovascular Disease

    Coronary Heart Disease, Stroke, Heart Failure

    Measured: 2000-2016

Secondary outcomes (1)

  1. Mortality

    All Cause

    Measured: 2000-2018

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted26 May 2000 (estimated)
  2. Study start19 Sep 2000
  3. Primary completion12 Aug 2025 (estimated)
  4. Study completion12 Aug 2025 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Prospective
Enrolment
5,306 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT00005485
Sponsor's protocol ID
5001
Other IDs
HHSN268201800010I, HHSN268201800011I, HHSN268201800012I, HHSN268201800013I, HHSN268201800014I, HHSN268201800015I
Acronym
JHS
Status last verified
Jun 2025
First submitted
25 May 2000
Last updated
9 Jul 2025
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Yes: The JHS adheres to NIH and NHLBI policies for data sharing of epidemiologic studies. Data from each cycle of an examination or follow-up component are prepared by the JHS Coordinating Center and sent to the NHLBI PO for distribution as a data set after the completion of each examination or two years after the baseline, follow-up, genetic, ancillary study, or other data set is finalized within the study for analysis for use in publication. De-identified data from Exams 1, 2 and 3 of the JHS are available and shared commonly through the JHS processes for presentation and publication and ancillary studies. Public datasets for Exam 1, Exam 2, and Exam 3 have been provided to BioLINCC and dbGaP.

Publications

  • Sempos CT, Bild DE, Manolio TA. Overview of the Jackson Heart Study: a study of cardiovascular diseases in African American men and women. Am J Med Sci. 1999 Mar;317(3):142-6. doi: 10.1097/00000441-199903000-00002.

    PubMed 10100686

  • Crook ED, Taylor H. Traditional and non-traditional risk factors for cardiovascular and renal disease in African Americans: a project of the Jackson Heart Study investigators. Am J Med Sci. 2002 Sep;324(3):115. doi: 10.1097/00000441-200209000-00001. No abstract available.

    PubMed 12240708

  • Wyatt SB, Williams DR, Calvin R, Henderson FC, Walker ER, Winters K. Racism and cardiovascular disease in African Americans. Am J Med Sci. 2003 Jun;325(6):315-31. doi: 10.1097/00000441-200306000-00003.

    PubMed 12811228

  • Crook ED, Taylor H. Traditional and nontraditional risk factors for cardiovascular and renal disease in African Americans (Part 2): a project of the Jackson Heart Study investigators. Am J Med Sci. 2003 Jun;325(6):305-6. doi: 10.1097/00000441-200306000-00001. No abstract available.

    PubMed 12811226

  • Taylor HA Jr. Establishing a foundation for cardiovascular disease research in an African-American community--the Jackson Heart Study. Ethn Dis. 2003 Fall;13(4):411-3.

    PubMed 14632260

  • Carpenter MA, Crow R, Steffes M, Rock W, Heilbraun J, Evans G, Skelton T, Jensen R, Sarpong D. Laboratory, reading center, and coordinating center data management methods in the Jackson Heart Study. Am J Med Sci. 2004 Sep;328(3):131-44. doi: 10.1097/00000441-200409000-00001.

    PubMed 15367870

  • Wyatt SB, Diekelmann N, Henderson F, Andrew ME, Billingsley G, Felder SH, Fuqua S, Jackson PB. A community-driven model of research participation: the Jackson Heart Study Participant Recruitment and Retention Study. Ethn Dis. 2003 Fall;13(4):438-55.

    PubMed 14632263

  • Taylor HA Jr, Clark BL, Garrison RJ, Andrew ME, Han H, Fox ER, Arnett DK, Samdarshi T, Jones DW. Relation of aortic valve sclerosis to risk of coronary heart disease in African-Americans. Am J Cardiol. 2005 Feb 1;95(3):401-4. doi: 10.1016/j.amjcard.2004.09.043.

    PubMed 15670554

  • Echouffo-Tcheugui JB, Mwasongwe SE, Musani SK, Hall ME, Correa A, Hernandez AF, Golden SH, Mentz RJ, Bertoni AG. Dysglycemia and incident heart failure among blacks: The jackson heart study. Am Heart J. 2022 Mar;245:1-9. doi: 10.1016/j.ahj.2021.11.003. Epub 2021 Nov 19.

    PubMed 34808103

  • Rao VN, Bush CG, Mongraw-Chaffin M, Hall ME, Clark D 3rd, Fudim M, Correa A, Hammill BG, O'Brien E, Min YI, Mentz RJ. Regional Adiposity and Risk of Heart Failure and Mortality: The Jackson Heart Study. J Am Heart Assoc. 2021 Jul 20;10(14):e020920. doi: 10.1161/JAHA.121.020920. Epub 2021 Jul 9.

    PubMed 34238024

  • Rosen DM, Kundel V, Rueschman M, Kaplan R, Guo N, Wilson JG, Min YI, Redline S, Shah N. Self-reported snoring and incident cardiovascular disease events: results from the Jackson Heart Study. Sleep Breath. 2019 Sep;23(3):777-784. doi: 10.1007/s11325-018-01776-1. Epub 2019 Feb 13.

    PubMed 30756321

Questions about this trial

What is this clinical trial studying?

An observational study of Cardiovascular Diseases and Heart Diseases, run by National Heart, Lung, and Blood Institute (NHLBI) at 1 site in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: under way, not looking for participants, as of the sponsor's last update on 9 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Cardiovascular Disease (time frame: 2000-2016). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT00005485, which also lists 11 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Jul 2025.

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