Clinical trials: Chronic Constipation
Constipation, Childhood Acute Lymphoblastic Leukemia
Comparison of Gastrointestinal Motility in Healthy Children and Children With Constipation
To gain a better understanding of the underlying dysmotility in constipation in children, we will use a novel minimal invasive method called 3D Transit.
- Conditions
- Constipation, Childhood Acute Lymphoblastic Leukemia, Neurofibromatosis 1, Chronic Constipation With Overflow
- Trial name
- NCT03981510
- Testing
- 3D-Transit
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Abdominal Pain, Constipation - Functional
Lactobacillus Reuteri in Treatment of Functional Abdominal Pain and Chronic Constipation in Children
Beneficial therapeutic effect of probiotics has been reported in children with irritable bowel syndrome, but not consistently in other functional gastrointestinal disorders.
- Trial name
- NCT01587846
- Testing
- Administration of L.reuteri in children with abdominal pain, Administration of L.reuteri in children with constipation
- Where
- Croatia
- Volunteers
- 300 people
- Sponsor
- Sisters of Mercy University Hospital
Chronic Constipation
A Study to Evaluate Dose Responses of Efficacy and Safety of ASP0456 in Patient With Chronic Constipation
The objective of this study is to investigate dose-responses of efficacy and safety of ASP0456 in patients with chronic constipation (diagnosed by Rome III criteria of functional constipation (FC), not including constipation due…
- Trial name
- NCT02425722
- Testing
- ASP0456
- Where
- 50 sites in Japan
- Volunteers
- 383 people
- Sponsor
- Astellas Pharma Inc
Chronic Constipation
Effect of PEG, Bisacodyl and Prucalopride on Colonic Motility in Healthy Subjects
This study aim was to evaluate the effect of pharmacological treatments normally used to treat functional constipation and in particular PEG, bisacodyl and prucalopride on colonic motility as assessed by high-resolution manometry.
- Trial name
- NCT03279341
- Testing
- polyethylene glycol, Bisacodyl, Prucalopride
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Chronic Constipation
General Clinical Study of AJG555 in Pediatric Patients With Chronic Constipation
This baseline-controlled, open-label, multicenter study evaluates the efficacy and safety of AJG555 orally administered for 2 weeks in pediatric participants with chronic constipation.
- Trial name
- NCT02961556
- Testing
- AJG555
- Where
- 11 sites in Japan
- Volunteers
- 39 people
- Sponsor
- EA Pharma Co., Ltd.
Irritable Bowel Syndrome
Prevalence of Intestinal Parasitic Infections in Patients With Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is common medical disorder and represent a group of diseases of the gastrointestinal tract that is characterized by chronic abdominal pain , bloating , passage of mucus or straining with bowel…
- Trial name
- NCT05830370
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sohag University
Constipation
An Observational Study to Evaluate the Quality of Life in Korean Female Participants With Chronic Constipation
The purpose of this observational study is to investigate health related quality of life (QoL) in Korean female participants with chronic constipation (long term decreased number of or difficulty making bowel movements) having…
- Trial name
- NCT01902537
- Testing
- Prucalopride; observational study
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Janssen Korea, Ltd., Korea
Chronic Constipation
Comparing Manual and Automatic Colonic Massage for Chronic Constipation.
The aim of this study is to do a systematic review and metanalysis of the scientific literature to compare the effectiveness of the manual vs the automatic colonic massage intervention in patients with chronic constipation.
- Trial name
- COMACOMACC (NCT06695754)
- Where
- Spain
- Volunteers
- 2,312 people
- Sponsor
- usMIMA S.L.
Chronic Idiopathic Constipation
Evaluation of the Bioequivalence of Sprinkle and Capsule Formulations of Lubiprostone, as Compared to Placebo
The purpose of this study is to evaluate the bioequivalence of sprinkle and capsule formulations of lubiprostone, as compared to placebo, when administered orally in participants with Chronic Idiopathic Constipation (CIC).
- Trial name
- NCT03097861
- Testing
- Lubiprostone
- Where
- 67 sites in United States
- Volunteers
- 552 people
- Sponsor
- Sucampo Pharma Americas, LLC
Constipation
Soy Polysaccharide Fiber for the Treatment of Chronic Constipation in Children: a Randomized, Double-blind Trial
The study tested the hypothesis that soy polysaccharide fiber reduces clinical symptoms of chronic constipation.
- Trial name
- SOYFIBER (NCT01267370)
- Testing
- Soy polysaccharide fiber
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of São Paulo
Constipation
Functional Magnetic Stimulation Enhances Gastrointestinal Motility in Patients With Chronic Constipation
The purpose of this study is to evaluate the effects of Functional Magnetic stimulation (FMS) on gastrointestinal motility in patients suffering from chronic constipation due to non-neurological issues.
- Trial name
- NCT01786837
- Testing
- Functional Magnetic Stimulation
- Where
- United States
- Sponsor
- The Cleveland Clinic
Constipation
Study Evaluating Oral MOA-728 for the Treatment of Opioid-Induced Bowel Dysfunction (OIBD) in Subjects With Chronic Non-Malignant Pain
The primary purpose of the protocol is to evaluate the safety, efficacy, and tolerability of MOA-728 in subjects with Opioid-Induced Bowel Dysfunction (OIBD) with associated chronic non-malignant pain.
- Trial name
- NCT00366431
- Testing
- MOA-728
- Where
- 67 sites in United States
- Volunteers
- 420 people
- Sponsor
- Bausch Health Americas, Inc.
Constipation
Probiotics for Alleviating Chronic Constipation in Adults
To investigate the clinical effects of probiotics in relieving intestinal motility and chronic constipation through regulating gut microbiota.
- Trial name
- NCT07152795
- Testing
- Probiotic
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Chronic Pain
Targin® for Chronic Pain Management in Patients With Spinal Cord Injury
The study will be investigating the effectiveness of oxycodone-naloxone (brand name Targin®) at treating chronic pain in individuals with spinal cord injury.
- Trial name
- NCT03179475
- Testing
- Oxycodone Naloxone Combination
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of British Columbia
Parkinson's Disease
A Phase 2 Study to Evaluate the Safety and Efficacy of RM-131 in Patients With Parkinson's Disease & Chronic Constipation
The purpose of this study, called MOVE-PD, is to investigate how individuals with Parkinson's disease (PD) and chronic constipation (CC) respond to RM-131 as compared to placebo.
- Trial name
- MOVE-PD (NCT01955616)
- Testing
- RM-131
- Where
- 13 sites in United States
- Volunteers
- 18 people
- Sponsor
- Motus Therapeutics, Inc.
Chronic Constipation, Functional Constipation
A Phase 2 Study to Evaluate Pharmacodynamics of YKP10811 in Patients With Chronic or Functional Constipation
This will be a single-center, randomized, parallel group, multiple dose administration, double-blind, placebo-controlled study to evaluate the effects of YKP10811 on gastric, small bowel, and colonic transit in patients with…
- Trial name
- NCT01523184
- Testing
- YKP10811 Drug Product Capsule
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- SK Life Science, Inc.
Male Subjects With Chronic Constipation
Evaluation of Prucalopride in Male Subjects With Chronic Constipation.
This is a multi-centre, randomised, parallel-group, double-blind, placebo-controlled phase III trial to evaluate the efficacy of prucalopride versus placebo over 12 weeks of treatment in male subjects with chronic constipation.
- Trial name
- NCT01147926
- Testing
- Prucalopride
- Where
- 73 sites in Belgium, Bulgaria and 8 more
- Volunteers
- 374 people
- Sponsor
- Shire
Chronic Idiopathic Constipation
An Efficacy and Safety Study of Plecanatide in Adolescents 12 to <18 Years of Age With Chronic Idiopathic Constipation
This is a study of efficacy and safety of Plecanatide in pediatric subjects aged 12 to < 18 years diagnosed with Chronic Idiopathic Constipation.
- Trial name
- NCT03120520
- Testing
- Plecanatide
- Where
- 36 sites in United States
- Volunteers
- 124 people
- Sponsor
- Bausch Health Americas, Inc.
Chronic Constipation
Effect of Transcutaneous Auricular Vagal Nerve Stimulation on Chronic Constipation
The worldwide prevalence of chronic constipation (CC) is 15%, and women are more likely to develop the disease than men. CC have a significant impact on quality of life and increase the burden of national health insurance.
- Trial name
- NCT05723731
- Testing
- taVNS, Laxative Agent
- Where
- 5 sites in China
- Volunteers
- 106 people
- Sponsor
- Air Force Military Medical University, China
Chronic Constipation
Study to Investigate Prucalopride vs. Polyethylene Glycol 3350 on Colon Activity
To evaluate the different effects of prucalopride and PEG 3350 + electrolytes on colon motor activity in subjects that are chronically constipated.
- Trial name
- NCT01707667
- Testing
- prucalopride, PEG 3350
- Where
- 3 sites in United States, Belgium and 1 more
- Volunteers
- 13 people
- Sponsor
- Shire